29782-68-1
Chemical Structure
Silydianin
- CAS No.: 29782-68-1
- Formula:C25H22O10
- Molecular Weight:482.44
IUPAC Name: (3R,3aR,6R,7aR,8R)-7a-hydroxy-8-(4-hydroxy-3-methoxyphenyl)-4-((2R,3R)-3,5,7-trihydroxy-4-oxochroman-2-yl)-2,3,3a,7a-tetrahydro-3,6-methanobenzofuran-7(6H)-one
InChIKey: CYGIJEJDYJOUAN-JSGXPVSSSA-N
SMILES: O=C1[C@]2([H])C=C([C@@H]3[C@@H](O)C(C4=C(O)C=C(O)C=C4O3)=O)[C@@]5([H])[C@]([C@H]2C6=CC=C(O)C(OC)=C6)([H])CO[C@]51O
Biological Activity: Silydianin is a flavonolignan. Silydianin can be obtained from Silybum marianum. Silydianin inhibits PTP1B with an IC50 of 17.38 μM. Silydianin inhibits both monophenolase and diphenolase of tyrosinase significantly, with IC50s of 2.6 μM and 16.5 μM, respectively. Silydianin induces Apoptosis and reduces cytokines (IL-4 and IL-5). Silymarin has antioxidant, cytoprotective and immunomodulatory effects. Silydianin has antitumor activity against prostate cancer. Silymarin can be used in allergic asthma research[1][2][3][4][5][6][7].
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Silydianin | 99.71% | Silydianin is a flavonolignan. Silydianin can be obtained from Silybum marianum. Silydianin inhibits PTP1B with an IC50 of 17.38 μM. Silydianin inhibits both monophenolase and diphenolase of tyrosinase significantly, with IC50s of 2.6 μM and 16.5 μM, respectively. Silydianin induces Apoptosis and reduces cytokines (IL-4 and IL-5). Silymarin has antioxidant, cytoprotective and immunomodulatory effects. Silydianin has antitumor activity against prostate cancer. Silymarin can be used in allergic asthma research. | ||||||||||||||||||||
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Silydianin (Standard) | ≥98% | Silydianin (Standard) is the analytical standard of Silydianin (HY-N0646). This product is intended for research and analytical applications. Silydianin is a flavonolignan. Silydianin can be obtained from Silybum marianum. Silydianin inhibits PTP1B with an IC50 of 17.38 μM. Silydianin inhibits both monophenolase and diphenolase of tyrosinase significantly, with IC50s of 2.6 μM and 16.5 μM, respectively. Silydianin induces Apoptosis and reduces cytokines (IL-4 and IL-5). Silymarin has antioxidant, cytoprotective and immunomodulatory effects. Silydianin has antitumor activity against prostate cancer. Silymarin can be used in allergic asthma research. | ||||||||||||||||||||
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- [1]. Kim JY, et al. Tyrosinase inhibitory study of flavonolignans from the seeds of Silybum marianum (Milk thistle). Bioorg Med Chem. 2019 Jun 15;27(12):2499-2507. [Content Brief]
- [2]. Zielińska-Przyjemska M, et al. An in vitro study of the protective effect of the flavonoid silydianin against reactive oxygen species. Phytother Res. 2006 Feb;20(2):115-9. [Content Brief]
- [3]. Dvorák Z, et al. Primary cultures of human hepatocytes as a tool in cytotoxicity studies: cell protection against model toxins by flavonolignans obtained from Silybum marianum. Toxicol Lett. 2003 Feb 3;137(3):201-12. [Content Brief]
- [4]. Davis-Searles PR, et al. Milk thistle and prostate cancer: differential effects of pure flavonolignans from Silybum marianum on antiproliferative end points in human prostate carcinoma cells. Cancer Res. 2005 May 15;65(10):4448-57. [Content Brief]
- [5]. Nasab EM, et al. Immunomodulatory effects of two silymarin isomers in a Balb/c mouse model of allergic asthma. Allergol Immunopathol (Madr). 2020 Nov-Dec;48(6):646-653. [Content Brief]
- [6]. Qin N, et al. Identification of flavonolignans from Silybum marianum seeds as allosteric protein tyrosine phosphatase 1B inhibitors. J Enzyme Inhib Med Chem. 2018 Dec;33(1):1283-1291. [Content Brief]
- [7]. Vostálová J, et al. Skin Protective Activity of Silymarin and its Flavonolignans. Molecules. 2019 Mar 14;24(6). [Content Brief]
Keywords
