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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
3 Results for "
PROTAC BRD4 Degrader-18
" in MedChemExpress (MCE) Product Catalog:
Products (3)
3 Results for "PROTAC BRD4 Degrader-18" in MCE Product Catalog:
Cat. No.: HY-134822
CAS No.: 1949837-13-1
Target:
Domaines de recherche:
PROTAC BRD4 Degrader-18 is a PROTAC BRD4 degrader. PROTAC BRD4 Degrader-18 binds to BRD4 and recruits E3 ubiquitin ligase, inducing ubiquitination and proteasomal degradation of BRD4. PROTAC BRD4 Degrader-18 exhibits antiproliferative activity against ovarian cancer cell lines. PROTAC BRD4 Degrader-18 can be used in research related to ovarian cancer .
Cat. No.: HY-184335
CAS No.: 3097564-20-7
Domaines de recherche:
PROTAC BET Degrader-18 is a PROTAC targeting BET, with a DC50 of 0.676 nM in HEK293-BRD4-HiBiT-KI cells. PROTAC BET Degrader-18 mainly targets and degrades BRD4 (EC50 = 59.91 nM), and exhibits weak degradation activity against BRD2. PROTAC BET Degrader-18 inhibits the expression of downstream oncoprotein c-Myc, thereby inducing cell cycle arrest and apoptosis, while suppressing oncoprotein expression. PROTAC BET Degrader-18 shows antiproliferative activity against acute myeloid leukemia cells and triple-negative breast cancer cells. PROTAC BET Degrader-18 demonstrates antitumor efficacy in xenograft mouse models. PROTAC BET Degrader-18 can be used for the research of acute myeloid leukemia and triple-negative breast cancer .
Cat. No.: HY-184339
Domaines de recherche:
BRD4-IN-42 is a BRD4 BD1 inhibitor with an IC50 of 108.50 nM. BRD4-IN-42 can be used for the synthesis of PROTACs and serves as the target protein moiety of PROTAC BET Degrader-18 (HY-184335). BRD4-IN-42 inhibits the proliferation of wild-type and SHP099-resistant acute myeloid leukemia cells. BRD4-IN-42 is applicable to research related to acute myeloid leukemia .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
