Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
3 Results for "
PROTAC CDK4/6 degrader-2
" in MedChemExpress (MCE) Product Catalog:
Products (3)
3 Results for "PROTAC CDK4/6 degrader-2" in MCE Product Catalog:
Cat. No.: HY-189460
CAS No.: 3135520-67-8
PROTAC CDK4/6 degrader-2 is an orally active and selective PROTAC degrader that targets CDK4/6 degradation by recruiting cereblon. PROTAC CDK4/6 degrader-2 exhibits DC50 values of 10.9 nM and 9.6 nM for CDK4 and CDK6, respectively. PROTAC CDK4/6 degrader-2 inhibits RB phosphorylation and cell cycle progression. PROTAC CDK4/6 degrader-2 is applicable for research on breast cancer and CDK4/6 inhibitor resistance .
Cat. No.: HY-178518
Research Areas:
Thalidomide-C1-O-CO-C2-Piperazine-CO-C1-Azacyclohexane-C1-Piperazine is an E3 ligase ligand-linker conjugate containing a cereblon (CRBN) ligand for E3 ubiquitin ligase and a linker. Thalidomide-C1-O-CO-C2-Piperazine-CO-C1-Azacyclohexane-C1-Piperazine can be used to synthesize PROTAC CDK4/6/9 degrader 2 (HY-178516) .
Cat. No.: HY-178517
Target:
Research Areas:
Thalidomide-C1-O-CO-C11 is a ligand for E3 ubiquitin ligase. Thalidomide-C1-O-CO-C11 can be connected to Aurora-A ligand 1 (HY-168440) by a linker (HY-178512) to form PROTAC CDK4/6/9 degrader 2 (HY-178516) .
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
