75 Results for "

Naphthoquinone

" in MedChemExpress (MCE) Product Catalog:
Products (75)

75 Results for "Naphthoquinone" in MCE Product Catalog:

31
31 Publications Verification
Cat. No.: HY-B0332
CAS No.: 58-27-5
Synonyms: Vitamin K3
Menadione is a naphthoquinone that is converted into active vitamin K2 in the body. Menadione is a potential anticancer agent and radiosensitizer .
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14
14 Cited Publications
Cat. No.: HY-13555
CAS No.: 4707-32-8
Purity:  99.93%
Synonyms: ARQ-501; NSC-26326
β-Lapachone (ARQ-501;NSC-26326) is a naturally occurring O-naphthoquinone, acts as a topoisomerase I inhibitor, and induces apoptosis by inhibiting cell cycle progression.
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6
6 Cited Publications
Cat. No.: HY-N1497
CAS No.: 481-42-5
Synonyms: 2-Methyljuglone
Plumbagin (2-Methyljuglone) is a naphthoquinone isolated from Plumbago zeylanica, exhibits anticancer and antiproliferative activities .
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3
3 Cited Publications
Cat. No.: HY-P0171
CAS No.: 664334-36-5
Synonyms: BKT140 (4-fluorobenzoyl); BL-8040; TF14016
Target:  

CXCR

Research Areas:  

Endocrinology Cancer

Motixafortide (BKT140 4-fluorobenzoyl) is a novel CXCR4 antagonist with an IC50 vakue of ~1 nM.
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3
3 Cited Publications
Cat. No.: HY-W015490
CAS No.: 130-15-4
1,4-Naphthoquinone is an inhibitor with broad-spectrum inhibitory activity targeting DNA polymerase, NF-κB and monoamine oxidase (MAO-A/B), with antibacterial and anti-biofilm efficacy. 1,4-Naphthoquinone is a competitive inhibitor of MAO-B (Ki=1.4 μM) and a non-competitive inhibitor of MAO-A (Ki=7.7 μM). 1,4-Naphthoquinone inhibits DNA polymerase pol α, β, γ, δ, ε, λ with IC50 ranging from 5.57-128 μM. 1,4-Naphthoquinone inhibits tumor cell proliferation, induces apoptosis and necrosis, and has anti-angiogenic and anti-inflammatory activities by inducing oxidative stress, depleting glutathione (GSH), inhibiting DNA polymerase-mediated DNA synthesis and blocking NF-κB nuclear translocation. 1,4-Naphthoquinone can be used in anti-bacterial , anti-tumor and anti-inflammatory studies, including inhibition of melanoma and colon cancer cell growth and endothelial cell function, as well as LPS-induced inflammation models .
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3
3 Cited Publications
Cat. No.: HY-N6961
CAS No.: 84-79-7
Lapachol, a natural naphthoquinone, is an orally active, potent DHODH inhibitor. Lapachol has immunosuppressive activity on lymphocytes through its direct ability to block DHODH activity and inhibit pyrimidine synthesis. Lapachol is a vitamin K antagonist with antitumor activity and can inhibit DNA and RNA synthesis in neoplastic cells. Lapachol has anti-Leishmania activity .
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3
3 Cited Publications
Cat. No.: HY-121632
CAS No.: 2797-51-5
Purity:  99.55%
Research Areas:  

Cancer

Quinoclamine, a naphthoquinone derivative, is a NF-κB inhibitor. Quinoclamine exhibits anti-cancer activity .
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2
2 Cited Publications
Cat. No.: HY-N2493
CAS No.: 83-72-7
Lawsone is an orally active naphthoquinone dye that can be isolated from the leaves of Lawsonia inermis. Lawsone can induce apoptosis. Lawsone has antibacterial, antitumor and antioxidant activities. Lawsone can be used in anti-tumor drug research .
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2
2 Cited Publications
Cat. No.: HY-P0009A
CAS No.: 145672-81-7
Synonyms: SB-75 acetate
Target:  

GnRH Receptor Apoptosis

Research Areas:  

Endocrinology

Cetrorelix (SB-75) acetate is a competitive gonadotropin-releasing hormone receptor (GnRHR) antagonist with a Kd of 0.19 nM. Cetrorelix acetate inhibits the secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), thereby suppressing the secretion of downstream sex steroids. Cetrorelix acetate prevents ovulation, induces reversible reproductive shutdown and azoospermia, reduces ovarian fibrosis, improves superovulation outcomes, and inhibits chemotherapy-induced mitochondria-dependent apoptosis. Cetrorelix acetate is applicable for fertility assistance research .
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1
1 Cited Publications
Cat. No.: HY-108011
CAS No.: 15687-37-3
Purity:  ≥99.0%
Research Areas:  

Cardiovascular Disease

Naftazone is a naphthoquinone derivative, it can be used for the research of venous insufciency. Naftazone protects blood vessels, increases venous tonicity and capillary resistance, and improves lymphatic and venous circulation .
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1
1 Cited Publications
Cat. No.: HY-N7526
CAS No.: 475-38-7
Synonyms: DHNQ; 5,8-Dihydroxy-1,4-Naphthoquinone
Naphthazarin (DHNQ) is a microtubule depolymerizing agent. Naphthazarin can improve motor function and reduce neuroinflammation in mouse models of Parkinson's disease. Naphthazarin can induce tumor cell apoptosis, autophagy, and cell cycle arrest. Naphthazarin can also induce erythrocyte apoptosis. Naphthazarin can be used in the research of tumors and neurodegenerative diseases .
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1
1 Cited Publications
Cat. No.: HY-N2188
CAS No.: 69091-17-4
Beta-Acetoxyisovalerylshikonin is a naturally occurring naphthoquinone-type shikonin derivative that is widely distributed in the roots and cell suspension cultures of *Arnebia euchroma*, *Arnebia guttata*, *Onosma hispidum* and *Lithospermum erythrorhizon*. Beta-Acetoxyisovalerylshikonin exhibits favorable antibacterial, anti-inflammatory, wound-healing promoting and antioxidant activities, and also possesses potential anti-tumor and anti-HIV properties .
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1
1 Cited Publications
Cat. No.: HY-N5112B
CAS No.: 24502-79-2
Synonyms: Isoarnebin I
β,β-Dimethylacrylshikonin (Isoarnebin I) is a naphthoquinone derivative that can be isolated from Lithospermum erythrorhizon Sieb. et Zucc. β,β-Dimethylacrylshikonin promotes angiogenesis by inducing eNOS, VEGF and HIF-1α expression through the PI3K-dependent pathway. β,β-Dimethylacrylshikonin inhibits Notch-1 activation. β,β-Dimethylacrylshikonin inhibtis tumor cell proliferation, induces tumor cell apoptosis, and inhibits tumor growth .
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1
1 Cited Publications
Cat. No.: HY-P4452
CAS No.: 209006-18-8
Research Areas:  

Endocrinology

PRL 2915 is a potent human somatostatin subtype 2 receptor (hsst2) antagonist with a Ki of 12 nM .
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Cat. No.: HY-N7116
CAS No.: 2348-82-5
Synonyms: 2-​Methoxy-​1,​4-​Naphthoquinone
Lawsone methyl ether (2-Methoxy-1,4-naphthoquinone), isolated from Impatiens balsamina L. and Swertia calycina, exhibits potent antifungal and antibacterial activities .
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Cat. No.: HY-115243
CAS No.: 1010-60-2
Purity:  98.38%
Research Areas:  

Others

2-Chloro-1,4-naphthoquinone (chloro-K3) is a vitamin-K-dependent carboxylation antagonist with an IC50 value of 146 μM. 2-Chloro-1,4-naphthoquinone has cytotoxic activity .
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Cat. No.: HY-N3488
CAS No.: 20175-84-2
Isodiospyrin, a natural dimeric naphthoquinone, is a human DNA topoisomerase I (Topoisomerase) inhibitor. Isodiospyrin can prevent both DNA relaxation and kinase activities of human topoisomerase I. Isodiospyrin shows anticancer, antibacterial and antifungal activities .
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Cat. No.: HY-W015490S
CAS No.: 26473-08-5
1,4-Naphthoquinone-d6 is the deuterium labeled 1,4-Naphthoquinone. 1,4-Naphthoquinone is an inhibitor with broad-spectrum inhibitory activity targeting DNA polymerase, NF-κB and monoamine oxidase (MAO-A/B), with antibacterial and anti-biofilm efficacy. 1,4-Naphthoquinone is a competitive inhibitor of MAO-B (Ki=1.4 μM) and a non-competitive inhibitor of MAO-A (Ki=7.7 μM). 1,4-Naphthoquinone inhibits DNA polymerase pol α, β, γ, δ, ε, λ with IC50 ranging from 5.57-128 μM. 1,4-Naphthoquinone inhibits tumor cell proliferation, induces apoptosis and necrosis, and has anti-angiogenic and anti-inflammatory activities by inducing oxidative stress, depleting glutathione (GSH), inhibiting DNA polymerase-mediated DNA synthesis and blocking NF-κB nuclear translocation. 1,4-Naphthoquinone can be used in anti-bacterial , anti-tumor and anti-inflammatory studies, including inhibition of melanoma and colon cancer cell growth and endothelial cell function, as well as LPS-induced inflammation models .
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Cat. No.: HY-N8139
CAS No.: 173043-38-4
2-Amino-3-carboxy-1,4-naphthoquinone is the electron transfer mediator. 2-Amino-3-carboxy-1,4-naphthoquinone changes glucose metabolism of the homofermentative lactic acid bacteria .
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Cat. No.: HY-B0332R
CAS No.: 58-27-5
Synonyms: Vitamin K3 (Standard)
Menadione (Standard) is the analytical standard of Menadione. This product is intended for research and analytical applications. Menadione is a naphthoquinone that is converted into active vitamin K2 in the body. Menadione is a potential anticancer agent and radiosensitizer .
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