3032208-24-2
Chemical Structure
PROTAC α-Synuclein/Tau degrader 1
- CAS No.: 3032208-24-2
- Formula:C37H39N5O9S
- Molecular Weight:729.80
InChIKey: PWVHWGSXBYTNNZ-UHFFFAOYSA-N
SMILES: O=C(N1C2C(NC(CC2)=O)=O)C3=CC=CC(OCC(NCCOCCOCCOCCNC4=CC=C(C(S5)=NC6=C5C=C(C)C=C6)C=C4)=O)=C3C1=O
Biological Activity: PROTAC α-Synuclein/Tau degrader 1 is a blood-brain barrier-penetrant dual PROTAC degrader of α-synuclein (α-Syn) and tau, with DC50 of 1.57 μM and 4.09 μM, respectively. PROTAC α-Synuclein/Tau degrader 1 binds to α-Syn and tau PFF, with KDs of 0.47 and 2.78 μM, respectively. PROTAC α-Synuclein/Tau degrader 1 exhibits degradation effect mediated by the ubiquitin-proteasome system (UPS). PROTAC α-Synuclein/Tau degrader 6 can be used for the study of Parkinson’s disease (PD) (Pink: α-Synuclein/Tau ligand (HY-151035); Blue: CRBN ligase ligand (HY-14658); Black: Linker (HY-128803))[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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PROTAC α-Synuclein/Tau degrader 1 | 98.65% | PROTAC α-Synuclein/Tau degrader 1 is a blood-brain barrier-penetrant dual PROTAC degrader of α-synuclein (α-Syn) and tau, with DC50 of 1.57 μM and 4.09 μM, respectively. PROTAC α-Synuclein/Tau degrader 1 binds to α-Syn and tau PFF, with KDs of 0.47 and 2.78 μM, respectively. PROTAC α-Synuclein/Tau degrader 1 exhibits degradation effect mediated by the ubiquitin-proteasome system (UPS). PROTAC α-Synuclein/Tau degrader 6 can be used for the study of Parkinson’s disease (PD) (Pink: α-Synuclein/Tau ligand (HY-151035); Blue: CRBN ligase ligand (HY-14658); Black: Linker (HY-128803)). | ||||||||||||||||||||
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Similarity Score 0.68
HY-169959OTs-PEG3-NHCO-Thalidomide -
Similarity Score 0.65
HY-107440AThalidomide-O-amido-PEG3-C2-NH2 hydrochloride -
Similarity Score 0.65
HY-107440Thalidomide-O-amido-PEG3-C2-NH2 -
Similarity Score 0.64
HY-W1130364Thalidomide-O-amido-PEG3-azide -
Similarity Score 0.64
HY-122710AThalidomide-O-amido-PEG4-C2-NH2 hydrochloride -
Similarity Score 0.64
HY-122710Thalidomide-O-amido-PEG4-C2-NH2 -
Similarity Score 0.64
HY-141013Thalidomide-O-amido-PEG4-propargyl -
Similarity Score 0.63
HY-115881SR-1114 -
Similarity Score 0.63
HY-103611RThalidomide-O-amido-PEG3-C2-NH2 TFA (Standard) -
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