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Results for "

PTP1B inhibitor (Standard)

" in MedChemExpress (MCE) Product Catalog:

7

Inhibitors & Agonists

3

Natural
Products

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-10704R
    PTP1B-IN-1 (Standard)

    PTP1B inhibitor (Standard)

    		 Reference Standards Phosphatase NF-κB Neurological Disease Inflammation/Immunology
    PTP1B-IN-1 (Standard) (PTP1B inhibitor (Standard)) is the analytical standard of PTP1B-IN-1 (HY-10704). This product is intended for research and analytical applications. PTP1B-IN-1 (Compound 7a) is a small molecule inhibitor of PTP1B with an IC50 value of 1.6 mM. It is often used as the mother core for derivatives of analogues .
    PTP1B-IN-1 (Standard)
  • HY-N2217R
    Rotundic acid (Standard)

    		Reference Standards Akt mTOR p38 MAPK Apoptosis Cardiovascular Disease Inflammation/Immunology Cancer
    Rotundic acid (Standard) is the analytical standard of Rotundic acid (HY-N2217). This product is intended for research and analytical applications. Rotundic acid is an orally effective triterpenoid with a Kd value of 51.3 µM for PTP1B. Rotundic acid downregulates the AKT/mTOR pro-survival pathway and modulates the MAPK pathway. Rotundic acid induces cell cycle S-phase arrest, DNA damage and apoptosis; it inhibits migration, invasion, angiogenesis and proliferation of cancer cells. Rotundic acid improves leptin sensitivity, regulates gut microbiota and reduces cellular senescence. Rotundic acid can be used in research related to hepatocellular carcinoma, obesity, aging, acute lung injury and type 2 diabetes .
    Rotundic acid (Standard)
  • HY-100462R
    PTP1B-IN-2 (Standard)

    		Phosphatase Reference Standards Metabolic Disease
    PTP1B-IN-2 (Standard) is the analytical standard of PTP1B-IN-2 (HY-100462). This product is intended for research and analytical applications. PTP1B-IN-2 is a potent protein tyrosine phosphatase 1B (PTP1B) inhibitor with an IC50 of 50 nM.
    PTP1B-IN-2 (Standard)
  • HY-N0646R
    Silydianin (Standard)

    		Reference Standards Phosphatase Endogenous Metabolite Tyrosinase Apoptosis Interleukin Related Inflammation/Immunology Cancer
    Silydianin (Standard) is the analytical standard of Silydianin (HY-N0646). This product is intended for research and analytical applications. Silydianin is a flavonolignan. Silydianin can be obtained from Silybum marianum. Silydianin inhibits PTP1B with an IC50 of 17.38 μM. Silydianin inhibits both monophenolase and diphenolase of tyrosinase significantly, with IC50s of 2.6 μM and 16.5 μM, respectively. Silydianin induces Apoptosis and reduces cytokines (IL-4 and IL-5). Silymarin has antioxidant, cytoprotective and immunomodulatory effects. Silydianin has antitumor activity against prostate cancer. Silymarin can be used in allergic asthma research .
    Silydianin (Standard)
  • HY-108196R
    PTP1B-IN-15 (Standard)

    		Reference Standards Phosphatase Endocrinology
    PTP1B-IN-15 (Standard) is the analytical standard of PTP1B-IN-15 (HY-108196). This product is intended for research and analytical applications. PTP1B-IN-15 is a potent and selective inhibitor of protein tyrosine phosphatase 1B (PTP1B). PTP1B-IN-15 has the potential for the research of type II diabetes and obesity .
    PTP1B-IN-15 (Standard)
  • HY-116474R
    Viridicatol (Standard)

    		Reference Standards JNK β-catenin NO Synthase PGE synthase Fungal STAT ERK MMP p38 MAPK Bacterial NF-κB Wnt Infection Metabolic Disease Inflammation/Immunology
    Viridicatol (Standard) is the analytical standard of Viridicatol (HY-116474). This product is intended for research and analytical applications. Viridicatol is a quinolone alkaloid with anti-inflammatory, antibacterial, antifungal, osteogenic and chondrogenic activities. Viridicatol reduces the phosphorylation levels of ERK, JNK, p38 and STAT6; inhibits MMP-2, MMP-9, NF-κB signaling pathway and PTP1B; downregulates genes related to mast cell activation; and binds to SHN3 to activate the Wnt/SHN3 signaling pathway. Viridicatol inhibits the expression of pro-inflammatory mediators and cytokines, and promotes osteogenic/chondrogenic differentiation. Viridicatol can be used in studies related to fibrosarcoma, allergy, bacterial infection, fungal infection and osteoporosis .
    Viridicatol (Standard)
  • HY-109041R
    Razuprotafib (Standard)

    AKB-9778 (Standard)

    		 Reference Standards Phosphatase Tie Inflammation/Immunology
    Razuprotafib (Standard) is the analytical standard of Razuprotafib (HY-109041). This product is intended for research and analytical applications. Razuprotafib (AKB-9778) is a potent and selective inhibitor of the catalytic activity of VE-PTP (vascular endothelial protein tyrosine phosphatase) with an IC50of 17 pM. Razuprotafib promotes TIE2 activation, enhances ANG1-induced TIE2 activation, and stimulates phosphorylation of signaling molecules in the TIE2 pathway, including AKT, eNOS, and ERK. Razuprotafib inhibits the structurally related phosphatase PTP1B with an IC50 of 780 nM. Razuprotafib shows excellent selectivity for VE-PTP versus a variety of phosphatases, with the exception of HPTPη (IC50=36 pM) and HPTPγ (100 pM) .
    Razuprotafib (Standard)

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