20175-84-2
20175-84-2
Chemical Structure
Isodiospyrin
- CAS No.: 20175-84-2
- Formula:C22H14O6
- Molecular Weight:374.34
IUPAC Name: 1',4-dihydroxy-2,3'-dimethyl-[1,2'-binaphthalene]-5,5',8,8'-tetraone
InChIKey: OEEOHKZVBKYMBA-UHFFFAOYSA-N
SMILES: O=C1C=CC(C2=C(C(C3=C4C(C=CC(C4=C(C=C3C)O)=O)=O)=C(C)C=C12)O)=O
Biological Activity: Isodiospyrin, a natural dimeric naphthoquinone, is a human DNA topoisomerase I (Topoisomerase) inhibitor. Isodiospyrin can prevent both DNA relaxation and kinase activities of human topoisomerase I. Isodiospyrin shows anticancer, antibacterial and antifungal activities[1][2][3].
| Cat. No. | Nom du produit | Pureté | Description | Pricing | |||||||||||||||||||
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Isodiospyrin | 99.72% | Isodiospyrin, a natural dimeric naphthoquinone, is a human DNA topoisomerase I (Topoisomerase) inhibitor. Isodiospyrin can prevent both DNA relaxation and kinase activities of human topoisomerase I. Isodiospyrin shows anticancer, antibacterial and antifungal activities. | ||||||||||||||||||||
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Maritinone | Maritinone is a compound with antiproliferative activity and exhibits strong cytostatic activity in various tumor cell lines. | |||||||||||||||||||||
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Skyrin | 97.0% | Skyrin is an anthraquinone compound that can be isolated from almond fruit. Skyrin is a receptor-selective glucagon antagonist. Skyrin can inhibit the growth of tumor cells. | ||||||||||||||||||||
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Alkannin | Alkannin is a potent and specific inhibitor of tumor-specific pyruvate kinase-M2 (PKM2). Alkannin does not inhibit PKM1 and pyruvate kinase-L (PKL). Alkannin acts as a potential anticancer agent. | |||||||||||||||||||||
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Ramentaceone | Ramentaceone (7-Methyljuglon), a naphthoquinone that can be isolated from Drosera sp., inhibits PI3K activity. Ramentaceone (7-Methyljuglon) reduces the expression of the PI3K protein and inhibits the phosphorylation of the Akt protein in breast cancer cells. Ramentaceone (7-Methyljuglon) induces apoptosis. | |||||||||||||||||||||
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Murayaquinone | Murayaquinone (PKF118-774) is a β-catenin/Tcf4 complex inhibitor with an IC50 of 2.4 μM. Murayaquinone is a nematicidal agent found in Streptomyces sp. AN140557. | |||||||||||||||||||||
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Anticoronavirus agent-1 | Anticoronavirus agent-1 (Compound IV-2) is a 1,4-naphthone compound and is a 3CL hydrolase inhibitor (3C-like proteinase) of the 19-nCoV novel coronavirus. Anticoronavirus agent-1 has low cytotoxity on HSF cells. Anticoronavirus agent-1 can be used for the study of the novel coronavirus. | |||||||||||||||||||||
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Pradimicin Q | Pradimicin Q is an antibiotic. The cytotoxicity (IC50) to human colon HCT-116 cells and murine melanoma B16-F10 cells are 75 and 100 μg/mL, respectively. | |||||||||||||||||||||
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Piloquinone | Piloquinone is a phenanthrene compound. Piloquinone has inhibitory effect on mycobacterium and protozoa, but the effect is not strong. | |||||||||||||||||||||
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Diospyrin | Diospyrin is a dinaphthoquinone anticancer agent with pro-apoptotic (apoptosis) activity, glutathione S-transferase (Glutathione S-transferase) inhibitory activity, and topoisomerase (Topoisomerase) I inhibitory activity. Diospyrin is present in the heartwood of various Diospyros plants and can be used for research on Ehrlich ascites carcinoma, acute myeloid leukemia, chronic myeloid leukemia, mammary adenocarcinoma, cervical epithelial carcinoma, malignant cutaneous melanoma, laryngeal epidermoid carcinoma, human osteosarcoma, and human lymphoblastic carcinoma. | |||||||||||||||||||||
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Dicatenarin | Dicatenarin is a caspase‑3 activator with growth‑inhibitory activity against human cancer cells. Dicatenarin increases caspase‑3 activity, induces intracellular ROS generation, and activates the mitochondrial‑mediated apoptotic pathway. Dicatenarin exerts growth‑inhibitory effects against a panel of human cancer cell lines. Dicatenarin can be used in research on pancreatic cancer, lung cancer, colon cancer, breast cancer, prostate cancer, and ovarian cancer. | |||||||||||||||||||||
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References
- [1]. Chun-Yuan Ting, et al. Isodiospyrin as a novel human DNA topoisomerase I inhibitor. Biochem Pharmacol. 2003 Nov 15;66(10):1981-91. [Content Brief]
- [2]. B A Adeniyi, et al. Antibacterial activity of diospyrin, isodiospyrin and bisisodiospyrin from the root of Diospyros piscatoria (Gurke) (Ebenaceae). Phytother Res. 2000 Mar;14(2):112-7. [Content Brief]
- [3]. Xiaoning Wang, et al. Antifungal metabolites from the roots of Diospyros virginiana by overpressure layer chromatography. Chem Biodivers. 2011 Dec;8(12):2331-40. [Content Brief]
