3135520-67-8
Chemical Structure
PROTAC CDK4/6 degrader-2
- CAS No.: 3135520-67-8
- Formula:C47H54N10O6
- Molecular Weight:855.00
InChIKey: GJOFHYBMGXGDRA-UHFFFAOYSA-N
SMILES: O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC(N4CC(N5CCC(CN6CCC(C7=CC=C(NC8=NC=C(C(C)=C(C(C)=O)C(N9C%10CCCC%10)=O)C9=N8)N=C7)CC6)CC5)C4)=C3)=O
Biological Activity: PROTAC CDK4/6 degrader-2 is an orally active and selective PROTAC degrader that targets CDK4/6 degradation by recruiting cereblon. PROTAC CDK4/6 degrader-2 exhibits DC50 values of 10.9 nM and 9.6 nM for CDK4 and CDK6, respectively. PROTAC CDK4/6 degrader-2 inhibits RB phosphorylation and cell cycle progression. PROTAC CDK4/6 degrader-2 is applicable for research on breast cancer and CDK4/6 inhibitor resistance[1].
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PROTAC CDK4/6 degrader-2 | PROTAC CDK4/6 degrader-2 is an orally active and selective PROTAC degrader that targets CDK4/6 degradation by recruiting cereblon. PROTAC CDK4/6 degrader-2 exhibits DC50 values of 10.9 nM and 9.6 nM for CDK4 and CDK6, respectively. PROTAC CDK4/6 degrader-2 inhibits RB phosphorylation and cell cycle progression. PROTAC CDK4/6 degrader-2 is applicable for research on breast cancer and CDK4/6 inhibitor resistance. | |||||||||||||||||||||
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