Search Result

Results for "

NOX

" in MedChemExpress (MCE) Product Catalog:

By Targets:	NADPH Oxidase (59) Adrenergic Receptor (3) Akt (6) Angiotensin-converting Enzyme (ACE) (3) AP-1 (3) Apoptosis (10) Autophagy (3) Bacterial (1) Caspase (1) CCR (4) COX (2) CXCR (2) Dengue Virus (1) DNA/RNA Synthesis (1) Dopamine Receptor (1) Endogenous Metabolite (1) Environmental Pollutants (1) ERK (1) Ferroptosis (5) Flavivirus (1) Fluorescent Dye (1) Formyl Peptide Receptor (FPR) (1) Fungal (3) Glutathione Peroxidase (2) HBV (1) Hepcidin (2) Herbicide (1) HSV (1) iGluR (1) Interleukin Related (3) Isotope-Labeled Compounds (1) JAK (1) JNK (3) mAChR (1) Monoamine Oxidase (1) mTOR (3) MyD88 (2) nAChR (2) NF-κB (7) NO Synthase (4) p38 MAPK (4) PAK (3) Parasite (1) PARP (1) Phospholipase (2) PKC (1) Ras (3) Reactive Oxygen Species (ROS) (25) Reference Standards (9) ROCK (3) SARS-CoV (1) Small Interfering RNA (siRNA) (10) SOD (1) STAT (1) TGF-beta/Smad (1) TGF-β Receptor (2) TNF Receptor (2) Toll-like Receptor (TLR) (2) TRP Channel (3) Tyrosinase (1)
By Research Areas:	Cancer (23) Cardiovascular Disease (25) Endocrinology (1) Infection (5) Inflammation/Immunology (30) Metabolic Disease (16) Neurological Disease (21)
Click Chemistry:	Alkynes (1)
Oligonucleotides:	Aptamers (3) Rat Pre-designed siRNA Sets (3) Mouse Pre-designed siRNA Sets (3) Human Pre-designed siRNA Sets (4) Antisense Oligonucleotides (4) siRNAs (10)

Inhibitors & Agonists

Fluorescent Dye

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

Targets Recommended: NADPH Oxidase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-10071

Y-27632 Maximum Cited Publications 534 Publications Verification	mTOR Ras ROCK NADPH Oxidase NF-κB Reactive Oxygen Species (ROS) Akt Apoptosis Autophagy PAK	Cancer
Y-27632 is a ROCK inhibitor with K_i values of 220 nM and 300 nM for ROCK1 and ROCK2, respectively. Y-27632 exerts anti-inflammatory and immunomodulatory effects in systemic lupus erythematosus models by inhibiting the ROCK/NF-κB pathway. Y-27632 enhances autophagy by inhibiting the AKT/mTOR pathway, thereby inducing apoptosis apoptosis in oral squamous cell carcinoma. Y-27632 induces the formation of tunneling nanotubes in ARPE-19 cells and significantly enhances mitochondrial transfer through these channels. Y-27632 promotes neurite outgrowth in PC12 cells by activating the *Rac1/NOX1/ROS/AKT/PAK1* signaling cascade .

HY-12298

Setanaxib 25+ Cited Publications GKT137831; GKT831	NADPH Oxidase Ferroptosis	Cardiovascular Disease
Setanaxib (GKT137831) is a selective NADPH oxidase (NOX1/4) inhibitor with K_is of 140 and 110 nM, respectively.

HY-100965

Diphenyleneiodonium chloride 55+ Cited Publications DPI	TRP Channel NADPH Oxidase Reactive Oxygen Species (ROS)	Neurological Disease Inflammation/Immunology
Diphenyleneiodonium chloride is a NADPH oxidase (NOX) inhibitor and also functions as a TRPA1 activator with an EC₅₀ of 1 to 3 μM. Diphenyleneiodonium chloride selectively inhibits intracellular reactive oxygen species.

HY-113324

NADPH Maximum Cited Publications 18 Publications Verification	Endogenous Metabolite	Cancer
NADPH is a coenzyme of glutathione reductase (GR), thioredoxin reductase (TrxR) and NADPH oxidase (NOX), and participates in redox reactions as a hydrogen donor. NADPH has the characteristic of selectively participating in the regulation of cellular redox homeostasis. NADPH exerts antioxidant activity and resists reactive oxygen species (ROS) damage by providing reducing equivalents for the regeneration of glutathione (GSH) and thioredoxin (Trx); at the same time, it acts as a substrate of NOX to generate superoxide anions, mediating oxidative stress and immune response. NADPH participates in maintaining the intracellular reducing environment, biosynthesis and regulating gene expression (such as the Nrf2 pathway), and is mainly used in the study of oxidative stress-related diseases (such as cardiovascular diseases, neurodegenerative diseases, cancer) and immune regulation mechanisms .

HY-108537

L 012 sodium salt 2 Publications Verification	Reactive Oxygen Species (ROS)	Inflammation/Immunology
L 012 sodium salt is a luminal-based chemiluminescent probe. L 012 sodium salt can detect NADPH oxidase (Nox)-derived superoxide and nitrogen species (reactive oxygen species (ROS) and reactive nitrogen species (RNS)) .

HY-18950

GSK2795039 70+ Cited Publications	NADPH Oxidase Reactive Oxygen Species (ROS) Apoptosis	Cancer
GSK2795039 is a NADPH oxidase 2 (NOX2) inhibitor with a mean pIC₅₀ of 6 in different cell-free assays. GSK2795039 inhibits reactive oxygen species (ROS) production and NADPH consumption . GSK2795039 reduces apoptosis .

HY-B0807A

Prochlorperazine dimaleate	Dopamine Receptor NADPH Oxidase Dengue Virus Flavivirus	Neurological Disease Inflammation/Immunology Cancer
Prochlorperazine dimaleate is an orally active phenothiazine-type dopamine D2 receptor (D2R) antagonist. Prochlorperazine exhibits anti-cancer activity in vitro against various cancer cell lines. Prochlorperazine dimaleate exhibits IC₅₀ values of 6.4 μM, 4.5 μM and 2.3 μM for *NOX1, NOX2* and *NOX5*, respectively. Prochlorperazine dimaleate has antedesmosidic activity against dengue virus (DENV). Prochlorperazine dimaleate can be used for research on nausea, vomiting, migraine, and schizophrenia .

HY-12805

ML171 15+ Cited Publications 2-Acetylphenothiazine; 2-APT	NADPH Oxidase	Cardiovascular Disease
ML171 (2-Acetylphenothiazine;2-APT) is a potent and selective NADPH oxidase 1 (Nox1) inhibitor that blocks Nox1-dependent ROS generation, with an IC₅₀ of 0.25 μM in HEK293-Nox1 confirmatory assay.

HY-100111

GLX351322 45+ Cited Publications	NADPH Oxidase	Metabolic Disease
GLX351322 is an inhibitor of NADPH oxidase 4 (Nox4), and inhibits hydrogen peroxide production from NOX4-overexpressing cells with an IC₅₀ of 5 μM.

HY-12804

VAS2870 15+ Cited Publications	NADPH Oxidase	Cardiovascular Disease
VAS2870 is a NADPH oxidase (NOX) inhibitor.

HY-N3610

Coclaurine 1 Publications Verification	nAChR	Cancer
Coclaurine is a class of tetrahydroisoquinoline alkaloids that can be isolated from Sarcopetalum harveyanum with anticancer activity. Coclaurine is a nicotinic acetylcholine receptor (nAChRs) antagonist. Coclaurine is a key molecule in S. tetrandra responsible for EFHD2 inhibition. Coclaurine can downregulate EFHD2-related NOX4-ABCC1 signaling and enhanced Cisplatin (HY-17394) sensitivity. Coclaurine suppresses the stemness and metastatic properties of NSCLC cells. Coclaurine disrupts the interaction between the transcription factor FOXG1 and the EFHD2 promoter, leading to a reduction in EFHD2 transcription .

HY-160041A

Olaptesed pegol sodium NOX-A12 sodium	CXCR	Cancer
Olaptesed pegol (NOX-A12) sodium is a L-oligoribonucleotide aptamer targeting CXCL12 based on a pegylated structure. Olaptesed pegol sodium neutralizes CXCL12, and CXCL12 inhibition mobilizes chronic lymphocytic leukemia cells into the circulation and prevents their homing into the protective microenvironment. Olaptesed pegol sodium can enhances the infiltration of human primary T cells and NK cells and inhibit tumor growth companied with anti-PD-1 antibody. Olaptesed pegol sodium can be used for researches of colon cancer and lymphocytic leukemia .

HY-160041

Olaptesed pegol NOX-A12	CXCR	Cancer
Olaptesed pegol (NOX-A12) is a L-oligoribonucleotide aptamer targeting CXCL12 based on a pegylated structure. Olaptesed pegol neutralizes CXCL12, and CXCL12 inhibition mobilizes chronic lymphocytic leukemia cells into the circulation and prevents their homing into the protective microenvironment. Olaptesed pegol can enhances the infiltration of human primary T cells and NK cells and inhibit tumor growth companied with anti-PD-1 antibody. Olaptesed pegol can be used for researches of colon cancer and lymphocytic leukemia .

HY-120801

APX-115 2 Publications Verification Ewha-18278	NADPH Oxidase	Metabolic Disease Inflammation/Immunology
APX-115 (Ewha-18278) is a potent, orally active pan NADPH oxidase (Nox) inhibitor with K_i values of 1.08 μM, 0.57 μM, and 0.63 μM for *Nox1, Nox2* and *Nox4*, respectively. APX-115 effectively prevents kidney injury .

HY-120801A

APX-115 free base 2 Publications Verification Ewha-18278 free base; Isuzinaxib free base	NADPH Oxidase	Inflammation/Immunology Endocrinology
APX-115 free base (Ewha-18278 free base) is a potent, orally active pan NADPH oxidase (Nox) inhibitor with K_i values of 1.08 μM, 0.57 μM, and 0.63 μM for *Nox1, Nox2* and *Nox4*, respectively. APX-115 free base effectively prevents kidney injury .

HY-101499

GKT136901 4 Publications Verification	NADPH Oxidase	Neurological Disease Metabolic Disease Inflammation/Immunology
GKT136901 is a potent, selective and orally active inhibitor of NADPH oxidase (NOX1/4), with K_is of 160 and 165 nM, respectively. GKT136901 is also a selective and direct scavenger of peroxynitrite. GKT136901 can be used for the research of diabetic nephropathy, stroke, and neurodegeneration. GKT136901 also has anti-inflammatory activity .

HY-118315

L-012 2 Publications Verification	Fluorescent Dye	Inflammation/Immunology
L-012 is a luminal-based chemiluminescent probe. L-012 sodium salt can detect NADPH oxidase (Nox)-derived superoxide and nitrogen species (reactive oxygen species (ROS) and reactive nitrogen species (RNS)) .

HY-148100

Emapticap pegol 1 Publications Verification NOX-E36	CCR	Inflammation/Immunology Cancer
Emapticap pegol (NOX-E36) is a inhibitor of pro-inflammatory chemokine C-C motif-ligand 2 (CCL2). Emapticap pegol is a 40-nucleotide oligonucleotide aptamer, displays different Spiegelmers (L-RNA aptamer) isform in human (NOX-E36) and mouse (mNOX-E36). mNOX-E36 is a murine-specific analogue of NOX-E36, an anti-MCP-1 L-RNA aptamer that was previously shown to attenuate liver fibrosis in mice .

HY-173591

T0080	Formyl Peptide Receptor (FPR) Apoptosis	Cardiovascular Disease Neurological Disease Inflammation/Immunology
T0080 is a central nervous system-penetrant FPR1 inhibitor. By functionally blocking the FPR1 signaling pathway, T0080 effectively reduces neutrophil infiltration into ischemic brain tissue and maintains the integrity of the blood-brain barrier. T0080 alleviates tPA-associated hemorrhagic transformation, inhibits demyelination responses and the expression of *NOX2. T0080 also possesses anti-apoptotic (apoptosis*) and anti-inflammatory properties, thereby protecting myelin and reducing neurological deficits. T0080 is widely used in studies related to ischemic stroke complicated by hemorrhagic transformation after tPA thrombolysis, as well as multiple sclerosis .

HY-P5381

gp91 ds-tat 1 Publications Verification	NADPH Oxidase Ferroptosis Reactive Oxygen Species (ROS) Glutathione Peroxidase TRP Channel	Cardiovascular Disease Neurological Disease Inflammation/Immunology
gp91 ds-tat, a biological active peptide, is a NADPH oxidase 2 (Nox2) inhibitor. gp91 ds-tat blocks NADPH oxidase-dependent superoxide production. gp91 ds-tat ameliorates high glucose-induced increase in total ROS, LPOs and iron levels. gp91 ds-tat inhibits homocysteine (Hcy)-induced activation of NLRP3 inflammasomes and restores Hcy-inhibited lysosomal TRPML1 channel activity. gp91 ds-tat improves cerebrovascular and cognitive function in APP/PS1 mice. gp91 ds-tat can be used for the study of Alzheimer’s disease (AD), glomerular inflammation and cardiovascular disease .

HY-N2255

Crebanine 4 Publications Verification	Akt Apoptosis NF-κB Reactive Oxygen Species (ROS) p38 MAPK ERK Interleukin Related TNF Receptor NO Synthase nAChR Bacterial	Cancer
Crebanine is an isoquinoline-like alkaloid that can be derived from Stephania. Crebanine is an antagonist of the α7-nAChR with an IC₅₀ of 19.1 μM. Crebanine suppresses the proliferation, migration, and invasion of cancer cells, triggers reactive oxygen species (ROS) burst, and promotes apoptosis. Crebanine inhibits the AKT/FoxO3a, NF-κB and MAPK signaling pathways. Crebanine attenuates NOX2 hyperactivation, exhibits antioxidant properties by reducing reactive oxygen species and peroxidation in microglia cells. Crebanine inhibits voltage-dependent Na ⁺ current in guinea-pig ventricular myocytes. Crebanine has high inhibitory activity against gram-positive animal pathogenic bacteria. Crebanine ameliorates ischemia-reperfusion brain damage in middle cerebral artery occlusion and reperfusion (MCAO/R) rats. Crebanine significantly improves Scopolamine (HY-N0296)-induced cognitive deficits in ICR mice. Crebanine can be used for the study of hepatocellular carcinoma (HCC), cerebral ischemia and Alzheimer's disease .

HY-152026

NADPH oxidase-IN-1	NADPH Oxidase	Neurological Disease
NADPH oxidase-IN-1 is an orally active NADPH oxidase (Nox) inhibitor, related with neuronal inflammation. NADPH oxidase-IN-1 can cross the blood-brain barrier (BBB), inhibits *Nox2* and *Nox4* with IC₅₀s of 1.9 μM and 2.47 μM, respectively. NADPH oxidase-IN-1 suppresses pro-inflammatory cytokines production and LPS-mediated microglial migration, also has in vivo efficacy .

HY-126195

Fluoflavine ML-090	NADPH Oxidase	Neurological Disease
Fluoflavine (ML-090) is a selective *NOX1* inhibitor and reactive oxygen species inhibitor. Fluoflavine reduces reactive oxygen species production, *NOX1*-mediated downstream signaling events, and oxygen-glucose deprivation-induced retinal ganglion cell death. Fluoflavine inhibits NADPH oxidase activity and pathological retinal neovascularization induced by oxygen-induced retinopathy in the retinas of ischemic mice. Fluoflavine can be used in studies related to retinal ischemia-reperfusion injury and proliferative retinopathy .

HY-P2222

DX600 3 Publications Verification	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
DX600 is a selective ACE2 specific inhibitor (K_D: 1.3 nM), and does not cross-react with ACE. DX600 exacerbates diabetes-induced cardiovascular dysfunction and the increase in cardiac and renal NOX activity .

HY-N3239

Mulberrofuran G	Tyrosinase NADPH Oxidase HBV SARS-CoV Reactive Oxygen Species (ROS) JAK STAT Apoptosis Caspase PARP	Infection Neurological Disease Inflammation/Immunology Cancer
Mulberrofuran G is a *NOX* inhibitor (IC₅₀: 6.9 μM) and tyrosinase inhibitor. Mulberrofuran G exhibits anti-inflammatory, antioxidant, antiviral, antitumor, and neuroprotective effects. Mulberrofuran G can be used in the research of tumors, nervous system diseases, and other conditions .

HY-Y0278

Chloranil Tetrachloro-p-benzoquinone; TCBQ	Environmental Pollutants JNK Fungal Toll-like Receptor (TLR) Reactive Oxygen Species (ROS) Apoptosis MyD88 Ferroptosis	Infection Neurological Disease Metabolic Disease Inflammation/Immunology
Chloranil (Tetrachloro-p-benzoquinone), an orally active metabolite of pentachlorophenol and hexachlorobenzene, is a widely used fungicide. Chloranil can induce ROS production. Chloranil induces neutrophil extracellular traps through the ROS-JNK-NOX2 pathway. Chloranil induces ferroptosis and neuroinflammation. Chloranil induces apoptosis of mouse embryonic stem cells .

HY-115062

MJ33 lithium salt	Phospholipase NADPH Oxidase p38 MAPK Akt NF-κB AP-1 Reactive Oxygen Species (ROS)	Cardiovascular Disease Inflammation/Immunology Cancer
MJ-33 lithium salt is a competitive phospholipase A₂ (PLA₂) inhibitor with an IC₅₀ of 0.3 μM. MJ-33 lithium salt inhibits *NOX2* activation and reduces ROS production by blocking the PLA₂ activity of Prdx6. MJ-33 lithium salt effectively inhibits the activity of acidic PLA₂ (pH 4.0) and reduces the degradation of alveolar surfactant phosphatidylcholine (PC), but exerts no effect on alkaline PLA₂ (pH 8.5). MJ-33 lithium salt significantly alleviates lung oxidative injury induced by ischemia-reperfusion (I/R). MJ-33 lithium salt significantly inhibits the invasion, migration and adhesion abilities of prostate cancer cells by suppressing the MAPK, AKT, NF-κB and AP-1 signaling pathways. MJ-33 lithium salt can be used for the research of ROS-related diseases and prostate cancer .

HY-153977

GLX481304	NADPH Oxidase	Cardiovascular Disease
GLX481304 is a specific inhibitor of *Nox-2 and -4, with IC₅₀*s of 1.25 μM. GLX481304 suppresses ROS production in isolated mouse cardiomyocytes and improves cardiomyocyte contractility. GLX481304 can be used for research of ischemic injury to the heart .

HY-P1435

NoxA1ds	NADPH Oxidase	Cardiovascular Disease Cancer
NoxA1ds is a potent and highly selective NADPH oxidase 1 (NOX1) inhibitor (IC₅₀=20 nM). NoxA1ds inhibits NOX1-derived O ^2- production in HT-29 human colon cancer cells. NoxA1ds attenuates VEGF-induced human pulmonary artery endothelial cell migration under hypoxic conditions in vitro. NoxA1ds can be used in the study of hypertension, atherosclerosis and tumors .

HY-119576

Phox-I2 1 Publications Verification	NADPH Oxidase Reactive Oxygen Species (ROS)	Inflammation/Immunology
Phox-I2 is a selective inhibitor of p67 ^phox-Rac1 interaction, binds to p67 ^phox with high affinity with a K_d of ~150 nM. Phox-I2 is a NADPH oxidase 2 (NOX2) inhibitor and inhibits reactive oxygen species (ROS) production .

HY-148100A

Emapticap pegol sodium 1 Publications Verification NOX-E36 sodium	CCR	Cancer
Emapticap pegol sodium is a inhibitor of pro-inflammatory chemokine C-C motif-ligand 2 (CCL2). Emapticap pegol sodium is a 40-nucleotide oligonucleotide aptamer, displays different Spiegelmers (L-RNA aptamer) isform in human (NOX-E36) and mouse (mNOX-E36) .

HY-111447

VAS 3947	NADPH Oxidase Apoptosis	Cardiovascular Disease Cancer
VAS 3947, a specific NADPH oxidase (NOX) inhibitor, exerts a potent antiplatelet effect. VAS3947 induces apoptosis independently of anti-NOX activity, via UPR activation, mainly due to aggregation and misfolding of proteins .

HY-101499A

GKT136901 hydrochloride 4 Publications Verification	NADPH Oxidase	Neurological Disease Metabolic Disease
GKT136901 hydrochloride is a potent, selective and orally active inhibitor of NADPH oxidase (NOX1/4), with K_is of 160 and 165 nM, respectively. GKT136901 hydrochloride is also a selective and direct scavenger of peroxynitrite. GKT136901 hydrochloride can be used for the research of diabetic nephropathy, stroke, and neurodegeneration. GKT136901 hydrochloride also has anti-inflammatory activity .

HY-W004643

Akardite II AK-II	Fungal Herbicide	Infection
Akardite II (AK-II) is a stabilizer for nitrocellulose (NC) propellants as it scavenges NO_x. Akardite II helps control a variety of plant pathogens and weeds, which can be used as fungicides and herbicides .

HY-156425A

NOX2-IN-2 diTFA	NADPH Oxidase	Inflammation/Immunology
NOX2-IN-2 diTFA (compound 33) is a potent *NOX2* inhibitor targeting the p47phox-p22phox protein-protein interaction with a K_i of 0.24 μM. NOX2-IN-2 diTFA inhibits ROS production derived from NOX2 in cells .

HY-165027

DL-1′-Acetoxychavicol acetate	NO Synthase COX	Others
DL-1′-Acetoxychavicol acetate is a compound with anti-inflammatory and anticancer preventive potential that inhibits the activities of NOX, iNOS, and COX-2 in inflammatory cells and exhibits preventive activity in multiple inflammation-related cancer models.

HY-10071A

Y-27632 hydrochloride hydrate 395+ Cited Publications	ROCK NF-κB Apoptosis Autophagy Akt mTOR NADPH Oxidase Reactive Oxygen Species (ROS) PAK Ras	Neurological Disease Inflammation/Immunology Cancer
Y-27632 hydrochloride hydrate is a ROCK inhibitor with K_i values of 220 nM and 300 nM for ROCK1 and ROCK2, respectively. Y-27632 hydrochloride hydrate exerts anti-inflammatory and immunomodulatory effects in systemic lupus erythematosus models by inhibiting the ROCK/NF-κB pathway. Y-27632 hydrochloride hydrate enhances autophagy by inhibiting the AKT/mTOR pathway, thereby inducing apoptosis apoptosis in oral squamous cell carcinoma. Y-27632 hydrochloride hydrate induces the formation of tunneling nanotubes in ARPE-19 cells and significantly enhances mitochondrial transfer through these channels. Y-27632 hydrochloride hydrate promotes neurite outgrowth in PC12 cells by activating the *Rac1/NOX1/ROS/AKT/PAK1* signaling cascade .

HY-174817

NOX5-IN-1	NADPH Oxidase Reactive Oxygen Species (ROS)	Cardiovascular Disease Neurological Disease Cancer
NOX5-IN-1 (Compound 13) is a selective NADPH oxidase 5 (NOX5) inhibitor with an IC₅₀s of 0.30  μM. NOX5-IN-1 significantly inhibits NOX5-dependent production of ROS in freestyle293 cells (EC₅₀: 0.86  μM). NOX5-IN-1 can be used for NOXs related diseases research, such as cardiovascular, cancer and neuroinflammation .

HY-12805R

ML171 (Standard) 2-Acetylphenothiazine (Standard); 2-APT (Standard)	NADPH Oxidase Reference Standards	Cardiovascular Disease
ML171 (Standard) is the analytical standard of ML171. This product is intended for research and analytical applications. ML171 (2-Acetylphenothiazine;2-APT) is a potent and selective NADPH oxidase 1 (Nox1) inhibitor that blocks Nox1-dependent ROS generation, with an IC50 of 0.25 μM in HEK293-Nox1 confirmatory assay.

HY-B0203B

(Rac)-Nebivolol (Rac)-R 065824	Adrenergic Receptor NADPH Oxidase	Cardiovascular Disease
(Rac)-Nebivolol ((Rac)-R 065824) is a racemic isomer of Nebivolol. Nebivolol is a selective β1-adrenergic receptor antagonist with an IC₅₀ value of 0.8 nM. Nebivolol can prevent up-regulation of Nox2/NADPH oxidase and lipoperoxidation in the early stages of ethanol-induced cardiac toxicity. Vasodilatory activity .

HY-N9097

Niazirin	Reactive Oxygen Species (ROS) SOD Glutathione Peroxidase PKC NADPH Oxidase	Metabolic Disease Inflammation/Immunology
Niazirin is an orally active antioxidant. Niazirin can be isolated from Moringa oleifera Lam. Niazirin reduces the production levels of ROS and MDA, while increasing the levels of superoxide dismutase SOD and glutathione peroxidase GPx. Niazirin also abolishes high glucose-induced PKCζ activation and inhibits *Nox4* protein expression. Niazirin exhibits excellent free radical scavenging activity. Niazirin significantly inhibits high glucose-induced proliferation of vascular smooth muscle cells. Niazirin can be used in the research of diabetic atherosclerosis .

HY-174818

NOX5-IN-2	NADPH Oxidase Reactive Oxygen Species (ROS)	Cardiovascular Disease Neurological Disease Cancer
NOX5-IN-2 (Compound 17) is a selective NADPH oxidase 5 (NOX5) inhibitor with an IC₅₀s of 0.70  μM. NOX5-IN-2 significantly inhibits NOX5-dependent production of ROS in freestyle293 cells (EC₅₀: 1.8  μM). NOX5-IN-2 can be used for NOXs related diseases research, such as cardiovascular, cancer and neuroinflammation .

HY-156425

NOX2-IN-2	NADPH Oxidase	Inflammation/Immunology
NOX2-IN-2 (compound 33) is a potent *NOX2* inhibitor targeting the p47phox-p22phox protein-protein interaction with a K_i of 0.24 μM. NOX2-IN-2 inhibits ROS production derived from NOX2 in cells .

HY-148936

GLX481372	NADPH Oxidase Reactive Oxygen Species (ROS)	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
GLX481372 is a NADPH Oxidase (NOX) inhibitor. GLX481372 potently inhibits *NOX4/5* activities with IC₅₀ values of 0.68 and 0.57 μM. GLX481372 also has weak inhibitory activity against NOX1, NOX2, and NOX3, with IC₅₀ values of 7, 16 and 3.2 μM respectively. GLX481372 can inhibit ROS production. GLX481372 can be used for the researches of inflammation, cardiovascular and metabolic disease, such as diabetes .

HY-12298R

Setanaxib (Standard) GKT137831 (Standard); GKT831 (Standard)	NADPH Oxidase Ferroptosis Reference Standards	Cardiovascular Disease
Setanaxib (Standard) is the analytical standard of Setanaxib. This product is intended for research and analytical applications. Setanaxib (GKT137831) is a selective NADPH oxidase (NOX1/4) inhibitor with Kis of 140 and 110 nM, respectively.

HY-177641A

Lexaptepid Pegol sodium NOX-H94 sodium	Hepcidin	Others
Lexaptepid Pegol sodium is a pegylated structured L-oligoribonucleotide. It binds and inhibits hepcidin.

HY-177641

Lexaptepid Pegol NOX-H94	Hepcidin	Others
Lexaptepid Pegol is a pegylated structured L-oligoribonucleotide. It binds and inhibits hepcidin.

HY-173096

NCATS-SM7270	NADPH Oxidase	Neurological Disease
NCATS-SM7270 is a highly specific *NOX2* inhibitor, with an IC₅₀ of 4.09 μM. NCATS-SM7270 protects mice from mild traumatic brain injury .

HY-P11319

RAP-103	CCR	Neurological Disease
RAP-103 is an orally active CCR antagonist that provides potent synaptic protection by inhibiting and reversing cytoskeletal changes induced by PrPC/NOX signaling. RAP-103 is potentially useful in Alzheimer's disease (AD) research .

HY-P2222A

DX600 TFA 3 Publications Verification	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease Metabolic Disease
DX600 TFA is a selective ACE2 specific inhibitor (K_D: 1.3 nM), and does not cross-react with ACE. DX600 TFA exacerbates diabetes-induced cardiovascular dysfunction and the increase in cardiac and renal NOX activity .

Cat. No.	Product Name	Type

HY-108537

L 012 sodium salt 2 Publications Verification	Fluorescent Dye
L 012 sodium salt is a luminal-based chemiluminescent probe. L 012 sodium salt can detect NADPH oxidase (Nox)-derived superoxide and nitrogen species (reactive oxygen species (ROS) and reactive nitrogen species (RNS)) .

HY-108537R

L 012 sodium salt (Standard)	Fluorescent Dye
L 012 sodium salt (Standard) is the analytical standard of L 012 (sodium salt) (HY-108537). This product is intended for research and analytical applications. L 012 sodium salt is a luminal-based chemiluminescent probe. L 012 sodium salt can detect NADPH oxidase (Nox)-derived superoxide and nitrogen species (reactive oxygen species (ROS) and reactive nitrogen species (RNS)) .

Cat. No.	Product Name	Target	Research Area

HY-P5381

gp91 ds-tat 1 Publications Verification	NADPH Oxidase Ferroptosis Reactive Oxygen Species (ROS) Glutathione Peroxidase TRP Channel	Cardiovascular Disease Neurological Disease Inflammation/Immunology
gp91 ds-tat, a biological active peptide, is a NADPH oxidase 2 (Nox2) inhibitor. gp91 ds-tat blocks NADPH oxidase-dependent superoxide production. gp91 ds-tat ameliorates high glucose-induced increase in total ROS, LPOs and iron levels. gp91 ds-tat inhibits homocysteine (Hcy)-induced activation of NLRP3 inflammasomes and restores Hcy-inhibited lysosomal TRPML1 channel activity. gp91 ds-tat improves cerebrovascular and cognitive function in APP/PS1 mice. gp91 ds-tat can be used for the study of Alzheimer’s disease (AD), glomerular inflammation and cardiovascular disease .

HY-P2222

DX600 3 Publications Verification	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
DX600 is a selective ACE2 specific inhibitor (K_D: 1.3 nM), and does not cross-react with ACE. DX600 exacerbates diabetes-induced cardiovascular dysfunction and the increase in cardiac and renal NOX activity .

HY-P1435

NoxA1ds	NADPH Oxidase	Cardiovascular Disease Cancer
NoxA1ds is a potent and highly selective NADPH oxidase 1 (NOX1) inhibitor (IC₅₀=20 nM). NoxA1ds inhibits NOX1-derived O ^2- production in HT-29 human colon cancer cells. NoxA1ds attenuates VEGF-induced human pulmonary artery endothelial cell migration under hypoxic conditions in vitro. NoxA1ds can be used in the study of hypertension, atherosclerosis and tumors .

HY-P11319

RAP-103	CCR	Neurological Disease
RAP-103 is an orally active CCR antagonist that provides potent synaptic protection by inhibiting and reversing cytoskeletal changes induced by PrPC/NOX signaling. RAP-103 is potentially useful in Alzheimer's disease (AD) research .

HY-P2222A

DX600 TFA 3 Publications Verification	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease Metabolic Disease
DX600 TFA is a selective ACE2 specific inhibitor (K_D: 1.3 nM), and does not cross-react with ACE. DX600 TFA exacerbates diabetes-induced cardiovascular dysfunction and the increase in cardiac and renal NOX activity .

HY-P1435A

NoxA1ds TFA	NADPH Oxidase	Cardiovascular Disease Cancer
NoxA1ds TFA is a potent and highly selective NADPH oxidase 1 (NOX1) inhibitor (IC₅₀=20 nM). NoxA1ds TFA inhibits NOX1-derived O ^2- production in HT-29 human colon cancer cells. NoxA1ds TFA attenuates VEGF-induced human pulmonary artery endothelial cell migration under hypoxic conditions in vitro. NoxA1ds TFA can be used in the study of hypertension, atherosclerosis and tumors .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-113324

NADPH Maximum Cited Publications 18 Publications Verification	Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Endogenous Metabolite
NADPH is a coenzyme of glutathione reductase (GR), thioredoxin reductase (TrxR) and NADPH oxidase (NOX), and participates in redox reactions as a hydrogen donor. NADPH has the characteristic of selectively participating in the regulation of cellular redox homeostasis. NADPH exerts antioxidant activity and resists reactive oxygen species (ROS) damage by providing reducing equivalents for the regeneration of glutathione (GSH) and thioredoxin (Trx); at the same time, it acts as a substrate of NOX to generate superoxide anions, mediating oxidative stress and immune response. NADPH participates in maintaining the intracellular reducing environment, biosynthesis and regulating gene expression (such as the Nrf2 pathway), and is mainly used in the study of oxidative stress-related diseases (such as cardiovascular diseases, neurodegenerative diseases, cancer) and immune regulation mechanisms .

HY-N3610

Coclaurine 1 Publications Verification	Alkaloids Structural Classification Phenols Polyphenols Plants Lauraceae Isoquinoline Alkaloids Lindera aggregata (Sims) Kosterm. Source Classification	nAChR
Coclaurine is a class of tetrahydroisoquinoline alkaloids that can be isolated from Sarcopetalum harveyanum with anticancer activity. Coclaurine is a nicotinic acetylcholine receptor (nAChRs) antagonist. Coclaurine is a key molecule in S. tetrandra responsible for EFHD2 inhibition. Coclaurine can downregulate EFHD2-related NOX4-ABCC1 signaling and enhanced Cisplatin (HY-17394) sensitivity. Coclaurine suppresses the stemness and metastatic properties of NSCLC cells. Coclaurine disrupts the interaction between the transcription factor FOXG1 and the EFHD2 promoter, leading to a reduction in EFHD2 transcription .

HY-N2255

Crebanine 4 Publications Verification	Cardiovascular Disease Structural Classification Alkaloids Stephania venosa Classification of Application Fields Other Alkaloids Plants Menispermaceae Inflammation/Immunology Disease Research Fields	Akt Apoptosis NF-κB Reactive Oxygen Species (ROS) p38 MAPK ERK Interleukin Related TNF Receptor NO Synthase nAChR Bacterial
Crebanine is an isoquinoline-like alkaloid that can be derived from Stephania. Crebanine is an antagonist of the α7-nAChR with an IC₅₀ of 19.1 μM. Crebanine suppresses the proliferation, migration, and invasion of cancer cells, triggers reactive oxygen species (ROS) burst, and promotes apoptosis. Crebanine inhibits the AKT/FoxO3a, NF-κB and MAPK signaling pathways. Crebanine attenuates NOX2 hyperactivation, exhibits antioxidant properties by reducing reactive oxygen species and peroxidation in microglia cells. Crebanine inhibits voltage-dependent Na ⁺ current in guinea-pig ventricular myocytes. Crebanine has high inhibitory activity against gram-positive animal pathogenic bacteria. Crebanine ameliorates ischemia-reperfusion brain damage in middle cerebral artery occlusion and reperfusion (MCAO/R) rats. Crebanine significantly improves Scopolamine (HY-N0296)-induced cognitive deficits in ICR mice. Crebanine can be used for the study of hepatocellular carcinoma (HCC), cerebral ischemia and Alzheimer's disease .

HY-N3239

Mulberrofuran G	Phenols Polyphenols Plants Moraceae Morus alba Linn. Source Classification	Tyrosinase NADPH Oxidase HBV SARS-CoV Reactive Oxygen Species (ROS) JAK STAT Apoptosis Caspase PARP
Mulberrofuran G is a *NOX* inhibitor (IC₅₀: 6.9 μM) and tyrosinase inhibitor. Mulberrofuran G exhibits anti-inflammatory, antioxidant, antiviral, antitumor, and neuroprotective effects. Mulberrofuran G can be used in the research of tumors, nervous system diseases, and other conditions .

HY-N9097

Niazirin	Structural Classification Moringa oleifera Lam. Moringaceae Plants Saccharides Monosaccharides Source Classification	Reactive Oxygen Species (ROS) SOD Glutathione Peroxidase PKC NADPH Oxidase
Niazirin is an orally active antioxidant. Niazirin can be isolated from Moringa oleifera Lam. Niazirin reduces the production levels of ROS and MDA, while increasing the levels of superoxide dismutase SOD and glutathione peroxidase GPx. Niazirin also abolishes high glucose-induced PKCζ activation and inhibits *Nox4* protein expression. Niazirin exhibits excellent free radical scavenging activity. Niazirin significantly inhibits high glucose-induced proliferation of vascular smooth muscle cells. Niazirin can be used in the research of diabetic atherosclerosis .

HY-N16527

7-O-Galloyl-D-sedoheptulose	Structural Classification Cornaceae Cornus officinalis Sieb. et Zucc. Phenols Polyphenols Plants Source Classification	TNF Receptor Interleukin Related NADPH Oxidase Reactive Oxygen Species (ROS) NF-κB COX NO Synthase JNK AP-1 TGF-β Receptor
7-O-Galloyl-D-sedoheptulose is an orally effective polyphenolic compound. 7-O-Galloyl-D-sedoheptulose lowers the serum levels of glucose, leptin, insulin, C-peptide, resistin, TNF-α, IL-6, and increases the serum level of adiponectin. 7-O-Galloyl-D-sedoheptulose significantly reduces the levels of ROS and lipid peroxidation products (TBARS) by down-regulating the protein expression of NADPH oxidase subunit Nox-4 and p22phox. 7-O-Galloyl-D-sedoheptulose down-regulates NF-κB and related pro-inflammatory factors (COX-2, iNOS), inhibits the phosphorylation of JNK and the activity of its downstream AP-1. 7-O-Galloyl-D-sedoheptulose reduces the expression of TGF-β1 and fibronectin, indicating its potential in anti-tissue fibrosis. 7-O-Galloyl-D-sedoheptulose can be used for the study of type 2 diabetes and its hepatic and pancreatic complications .

HY-N17375

Saikosaponin bk1	Structural Classification Polysaccharides Terpenoids Apiaceae Bupleurum kunmingense Yin Li & S. L. Pan Plants Pentacyclic Triterpenoids Saccharides Source Classification	NADPH Oxidase
Saikosaponin bk1 is a NADPH-oxidase 5(NOX5) dehydrogenase domain binder and hepatoprotective agent. Saikosaponin bk1 forms stable interactions with the dehydrogenase domain of *NOX5* from Cylindrospermum stagnale. Saikosaponin bk1 is applicable to research related to COVID-19 and alcoholic liver injury .

Species:	Human (4)
Tag:	His (4)
Source:	E. coli Cell-free (2) E. coli (2)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P790059

	NOX4 Protein, Human (Cell-Free, His) NOX4; RENOX; NADPH oxidase 4; Kidney oxidase-1; KOX-1; Kidney superoxide-producing NADPH oxidase; Renal NAD(P)H-oxidase	Human	E. coli Cell-free
	When NOX4 protein complexes with CYBA/p22phox, superoxide is generated in cells. It regulates signaling cascades and inhibits phosphatases. NOX4 Protein, Human (His) is the recombinant human-derived NOX4, expressed by E. coli Cell-free, with N-10*His labeled tag.

HY-P70290

	Neutrophil cytosol factor 1 Protein, Human (His) rHuNeutrophil cytosol factor 1/NCF1, His; NCF-1; 47 kDa autosomal chronic granulomatous disease protein/47 kDa neutrophil oxidase factor; NCF-47K; Neutrophil NADPH oxidase factor 1; NOX organizer 2; NOX-organizing protein 2/SH3 and PX domain-containing protein 1A; p47-phox	Human	E. coli
	Neutrophil cytoplasmic factor 1 (NCF1) is essential for activation of the NADPH oxidase complex, which is essential for superoxide production. It cooperates with NCF2 to form a core association in the complex, interacting with NCF4, CYBB and CYBA. Neutrophil cytosol factor 1 Protein, Human (His) is the recombinant human-derived Neutrophil cytosol factor 1 protein, expressed by E. coli , with C-6*His labeled tag.

HY-P702387

	NOX1 Protein, Human (Cell-Free, His) NADPH oxidase 1; Mitogenic oxidase 1; MOX-1; NADH/NADPH mitogenic oxidase subunit P65-MOX; NOH-1	Human	E. coli Cell-free
	The NOX1 protein contains two isoforms with different functions. NOH-1S acts as a voltage-gated proton channel, manages H(+) currents in quiescent phagocytes and tissues, affects cellular pH, and is inhibited by zinc. NOX1 Protein, Human (Cell-Free, His) is the recombinant human-derived NOX1 protein, expressed by E. coli Cell-free , with N-10*His labeled tag.

HY-P72161

	*CYBB/Nox2 Protein, Human (His)* AMCBX2; CGD; CGD91-phox; CY24B_HUMAN; CYBB; Cytochrome b 245; beta polypeptide; Cytochrome b558; beta chain; Cytochrome b558; subunit beta; Cytochrome b-245 heavy chain; Cytochrome b558 subunit beta; GP91 PHOX; gp91-1; gp91-phox; GP91PHOX; Heme-binding membrane glycoprotein gp91phox;	Human	E. coli
	The CYBB/Nox2 protein is an important membrane-bound oxidase in phagocytes and is critical for superoxide production. As the terminal element of the respiratory chain, it transfers a single electron from NADPH to molecular oxygen. CYBB/Nox2 Protein, Human (His) is the recombinant human-derived CYBB/Nox2 protein, expressed by E. coli , with N-6*His labeled tag.

Compare Products


Products	In-stock - + Add to Cart
Cat. No.
Species
Source
Tag
Accession
Gene ID
Molecular Weight
Purity
Endotoxin Level
Biological Activity
Appearance
Formulation
Storage & Stability
Shipping
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Product Name	Chemical Structure

HY-B0203BS2

(Rac)-Nebivolol-d2,15N

(Rac)-Nebivolol-d₂, ¹⁵N is ¹⁵N and deuterated labeled (Rac)-Nebivolol (HY-B0203B). (Rac)-Nebivolol ((Rac)-R 065824) is a racemic isomer of Nebivolol. Nebivolol is a selective β1-adrenergic receptor antagonist with an IC₅₀ value of 0.8 nM. Nebivolol can prevent up-regulation of Nox2/NADPH oxidase and lipoperoxidation in the early stages of ethanol-induced cardiac toxicity. Vasodilatory activity .

Host:	Rabbit (5)
Reactivity:	Human (5) Rat (5) Mouse (5)
Application:	IHC-P (4) ICC/IF (4) IP (4) IHC-F (2) WB (5) ELISA (2)
Isotype:	IgG (5)
Conjugation:	Non-conjugated (5)
Clonality:	Polyclonal (2) Monoclonal (3) Recombinant (2)
Modification:	Unmodified (5)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P87174

	NOX2 Antibody (YA6865) CYBB; NOX2; Cytochrome b-245 heavy chain; CGD91-phox; Cytochrome b; 558; subunit beta; Cytochrome b558 subunit beta; Heme-binding membrane glycoprotein gp91phox; NADPH oxidase 2Neutrophil cytochrome b 91 kDa polypeptide; Superoxide-generating NADPH oxidase heavy chain subunit; gp91-1; gp91-phox; p22 phagocyte B-cytochrome	WB, IHC-P, IHC-F, ICC/IF, IP	Human, Mouse, Rat
	NOX2 Antibody (YA6865) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to NOX2.

HY-P86638

	NOX2 Antibody (YA6330) CYBB; NOX2; Cytochrome b-245 heavy chain; CGD91-phox; Cytochrome b; 558; subunit beta; Cytochrome b558 subunit beta; Heme-binding membrane glycoprotein gp91phox; NADPH oxidase 2Neutrophil cytochrome b 91 kDa polypeptide; Superoxide-generating NADPH oxidase heavy chain subunit; gp91-1; gp91-phox; p22 phagocyte B-cytochrome	WB, IP, ELISA	Human, Mouse, Rat
	NOX2 Antibody (YA6330) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to NOX2.

HY-P80762

	NADPH Oxidase 4 Antibody NADPH oxidase 4; Kidney oxidase-1; KOX-1; KOX1; Kidney superoxide-producing NADPH oxidase; Renal NAD(P)H-oxidase; NOX4; RENOX	WB, IHC-P, ICC/IF, IP	Human, Mouse, Rat
	NADPH Oxidase 4 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to NADPH Oxidase 4.

HY-P80762A

	NADPH Oxidase 4 Antibody (YA4640) 1 Publications Verification NADPH oxidase 4; Kidney oxidase-1; KOX-1; KOX1; Kidney superoxide-producing NADPH oxidase; Renal NAD(P)H-oxidase; NOX4; RENOX	WB, IHC-P, ICC/IF, IP	Human, Mouse, Rat
	NADPH Oxidase 4 Antibody (YA4640) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to NADPH Oxidase 4.

HY-P81195

	NOX2 Antibody AMCBX2; CGD; CGD91-phox; CY24B_HUMAN; CYBB; Cytochrome b 245, beta polypeptide; Cytochrome b(558) beta chain; Cytochrome b(558) subunit beta; Cytochrome b-245 heavy chain; Cytochrome b558 subunit beta; GP91 PHOX; gp91-1; gp91-phox; GP91PHOX; Heme-binding membrane glycoprotein gp91phox; NADPH oxidase 2; Neutrophil cytochrome b 91 kDa polypeptide; p22 phagocyte B-cytochrome; P91 PHOX; p91-PHOX; Superoxide-generating NADPH oxidase heavy chain subunit.	WB, ELISA, IHC-P, IHC-F, ICC/IF	Human, Mouse, Rat
	NOX2 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to NOX2.

Compare Products


Products	In-stock - + Add to Cart
Cat. No.
Host
Reactivity
Application
Dilution Ratio
Molecular Weight
Conjugation
Clonality
Immunogen
Appearance
Isotype
Gene ID
SwissProt ID
Purity
Formulation
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Product Name		Classification

HY-172451

MC4762		Alkynes
MC4762 is an inhibitor of *NOX2* and MAOB, with IC₅₀ values of 0.155 μM and 0.182 μM, respectively. MC4762 has anti-inflammatory activity, can inhibit the production of ROS, and downregulate the expression of pro-inflammatory cytokines iNOS, IL-1β, and IL-6 .

Cat. No.	Product Name		Classification

HY-160041A

Olaptesed pegol sodium NOX-A12 sodium		Antisense Oligonucleotides
Olaptesed pegol (NOX-A12) sodium is a L-oligoribonucleotide aptamer targeting CXCL12 based on a pegylated structure. Olaptesed pegol sodium neutralizes CXCL12, and CXCL12 inhibition mobilizes chronic lymphocytic leukemia cells into the circulation and prevents their homing into the protective microenvironment. Olaptesed pegol sodium can enhances the infiltration of human primary T cells and NK cells and inhibit tumor growth companied with anti-PD-1 antibody. Olaptesed pegol sodium can be used for researches of colon cancer and lymphocytic leukemia .

HY-160041

Olaptesed pegol NOX-A12		Antisense Oligonucleotides
Olaptesed pegol (NOX-A12) is a L-oligoribonucleotide aptamer targeting CXCL12 based on a pegylated structure. Olaptesed pegol neutralizes CXCL12, and CXCL12 inhibition mobilizes chronic lymphocytic leukemia cells into the circulation and prevents their homing into the protective microenvironment. Olaptesed pegol can enhances the infiltration of human primary T cells and NK cells and inhibit tumor growth companied with anti-PD-1 antibody. Olaptesed pegol can be used for researches of colon cancer and lymphocytic leukemia .

HY-148100

Emapticap pegol 1 Publications Verification NOX-E36		Aptamers
Emapticap pegol (NOX-E36) is a inhibitor of pro-inflammatory chemokine C-C motif-ligand 2 (CCL2). Emapticap pegol is a 40-nucleotide oligonucleotide aptamer, displays different Spiegelmers (L-RNA aptamer) isform in human (NOX-E36) and mouse (mNOX-E36). mNOX-E36 is a murine-specific analogue of NOX-E36, an anti-MCP-1 L-RNA aptamer that was previously shown to attenuate liver fibrosis in mice .

HY-148100A

Emapticap pegol sodium 1 Publications Verification NOX-E36 sodium		Aptamers
Emapticap pegol sodium is a inhibitor of pro-inflammatory chemokine C-C motif-ligand 2 (CCL2). Emapticap pegol sodium is a 40-nucleotide oligonucleotide aptamer, displays different Spiegelmers (L-RNA aptamer) isform in human (NOX-E36) and mouse (mNOX-E36) .

HY-177641A

Lexaptepid Pegol sodium NOX-H94 sodium		Antisense Oligonucleotides
Lexaptepid Pegol sodium is a pegylated structured L-oligoribonucleotide. It binds and inhibits hepcidin.

HY-177641

Lexaptepid Pegol NOX-H94		Antisense Oligonucleotides
Lexaptepid Pegol is a pegylated structured L-oligoribonucleotide. It binds and inhibits hepcidin.

HY-RS09461

NOX4 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
NOX4 Human Pre-designed siRNA Set A contains three designed siRNAs for NOX4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS09459

Nox1 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Nox1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Nox1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS27298

Nox3 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Nox3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Nox3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS09458

Nox1 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Nox1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Nox1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS09464

NOX5 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
NOX5 Human Pre-designed siRNA Set A contains three designed siRNAs for NOX5 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS20784

Nox3 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Nox3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Nox3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS09457

NOX1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
NOX1 Human Pre-designed siRNA Set A contains three designed siRNAs for NOX1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS09462

Nox4 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Nox4 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Nox4 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS09460

NOX3 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
NOX3 Human Pre-designed siRNA Set A contains three designed siRNAs for NOX3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS09463

Nox4 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Nox4 Rat Pre-designed siRNA Set A contains three designed siRNAs for Nox4 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-177933

mNOX-E36		Aptamers
mNOX-E36 is a murine-specific analogue of NOX-E36 (HY-148100), an anti-CCL-2 L-RNA aptamer that binds and neutralises the mouse chemokine CCL-2. mNOX-E36 reduces scarring in an experimental murine model of glaucoma filtration surgery (GFS). mNOX-E36 ameliorates lupus nephritis in mice. mNOX-E36 can be used for GFS and lupus nephritis research .

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks