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Results for "

Ni

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Amylin Receptor (1) Antibiotic (1) Bacterial (2) Biochemical Assay Reagents (14) CD3 (1) CXCR (2) DNA/RNA Synthesis (1) Drug Intermediate (1) Endogenous Metabolite (1) Environmental Pollutants (2) Epigenetic Reader Domain (3) FAP (1) Ferrochelatase (1) Fluorescent Dye (1) Fungal (1) HDAC (1) IFNAR (1) Influenza Virus (1) Interleukin Related (2) Lipase (1) Liposome (1) MOFs (10) Parasite (1) Potassium Channel (1) PSMA (1) Reference Standards (3) Toll-like Receptor (TLR) (1) Transthyretin (TTR) (2)
By Research Areas:	Cancer (11) Cardiovascular Disease (2) Infection (5) Inflammation/Immunology (7) Metabolic Disease (1) Neurological Disease (2)
Oligonucleotides:	Phospholipids (1)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

MCE Kits

Inhibitory Antibodies

Natural
Products

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P99191

Emapalumab Ni-0501	IFNAR	Inflammation/Immunology
Emapalumab (NI-0501) is a human monoclonal IgG1 antibody that noncompetitively inhibits IFN-γ. Emapalumab binds with high affinity (K_d= 1.4 pM) to both free IFN-γ as well as IFN-γ bound to its receptor. Emapalumab can be used in research of hemophagocytic lymphohistiocytosis (HLH) .

HY-P0294

Hexa-His 6X His Tag	Biochemical Assay Reagents	Others
Hexa-His (6X His Tag) is a commonly used affinity tag made up of six histidine residues. HEXA-HIS can bind to affinity chromatography media containing transition metal ions like nickel (Ni ²⁺) or cobalt (Co ²⁺), making it useful for protein purification .

HY-19537

NI-57 1 Publications Verification	Epigenetic Reader Domain	Inflammation/Immunology Cancer
NI-57, a chemical probe, is an inhibitor of bromodomain and plant homeodomain finger-containing (BRPF) famlily of proteins, with IC₅₀s of 3.1, 46 and 140 nM for BRPF1, BRPF2 (BRD1) and BRPF3, respectively.

HY-P99199

Foralumab Ni-0401	CD3	Inflammation/Immunology
Foralumab (NI-0401) is a potent, orally active human monoclonal antibody targeting the CD3. Foralumab modulates immune responses by human cells in NSG mice that were reconstituted with human hematopoietic stem cells .

HY-P991128

Cliramitug Ni-006; ALXN2220	Transthyretin (TTR)	Cardiovascular Disease Neurological Disease
Cliramitug (NI-006; ALXN2220) is a monoclonal antibody that targets human transthyretin (TTR). Cliramitug binds to TTR and inhibits its amyloidogenic process, exerting amyloid formation-inhibiting activity. Cliramitug can be used in the research of transthyretin amyloidosis-related diseases, such as certain neurological and cardiovascular diseases .

HY-126823

Phen Green SK diacetate (5/6-mixture) PGSK diacetate (5/6-mixture)	Fluorescent Dye	Others
Phen green SK (PGSK) diacetate (PGSK diacetate (5/6-mixture)) is a metal ion-sensitive fluorescent probe that can penetrate cell membranes. Phen green SK (PGSK) diacetate can react with a variety of metal ions, including Fe ²⁺, Cd ²⁺, Co ²⁺, Ni ²⁺, Zn ²⁺, etc. Phen green SK (PGSK) diacetate chelates Fe ²⁺, resulting in fluorescence quenching, which can be restored when a membrane-permeable chelator is added, thereby reflecting the changes in the intracellular chelatable iron pool. The excitation/emission maxima of Phen green SK diacetate are 507/532 nm, respectively .

HY-145645

Paridiprubart Ni-0101	Toll-like Receptor (TLR)	Inflammation/Immunology
Paridiprubart (NI-0101) is a humanised anti-TLR4 monoclonal antibody. Paridiprubar inhibits the production of pro-inflammatory cytokines by monocytes from rheumatoid arthritis specimen induced by rheumatoid arthritis synovial fluid (RASF). Paridiprubart can be used for the study of rheumatoid arthritis .

HY-P99424

Afasevikumab RG 7624; RO 5553110; Ni-1401	Interleukin Related	Inflammation/Immunology
Afasevikumab (RG 7624; RO 5553110; NI-1401) is a fully human monoclonal IgG1κ antibody neutralizing both IL-17A and IL-17F. Afasevikumab has anti-inflammatory activities .

HY-W011060

Cryptand 2.2.2 4,7,13,16,21,24-Hexaoxa-1,10-diazabicyclo[8.8.8]hexacosane	Biochemical Assay Reagents	Others
Cryptand 2.2.2 (4,7,13,16,21,24-Hexaoxa-1,10-diazabicyclo[8.8.8]hexacosane) is a metal ion chelator. Cryptand 2.2.2 forms stable mononuclear, protonated and dinuclear complexes with copper (II) ions; forms protonated complexes with hydrogen ions; and also forms stable complexes with Zn ²⁺, Co ²⁺, Ni ²⁺, Cd ²⁺, Hg ²⁺ and Pb ²⁺ ions. Cryptand 2.2.2 can be used for the preparation of nanoparticles, transition metal compounds, etc.

HY-Y1422I

Lipase,Pseudomonas fluorescens (Immobilized)	Environmental Pollutants Biochemical Assay Reagents Lipase	Others
Lipase, Pseudomonas fluorescens (Immobilized) is an immobilized biocatalyst derived from Pseudomonas fluorescens. Lipase, Pseudomonas fluorescens (Immobilized) efficiently catalyzes the hydrolysis, esterification and transesterification of triacylglycerols in solvent-free systems, and is particularly suitable for biodiesel production from soybean oil and selective modification of oils rich in EPA and DHA. Lipase, Pseudomonas fluorescens (Immobilized) exhibits optimal activity at pH 8.5 and 45°C, and retains residual activity after repeated cycles of use. Lipase, Pseudomonas fluorescens (Immobilized) is activated by Ca ²⁺, but inhibited by Co ²⁺, Ni ²⁺, Fe ³⁺, Fe ²⁺ and EDTA .

HY-101121

NI-42	Epigenetic Reader Domain	Cancer
NI-42 (compound 13-d), a structurally orthogonal chemical probe for the BRPFs, is a biased, potent inhibitor of the BRD of the BRPFs (IC₅₀s of BRPF1/2/3=7.9/48/260 nM; K_ds of BRPF1/2/3=40/210/940 nM) with excellent selectivity over nonclass IV BRD proteins .

HY-N15871

18:1 DGS-NTA(Ni)	Liposome	Others
18:1 DGS-NTA(Ni) is a nickel chelating lipid. 18:1 DGS-NTA(Ni) has high affinity for histidine-tags and can bind histidine tags of recombinant proteins. 18:1 DGS-NTA(Ni) can be used for preparation of liposomes and nanosize multilamellar vesicles (NMVs) which are used in protein and peptide binding studies and antigen delivery .

HY-W012683

Iminodiacetic acid	Biochemical Assay Reagents	Cancer
Iminodiacetic acid is a metal ion chelator targeting Cr ⁶⁺, Cd ²⁺, Ni ²⁺, and Pb ²⁺. Iminodiacetic acid selectively and irreversibly binds metal ions through the coordination of carboxyl and imino groups, reduces the toxicity of metal ions and promotes their adsorption and separation. Iminodiacetic acid has the functions of heavy metal ion removal and coordination complex stabilization. Iminodiacetic acid is often used in environmental pollution control (such as heavy metal adsorption in water) and coordination chemistry (such as metal ion detection and separation) research .

HY-111934

Cymarin	Parasite Potassium Channel	Others Cancer
Cymarin, a cardiac glycoside, potently inhibits the Palytoxin (PTX)-induced K ⁺ release (IC₅₀=0.42 μM). Cymarin reveals an antitumor activity against breast cancer and pancreatic cancer. Cymarin exhibits antifeedant and growth inhibitory effects as crop protectant .

HY-W012898

Dimethylglyoxime Biacetyl dioxime	Biochemical Assay Reagents	Others
Dimethylglyoxime (Biacetyl dioxime) belongs to the class of oximes and consists of two acetyl groups attached to a nitrogen atom, which in turn is attached to another nitrogen atom through a diimine bond. Dimethylglyoxime is a specific chelator of Ni that inhibits or slows the aggregation of Aβ peptides in vitro .

HY-Y0850U5

PVA (Mw 27000, 98-99% hydrolyzed, ~600 polymerization) Polyvinyl alcohol (Mw 27000, 98-99% hydrolyzed, ~600 polymerization); Poly(Ethenol) (Mw 27000, 98-99% hydrolyzed, ~600 polymerization)	Biochemical Assay Reagents Fungal	Infection
PVA (Polyvinyl alcohol) (Mw 27000, 98-99% hydrolyzed, ~600 polymerization) is a nonionic ethanol homopolymer with hydrophilicity, water solubility and biodegradability. PVA (Mw 27000, 98-99% hydrolyzed, ~600 polymerization) exhibits biocompatibility, non-toxicity and non-carcinogenicity, as well as antibacterial activity against Gram-positive bacteria, Gram-negative bacteria and fungal strains. PVA (Mw 27000, 98-99% hydrolyzed, ~600 polymerization) can serve as a solubilizer, stabilizer, mucoadhesive agent and sustained-release agent, and has a synergistic solubilizing effect on voriconazole/sulfobutyl ether β-cyclodextrin complexes. By stabilizing such complexes, PVA (Mw 27000, 98-99% hydrolyzed, ~600 polymerization) forms freeze-thaw hydrogels with high mucoadhesion, sustained drug release and ex vivo corneal permeability. When compounded with hyaluronic acid hydrogels, PVA (Mw 27000, 98-99% hydrolyzed, ~600 polymerization) supports chondrocyte growth in vitro, and also forms complexes with Cu ²⁺, Co ²⁺, Ni ²⁺ and Zn ²⁺ ions. PVA (Mw 27000, 98-99% hydrolyzed, ~600 polymerization) can be used in studies related to fungal keratitis, bacterial infections and fungal infections .

HY-170779

DOTA-NI-FAPI-04	FAP	Cancer
DOTA-NI-FAPI-04 is a FAP inhibitor (IC₅₀ = 7.44 nM). By integrating FAP targeting with hypoxia-sensitive groups (nitroimidazole), DOTA-NI-FAPI-04 significantly enhances tumor uptake and retention capabilities. DOTA-NI-FAPI-04 chelates metallic isotopes (such as 68Ga and 177Lu) through DOTA to produce radioactive probes ([68Ga]Ga/DOTA-NI-FAPI-04 and [177Lu]Lu/DOTA-NI-FAPI-04), which can be used for research in tumor diagnostics and therapeutic agents. DOTA-NI-FAPI-04 holds dual targeting potential in the fields of cancer imaging, tumor microenvironment analysis, and radionuclide therapy, particularly suitable for scenarios where the tumor stroma and hypoxic regions synergistically interact .

HY-P990638

NI-0701	CXCR	Inflammation/Immunology
NI-0701 is a humanized antibody expressed in CHO cells that targets CCL5/RANTES. NI-0701 has a huIgG2 heavy chain and a huλ light chain, with a predicted molecular weight (MW) of 145 kDa. The isotype control for NI-0701 can be referenced as Human IgG2 lambda, Isotype Control (HY-P991206).

HY-136476C

Ni(II) protoporphyrin IX	Biochemical Assay Reagents Ferrochelatase	Others
Ni(II) protoporphyrin IX is a metalloporphyrin that has a low tendency toward axial ligation, becomes distorted when bound to ferrochelatase .

HY-W017512

2-Methylindanone	Drug Intermediate	Others
2-Methylindanone is a cyclic ketone compound. 2-Methylindanone is an important substrate for evaluating the effects of Pd and Ni in asymmetric α-arylation reactions. 2-Methylindanone can also be used as a drug intermediate .

HY-P991249

NI-203	Amylin Receptor	Metabolic Disease
NI-203 is a monoclonal antibody inhibitor that targets amylin. NI-203 is promising for research of type 2 diabetes .

HY-P991602

NI-1201 TZLS-501	Interleukin Related	Cancer
NI-1201 is a monoclonal antibody that targets, in the human IL-6R sequence, the epitope recognized by 25F10 for mice. NI-1201 inhibits both IL-6 cis- and trans-signaling. NI-1201 targets site IIb of hIL-6R. NI-1201 inhibits gp130 binding to IL-6R .

HY-W1113135

Carboxymethyl-β-cyclodextrin sodium salt	Biochemical Assay Reagents	Others
Carboxymethyl-β-cyclodextrin sodium salt is a negatively charged β-cyclodextrin derivative, as well as a metal ion chelator and solubilizing reagent. Carboxymethyl-β-cyclodextrin sodium salt forms stable aqueous complexes with Ba ²⁺, Ca ²⁺, Cd ²⁺, Ni ²⁺, Pb ²⁺, Sr ²⁺, and Zn ²⁺ ions. Carboxymethyl-β-cyclodextrin sodium salt derived hydrogel carriers support oral insulin delivery via paracellular permeation across Caco-2 monolayers and produce sustained hypoglycemic effects in diabetic mice. Carboxymethyl-β-cyclodextrin sodium salt can be conjugated onto folate-modified BSA nanoparticles to boost folate receptor-mediated endocytosis, elevate intracellular anticancer drug uptake and trigger cell apoptosis. Carboxymethyl-β-cyclodextrin sodium salt can be utilized for chiral separation in capillary electrophoresis, development of nanoscale drug carriers and nucleic acid transfection research .

HY-P11261

AAZTA-NI-PSMA-093	PSMA	Cancer
AAZTA-NI-PSMA-093 is a bispecific agent targeting prostate-specific membrane antigen (PSMA) with an IC₅₀ value for PSMA of 87.48 nM. AAZTA-NI-PSMA-093 has a PSMA targeting module and an oxygen-sensitivity module (hypoxia-sensitive NI-moiety). AAZTA-NI-PSMA-093 can utilize the PSMA targeting property as a "navigation system" to efficiently concentrate the entire molecule within prostate cancer cells, and once the cells are in an oxygen-deficient state, the molecule will irreversibly capture and remain in the oxygen-deficient cells, achieving "secondary enrichment". AAZTA-NI-PSMA-093 can be labeled with ⁶⁸Ga and ¹⁷⁷Lu, and has high accumulation and rapid clearance characteristics in mouse models. AAZTA-NI-PSMA-093 can be used for the study of prostate cancer .

HY-W012683R

Iminodiacetic acid (Standard)	Biochemical Assay Reagents Reference Standards	Cancer
Iminodiacetic acid is a metal ion chelator targeting Cr6+, Cd2+, Ni2+, and Pb2+. Iminodiacetic acid selectively and irreversibly binds metal ions through the coordination of carboxyl and imino groups, reduces the toxicity of metal ions and promotes their adsorption and separation. Iminodiacetic acid has the functions of heavy metal ion removal and coordination complex stabilization. Iminodiacetic acid is often used in environmental pollution control (such as heavy metal adsorption in water) and coordination chemistry (such as metal ion detection and separation) research .

HY-P991412

NI-301	Transthyretin (TTR)	Cardiovascular Disease Neurological Disease
NI-301 is a human monoclonal antibody (mAb) targeting Transthyretin/TTR. NI-301 can be used in Cardiomyopathies and Familial amyloid neuropathy research .

HY-114900

BB-3497	Antibiotic	Infection Others
BB-3497 is a potent, orally active and selective peptide deformylase (PDF) inhibitor. BB-3497 is highly selective for PDF (IC₅₀ = 7 nM for E. coli PDF.Ni) over the other mammalian metalloenzymes (MMP-1/2/3/7 and enkephalinase). BB-3497 exhibits potent activity against gram-positive bacteria and some gram-negative pathogens. BB-3497 protects mice from infection in systemic models of Staphylococeus aureus. BB-3497 can be used for anti-bacterial infection research .

HY-P990639

NI-0801	CXCR	Inflammation/Immunology
NI-0801 is a humanized antibody expressed in CHO, targeting CXCL10/IP-10. NI-0801 contains huIgG1 heavy chain and huκ light chain, with a predicted molecular weight (MW) of 145 kDa. The isotype control for NI-0801 can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).

HY-139701

NI-Pano	HDAC	Cancer
NI-Pano (CH-03) is a novel hypoxia-activated KDAC inhibitor. NI-Pano (CH-03) is reduced in an O₂-dependent manner to release panobinostat.

HY-N15779

16:0 DGS-NTA(Ni)	Biochemical Assay Reagents	Others
16:0 DGS-NTA(Ni) is a chelator.

HY-156291

XSJ2-46	DNA/RNA Synthesis Influenza Virus	Infection
XSJ2-46, 5'-amino NI analog, is an antiviral agent. XSJ2-46 has anti-Zika virus activity. XSJ2-46 exhibits reasonable inhibition of RNA-dependent RNA polymerases (RdRp) with an IC₅₀ value of 8.78 μM .

HY-157917

Nitro-PAPS disodium dihydrate	Biochemical Assay Reagents	Others
Nitro-PAPS disodium dihydrate is a highly sensitive colometric reagent for Fe(II) detection with a maximal absorption wavelength of 592 nm. Nitro-PAPS disodium dihydrate is suitable for the determination of Fe(II) in serum and also be used to determine micro molar levels of Cu, Zn, Ni, Co and V .

HY-143249

MtMetAP1-IN-1	Bacterial	Infection
MtMetAP1-IN-1 is an inhibitor of Mycobacterium tuberculosis (Mtb), targeting methionine aminopeptidase 1 (MetAP1). MtMetAP1-IN-1 exerts antimycobacterial activity .

HY-W130303

Diacetamide N-Acetylacetamide; Diacetylamine; Diacetimide	Biochemical Assay Reagents	Others
Diacetamide is shown to form a variety of new compounds with a general formula [M(C₄H₇O₂N) ₃](ClO₄)₂, where M = Mn(II), Fe(II), Co(II), Ni(II), or Zn(II). Diacetamide ligands can be used in uranium extraction from wastewater. Diacetamide can be used for amidase synthesis .

HY-W011060R

Cryptand 2.2.2 (Standard) 4,7,13,16,21,24-Hexaoxa-1,10-diazabicyclo[8.8.8]hexacosane (Standard)	Biochemical Assay Reagents Reference Standards	Others
Cryptand 2.2.2 (Standard) is the analytical standard of Cryptand 2.2.2 (HY-W011060). This product is intended for research and analytical applications. Cryptand 2.2.2 is a metal ion chelating agent that can selectively form complexes with metal ions. At room temperature, Cryptand 2.2.2 can serve as a host molecule, using the chelation effect to selectively bind desired ions (such as Zn ²⁺, Co ²⁺, Ni ²⁺, Cu ²⁺). Cryptand 2.2.2 can be used in the preparation of nanoparticles, transition metal compounds, and so on .

HY-W124347

MOF-74-Ni Ni-MOF-74	MOFs	Others
MOF-74-Ni(Ni-MOF-74) is a metal-organic framework (MOF).

HY-W543351

SIFSIX-3-Ni	MOFs	Others
SIFSIX-3-Ni is a metal-organic framework (MOF).

HY-W1049768

TIFSIX-3-Ni	MOFs	Others
TIFSIX-3-Ni is a metal-organic framework (MOF).

HY-101121R

NI-42 (Standard)	Epigenetic Reader Domain Reference Standards	Cancer
NI-42 (Standard) is the analytical standard of NI-42 (HY-101121). This product is intended for research and analytical applications. NI-42 (compound 13-d), a structurally orthogonal chemical probe for the BRPFs, is a biased, potent inhibitor of the BRD of the BRPFs (IC50s of BRPF1/2/3=7.9/48/260 nM; Kds of BRPF1/2/3=40/210/940 nM) with excellent selectivity over nonclass IV BRD proteins .

HY-W115813

IRMOF-74-II-Ni	MOFs	Others
IRMOF-74-II-Ni is a metal-organic framework (MOF).

HY-W112985

meso-Tetrakis(4-chlorophenyl)porphyrin-Ni(II) Tetra(4-chlorophenyl)porphinato Nickel	MOFs	Others
meso-?Tetrakis(4-?chlorophenyl)?porphyrin-?Ni(II) (Tetra(4-chlorophenyl)porphinato nickel) is a metal-organic framework (MOF).

HY-W249567

DUT-8(Ni) (1,4-Diazabicyclo[2.2.2]octane-κN1)bis[μ-[2,6-naphthalenedicarboxylato(2-)-κO2:κO′2]]diNickel	MOFs	Others
DUT-8(Ni) ((1,4-Diazabicyclo[2.2.2]octane-κN1)bis[μ-[2,6-naphthalenedicarboxylato(2-)-κO2:κO′2]]dinickel) is a metal-organic framework (MOF).

HY-W113008

5,10,15,20-Tetra(4-methylphenyl)-21H,23H-porphine nickel meso-Tetratolylporphyrin-Ni(II)	MOFs	Others
5,?10,?15,?20-?Tetra(4-?methylphenyl)?-?21H,?23H-?porphine nickel (meso-Tetratolylporphyrin-Ni(II)) is a metal-organic framework (MOF).

HY-W112935

Ni(ii) meso-tetra(n-methyl-4-pyridyl) porphine tetrachloride Nickel(II) meso -tetra(N-methyl-4-pyridyl)porphine tetrachloride	MOFs	Others
Ni(ii) meso-?tetra(n-?methyl-?4-?pyridyl) porphine tetrachloride(Nickel(II) meso -tetra(N-methyl-4-pyridyl)porphine tetrachloride) is a metal-organic framework (MOF).

HY-W075610

Nickelate(4-), [[4,4',4'',4'''-(21H,23H-porphine-5,10,15,20-tetrayl)tetrakis[benzoato]](6-)-N21,N22,N23,N24]-, tetrahydrogen, (SP-4-1)- TCPP-Ni(2+)	MOFs	Others
Nickelate(4-), [[4,4',4'',4'''-(21H,23H-porphine-5,10,15,20-tetrayl)tetrakis[benzoato]](6-)-N21,N22,N23,N24]-, tetrahydrogen, (SP-4-1)-(TCPP-Ni(2+)) is a metal-organic framework (MOF).

HY-W008952

Tributyltetradecyl phosphonium chloride	Environmental Pollutants Biochemical Assay Reagents	Others
Tributyltetradecyl phosphonium chloride is a quaternary phosphonium salt cation. Tributyltetradecyl phosphonium chloride can form an acidic aqueous biphasic system with acid and water, exhibits temperature-induced phase separation behavior with a lower critical solution temperature, enables the partitioning of Co ²⁺, Fe ³⁺, Pt ⁴⁺ and Ni ²⁺ between the two phases, and also promotes the separation of Co ²⁺ and Ni ²⁺ .

HY-185401

ATSM	MOFs	Cancer
ATSM is a ligand that forms complexes with Cu ²⁺, Ni ²⁺, Zn ²⁺, and Fe ²⁺, with the highest affinity for Cu ²⁺. ATSM forms Cu-ATSM with copper, which is used for PET imaging to detect tumor hypoxia. ATSM is commonly used in coordination chemistry and radiopharmaceutical research .

HY-W722245

Pyochelin	Endogenous Metabolite Bacterial	Infection
Pyochelin is a salicylate-based nonribosomal peptide siderophore produced by Pseudomonas aeruginosa. Pyochelin chelates Fe ³⁺ and transports it back into bacterial cells, providing the iron essential for bacterial survival. Pyochelin can also chelate other metals such as Zn ²⁺, Co ²⁺, and Ni ²⁺, which helps bacteria maintain intracellular metal ion homeostasis by chelating and excreting excess metals in response to toxic metal stress. Pyochelin can be used in studies related to Pseudomonas aeruginosa infection .

Cat. No.	Product Name	Type

HY-W011060

Cryptand 2.2.2

4,7,13,16,21,24-Hexaoxa-1,10-diazabicyclo[8.8.8]hexacosane

Biochemical Assay Reagents

Cryptand 2.2.2 (4,7,13,16,21,24-Hexaoxa-1,10-diazabicyclo[8.8.8]hexacosane) is a metal ion chelator. Cryptand 2.2.2 forms stable mononuclear, protonated and dinuclear complexes with copper (II) ions; forms protonated complexes with hydrogen ions; and also forms stable complexes with Zn ²⁺, Co ²⁺, Ni ²⁺, Cd ²⁺, Hg ²⁺ and Pb ²⁺ ions. Cryptand 2.2.2 can be used for the preparation of nanoparticles, transition metal compounds, etc.

HY-W012898

Dimethylglyoxime Biacetyl dioxime	Biochemical Assay Reagents
Dimethylglyoxime (Biacetyl dioxime) belongs to the class of oximes and consists of two acetyl groups attached to a nitrogen atom, which in turn is attached to another nitrogen atom through a diimine bond. Dimethylglyoxime is a specific chelator of Ni that inhibits or slows the aggregation of Aβ peptides in vitro .

HY-Y0850U5

PVA (Mw 27000, 98-99% hydrolyzed, ~600 polymerization)

Polyvinyl alcohol (Mw 27000, 98-99% hydrolyzed, ~600 polymerization); Poly(Ethenol) (Mw 27000, 98-99% hydrolyzed, ~600 polymerization)

Biochemical Assay Reagents

PVA (Polyvinyl alcohol) (Mw 27000, 98-99% hydrolyzed, ~600 polymerization) is a nonionic ethanol homopolymer with hydrophilicity, water solubility and biodegradability. PVA (Mw 27000, 98-99% hydrolyzed, ~600 polymerization) exhibits biocompatibility, non-toxicity and non-carcinogenicity, as well as antibacterial activity against Gram-positive bacteria, Gram-negative bacteria and fungal strains. PVA (Mw 27000, 98-99% hydrolyzed, ~600 polymerization) can serve as a solubilizer, stabilizer, mucoadhesive agent and sustained-release agent, and has a synergistic solubilizing effect on voriconazole/sulfobutyl ether β-cyclodextrin complexes. By stabilizing such complexes, PVA (Mw 27000, 98-99% hydrolyzed, ~600 polymerization) forms freeze-thaw hydrogels with high mucoadhesion, sustained drug release and ex vivo corneal permeability. When compounded with hyaluronic acid hydrogels, PVA (Mw 27000, 98-99% hydrolyzed, ~600 polymerization) supports chondrocyte growth in vitro, and also forms complexes with Cu ²⁺, Co ²⁺, Ni ²⁺ and Zn ²⁺ ions. PVA (Mw 27000, 98-99% hydrolyzed, ~600 polymerization) can be used in studies related to fungal keratitis, bacterial infections and fungal infections .

HY-157917

Nitro-PAPS disodium dihydrate	Biochemical Assay Reagents
Nitro-PAPS disodium dihydrate is a highly sensitive colometric reagent for Fe(II) detection with a maximal absorption wavelength of 592 nm. Nitro-PAPS disodium dihydrate is suitable for the determination of Fe(II) in serum and also be used to determine micro molar levels of Cu, Zn, Ni, Co and V .

HY-W011060R

Cryptand 2.2.2 (Standard)

4,7,13,16,21,24-Hexaoxa-1,10-diazabicyclo[8.8.8]hexacosane (Standard)

Biochemical Assay Reagents

Cryptand 2.2.2 (Standard) is the analytical standard of Cryptand 2.2.2 (HY-W011060). This product is intended for research and analytical applications. Cryptand 2.2.2 is a metal ion chelating agent that can selectively form complexes with metal ions. At room temperature, Cryptand 2.2.2 can serve as a host molecule, using the chelation effect to selectively bind desired ions (such as Zn ²⁺, Co ²⁺, Ni ²⁺, Cu ²⁺). Cryptand 2.2.2 can be used in the preparation of nanoparticles, transition metal compounds, and so on .

Cat. No.	Product Name	Target	Research Area

HY-P0294

Hexa-His 6X His Tag	Biochemical Assay Reagents	Others
Hexa-His (6X His Tag) is a commonly used affinity tag made up of six histidine residues. HEXA-HIS can bind to affinity chromatography media containing transition metal ions like nickel (Ni ²⁺) or cobalt (Co ²⁺), making it useful for protein purification .

HY-P11261

AAZTA-NI-PSMA-093	PSMA	Cancer
AAZTA-NI-PSMA-093 is a bispecific agent targeting prostate-specific membrane antigen (PSMA) with an IC₅₀ value for PSMA of 87.48 nM. AAZTA-NI-PSMA-093 has a PSMA targeting module and an oxygen-sensitivity module (hypoxia-sensitive NI-moiety). AAZTA-NI-PSMA-093 can utilize the PSMA targeting property as a "navigation system" to efficiently concentrate the entire molecule within prostate cancer cells, and once the cells are in an oxygen-deficient state, the molecule will irreversibly capture and remain in the oxygen-deficient cells, achieving "secondary enrichment". AAZTA-NI-PSMA-093 can be labeled with ⁶⁸Ga and ¹⁷⁷Lu, and has high accumulation and rapid clearance characteristics in mouse models. AAZTA-NI-PSMA-093 can be used for the study of prostate cancer .

Cat. No.	Product Name

HY-K0238

Ni-IDA Agarose
MCE Ni-IDA Agarose can be used for the detection and purification of His-tag proteins.

HY-K0241

Ni-NTA Magnetic Agarose Beads 1 Publications Verification
MCE Ni-NTA Magnetic Agarose Beads can be used for the detection and purification of His-tag proteins from various expression sources.

HY-K0240

Ni-IDA Magnetic Agarose Beads
MCE Ni-IDA Magnetic Agarose Beads can be used for the detection and purification of His-tag proteins from various expression sources.

HY-K0210

Ni-NTA His-Tag Purification Agarose Maximum Cited Publications 30 Publications Verification
MCE Ni-NTA His-Tag Purification Agarose, a 6% highly cross-linked agarose reagent, enables high-yield, high-purity purification of his-tagged proteins.

HY-K0220

Ni-NTA 6FF Prepacked Column 1 Publications Verification
MCE Ni-NTA 6FF Prepacked Column is ideal for high performance purification of polyhistidine-tagged proteins expressed in E.coli, yeast, insect and mammalian expression systems.

HY-K0256

Chelating Agarose (IDA) 6FF
MCE Chelating Agarose (IDA) 6FF allows flexible chelation with metal ions such as Zn²⁺, Ni²⁺, or Cu²⁺, and is suitable for the purification of His-tagged recombinant proteins expressed in bacterial, mammalian, insect, and baculovirus systems.

HY-K0255

IMAC Agarose (NTA) 6FF

MCE IMAC Agarose (NTA) 6FF is prepared by covalently coupling tetradentate nitrilotriacetic acid (NTA) to an agarose matrix. It features high binding capacity, excellent specificity, and superior ligand stability. The resin allows flexible chelation with metal ions such as Zn²⁺, Ni²⁺, or Cu²⁺, and is suitable for the purification of His-tagged recombinant proteins expressed in bacterial, mammalian, insect, and baculovirus systems.

Cat. No.	Product Name	Target	Research Area	Image

HY-P99191

Emapalumab Ni-0501	IFNAR	Inflammation/Immunology
Emapalumab (NI-0501) is a human monoclonal IgG1 antibody that noncompetitively inhibits IFN-γ. Emapalumab binds with high affinity (K_d= 1.4 pM) to both free IFN-γ as well as IFN-γ bound to its receptor. Emapalumab can be used in research of hemophagocytic lymphohistiocytosis (HLH) .

HY-P99199

Foralumab Ni-0401	CD3	Inflammation/Immunology
Foralumab (NI-0401) is a potent, orally active human monoclonal antibody targeting the CD3. Foralumab modulates immune responses by human cells in NSG mice that were reconstituted with human hematopoietic stem cells .

HY-P991128

Cliramitug Ni-006; ALXN2220	Transthyretin (TTR)	Cardiovascular Disease Neurological Disease
Cliramitug (NI-006; ALXN2220) is a monoclonal antibody that targets human transthyretin (TTR). Cliramitug binds to TTR and inhibits its amyloidogenic process, exerting amyloid formation-inhibiting activity. Cliramitug can be used in the research of transthyretin amyloidosis-related diseases, such as certain neurological and cardiovascular diseases .

HY-145645

Paridiprubart Ni-0101	Toll-like Receptor (TLR)	Inflammation/Immunology
Paridiprubart (NI-0101) is a humanised anti-TLR4 monoclonal antibody. Paridiprubar inhibits the production of pro-inflammatory cytokines by monocytes from rheumatoid arthritis specimen induced by rheumatoid arthritis synovial fluid (RASF). Paridiprubart can be used for the study of rheumatoid arthritis .

HY-P99424

Afasevikumab RG 7624; RO 5553110; Ni-1401	Interleukin Related	Inflammation/Immunology
Afasevikumab (RG 7624; RO 5553110; NI-1401) is a fully human monoclonal IgG1κ antibody neutralizing both IL-17A and IL-17F. Afasevikumab has anti-inflammatory activities .

HY-P990638

NI-0701	CXCR	Inflammation/Immunology
NI-0701 is a humanized antibody expressed in CHO cells that targets CCL5/RANTES. NI-0701 has a huIgG2 heavy chain and a huλ light chain, with a predicted molecular weight (MW) of 145 kDa. The isotype control for NI-0701 can be referenced as Human IgG2 lambda, Isotype Control (HY-P991206).

HY-P991249

NI-203	Amylin Receptor	Metabolic Disease
NI-203 is a monoclonal antibody inhibitor that targets amylin. NI-203 is promising for research of type 2 diabetes .

HY-P991602

NI-1201 TZLS-501	Interleukin Related	Cancer
NI-1201 is a monoclonal antibody that targets, in the human IL-6R sequence, the epitope recognized by 25F10 for mice. NI-1201 inhibits both IL-6 cis- and trans-signaling. NI-1201 targets site IIb of hIL-6R. NI-1201 inhibits gp130 binding to IL-6R .

HY-P991412

NI-301	Transthyretin (TTR)	Cardiovascular Disease Neurological Disease
NI-301 is a human monoclonal antibody (mAb) targeting Transthyretin/TTR. NI-301 can be used in Cardiomyopathies and Familial amyloid neuropathy research .

HY-P990639

NI-0801	CXCR	Inflammation/Immunology
NI-0801 is a humanized antibody expressed in CHO, targeting CXCL10/IP-10. NI-0801 contains huIgG1 heavy chain and huκ light chain, with a predicted molecular weight (MW) of 145 kDa. The isotype control for NI-0801 can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).

Host:	Mouse (2) Rabbit (1)
Reactivity:	Human (3)
Application:	IHC-P (1) ICC/IF (3) IP (1) WB (1) FC (3)
Isotype:	IgG (1) IgG1 (2)
Conjugation:	Non-conjugated (3)
Clonality:	Monoclonal (2) Recombinant (1)
Modification:	Unmodified (2)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P88821

	ADI1 Antibody (YA8505) APL1; ARD; Fe-ARD; HMFT1638; MTCBP1; mtnD; Ni-ARD; SIPL	ICC/IF, FC	Human
	ADI1 Antibody (YA8505) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ADI1.

HY-P88821A

	ADI1 Antibody (YA8505)(PBS only) APL1; ARD; Fe-ARD; HMFT1638; MTCBP1; mtnD; Ni-ARD; SIPL	ICC/IF, FC	Human
	ADI1 Antibody (YA8505) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ADI1.

HY-P81675

	Nogo Antibody (YA1420) ASY; Foocen; Ni220/250; NOGO; NOGOC; NSP; rat N; RTN X; Rtn4; RTN4-A; RTN4-B1; RTN4-B2; RTN4-C; Vp20	WB, IHC-P, ICC/IF, FC, IP	Human
	Nogo Antibody (YA1420) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Nogo.

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HY-N15871

18:1 DGS-NTA(Ni)		Phospholipids
18:1 DGS-NTA(Ni) is a nickel chelating lipid. 18:1 DGS-NTA(Ni) has high affinity for histidine-tags and can bind histidine tags of recombinant proteins. 18:1 DGS-NTA(Ni) can be used for preparation of liposomes and nanosize multilamellar vesicles (NMVs) which are used in protein and peptide binding studies and antigen delivery .

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