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Cat. No.: HY-169959

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OTs-PEG3-NHCO-Thalidomide

OTs-PEG3-NHCO-Thalidomide is a ubiquitin E3 ligase and linker for PROTAC α-synuclein degrader 6 (HY-157839), which can be used in research on neurodegenerative diseases.

For research use only. We do not sell to patients.

CAS No.: 2716123-18-9
Formula: C₃₀H₃₅N₃O₁₂S
Molecular Weight:661.68

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

OTs-PEG3-NHCO-Thalidomide Chemical Structure

CAS No.: 2716123-18-9

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

OTs-PEG3-NHCO-Thalidomide is a ubiquitin E3 ligase and linker for PROTAC α-synuclein degrader 6 (HY-157839), which can be used in research on neurodegenerative diseases^[1].

All E3 Ligase Ligand-Linker Conjugates Isoforms :

Chemical Information

CAS No. 2716123-18-9
Molecular Weight 661.68
Formula C₃₀H₃₅N₃O₁₂S
SMILES

O=C(N1C2C(NC(CC2)=O)=O)C3=CC=CC(OCC(NCCOCCOCCOCCOS(C4=CC=C(C=C4)C)(=O)=O)=O)=C3C1=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Wentao Zhu, et al. Discovery of Effective Dual PROTAC Degraders for Neurodegenerative Disease-Associated Aggregates. J Med Chem. 2024 Mar 14;67(5):3448-3466. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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OTs-PEG3-NHCO-Thalidomide

All E3 Ligase Ligand-Linker Conjugates Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

OTs-PEG3-NHCO-Thalidomide Related Classifications

HY-169959 Related Classifications