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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
55 Results for "
PTHR
" in MedChemExpress (MCE) Product Catalog:
Products (55)
55 Results for "PTHR" in MCE Product Catalog:
15
15 Publications Verification
Cat. No.: HY-P0059
CAS No.: 52232-67-4
Synonyms: Human parathyroid hormone-(1-34); hPTH (1-34)
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3 Cited Publications
Synonyms: BA 058; BIM 44058
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1 Cited Publications
Cat. No.: HY-P1852
CAS No.: 277302-47-3
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PCO371 is an orally active full agonist of parathyroid hormone receptor 1 (PTHR1), with no effect on PTH type 2 receptor.
Cat. No.: HY-P4385
CAS No.: 129622-68-0
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AH3960 (compound 16c) is an antagonist of androgen receptor. AH3960 binds wild as well as T877 mutant type androgen receptors. AH3960 selectively inhibits T877 with an IC50 value of 0.82 μM. AH3960 also serves as an agonist of parathyroid hormone receptor-1 (PTHR1) .
Human PTHrP-(1-36) is a secretory form of PTHrP with anticalciuric effects. Human PTHrP-(1-36) enhances beta cell function and proliferation. Human PTHrP-(1-36) can be used in the research of humoral hypercalcemia of malignancy (HHM) and hyperparathyroidism. Human PTHrP-(1-36) sequence is highly conserved and can be used for experiments in human samples, mice, and rats .
DS69910557 is a potent, selective and orally activehuman parathyroid hormone receptor 1 (hPTHR1) antagonist. DS69910557 has antagonistic activity for PTHR1 with an IC50 value of 0.08 μM. DS69910557 can be used for the research of hyperparathyroidism, hypercalcemia of malignancy and osteoporosis .
Cat. No.: HY-P10909
CAS No.: 2925554-87-4
Synonyms: MBX 2109
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Canvuparatide (MBX 2109) is a PTH analog prodrug that releases the biologically active peptide through temperature- and pH-controlled intramolecular cyclization. The peptide released by Canvuparatide binds to and activates the PTH1 receptor, stimulating dose-dependent cAMP accumulation. Canvuparatide can be used in research on hypoparathyroidism .
Cat. No.: HY-P4823
CAS No.: 136799-54-7
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Cat. No.: HY-P4821
CAS No.: 83139-29-1
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DS08210767 is a highly potent, orally bioavailable PTHR1 antagonist with IC50 of 90 nM .
Cat. No.: HY-P3075
CAS No.: 112540-82-6
Synonyms: PTHRP (1-34)
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PTHR PKA PKC PI3K Akt ERK NADPH Oxidase Reactive Oxygen Species (ROS) TGF-beta/Smad Caspase Apoptosis NO Synthase
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pTH-Related Protein (1-34) (human,mouse,rat) (pTHrP (1-34)) is a parathyroid hormone-related protein fragment. Binding of pTH-Related Protein (1-34) (human,mouse,rat) to PTH1R triggers cAMP/PKA and PKC signaling, PI3K-mediated Akt and ERK1/2 phosphorylation, NADPH oxidase-dependent ROS generation, and TGF-beta1 and p47phox expression. pTH-Related Protein (1-34) (human,mouse,rat) induces fibronectin upregulation, osteoblast differentiation, osteoclastic bone resorption, bone formation, eNOS/NO-mediated vasodilation, and sensitization of type II pneumocytes to ultraviolet-induced apoptosis (apoptosis) via caspase 3. pTH-Related Protein (1-34) (human,mouse,rat) can be used in research on diabetic nephropathy, breast cancer, acute lung injury, humoral hypercalcemia of malignancy, osteoporosis, and cartilage degeneration .
Cat. No.: HY-16498
CAS No.: 848084-83-3
Synonyms: PCK-3145
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Cat. No.: HY-113918
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SW-106 is a selective antagonist of parathyroid hormone/parathyroid hormone-related peptide receptor (PPR) and PTHR1, with an IC50 value of 0.99 μM against PPR. SW-106 antagonizes cAMP responses. SW-106 can be used in the research of osteoporosis .
Cat. No.: HY-P4856
CAS No.: 120298-73-9
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Cat. No.: HY-120398
CAS No.: 1253919-92-4
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CH5447240 is an orally active agonist of parathyroid hormone receptor 1 (PTHR1). CH5447240 stimulates cAMP production in HKRK-B7 cells expressing hPTHR1, with an EC50 of 12 μM. CH5447240 exhibits PTH-like activity, elevating serum calcium and reducing serum phosphate. CH5447240 can be used for research on hypoparathyroidism .
Cat. No.: HY-P4827
CAS No.: 521986-14-1
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Cat. No.: HY-RS11395
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PTH1R Human Pre-designed siRNA Set A contains three designed siRNAs for PTH1R gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
