3 Results for "

Ly6E Antibody

" in MedChemExpress (MCE) Product Catalog:
Products (3)

3 Results for "Ly6E Antibody" in MCE Product Catalog:

Cat. No.: HY-P990659
Synonyms: RG-7841 Antibody

Target:  

Inhibitory Antibodies

Research Areas:  

Inflammation/Immunology

Anti-LY6E Antibody (MLYE4489A) (RG-7841 antibody) is a humanized antibody expressed in CHO targeting Ly6E. Anti-LY6E Antibody (MLYE4489A) contains huIgG2 heavy chain and huκ light chain, with a predicted molecular weight (MW) of 150 kDa. The isotype control for Anti-LY6E Antibody (MLYE4489A) can refer to Human IgG2 kappa, Isotype Control (HY-P99002).
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Cat. No.: HY-P992056

Target:  

Autophagy

Research Areas:  

Cancer

Anti-Human/Mouse LY6E Antibody (9B12) is a high-affinity, multi-target antibody that binds specifically to LY6E. Anti-Human/Mouse LY6E Antibody (9B12) binds specifically to cell-surface LY6E and enters lysosomes via lipid raft-dependent endocytosis, thereby effectively inhibiting the growth of various LY6E-expressing solid tumors (such as breast cancer and lung cancer) in both in vitro and in vivo models. Anti-Human/Mouse LY6E Antibody (9B12) exerts a dual mechanism of action: on one hand, it blocks the interaction between PILRα and CD8α, specifically reduces the survival rate of peripheral CD8 + T cells and induces their activation, breaking the state of cellular quiescence; on the other hand, it recognizes and immunoprecipitates IDE under both non-denaturing and denaturing conditions, which is applicable to studies on the subcellular localization and protein interactions of IDE. The regulatory effect of Anti-Human/Mouse LY6E Antibody (9B12) on CD8 + T cells strictly depends on the presence of PILRα, and it does not affect CD4 + T cells or T cell development in the thymus, exhibiting high specificity .
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Cat. No.: HY-P82773
Synonyms: Ly-6A.2/Ly-6E.1; Ly6a; Ly6al; Lymphocyte antigen 6A-2/6E-1; Lymphocyte antigen Ly 6A.2/Ly 6E.1; SCA-1; Stem cell antigen 1; T cell activating protein; TAP

Host:  

Rabbit

Application:  

WB, IHC-P

Reactivity:  

Mouse

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