2-Chloro-1,4-naphthoquinone
2-Chloro-1,4-naphthoquinone (chloro-K3) is a vitamin-K-dependent carboxylation antagonist with an IC50 value of 146 μM. 2-Chloro-1,4-naphthoquinone has cytotoxic activity.
For research use only. We do not sell to patients.
- Purity: 98.38%
- CAS No.: 1010-60-2
- Formula: C10H5ClO2
- Molecular Weight:192.60
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HL-60 | IC50 |
11.48 μM
Compound: 11
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Cytotoxicity against human HL60 cells after 24 hrs by MTT assay
Cytotoxicity against human HL60 cells after 24 hrs by MTT assay
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[PMID: 30007564] |
| HL-60 | IC50 |
6.32 μM
Compound: 11
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Cytotoxicity against human HL60 cells after 48 hrs by MTT assay
Cytotoxicity against human HL60 cells after 48 hrs by MTT assay
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[PMID: 30007564] |
| WI-38 | IC50 |
21.58 μM
Compound: 11
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Cytotoxicity against human WI38 cells after 48 hrs by MTT assay
Cytotoxicity against human WI38 cells after 48 hrs by MTT assay
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[PMID: 30007564] |
2-Chloro-1,4-naphthoquinone (48 h) shows cytotoxic activity against HL-60 and WI-38 cell with IC50 values of 6.32μM and 23.58 μM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1010-60-2
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Appearance Solid
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Molecular Weight 192.60
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Formula C10H5ClO2
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Color Light yellow to yellow
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SMILES
O=C1C(Cl)=CC(C2=C1C=CC=C2)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (519.21 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
Purity & Documentation
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Data Sheet (275 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 5.1921 mL | 25.9605 mL | 51.9211 mL | 129.8027 mL |
| 5 mM | 1.0384 mL | 5.1921 mL | 10.3842 mL | 25.9605 mL | |
| 10 mM | 0.5192 mL | 2.5961 mL | 5.1921 mL | 12.9803 mL | |
| 15 mM | 0.3461 mL | 1.7307 mL | 3.4614 mL | 8.6535 mL | |
| 20 mM | 0.2596 mL | 1.2980 mL | 2.5961 mL | 6.4901 mL | |
| 25 mM | 0.2077 mL | 1.0384 mL | 2.0768 mL | 5.1921 mL | |
| 30 mM | 0.1731 mL | 0.8654 mL | 1.7307 mL | 4.3268 mL | |
| 40 mM | 0.1298 mL | 0.6490 mL | 1.2980 mL | 3.2451 mL | |
| 50 mM | 0.1038 mL | 0.5192 mL | 1.0384 mL | 2.5961 mL | |
| 60 mM | 0.0865 mL | 0.4327 mL | 0.8654 mL | 2.1634 mL | |
| 80 mM | 0.0649 mL | 0.3245 mL | 0.6490 mL | 1.6225 mL | |
| 100 mM | 0.0519 mL | 0.2596 mL | 0.5192 mL | 1.2980 mL |
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