322-35-0
322-35-0
Chemical Structure
Benserazide
Synonym(s): Ro 4-4602
- CAS. Nr.: 322-35-0
- Formula:C10H15N3O5
- Molecular Weight:257.24
IUPAC Name: 2-amino-3-hydroxy-N'-(2,3,4-trihydroxybenzyl)propanehydrazide
InChIKey: BNQDCRGUHNALGH-UHFFFAOYSA-N
SMILES: NC(C(NNCC1=CC=C(C(O)=C1O)O)=O)CO
Biological Activity: Benserazide is an aromatic L-amino acid decarboxylase (AADC) and L-DOPA decarboxylase inhibitor. Benserazide is also a PKM2 inhibitor. Benserazide directly binds to and blocks PKM2 enzyme activity, leading to inhibition of aerobic glycolysis concurrent up-regulation of OXPHOS. Benserazide can be used for the study of Parkinson's disease and melanoma[1][2][3].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Benserazide | 98.43% | Benserazide is an aromatic L-amino acid decarboxylase (AADC) and L-DOPA decarboxylase inhibitor. Benserazide is also a PKM2 inhibitor. Benserazide directly binds to and blocks PKM2 enzyme activity, leading to inhibition of aerobic glycolysis concurrent up-regulation of OXPHOS. Benserazide can be used for the study of Parkinson's disease and melanoma. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
DHMPA | DHMPA is an effective depletor of norepinephrine content of the heart, brain and spleen in mouse and rat. DHMPA has antihypertensive effects. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
CSRM617 hydrochloride | 99.97% | CSRM617 hydrochloride is a selective small-molecule inhibitor of the transcription factor ONECUT2 (OC2, a master regulator of androgen receptor) with a Kd of 7.43 uM in SPR assays, binding to OC2-HOX domain directly. CSRM617 hydrochloride induces apoptosis by appearance of cleaved Caspase-3 and PARP. CSRM617 hydrochloride is well tolerated in the prostate cancer mouse model | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
CSRM617 (Standard) | ≥98% | CSRM617 (Standard) is the analytical standard of CSRM617. This product is intended for research and analytical applications. CSRM617 is a selective small-molecule inhibitor of the transcription factor ONECUT2 (OC2, a master regulator of androgen receptor) with a Kd of 7.43 uM in SPR assays, binding to OC2-HOX domain directly. CSRM617 induces apoptosis by appearance of cleaved Caspase-3 and PARP. CSRM617 is well tolerated in the prostate cancer mouse model | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
N-β-alanyldopamine hydrochloride | 99.94% | N-β-alanyldopamine hydrochloride (NBAD hydrochloride) is a tyrosine metabolite, Antibacterial agent and Antifungal agent. N-β-alanyldopamine hydrochloride exists in the hemolymph and cuticle during pupal cuticle tanning of the tobacco hornworm (Manduca sexta). N-β-alanyldopamine hydrochloride is the preferred substrate for pupal cuticular o-Diphenol oxidase during insect pupal cuticle tanning. N-β-alanyldopamine hydrochloride inhibits the growth of Escherichia coli, Bacillus megaterium and Saccharomyces cerevisiae in vitro. N-β-alanyldopamine hydrochloride can be used in studies related to microbial infections. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Carbidopa monohydrate | 99.84% | Carbidopa ((S)-(-)-Carbidopa) monohydrate, a peripheral decarboxylase inhibitor, can be used for the research of Parkinson's disease. Carbidopa monohydrate is a selective aryl hydrocarbon receptor (AhR) modulator. Carbidopa monohydrate inhibits pancreatic cancer cell and tumor growth. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Benserazide hydrochloride (Standard) | 99.89% | Benserazide hydrochloride (Standard) (Serazide (Standard)) is the analytical standard of Benserazide hydrochloride (HY-B0404A). This product is intended for research and analytical applications. Benserazide hydrochloride (Serazide) is an aromatic L-amino acid decarboxylase (AADC) and L-DOPA decarboxylase inhibitor. Benserazide hydrochloride is also a PKM2 inhibitor. Benserazide hydrochloride directly binds to and blocks PKM2 enzyme activity, leading to inhibition of aerobic glycolysis concurrent up-regulation of OXPHOS. Benserazide hydrochloride can be used for the study of Parkinson's disease and melanoma. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
2,3,-Dihydroxybenzoylserine | 98.10% | 2,3,-Dihydroxybenzoylserine (2,3-Dihydroxy-N-benzoylserine) is a conjugate of 2,3-dihydroxybenzoic acid and serine. 2,3,-Dihydroxybenzoylserine can be isolated from the culture of E.coli. 2,3,-Dihydroxybenzoylserine is a growth factor with growth-promoting activity in multiple aromatic auxotrophs such as E.coli KI2, strain AB2830. 2,3,-Dihydroxybenzoylserine is a degradation product of biological active compounds. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Melevodopa hydrochloride | 99.76% | Melevodopa (Levodopa methylester) hydrochloride is an orally active methylated prodrug of Levodopa (HY-N0304), a dopamine precursor. When used in combination with Carbidopa (HY-B0311) in an effervescent tablet formulation, Melevodopa hydrochloride inhibits motor fluctuations in Parkinson's disease. Melevodopa hydrochloride suppresses subcutaneous tumor growth, pulmonary metastasis proliferation, and primary mass invasiveness of melanoma. Melevodopa hydrochloride induces lipid peroxidation by increasing malondialdehyde levels in melanoma and improves the survival rate of melanoma-bearing mice. Melevodopa hydrochloride can be used in research related to Parkinson's disease (with motor fluctuations) and melanoma. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
2,2'-(2,5-Dihydroxy-1,4-phenylene)diacetic acid | 98.56% | 2,2'-(2,5-Dihydroxy-1,4-phenylene)diacetic acid (2,5-Dihydroxy-p-benzenediacetic acid) is a metal-organic framework (MOF). | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
1,4-Benzenedicarboxylic acid,2,3-dihydroxy-,1,4-dihydrazide | 1,?4-?Benzenedicarboxylic acid,2,3-dihydroxy-?,1,4-dihydrazide (2,3-Dihydroxyterephthalohydrazide) is a metal-organic framework (MOF). | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Zhou Y, et al. Benserazide is a novel inhibitor targeting PKM2 for melanoma treatment. Int J Cancer. 2020 Jul 1;147(1):139-151. [Content Brief]
- [2]. Shen H, et al. Effects of benserazide on L-DOPA-derived extracellular dopamine levels and aromatic L-amino acid decarboxylase activity in the striatum of 6-hydroxydopamine-lesioned rats. Tohoku J Exp Med. 2003 Mar;199(3):149-59. [Content Brief]
- [3]. Chandel TI, et al. A multiparametric analysis of the synergistic impact of anti-Parkinson's drugs on the fibrillation of human serum albumin. Biochim Biophys Acta Proteins Proteom. 2019 Mar;1867(3):275-285. [Content Brief]
