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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
7 Results for "
PROTAC α-synuclein degrader
" in MedChemExpress (MCE) Product Catalog:
Products (7)
7 Results for "PROTAC α-synuclein degrader" in MCE Product Catalog:
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PROTAC α-Synuclein/Tau degrader 1 is a blood-brain barrier-penetrant dual PROTAC degrader of α-synuclein (α-Syn) and tau, with DC50 of 1.57 μM and 4.09 μM, respectively. PROTAC α-Synuclein/Tau degrader 1 binds to α-Syn and tau PFF, with KDs of 0.47 and 2.78 μM, respectively. PROTAC α-Synuclein/Tau degrader 1 exhibits degradation effect mediated by the ubiquitin-proteasome system (UPS). PROTAC α-Synuclein/Tau degrader 6 can be used for the study of Parkinson’s disease (PD) (Pink: α-Synuclein/Tau ligand (HY-151035); Blue: CRBN ligase ligand (HY-14658); Black: Linker (HY-128803)) .
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PROTAC α-synuclein degrader 5 is a selective PROTAC degrader targeting α‑synuclein aggregates, with a DC50 of 7.51 μM. PROTAC α-synuclein degrader 5 binds to αSyn aggregates, recruits the CRBN E3 ubiquitin ligase, and mediates the ubiquitination and subsequent degradation of α‑synuclein aggregates. PROTAC α-synuclein degrader 5 activates the autophagy-lysosome pathway. PROTAC α-synuclein degrader 5 reduces ROS levels in neuroblastoma cells, restores mitochondrial membrane potential, rescues cell viability, and decreases LDH release. PROTAC α-synuclein degrader 5 degrades αSyn aggregates in Caenorhabditis elegans and ameliorates oxidative stress. PROTAC α-synuclein degrader 5 is used for the research of synucleinopathies, such as Parkinson's disease .
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PROTAC α-synuclein degrader 3 is a selective α-Synuclein PROTAC degrader. PROTAC α-synuclein degrader 3 promotes ubiquitination and degradation of α-Synuclein. PROTAC α-synuclein degrader 3 can be used in research related to Parkinson's disease and Alzheimer's disease .
Cat. No.: HY-136000
CAS No.: 2412273-76-6
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PROTAC α-synuclein degrader 2 is a potent α-synuclein PROTAC degrader. PROTAC α-synuclein degrader 2 induces ubiquitination and proteasomal degradation of α-synuclein by bridging α-synuclein with the VHL E3 ubiquitin ligase. PROTAC α-synuclein degrader 2 can be used in the research of Parkinson's disease and Alzheimer's disease .
Cat. No.: HY-135999
CAS No.: 2412273-73-3
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PROTAC α-synuclein degrader 1 is a α-synuclein PROTAC degrader that can recruit VHL. PROTAC α-synuclein degrader 1 induces ubiquitination and degradation of α-synuclein, and is applicable to researches on Parkinson's disease, Alzheimer's disease, dementia with Lewy bodies, multiple system atrophy, etc.
Cat. No.: HY-169959
CAS No.: 2716123-18-9
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OTs-PEG3-NHCO-Thalidomide is a ubiquitin E3 ligase and linker for PROTAC α-synuclein degrader 6 (HY-157839), which can be used in research on neurodegenerative diseases .
Cat. No.: HY-187000
CAS No.: 749927-21-7
Research Areas:
α-Synuclein ligand-1 is a α-Synuclein ligand, which can be used for the synthesis of PROTACs, such as PROTAC α-synuclein degrader 5 (HY-155021) .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
