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Phe

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-101444A

PAβN dihydrochloride 10+ Cited Publications MC-207,110 dihydrochloride; Phe-Arg-β-naphthylamide dihydrochloride	Bacterial	Infection
PAβN dihydrochloride (MC-207110 dihydrochloride) is an efflux pump inhibitor.

HY-101399

γ-Glu-Phe 1 Publications Verification H-γ-Glu-Phe-OH; γ-GlutamylPhenylalanine	Endogenous Metabolite	Others
γ-Glu-Phe is synthesized by Bacillus amyloliquefaciens (GBA) and Aspergillus oryzae (GAO). γ-Glu-Phe or the post-enzymatic reaction mixture enhances the umami intensity of commercial soy sauce and model chicken broth .

HY-W007970

*H-Phe-Phe-OH*	Endogenous Metabolite	Neurological Disease
H-Phe-Phe-OH is a peptide made of two phenylalanine molecules; Phenylalanine is an essential amino acid and the precursor for the amino acid tyrosine.

HY-115733

Cathepsin L-IN-2 1 Publications Verification (Rac)-Z-Phe-Phe-FMK	Cathepsin	Cancer
Cathepsin L-IN-2 ((Rac)-Z-Phe-Phe-FMK) is an isomer of the Cathepsin L inhibitor Z-Phe-Phe-FMK (HY-141867), with an IC₅₀ of 15 μM for cathepsin L. Z-Phe-Phe-FMK irreversibly blocks the proteolytic function of cathepsins by covalently binding to the cysteine residues in the active center of the enzyme. Cathepsin L-IN-2 and Z-Phe-Phe-FMK can be used to study neurodegenerative diseases (such as GRN-related frontotemporal dementia) and cancer invasion and metastasis.

HY-P1795

Boc-dPhe-Leu-dPhe-Leu-Phe 2 Publications Verification	Formyl Peptide Receptor (FPR)	Inflammation/Immunology
Boc-dPhe-Leu-dPhe-Leu-Phe (Boc-fLfLF) is a selective N-formyl peptide receptor1 (FPR1) antagonist. Boc-dPhe-Leu-dPhe-Leu-Phe inhibits fMIFL(HY-P0224)-induced NADPH oxidase activity. Boc-dPhe-Leu-dPhe-Leu-Phe can be used for the study of inflammation .

HY-P4425

*Gly-Phe-AMC*	Biochemical Assay Reagents	Others
Gly-Phe-AMC is a fluorogenic peptide substrate consisting of a peptide sequence composed of glycine and phenylalanine, linked to the fluorophore AMC. Gly-Phe-AMC also serves as a cathepsin C substrate. Gly-Phe-AMC is widely used to detect the activity of various proteases .

HY-W092109

*H-Phe-Trp-OH* Phenylalanyltryptophan; Phe-Trp	Endogenous Metabolite	Neurological Disease Cancer
H-Phe-Trp-OH (Phenylalanyltryptophan) is an endogenous metabolite. H-Phe-Trp-OH can be used in the research of hepatocellular carcinoma and tic disorders .

HY-137199

*Pro-Phe-Arg-AMC*	Biochemical Assay Reagents	Others
Pro-Phe-Arg-AMC is a synthetic peptide substrate of Cysteine peptidases (CPs) .

HY-W141936

Phe-Gly L-Phenylalanylglycine; H-Phe-Gly-OH	Amino Acid Derivatives	Others
Phe-Gly hydrate is a Glycine (HY-Y0966) derivative .

HY-141867

Z-FF-FMK Z-Phe-Phe-FMK	Cathepsin MEK Caspase DNA/RNA Synthesis Apoptosis	Cardiovascular Disease Neurological Disease
Z-FF-FMK (Z-Phe-Phe-FMK) is a cell-permeable, irreversible, and cysteine protease inhibitor targeting cathepsin-L. Z-FF-FMK inhibits angiotensin II-induced MEK activation in vascular walls, aortic medial remodeling, blood pressure elevation, and upregulation of cystatin C in aortic walls. Z-FF-FMK prevents β-amyloid-mediated caspase-3 activation, poly (ADP-ribose) polymerase cleavage, DNA fragmentation, and apoptosis of cortical neurons (apoptosis). Z-FF-FMK can be used in research related to hypertension and Alzheimer's disease .

HY-W068839

*H-Phe-Leu-OH* L-Phenylalanyl-L-leucine; Phe-Leu	Amino Acid Derivatives	Others
H-Phe-Leu-OH is a leucine derivative .

HY-W009602

Phenylalanylalanine Phe-ala	Neprilysin	Others
Phenylalanylalanine (H-Phe-Ala-OH) is a dipeptide composed of phenylalanine and alanine. Phenylalanylalanine is an incomplete breakdown product of protein digestion or protein catabolism .

HY-P4270

*Met-Arg-Phe-Ala* 1 Publications Verification	Neprilysin	Neurological Disease
Met-Arg-Phe-Ala is a peptide. Met-Arg-Phe-Ala also is a potent competitive inhibitor for enkephalin-generating endopeptidase (EGE). Met-Arg-Phe-Ala can be used for the research of neurological disease .

HY-W008733

L-Phenylalanyl-L-valine L-Phe-L-Val; Phe-Val; H-Phe-Val-OH	Amino Acid Derivatives	Others
L-Phenylalanyl-L-valine (L-Phe-L-Val) is a valine derivative .

HY-P4560

*H-Pro-Phe-OH* Pro-Phe	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
H-Pro-Phe-OH is a dipeptide containing proline and phenylalanine, which can serve as a substrate for prolinase. H-Pro-Phe-OH can also be used for polypeptide synthesis, where phenylalanine is an aromatic amino acid that can inhibit the activity of Angiotensin-converting enzyme (ACE, HY-P2983) .

HY-129362

Phe-Lys(Fmoc)-PAB	ADC Linker	Cancer
Phe-Lys(Fmoc)-PAB is a cathepsin cleavable ADC linker used for the antibody-drug conjugates (ADCs) .

HY-P3318

Boc-Phe-Leu-Phe-Leu-Phe L-BOC2	Leukotriene Receptor	Inflammation/Immunology
Boc-Phe-Leu-Phe-Leu-Phe (Boc-FLFLF) is a N-formyl peptide receptors (FPR) inhibitor. Boc-Phe-Leu-Phe-Leu-Phe abolishes the FMLP-induced release of peptide leukotrienes. Boc-Phe-Leu-Phe-Leu-Phe inhibits the sprouting of human umbilical vein endothelial cell (HUVEC) spheroids mediated by proliferative diabetic retinopathy (PDR) vitreous and vascular endothelial growth factor (VEGF) respectively in a three-dimensional fibrin gel. Boc-Phe-Leu-Phe-Leu-Phe inhibits the anti-inflammatory and antifibrotic effects of Ac2-26 (HY-P1098). Boc-Phe-Leu-Phe-Leu-Phe can be used for the study of immunology .

HY-P4306

*Z-Phe-Phe-Diazomethylketone*	Cathepsin	Inflammation/Immunology
Z-Phe-Phe-Diazomethylketone is a selective inhibitor of cathepsin L .

HY-P2355

BOC-FlFlF BOC2; Boc-Phe-dLeu-Phe-dLeu-Phe	Formyl Peptide Receptor (FPR)	Inflammation/Immunology
BOC-FlFlF (Boc-Phe-dLeu-Phe-dLeu-Phe) is a selective FPR1 antagonist. Boc-FlFlF has an apparent dissociation constant (K_D) of 230 nM as determined by the intracellular calcium mobilization assay. Boc-FlFlF can be used for the study of inflammation .

HY-P4641

*H-Trp-Phe-OH* Trp-Phe	Angiotensin-converting Enzyme (ACE) Endothelin Receptor	Cardiovascular Disease
H-Trp-Phe-OH (Trp-Phe) is an ACE inhibitor and endothelial function regulator, with an ACE IC₅₀ of 0.318 mg/mL. H-Trp-Phe-OH increases nitric oxide concentration, reduces endothelin-1 (ET-1) levels, and reverses norepinephrine-mediated endothelial cell dysfunction. H-Trp-Phe-OH exhibits antihypertensive activity. H-Trp-Phe-OH can be used in studies related to hypertension and atherosclerosis .

HY-P4554

*H-Phe-Arg-OH* Phe-Arg	Endogenous Metabolite	Metabolic Disease
H-Phe-Arg-OH is a dipeptide containing phenylalanine and arginine. H-Phe-Arg-OH can be separated from Bradykinin (HY-P0206) through Angiotensin-converting enzyme (ACE, HY-P2983). H-Phe-Arg-OH can be used for metabolic research .

HY-P4360

*Suc-Ala-Phe-Lys-AMC*	Fluorescent Dye	Others
Suc-Ala-Phe-Lys-AMC is a highly sensitive fluorogenic substrate for plasmin. Suc-Ala-Phe-Lys-AMC is also used for assaying gingipain K .

HY-P4515

*Z-Phe-Arg-pNA*	Cathepsin	Others
Z-Phe-Arg-pNA is a substrate of Cathepsin L .

HY-P4637

Ile-Phe H-Ile-Phe-OH	Amyloid-β	Others
Ile-Phe is a dipeptide that self-associates in aqueous solution to form a transparent thermoreversible gel formed by a network of fibrillar nanostructures. It may be involved in triggering self-assembly processes such as amyloid formation.

HY-P10144

*Ac-Orn-Phe-Arg-AMC*	Biochemical Assay Reagents	Others
Ac-Orn-Phe-Arg-AMC is a potent fluorescent substrate of cd-Tryptase and β 1-Tryptase. Ac-Orn-Phe-Arg-AMC releases amino-4-methylcoumarin (AMC) for fluorescence detection .

HY-79131S2

*Fmoc-Phe-OH-d5*	Isotope-Labeled Compounds	Others
Fmoc-Phe-OH-d₅ is the deuterium labeled Fmoc-Phe-OH .

HY-138208

*Z-Phe-Tyr(tBu)-diazomethylketone* 1 Publications Verification	Cathepsin SARS-CoV	Infection
Z-Phe-Tyr(tBu)-diazomethylketone is a potent cathepsin L inhibitor. Z-Phe-Tyr(tBu)-diazomethylketone mediates reovirus disassembly. Z-Phe-Tyr(tBu)-diazomethylketone decreases viral detection .

HY-P4582

*Suc-Phe-Ala-Ala-Phe-pNA* Suc-FAAF-pNA	Ser/Thr Protease	Others
Suc-Phe-Ala-Ala-Phe-pNA (Suc-FAAF-pNA) is a chromogenic polypeptide substrate that can be used for the quantitative activity assay of intracellular subtilisin (ISP) and neutral metalloprotease (NPS) derived from Saccharomonospora canescens. Suc-Phe-Ala-Ala-Phe-pNA is hydrolyzed by the catalytic triad of mature proteases to release the chromophore pNA. Suc-Phe-Ala-Ala-Phe-pNA is applicable to enzymological studies .

HY-W549438

*Cyclo(Phe-Phe)*	Amino Acid Derivatives	Others
Cyclo(Phe-Phe) is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .

HY-P4561

*H-Pro-Thr-Glu-Phe-p-nitro-Phe-Arg-Leu-OH*	Cathepsin	Others
H-Pro-Thr-Glu-Phe-p-nitro-Phe-Arg-Leu-OH is a water-soluble polypeptide that can serve as a substrate for cathepsin D, pepsin and pepsinogen. H-Pro-Thr-Glu-Phe-p-nitro-Phe-Arg-Leu-OH has potential applications in biochemical analysis .

HY-P4678

*(Phe2,Orn8)-Oxytocin*	Vasopressin Receptor	Neurological Disease
(Phe2,Orn8)-Oxytocin is a selective V1 vasopressin agonist. (Phe2,Orn8)-Oxytocin induces a sustained contractility of rabbit epididymis with EC₅₀ value of 280 nM .

HY-135514

Lys-Phe H-Lys-Phe-OH	Amino Acid Derivatives	Cardiovascular Disease
Lys-Phe is a dipeptide that inhibits both cell sickling and the gelation of solutions of sickle-cell haemoglobin .

HY-P1591

*N-Formyl-Nle-Leu-Phe-Nle-Tyr-Lys* For-Nle-Leu-Phe-Nle-Tyr-Lys-OH	Formyl Peptide Receptor (FPR)	Inflammation/Immunology
N-Formyl-Nle-Leu-Phe-Nle-Tyr-Lys TFA (For-Nle-Leu-Phe-Nle-Tyr-Lys-OH TFA) is a formyl peptide receptor (FPR) agonist .

HY-79131S4

*Fmoc-Phe-OH-d8*	Isotope-Labeled Compounds	Others
Fmoc-Phe-OH-d₈ is the deuterium labeled Fmoc-Phe-OH.

HY-129349

Phe-Lys(Trt)-PAB	ADC Linker	Cancer
Phe-Lys(Trt)-PAB is a cathepsin cleavable ADC linker used for the antibody-drug conjugates (ADCs) .

HY-W967223

L-Phenylalanyl-L-threonine Phe-Thr; H-Phe-Thr-OH	Amino Acid Derivatives	Others
L-Phenylalanyl-L-threonine is a dipeptide containing Phenylalanine and threonine. L-Phenylalanyl-L-threonine can be used to synthesize the cyclic hexapeptide Banyascyclamide A .

HY-P10095

*D-Val-Phe-Lys-CMK* D-Val-Phe-Lys Chloromethyl ketone	Ser/Thr Protease	Metabolic Disease
D-Val-Phe-Lys-CMK (D-Val-Phe-Lys Chloromethyl ketone) can inhibit plasmin activity .

HY-P10095A

*D-Val-Phe-Lys-CMK diTFA* D-Val-Phe-Lys Chloromethyl ketone diTFA	Ser/Thr Protease	Metabolic Disease
D-Val-Phe-Lys-CMK (D-Val-Phe-Lys Chloromethyl ketone) diTFA can inhibit plasmin activity .

HY-W092109R

*H-Phe-Trp-OH (Standard)* Phenylalanyltryptophan (Standard); Phe-Trp (Standard)	Reference Standards Endogenous Metabolite	Neurological Disease
H-Phe-Trp-OH (Phenylalanyltryptophan; Phe-Trp) (Standard) is an analytical standard of H-Phe-Trp-OH (HY-W092109). This product is intended for research and analytical applications. H-Phe-Trp-OH, a dipeptide, is an endogenous metabolite. H-Phe-Trp-OH can be used for the research of tic disorder .

HY-P4470

Phe-Pro-Ala-pNA	Ser/Thr Protease	Cancer
Phe-Pro-Ala-pNA is a chromogenic substrate of tripeptidyl peptidase. Phe-Pro-Ala-pNA can be used to test tripeptidyl peptidase activity .

HY-P4464

*Ala-Phe-Pro-pNA*	Ser/Thr Protease	Cancer
Ala-Phe-Pro-pNA is a chromogenic substrate of tripeptidyl peptidase. Ala-Phe-Pro-pNA can be used to test tripeptidyl peptidase activity .

HY-P4464A

*Ala-Phe-Pro-pNA TFA*	Ser/Thr Protease	Cancer
Ala-Phe-Pro-pNA TFA is a chromogenic substrate of tripeptidyl peptidase. Ala-Phe-Pro-pNA TFA can be used to test tripeptidyl peptidase activity .

HY-P4295

*Z-Phe-Ala-diazomethylketone* PADK	Cathepsin γ-secretase	Neurological Disease
Z-Phe-Ala-diazomethylketone binds directly to Aβ42 monomers and small oligomers. Z-Phe-Ala-diazomethylketone inhibits the formation of Aβ42 dodecamers and inhibits Aβ42 fibril formation in the solution. Z-Phe-Ala-diazomethylketone has the potential for neurodegenerative disorders research .

HY-P4680

*(Phe13,Tyr19)-MCH (human, mouse, rat)*	MCHR1 (GPR24)	Neurological Disease
(Phe13,Tyr19)-MCH (human, mouse, rat) is a potent SLC-1 and S643b receptor ligand. (Phe13,Tyr19)-MCH (human, mouse, rat) can be used as an agonist for SLC-1 and S643b receptor .

HY-79131S5

*Fmoc-Phe-OH-13C*	Isotope-Labeled Compounds	Others
Fmoc-Phe-OH- ¹³C is the ¹³C labeled Fmoc-Phe-OH . Fmoc-Phe-OH is a phenylalanine derivative .

HY-P3962

*[Phe2]-TRH*	Thyroid Hormone Receptor	Endocrinology
[Phe2]-TRH is a thyrotropin releasing hormone analogue, equipping a conformational similarity with Leu5-enkephalin .

HY-P4681

*(Phe2,Nle4)-ACTH (1-24) (human, bovine, rat)*	Melanocortin Receptor	Metabolic Disease
(Phe2,Nle4)-ACTH (1-24) (human, bovine, rat) is a fragment of the ACTH hormone. (Phe2,Nle4)-ACTH (1-24) (human, bovine, rat) can be labeled with I125 on Tyr23 to produce a radiolabeled ligand .

HY-P4524

FA-Phe-Phe	Angiotensin-converting Enzyme (ACE)	Others
FA-Phe-Phe is a furylacryloyl (fa)-amino acid derivative, targeting to Angiotensin-converting Enzyme (ACE). FA-Phe-Phe is also a specific substrate of Cathepsin A .

HY-P0249A

Phe-Met-Arg-Phe amide trifluoroacetate	Potassium Channel	Neurological Disease
Phe-Met-Arg-Phe amide trifluoroacetate is an activator of K ⁺ current, with ED₅₀ of 23 nM in the peptidergic caudodorsal neurons.

HY-W092110

Phe-Tyr	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
Phe-Tyr is an ACE inhibitor. Phe-Tyr can be isolated from wakame. Phe-Tyr exhibits mild concentration-dependent toxicity to fibroblasts. Phe-Tyr can be used in studies related to hypertension and cardiovascular diseases .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-13948

Angiotensin II human 220+ Cited Publications Angiotensin II; Ang II; DRVYIHPF	Structural Classification Natural Products Classification of Application Fields Endogenous metabolite Disease Research Fields Endocrinology Source Classification Cancer	Angiotensin Receptor Apoptosis
Angiotensin II (Angiotensin II) is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. Angiotensin II human plays a central role in regulating human blood pressure, which is mainly mediated by interactions between Angiotensin II and the G-protein-coupled receptors (GPCRs) Angiotensin II type 1 receptor (AT1R) and Angiotensin II type 2 receptor (AT2R). Angiotensin II human stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions. Angiotensin II human induces growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. Angiotensin II human also induces apoptosis. Angiotensin II induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway .

HY-P0017

Aprotinin 30+ Cited Publications	Cardiovascular Disease Natural Products Animals Disease Research Fields Source Classification	Influenza Virus Ser/Thr Protease
Aprotinin is a bovine pancreatic trypsin inhibitor (BPTI) inhibitor which inhibits trypsin and chymotrypsin with K_is of 0.06 pM and 9 nM, respectively.

HY-P0201

Substance P 30+ Cited Publications Neurokinin P	Structural Classification Natural Products Neurological Disease Classification of Application Fields Endogenous metabolite Disease Research Fields Endocrinology Source Classification	Neurokinin Receptor Endogenous Metabolite
Substance P (Neurokinin P) is a CNS-penetrant neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, NK1R).

HY-A0190

Caerulein 130+ Cited Publications Ceruletide; Cerulein; FI-6934	Cardiovascular Disease Alkaloids Structural Classification Animals Classification of Application Fields Disease Research Fields Endocrinology Indole Alkaloids Source Classification	Cholecystokinin Receptor
Caerulein is a decapeptide and a potent cholecystokinin receptor agonist. Caerulein is a safe and effective cholecystokinetic agent with a direct spasmogenic effect on the gallbladder muscle and bile ducts .

HY-150012

N-Lactoyl-phenylalanine 4 Publications Verification Lac-Phe	Structural Classification Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Endogenous Metabolite
N-Lactoyl-phenylalanine is a blood-derived signaling metabolite that can be induced by exercise. N-Lactoyl-phenylalanine can reduce obesity and improve glucose tolerance .

HY-B1811

Vasopressin 5+ Cited Publications Arginine vasopressin; Antidiuretic hormone	Structural Classification Neurological Disease Classification of Application Fields Cyclopeptides Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Vasopressin is a cyclic nonapeptide that is synthesized centrally in the hypothalamus. Vasopressin participates in the hypothalamic-pituitary-adrenal axis, and regulates pituitary corticotropin secretion by potentiating the stimulatory effects of corticotropin releasing factor. Vasopressin also can act as a neurotransmitter, exerting its action by binding to specific G protein-coupled receptors .

HY-P0206

Bradykinin 15+ Cited Publications	Natural Products Classification of Application Fields Endogenous metabolite Disease Research Fields Endocrinology Source Classification	Bradykinin Receptor Endogenous Metabolite Ser/Thr Protease
Bradykinin is an effective endothelium-dependent vasodilator that can lower blood pressure. Bradykinin can induce contraction of bronchial and intestinal non-vascular smooth muscle, increase vascular permeability, and participate in the mechanism of pain .

HY-P1934A

*Cyclo(L-Phe-L-Pro)*	Natural Products Microorganisms Classification of Application Fields Inflammation/Immunology Disease Research Fields Source Classification Cancer	Fungal Bacterial IFNAR Reactive Oxygen Species (ROS)
Cyclo(L-Phe-L-Pro), isolated from Pseudomonas fluorescens and Pseudomonas alcaligenes cell-free culture supernatants is an antifungal cyclic dipeptide . Cyclo(L-Phe-L-Pro) inhibits IFN-β production by interfering with retinoic-acid-inducible gene-I (RIG-I) activation . Cyclo(L-Phe-L-Pro) exhibits free-radical scavenging activity with the IC₅₀ of 24 µM in the DPPH assay .

HY-P1902

Cardiotoxin Analog (CTX) IV (6-12) 5+ Cited Publications	Cardiovascular Disease Natural Products Animals Disease Research Fields Source Classification	Apoptosis
Cardiotoxin Analog (CTX) IV (6-12) is a membrane active peptide that specifically targets negatively charged phospholipid membranes (such as phosphatidylserine and phosphatidylinositol). Cardiotoxin Analog (CTX) IV (6-12) was discovered in the venom of the Taiwan cobra. Cardiotoxin Analog (CTX) IV (6-12) is a chemically synthesized snake venom cardiotoxin that binds to cell membranes and embeds into lipid bilayers through hydrophobic interactions and electrostatic attraction, thereby destroying the stability of membrane structure. Cardiotoxin Analog (CTX) IV (6-12) can induce membrane lipid disorder and cell lysis, exhibiting hemolysis and cytotoxicity .

HY-P0288

[Leu5]-Enkephalin 2 Publications Verification Leu-enkephalin; Leucine enkephalin; Leucyl-enkephalin	Natural Products Monophenols Phenols Endogenous metabolite Source Classification	Opioid Receptor Endogenous Metabolite
[Leu5]-Enkephalin is a pentapeptide with morphine like properties. [Leu5]-Enkephalin is a five amino acid endogenous peptide that acts as an agonist at opioid receptors.

HY-P0190

Iberiotoxin 2 Publications Verification	Cardiovascular Disease Natural Products Animals Classification of Application Fields Disease Research Fields Source Classification	Potassium Channel
Iberiotoxin is a toxin isolated from Buthus tamulus scorpion venom. Iberiotoxin is a selective high conductance high conductance Ca ²⁺-activated K ⁺ channel inhibitor with a K_d of ~1 nM. Iberiotoxin does not block other types of voltage-dependent ion channels .

HY-P0173A

Chlorotoxin 2 Publications Verification	Natural Products Animals Classification of Application Fields Disease Research Fields Source Classification Cancer	Chloride Channel
Chlorotoxin is a 36 amino-acid peptide from the venom of the Israeli scorpion Leiurus quinquestriatus with anticancer activity. Chlorotoxin is a chloride channel blocker.

HY-P2358

PSMα3	Structural Classification Natural Products Microorganisms Classification of Application Fields Inflammation/Immunology Disease Research Fields Source Classification	NF-κB p38 MAPK
PSMα3 is an inhibitor of NF-κB p65 and p38 MAPK. PSMα3 forms membrane pores and binds to residues of human insulin B chain to inhibit insulin aggregation. PSMα3 forms α-type amyloid-like fibrils to exert cytotoxic effects, and acts as a functional amyloid virulence determinant of Staphylococcus aureus. PSMα3 is applicable to research related to spondyloarthritis, rheumatoid arthritis, insulin-derived amyloidosis, and Staphylococcus aureus infection .

HY-P1902A

Cardiotoxin Analog (CTX) IV (6-12) TFA 5+ Cited Publications	Structural Classification Pyrrole Alkaloids Animals Other Diseases Disease Research Fields Source Classification	Apoptosis
Cardiotoxin Analog (CTX) IV (6-12) TFA is a membrane active peptide that specifically targets negatively charged phospholipid membranes (such as phosphatidylserine and phosphatidylinositol). Cardiotoxin Analog (CTX) IV (6-12) TFA was discovered in the venom of the Taiwan cobra. Cardiotoxin Analog (CTX) IV (6-12) TFA is a chemically synthesized snake venom cardiotoxin that binds to cell membranes and embeds into lipid bilayers through hydrophobic interactions and electrostatic attraction, thereby destroying the stability of membrane structure. Cardiotoxin Analog (CTX) IV (6-12) TFA can induce membrane lipid disorder and cell lysis, exhibiting hemolysis and cytotoxicity .

HY-101399

γ-Glu-Phe 1 Publications Verification H-γ-Glu-Phe-OH; γ-GlutamylPhenylalanine	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
γ-Glu-Phe is synthesized by Bacillus amyloliquefaciens (GBA) and Aspergillus oryzae (GAO). γ-Glu-Phe or the post-enzymatic reaction mixture enhances the umami intensity of commercial soy sauce and model chicken broth .

HY-P0270

Magainin 2 Magainin II	Infection Structural Classification Natural Products Animals Classification of Application Fields Disease Research Fields Source Classification	Bacterial Antibiotic Fungal
Magainin 2 (Magainin II) is an antimicrobial peptide (AMP) isolated from the skin of the African clawed frog Xenopus laevis. Magainin 2 displays antibiotic activity against numerous gram-negative and gram-positive bacteria. Magainin 2 also is active against protozoa . Magainin 2 exerts its cytotoxicity effects by preferential interactions with anionic phospholipids abundant in bacterial membranes .

HY-P0185

Endomorphin 1 3 Publications Verification	Natural Products Monophenols Pyrrole Alkaloids Neurological Disease Phenols Endogenous metabolite Disease Research Fields Indole Alkaloids Source Classification	Opioid Receptor
Endomorphin 1, a high affinity, highly selective agonist of the μ-opioid receptor (K_i: 1.11 nM), displays reasonable affinities for kappa₃ binding sites, with K_i value between 20 and 30 nM. Endomorphin 1 has antinociceptive properties .

HY-P0241

Neuromedin B 1 Publications Verification	Natural Products Animals Endogenous metabolite Source Classification	Endogenous Metabolite
Neuromedin B (NMB) is a member of Bombesin (BN)-like peptide family in mammals.

HY-W007970

*H-Phe-Phe-OH*	Natural Products Endogenous metabolite Source Classification	Endogenous Metabolite
H-Phe-Phe-OH is a peptide made of two phenylalanine molecules; Phenylalanine is an essential amino acid and the precursor for the amino acid tyrosine.

HY-W012161

Alanylphenylalanine L-Alanyl-L-Phenylalanine; H-Ala-Phe-OH	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite Drug Intermediate
Alanylphenylalanine (L-Alanyl-L-phenylalanine) is a dipeptide. Alanylphenylalanine forms a mononuclear Au (III) complex through bidentate coordination via its carboxyl oxygen atom and deprotonated amide nitrogen atom .

HY-106302

Duramycin Moli1901; Lancovutide	Microorganisms Classification of Application Fields Inflammation/Immunology Disease Research Fields Source Classification	Bacterial
Duramycin (Moli1901) is a lantibiotic derived from Streptomyces cinnamoneuma. Duramycin also is a antimicrobial peptide. Duramycin can be used for the research of cystic fibrosis (CF) .

HY-P2159

Dynorphin A (1-8)	Structural Classification Natural Products Neurological Disease Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification	Opioid Receptor Endogenous Metabolite
Dynorphin A (1-8) is a ligand with preference for the κ-opioid receptor, and its IC₅₀ value against human placental κ-opioid receptor is 330 nM. Dynorphin A (1-8) mediates neuroprotective effects by inhibiting oxidative stress, suppressing apoptosis, and competitively displacing the binding of κ partial agonists. Dynorphin A (1-8) is the dominant opioid peptide in human placental villi and tissue extracts; it undergoes rapid hydrolysis and can enter the central nervous system via intranasal administration. Dynorphin A (1-8) can be used in studies related to ischemic stroke .

HY-P0244

Dermorphin	Natural Products Animals Phenols Polyphenols Source Classification	Opioid Receptor
Dermorphin is a natural heptapeptide μ-opioid receptor (MOR) agonist found in amphibian skin. Inhibition of neuropathic pain .

HY-W092109

*H-Phe-Trp-OH* Phenylalanyltryptophan; Phe-Trp	Natural Products Animals Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
H-Phe-Trp-OH (Phenylalanyltryptophan) is an endogenous metabolite. H-Phe-Trp-OH can be used in the research of hepatocellular carcinoma and tic disorders .

HY-W009602

Phenylalanylalanine Phe-ala	Classification of Application Fields Ketones, Aldehydes, Acids Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Neprilysin
Phenylalanylalanine (H-Phe-Ala-OH) is a dipeptide composed of phenylalanine and alanine. Phenylalanylalanine is an incomplete breakdown product of protein digestion or protein catabolism .

HY-107378

L-Valyl-L-phenylalanine ValylPhenylalanine; H-VAL-Phe-OH	Natural Products Classification of Application Fields Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	Endogenous Metabolite
L-Valyl-L-phenylalanine (Valylphenylalanine; H-VAL-PHE-OH) has been reported as biocompatible polymer.

HY-P0269

Magainin 1 Magainin I	Infection Structural Classification Natural Products Animals Classification of Application Fields Disease Research Fields Source Classification	Bacterial Fungal Antibiotic
Magainin 1 (Magainin I) is an antimicrobial and amphipathic peptide isolated from the skin of Xenopus laevis. Magainin 1 exhibits antibiotic activity against numerous Gram-negative and Gram-positive bacteria .

HY-P0004

Lysipressin 2 Publications Verification Lysine vasopressin; [Lys8]-Vasopressin	Monophenols Animals Classification of Application Fields Other Diseases Phenols Disease Research Fields Source Classification	Adenylate Cyclase Oxytocin Receptor
Lysipressin (Lysine vasopressin) is antidiuretic hormone that have been found in pigs. Lysipressin activates Oxytocin receptors and adenylate-cyclase. Lysipressin adjusts blood pressure and heart rate. Lysipressin shows antinociceptive activity .

HY-P1189

Echistatin	Natural Products Animals Classification of Application Fields Inflammation/Immunology Disease Research Fields Source Classification	Integrin
Echistatin, the smallest active RGD protein belonging to the family of disintegrins that are derived from snake venoms, is a potent inhibitor of platelet aggregation. Echistatin is a potent inhibitor of bone resorption in culture. Echistatin is a potent antagonist of α_IIbβ₃, α_vβ₃ and α₅β₁ .

HY-P1255

Kinetensin Kinetensin (human)	Natural Products Monophenols Neurological Disease Phenols Endogenous metabolite Disease Research Fields Endocrinology Source Classification	Neurotensin Receptor Endogenous Metabolite
Kinetensin is a neurotensin-like peptide isolated from pepsin-treated human plasma.

HY-P0285

Rabies Virus Glycoprotein 1 Publications Verification	Infection Structural Classification Natural Products Microorganisms Classification of Application Fields Disease Research Fields Source Classification	RABV
Rabies Virus Glycoprotein is a 29-amino-acid cell penetrating peptide derived from a rabies virus glycoprotein that can cross the blood-brain barrier (BBB) and enter brain cells.

HY-P0173B

Chlorotoxin TFA 2 Publications Verification	Natural Products Classification of Application Fields Animals Disease Research Fields Cancer Source Classification	Chloride Channel
Chlorotoxin TFA is a peptide isolated from the venom of the scorpion Leiurus quinquestriatus, acts as a chloride channel blocker . Anti-cancer activity .

HY-P1280

Margatoxin 1 Publications Verification	Natural Products Animals Neurological Disease Disease Research Fields Source Classification	Potassium Channel
Margatoxin, an alpha-KTx scorpion toxin, is a high affinity inhibitor of Kv1.3 (K_d=11.7 pM). Margatoxin inhibits the Kv1.2 (K_d=6.4 pM) and Kv1.1 (K_d=4.2 nM). Margatoxin, a 39 amino-acid-long peptide, is isolated from the venom of the scorpion Centruroides margaritatus and widely used in ion channel research .

HY-P1189A

Echistatin TFA	Natural Products Animals Classification of Application Fields Metabolic Disease Inflammation/Immunology Disease Research Fields Source Classification	Integrin
Echistatin TFA, the smallest active RGD protein belonging to the family of disintegrins that are derived from snake venoms, is a potent inhibitor of platelet aggregation. Echistatin is a potent inhibitor of bone resorption in culture. Echistatin is a potent antagonist of α_IIbβ₃, α_vβ₃ and α₅β₁ .

HY-P1904

Phe-Met-Arg-Phe Like Peptide, Snail Helix aspersa	Natural Products Animals Source Classification	Others
Phe-Met-Arg-Phe Like Peptide, Snail Helix aspersa is a FMRF-like peptide from visceral and somatic muscles of the snail Helix aspersa. FMRF (Phe-Met-Arg-Phe) is a neuropeptide peptide consisting of 4 amino acid residues .

HY-P5714

Abaecin	Animals Ketones, Aldehydes, Acids Source Classification	Bacterial
Abaecin is an antibacterial response peptide. Abaecin shows specific activity against an Apidaecin-resistant Xanthomonas strain .

HY-P0259

Xenin	Natural Products Endogenous metabolite Source Classification	Endogenous Metabolite
Xenin is a 25-amino acid peptide initially isolated from human gastric mucosa. Xenin is a gut hormone that can reduce food intake.

HY-P1346

APETx2	Natural Products Animals Source Classification	Sodium Channel
APETx2, a sea anemone peptide from Anthopleura elegantissima, is a selective and reversible ASIC3 inhibitor, with an IC₅₀ of 63 nM. APETx2 directly inhibits the ASIC3 channel by acting at its external side. APETx2 could reverses acid‐induced and inflammatory pain .

HY-W295873

*Cyclo(Phe-Gly)* 1 Publications Verification	Infection Natural Products Classification of Application Fields Plants Compositae Disease Research Fields Source Classification Gueldenstaedtia verna (Georgi) Boriss. Cancer	Bacterial
Cyclo(Phe-Gly) is a cyclodipeptides with antimicrobial and anticancer activities, isolated from broth culture of endophytic Streptomyces YIM 64018 associated with Paraboea sinensis .

HY-P0303

Crustacean cardioactive peptide，free acid	Cardiovascular Disease Natural Products Animals Neurological Disease Classification of Application Fields Disease Research Fields Source Classification	G Protein-coupled Receptor Kinase (GRK)
Crustacean cardioactive peptide, free acid is a highly conserved, amidated cyclic nonapeptide, first isolated from the pericardial organs of the shore crab Carcinus maenas, where it has a role in regulating heartbeat; Crustacean cardioactive peptide, free acid also modulates the neuronal activity in other arthropods.

HY-P1866A

β-Endorphin, equine TFA 1 Publications Verification	Natural Products Endogenous metabolite Source Classification	Opioid Receptor
β-Endorphin, equine TFA is an endogenous opioid peptide, which binds at high affinity to both μ/δ opioid receptors. β-Endorphin, equine TFA has analgesic properties .

HY-W092109R

*H-Phe-Trp-OH (Standard)* Phenylalanyltryptophan (Standard); Phe-Trp (Standard)	Natural Products Animals Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite
H-Phe-Trp-OH (Phenylalanyltryptophan; Phe-Trp) (Standard) is an analytical standard of H-Phe-Trp-OH (HY-W092109). This product is intended for research and analytical applications. H-Phe-Trp-OH, a dipeptide, is an endogenous metabolite. H-Phe-Trp-OH can be used for the research of tic disorder .

HY-N12513

*Cyclo(L-Phe-trans-4-OH-L-Pro)*	Natural Products Microorganisms Source Classification	Fungal
Cyclo(L-Phe-trans-4-OH-L-Pro) is an antifungal peptides .

HY-N3655

*Cyclo(D-Phe-L-Pro)* NSC 255998	Alkaloids Microorganisms Other Alkaloids Source Classification	Others
Cyclo(D-Phe-L-Pro) (NSC 255998) is a flavonoid product that can be isolated from Rhododendron mucronulatum .

HY-101399R

*γ-Glu-Phe* (Standard)** H-γ-Glu-Phe-OH (Standard); γ-GlutamylPhenylalanine (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite
Ceftezole (sodium) (Standard) is the analytical standard of Ceftezole (sodium). This product is intended for research and analytical applications. Ceftezole sodium (CTZ sodium) is a broad-spectrum cephem antibiotic against many species of gram-positive and gram-negative bacteria. Ceftezole sodium (CTZ sodium) is an alpha-glucosidase inhibitor with in vivo anti-diabetic activity .

HY-P1841

Glucagon-Like Peptide (GLP) II, human	Natural Products Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite Apoptosis
Glucagon-Like Peptide (GLP) II, human is a 33-amino acid peptide derived from the C-terminal of proglucagon and mainly produced by the intestinal L cells. Glucagon-Like Peptide (GLP) II, human stimulates intestinal mucosal growth and decreases apoptosis of enterocytes .

HY-P4196

Met-Enkephalin-Arg-Phe	Monophenols Phenols Endogenous metabolite Source Classification	Opioid Receptor
Met-Enkephalin-Arg-Phe is a naturally occurring heptapeptide with analgesic activity .

HY-P3065

Calcicludine	Natural Products Animals Source Classification	Calcium Channel
Calcicludine is a protein toxin from the venom of the green mamba that inhibits high-voltage-activated calcium channel, especially L-type calcium channel .

HY-105088A

Pexiganan acetate MSI 78	Structural Classification Natural Products Animals Source Classification	Bacterial
Pexiganan (MSI 78) acetate is an orally active antimicrobial peptide with broad-spectrum bactericidal. Pexiganan TFA disrupts bacterial cell membranes, induces peptidoglycan damage and cell lysis. Pexiganan acetate can be used for the research of bacterial infection .

HY-P5719

Andropin	Animals Ketones, Aldehydes, Acids Source Classification	Bacterial
Andropin is a male-specific antibacterial peptide that can be found in Drosophila melanogaster .

Cat. No.	Product Name	Chemical Structure

HY-114118S3

Semaglutide-13C6,15N TFA

Semaglutide- ¹³C₆, ¹⁵N TFA is the ¹³C- and ¹⁵N-labeled Semaglutide TFA (HY-114118A). Semaglutide TFA is a long-acting, selective, competitive GLP-1R agonist that can penetrate the blood-brain barrier. After activating GLP-1R, Semaglutide TFA promotes insulin secretion, inhibits gastric emptying and appetite, and at the same time enhances autophagy, inhibits oxidative stress and apoptosis. Semaglutide TFA also regulates mitochondrial function and lipid metabolism (such as reducing de novo lipogenesis in the liver). Semaglutide TFA has activities such as lowering blood sugar, reducing weight, neuroprotection (such as improving motor function in Parkinson's disease models, reducing α-synuclein aggregation) and improving hepatic steatosis. Semaglutide TFA can be used for the study of neurodegenerative diseases and liver diseases such as type 2 diabetes, obesity, Parkinson's disease, metabolic associated fatty liver disease (MASLD), and cancer .

HY-114118S1

Semaglutide-d8 tetraTFA

Semaglutide-d₈ tetraTFA is the deuterium labeled Semaglutide (HY-114118). Semaglutide is a long-acting, selective, competitive GLP-1R agonist that can penetrate the blood-brain barrier. After activating GLP-1R, Semaglutide promotes insulin secretion, inhibits gastric emptying and appetite, and at the same time enhances autophagy, inhibits oxidative stress and apoptosis. Semaglutide also regulates mitochondrial function and lipid metabolism (such as reducing de novo lipogenesis in the liver). Semaglutide has activities such as lowering blood sugar, reducing weight, neuroprotection (such as improving motor function in Parkinson's disease models, reducing α-synuclein aggregation) and improving hepatic steatosis. Semaglutide can be used for the study of neurodegenerative diseases and liver diseases such as type 2 diabetes, obesity, Parkinson's disease, metabolic associated fatty liver disease (MASLD), and cancer .

HY-114118S

Semaglutide-d8

Semaglutide-d₈ is the deuterium labeled Semaglutide (HY-114118). Semaglutide is a long-acting, selective, competitive GLP-1R agonist that can penetrate the blood-brain barrier. After activating GLP-1R, Semaglutide promotes insulin secretion, inhibits gastric emptying and appetite, and at the same time enhances autophagy, inhibits oxidative stress and apoptosis. Semaglutide also regulates mitochondrial function and lipid metabolism (such as reducing de novo lipogenesis in the liver). Semaglutide has activities such as lowering blood sugar, reducing weight, neuroprotection (such as improving motor function in Parkinson's disease models, reducing α-synuclein aggregation) and improving hepatic steatosis. Semaglutide can be used for the study of neurodegenerative diseases and liver diseases such as type 2 diabetes, obesity, Parkinson's disease, metabolic associated fatty liver disease (MASLD), and cancer .

HY-P0014S1

Liraglutide-13C5,15N tetraTFA
Liraglutide- ¹³C₆, ¹⁵ tetraTFA is the ¹³C and ¹⁵N labeled Liraglutide (HY-P0014) . Liraglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist used for the study of type 2 diabetes mellitus .

HY-79131S2

*Fmoc-Phe-OH-d5*
Fmoc-Phe-OH-d₅ is the deuterium labeled Fmoc-Phe-OH .

HY-79131S1

*Fmoc-Phe-OH-13C9,15N*
Fmoc-Phe-OH- ¹³C₉, ¹⁵N is a ¹⁵N-labeled and ¹³C-labled Fmoc-Phe-OH (HY-79131). Fmoc-Phe-OH is a phenylalanine derivative .

HY-79131S4

*Fmoc-Phe-OH-d8*
Fmoc-Phe-OH-d₈ is the deuterium labeled Fmoc-Phe-OH.

HY-150012S1

N-Lactoyl-phenylalanine-13C6
N-Lactoyl-phenylalanine- ¹³C₆ (Lac-Phe- ¹³C₆) is ¹³C labeled N-Lactoyl-phenylalanine. N-Lactoyl-phenylalanine is a blood-derived signaling metabolite that can be induced by exercise. N-Lactoyl-phenylalanine can reduce obesity and improve glucose tolerance .

HY-79131S5

*Fmoc-Phe-OH-13C*
Fmoc-Phe-OH- ¹³C is the ¹³C labeled Fmoc-Phe-OH . Fmoc-Phe-OH is a phenylalanine derivative .

HY-101399SA

*γ-Glu-(Phe-13C9,15N) TFA*
γ-Glu-(Phe-13C9,15N) (γ-Glutamylphenylalanine-13C9,15N) TFA is the ¹³C- and ¹⁵N-labeled γ-Glu-Phe TFA (HY-101399A). γ-Glu-Phe TFA is synthesized by Bacillus amyloliquefaciens (GBA) and Aspergillus oryzae (GAO). γ-Glu-Phe TFA or the post-enzymatic reaction mixture enhances the umami intensity of commercial soy sauce and model chicken broth .

HY-P1363S

β-Amyloid-15N (1-42), human TFA
β-Amyloid- ¹⁵N (1-42), human (TFA) is the ¹⁵N-labledβ-Amyloid (1-42) (TFA). β-Amyloid (1-42), human TFA (Amyloid β-Peptide (1-42) (human) TFA) is a 42-amino acid peptide which plays a key role in the pathogenesis of Alzheimer disease .

HY-P1624S1

Teduglutide-Leu(13C6,15N) sodium

Teduglutide-Leu( ¹³C₆, ¹⁵N) (ALX-0600-Leu( ¹³C₆, ¹⁵N)) sodium is the ¹³C- and ¹⁵N-labeled Teduglutide (HY-P1624). Teduglutide (ALX-0600) is an analog of human glucagon like peptide-2 (GLP-2). Teduglutide can activate the expression of nuclear receptor subfamily 4 group a member 1 (NR4a1)/nur77 and intestinal FXR signaling in human hepatic stellate cells, thereby improving liver inflammation and fibrosis in mice with sclerosing cholangitis. Teduglutide can alleviate intestinal dysfunction in mice, improve lung injury, alleviate obesity related neuroinflammation and cell apoptosis .

HY-P0014AS

Liraglutide-d8 tetraTFA
Liraglutide-d₈ tetraTFA is deuterium labeled Liraglutide (HY-P0014). Liraglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist used for the study of type 2 diabetes mellitus .

HY-79131S

*Fmoc-Phe-OH-13C6*
Fmoc-Phe-OH- ¹³C₆ is a ¹³C-labeled Fmoc-Phe-OH (HY-79131). Fmoc-Phe-OH is a phenylalanine derivative .

HY-P4473S

H-Phe-Ile-OH-13C6,15N TFA

H-Phe-Ile-OH- ¹³C₆, ¹⁵N TFA is the ¹³C- and ¹⁵N-labeled H-Phe-Ile-OH (HY-P4473). H-Phe-Ile-OH is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .

HY-P0265AS

β-Amyloid-15N (1-40) TFA
β-Amyloid- ¹⁵N (1-40) (TFA) is the ¹⁵N-labledβ-Amyloid (1-40) (TFA). β-Amyloid (1-40) is a primary protein in plaques found in the brains of patients with Alzheimer's disease .

HY-P1363S1

β-Amyloid (1-42), human, Ala(13C3,15N) TFA

β-Amyloid (1-42), human, Ala( ¹³C₃, ¹⁵N) TFA is the ¹³C and ¹⁵N-labeled β-Amyloid (1-42), human (HY-P1363A). β-Amyloid (1-42) (Amyloid β-peptide (1-42)), human, a 42-amino acid peptide that has not been treated with HFIP, is a brain-penetrant amyloid protein fragment, which can be used in research on Alzheimer's disease and Down’s syndrome. β-Amyloid (1-42), human remaining as a monomer exhibits antioxidant and neuroprotective effects. β-Amyloid (1-42), human, after being monomericized by HFIP and dissolved in DMSO to form the stock solution, on the one hand, can form soluble oligomers (AβOs) when incubated at 4 °C, which have synaptic toxicity and neurotoxicity; on the other hand, it can be incubated at 37 °C to form insoluble fibrils, with lower neurotoxicity, and participating in the oxidative damage process. Aβ42 oligomers bind to various neuronal surface receptors (such as PrPc, mGluR5, NMDA receptors, etc.), triggering oxidative stress, calcium homeostasis imbalance, and synaptic toxicity via activating downstream signaling pathways, leading to neuronal dysfunction and death .

HY-P11532S

IFQGCQF-(Arg-13C6,15N4) TFA
IFQGCQF-(Arg- ¹³C₆, ¹⁵N₄) TFA is the ¹³C- and ¹⁵N-labeled IFQGCQF.

HY-P0014S2

Liraglutide-13C6,15N TFA
Liraglutide- ¹³C₆, ¹⁵ TFA is the ¹³C and ¹⁵N labeledLiraglutide(HY-P0014). Liraglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist used for the study of type 2 diabetes mellitus .

HY-13443S

Exendin-4 (Leu-13C6,15N) TFA
Exendin-4 (Leu- ¹³C₆, ¹⁵N) (Exenatide (Leu- ¹³C₆, ¹⁵N)) TFA is the ¹³C- and ¹⁵N-labeled Exendin-4 TFA (HY-13443). Exendin-4 (Exenatide), a 39 amino acid peptide, is a long-acting glucagon-like peptide-1 receptor agonist with an IC₅₀ of 3.22 nM .

HY-P3207S

DLPLTFGGGT-Lys-13C6,15N2 TFA
DLPLTFGGGT-Lys-13C6,15N2 (TFA) is a deuterated labeled DLPLTFGGGTK .

HY-P5168S

GPSVFPLAPSSK-13C6,15N2
GPSVFPLAPSSK- ¹³C₆, ¹⁵N₂ is the ¹³C- and ¹⁵N-labeled GPSVFPLAPSSK. GPSVFPLAPSSK is an IgG1 signature peptide of anti-SARS-CoV-2 antibodies. GPSVFPLAPSSK can be used for the quantification of the specific isolation of anti-SARS-CoV-2 antibodies .

HY-79131S3

*Fmoc-Phe-OH-15N*
Fmoc-Phe-OH- ¹⁵N is a ¹⁵N-labeled Fmoc-Phe-OH (HY-79131). Fmoc-Phe-OH is a phenylalanine derivative .

HY-W738325

*H-Phe-OMe.hydrochloride-d5*
H-Phe-OMe.hydrochloride-d₅ is the deuterium labeled H-Phe-OMe.hydrochloride (HY-Y1394). H-Phe-OMe.hydrochloride is a phenylalanine derivative .

HY-W011026S1

*Fmoc-D-Phe-OH-d8*
Fmoc-D-Phe-OH-d₈ is the deuterium labeled Fmoc-D-Phe-OH.

HY-W011026S

*Fmoc-D-Phe-OH-d5*
Fmoc-D-Phe-OH-d₅ is the deuterium labeled Fmoc-D-Phe-OH.

HY-159191S

*VQPGQN(Phe-13C9,15N)HMFTKEKLEEVIKDI TFA*
VQPGQN(Phe- ¹³C9, ¹⁵N)HMFTKEKLEEVIKDI (TFA) is the ¹³C and ¹⁵N labeled isotope of VQPGQN-HMFTKEKLEEVIKDI (TFA) .

HY-101399S

*γ-Glu-(Phe-13C9,15N)*
γ-Glu-(Phe- ¹³C9, ¹⁵N) is the ¹³C and ¹⁵N labeled isotope of γ-Glu-Phe(HY-101399).γ-Glu-Phe or the postenzymatic reaction mixture enhanced the umami intensity of commercial soy sauce and model chicken soup.

HY-131990S

*MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH-d5*
MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH-d₅ is deuterated labeled MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH .

HY-W013998S

Glycyl-L-phenylalanine-d2
Glycyl-L-phenylalanine-d₂ is a deuterium labeled Glycyl-L-phenylalanine (HY-W013998). Glycyl-L-phenylalanine is a phenylalanine derivative.

HY-W585934S

Fructose-phenylalanine-13C6
Fructose-phenylalanine- ¹³C₆ is ¹³C labeled Fructose-phenylalanine.

HY-15448S1

Tezacaftor-d6

Tezacaftor-d₆ (VX-661-d₆) is deuterium labeled Tezacaftor. Tezacaftor (VX-661) is a F508del CFTR corrector. It helps CFTR protein reach the cell surface. However, Ivacaftor (VX-770, HY-13017), a CFTR potentiator, helps to prolong the opening time of cell surface CFTR protein channels. Tezacaftor combining with Ivacaftor, shows potent efficacy against cystic fibrosis and diseases with homozygous for the CFTR Phe508del mutation. Moreover, Elexacaftor (VX-445, HY-111772) is also a CFTR corrector. Elexacaftor-Tezacaftor-Ivacaftor aims at with cystic fibrosis (CF) with at least one Phe508del mutation, often avoids the indication for lung transplantation .

HY-P0206S1

RPP-(Gly-13C2,15N)-FSPFR TFA
RPP-(Gly-1 ¹³C₂, ¹⁵N)-FSPFR TFA is ¹³C- and ¹⁵N-labeled Bradykinin (HY-P0206). Bradykinin is an effective endothelium-dependent vasodilator that can lower blood pressure. Bradykinin can induce contraction of bronchial and intestinal non-vascular smooth muscle, increase vascular permeability, and participate in the mechanism of pain .

HY-P0206S

RPPGFSPF-(Arg-13C6,15N) TFA
RPPGFSPF-(Arg- ¹³C₆, ¹⁵N) TFA is the ¹³C- and ¹⁵N-labeled RPPGFSPF.

HY-163426S

AFFGHYLYEVAR-(Arg-13C6,15N4)
AFFGHYLYEVAR-(Arg- ¹³C₆, ¹⁵N₄) is ¹³C and ¹⁵N labeled AFFGHYLYEVAR-(Arg) .

HY-156345S1

LPFTFGQGTK-(Lys-13C6,15N2) TFA
LPFTFGQGTK-(Lys- ¹³C₆, ¹⁵N₂) TFA is the peptide containing ¹³C- and ¹⁵N-labeled Lys.

HY-163427S

FNLEALVTHTLPFEK-(Lys-13C6,15N2)
FNLEALVTHTLPFEK-(Lys- ¹³C₆, ¹⁵N₂) is ¹³C and ¹⁵N labeled FNLEALVTHTLPFEK-(Lys) .

HY-P2625S1

GLP-2(3-33) (Leu-13C6,15N) TFA
GLP-2(3-33) (Leu- ¹³C₆, ¹⁵N) TFA is ¹³C and ¹⁵N labeled GLP-2(3-33) (HY-P2625). GLP-2(3-33), generated naturally by dipeptidylpeptidase IV (DPPIV), acts as a partial agonist on GLP-2 receptor (EC₅₀=5.8 nM).

HY-P2625S

GLP-2(3-33) (Leu-13C6,15N)
GLP-2(3-33) (Leu- ¹³C₆, ¹⁵N) is ¹³C and ¹⁵N labeled GLP-2(3-33) (HY-P2625). GLP-2(3-33), generated naturally by dipeptidylpeptidase IV (DPPIV), acts as a partial agonist on GLP-2 receptor (EC₅₀=5.8 nM).

HY-P1624S

Teduglutide-Ala(13C3,15N) sodium

Teduglutide-Ala( ¹³C₃, ¹⁵N) (ALX-0600-Ala( ¹³C₃, ¹⁵N)) sodium is the ¹³C- and ¹⁵N-labeled Teduglutide (HY-P1624). Teduglutide (ALX-0600) is an analog of human glucagon like peptide-2 (GLP-2). Teduglutide can activate the expression of nuclear receptor subfamily 4 group a member 1 (NR4a1)/nur77 and intestinal FXR signaling in human hepatic stellate cells, thereby improving liver inflammation and fibrosis in mice with sclerosing cholangitis. Teduglutide can alleviate intestinal dysfunction in mice, improve lung injury, alleviate obesity related neuroinflammation and cell apoptosis .

HY-P1142S

GLP-2(rat) (Ala-13C3,15N)
GLP-2(rat) (Ala- ¹³C3, ¹⁵N) is ¹³C and ¹⁵N labeled GLP-2(rat) (HY-P1142). GLP-2(rat) is an intestinal growth factor. GLP-2(rat) stimulates cell proliferation and inhibits apoptosis. GLP-2(rat) enhances mucosal mass and function in residual small intestine after massive small bowel resection (MSBR).

HY-P1142S1

GLP-2(rat) (Ala-13C3,15N) TFA
GLP-2(rat) (Ala- ¹³C3, ¹⁵N) TFA is ¹³C and ¹⁵N labeled GLP-2(rat) (HY-P1142). GLP-2(rat) is an intestinal growth factor. GLP-2(rat) stimulates cell proliferation and inhibits apoptosis. GLP-2(rat) enhances mucosal mass and function in residual small intestine after massive small bowel resection (MSBR).

HY-P0058S

Pramlintide-(Ala-13C3,15N)
Pramlintide-(Ala- ¹³C₃, ¹⁵N) is the ¹³C- and ¹⁵N-labeled Pramlintide. Pramlintide is a polypeptide analogue of human amylin. Pramlintide, an antidiabetic agent, is antineoplastic in colorectal cancer .

HY-P0119S

Lixisenatide (Leu-13C6,15N) TFA

Lixisenatide (Leu- ¹³C₆, ¹⁵N) TFA is the ¹³C- and ¹⁵N-labeled Lixisenatide (HY-P0119). Lixisenatide is a glucagon-like peptide-1 (GLP-1) receptor agonist. Lixisenatide inhibits the inflammatory response through down regulation of pro-inflammatory cytokines, and suppresses of the Akt-MEK1/2 signaling pathway. Lixisenatide can inhibit oxidative stress, mitochondrial dysfunction and apoptosis. Lixisenatide can be used for the researches of inflammation, metabolic disease, neurological disease and cardiovascular disease, such as rheumatoid arthritis, diabetes, Alzheimer's disease and atherosclerosis .

HY-173101S

GHFP(Leu-13C6,15N)AER TFA
GHFP(Leu- ¹³C₆, ¹⁵N)AER TFA is the ¹³C- and ¹⁵N-labeled GHFP(Leu)AER TFA.

HY-163424S

SSVFVADPK-(Lys-13C6,15N2)
SSVFVADPK-(Lys- ¹³C₆, ¹⁵N₂) is ¹³C and ¹⁵N labeled SSVFVADPK-(Lys).

HY-P5168AS

GPSVFPLAPSSK-13C6,15N2 TFA
GPSVFPLAPSSK- ¹³C₆, ¹⁵N₂ TFA is the ¹³C- and ¹⁵N-labeled GPSVFPLAPSSK. GPSVFPLAPSSK is an IgG1 signature peptide of anti-SARS-CoV-2 antibodies. GPSVFPLAPSSK can be used for the quantification of the specific isolation of anti-SARS-CoV-2 antibodies .

HY-P11536S

STEDTAEYSPF-(Lys-13C6,15N2) TFA
STEDTAEYSPF-(Lys- ¹³C₆, ¹⁵N₂) TFA is the ¹³C- and ¹⁵N-labeled STEDTAEYSPF.

HY-P1033S

[Pyr1]-Apelin-13, Gly(15N) TFA
Pyr1]-Apelin-13, Gly(15N) TFA is a Gly ¹⁵N labeled [Pyr1]-Apelin-13. [Pyr1]-Apelin-13 is a highly potent, selective endogenous apelin receptor agonist .

HY-158992S

SP-(Val-13C5,15N)-EKNQ-(Leu-13C6,15N)-TIDFINIVKDPVPHNEYKT TFA
SP-(Val- ¹³C₅, ¹⁵)-EKNQ-(Leu- ¹³C₆, ¹⁵)-TIDFINIVKDPVPHNEYKT TFA is a ¹³C- and ¹⁵N-labeled peptide containing ¹³C₅, ¹⁵N-labeled valine (Val) and ¹³C₆, ¹⁵N-labeled leucine (Leu).

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-131833G

Fmoc-Gly-Gly-Phe-OH	ADC Linker	Cancer
Fmoc-Gly-Gly-Phe-OH GMP is a GMP grade Fmoc-Gly-Gly-Phe-OH (HY-131833). Fmoc-Gly-Gly-Phe-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .

HY-131990G

MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH	ADC Linker	Cancer
MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH GMP is a GMP grade MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH (HY-131990). MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .

HY-45672G

Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH	ADC Linker	Cancer
Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH GMP is a GMP grade Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH (HY-45672). Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH is an ADC Linker that can be used to synthesize Drug-Linker Conjugates for ADC. Especially for the synthesis of Deruxtecan (HY-13631E), a toxic drug-linker conjugate .

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