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Results for "

Phosphorylase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Phosphorylase (20) Adenosine Kinase (2) Amino Acid Derivatives (1) Antibiotic (6) Apoptosis (10) Autophagy (1) Bacterial (5) Biochemical Assay Reagents (20) CaMK (1) Cathepsin (1) Deubiquitinase (1) DNA/RNA Synthesis (16) Drug Derivative (5) Drug Intermediate (3) Drug Metabolite (4) Endogenous Metabolite (23) Fluorescent Dye (1) Fungal (2) Glycosyltransferase (2) Histone Methyltransferase (2) HIV (3) Influenza Virus (2) Isotope-Labeled Compounds (7) Methionine Adenosyltransferase (MAT) (3) Nucleoside Antimetabolite/Analog (27) Orthopoxvirus (2) Phosphatase (4) PKA (5) PKC (7) Reference Standards (16) Ser/Thr Protease (2) Thymidylate Synthase (3) Trk Receptor (1) Urease (1)
By Research Areas:	Cancer (60) Cardiovascular Disease (11) Endocrinology (2) Infection (16) Inflammation/Immunology (9) Metabolic Disease (35) Neurological Disease (7)
Oligonucleotides:	Adenosine (1) Guanosine (3) Nucleotide Analogs (2) Nucleoside Analogs (6) Inosine (1) Cytidine (1) Adenine Nucleotide (1)

128

Inhibitors & Agonists

Screening Libraries

Fluorescent Dyes

Biochemical Assay Reagents

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Targets Recommended: Phosphorylase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-15141

Staurosporine Maximum Cited Publications 207 Publications Verification Antibiotic AM-2282; STS; AM-2282	PKC PKA Apoptosis Bacterial Fungal Antibiotic	Infection Cancer
Staurosporine is a potent, ATP-competitive and non-selective inhibitor of protein kinases with IC₅₀s of 6 nM, 15 nM, 2 nM, and 3 nM for PKC, PKA, c-Fgr, and Phosphorylase kinase respectively. Staurosporine also inhibits TAOK2 with an IC₅₀ of 3 μM. Staurosporine is an apoptosis inducer .

HY-B0016

Capecitabine 25+ Cited Publications	DNA/RNA Synthesis Nucleoside Antimetabolite/Analog Apoptosis	Cancer
Capecitabine is an oral proagent that is converted to its active metabolite, 5-FU, by thymidine phosphorylase.

HY-15424

5-Iodotubercidin 10+ Cited Publications NSC 113939; 5-ITu	Adenosine Kinase	Cancer
5-Iodotubercidin (NSC 113939), an ATP mimetic, is a potent adenosine kinase inhibitor with an IC₅₀ of 26 nM. 5-Iodotubercidin (NSC 113939) initiates glycogen synthesis in isolated hepatocytes by causing inactivation of phosphorylase and activation of glycogen synthase. 5-Iodotubercidin (NSC 113939) also inhibits CK1, insulin receptor tyrosine kinase, phosphorylase kinase, PKA, CK2, PKC and Haspin .

HY-B0307

Idoxuridine 5+ Cited Publications 5-Iodo-2′-deoxyuridine; 5-IUdR; IdUrd	DNA/RNA Synthesis Phosphatase Orthopoxvirus	Infection Cancer
Idoxuridine (5-Iodo-2′-deoxyuridine, 5-IUdR, IdUrd) is an iodinated thymidine analogue that competitively inhibits *phosphorylases. Idoxuridine can inhibit viral activity, particularly viral eye infections, including herpes simplex keratitis, by inhibiting DNA polymerase* and affecting viral replication. Idoxuridine against feline herpesvirus has the IC₅₀ value of 4.3 μM . Idoxuridine shows anti-orthopoxvirus activity.

HY-106406

Benzylacyclouridine 2 Publications Verification BAU; 5-Benzylacyclouridine	Drug Derivative	Cancer
Benzylacyclouridine (BAU) is a potent and specific inhibitor of uridine phosphorylase, the first enzyme in the catabolism of uridine. Benzylacyclouridine inhibits the metabolic activity of UPP1 and the activity of UPP2. Benzylacyclouridine can modulate the cytotoxic side effects of 5-fluorouracil (5-FU) and its derivatives .

HY-16210

Forodesine 15+ Cited Publications BCX-1777; Immucillin-H	Nucleoside Antimetabolite/Analog Apoptosis	Cancer
Forodesine (BCX-1777) is a highly potent and orally active *purine nucleoside phosphorylase* (PNP) inhibitor with IC₅₀ values ranging from 0.48 to 1.57 nM for human, mouse, rat, monkey and dog PNP. Forodesine is a potent human lymphocyte proliferation inhibitor. Forodesine could induce apoptosis** in leukemic cells by increasing the dGTP levels .

HY-A0063

Tipiracil hydrochloride 5 Publications Verification	Nucleoside Antimetabolite/Analog	Cancer
Tipiracil (hydrochloride) is a thymidine phosphorylase inhibitor (TPI), used for cancer research.

HY-156680

Vopimetostat TNG-462	Histone Methyltransferase	Cancer
TNG-462 is an orally active and selective PRMT5 inhibitor with anti-tumor activity against methylthioadenosine phosphorylase (MTAP) deficiency and/or methylthioadenosine (MTA) accumulation cancers .

HY-101496

MT-DADMe-ImmA 4 Publications Verification MTDIA; Methylthio-DADMe-Immucillin A	Histone Methyltransferase	Cancer
MT-DADMe-ImmA is an inhibitor of human 5'-methylthioadenosine phosphorylase (MTAP) with a K_i of 90 pM.

HY-D0995

7-Methyl-6-thioguanosine 2 Publications Verification MESG	Fluorescent Dye	Others
7-Methyl-6-thioguanosine (MESG) is a chromogenic substrate that can be converted to 7-methyl-6-thioguanine in the presence of purine nucleoside phosphorylase and inorganic phosphate. 7-Methyl-6-thioguanosine can be used to quantify inorganic phosphate. 7-Methyl-6-thioguanosine can also be used to determine the activities of purine nucleoside phosphorylase and protein phosphatases .

HY-13525

CP-91149 5+ Cited Publications	Biochemical Assay Reagents	Metabolic Disease Cancer
CP-91149 is a GP (glycogen phosphorylase) inhibitor. CP-91149 promotes glycogen resynthesis, but not its overaccumulation. CP-91149 has the potential for Type II (insulin-dependent) diabetes study .

HY-P1821

Myelin Basic Protein 2 Publications Verification MHP4-14	PKC	Neurological Disease
Myelin Basic Protein (MHP4-14), a synthetic peptide comprising residues 4-14 of myelin basic protein, is a very selective PKC substrate (K_m=7 μM). Myelin Basic Protein is not phosphorylated by cyclic AMP-dependent protein kinase, casein kinases I and II, Ca ²⁺/calmodulin-dependent protein kinase II, or phosphorylase kinase, and can be routinely used for the assay of protein kinase C with low background in the crude tissue extracts .

HY-A0063A

Tipiracil 5 Publications Verification	Thymidylate Synthase Nucleoside Antimetabolite/Analog	Cancer
Tipiracil is a thymidine phosphorylase (TPase) inhibitor.

HY-42680

D-Tagatose D-(-)-Tagatose	Endogenous Metabolite	Metabolic Disease Inflammation/Immunology Cancer
D-Tagatose (D-(-)-Tagatose) is a natural low-calorie rare sugar. D-Tagatose inhibits the activities of sucrase, maltase and intestinal disaccharidases, reduces the digestion of sucrose and starch, and blocks the absorption of sucrose, maltose and glucose. D-Tagatose promotes glucokinase activity and inhibits glycogen phosphorylase activity via tagatose-1-phosphate, regulates the synthesis and decomposition of hepatic glycogen, reduces postprandial and fasting blood glucose levels, and improves hyperinsulinemia. D-Tagatose regulates lipid profiles, stimulates GLP-1 secretion, and exhibits prebiotic effects. D-Tagatose is a bulking sweetener. D-Tagatose can be used in research related to diabetes, hyperlipidemia, dental caries, atherosclerosis and type 2 diabetes .

HY-16933

L-Alanosine 1 Publications Verification NSC-153353; SDX-102	Antibiotic DNA/RNA Synthesis	Infection Cancer
L-Alanosine (NSC-153353), an antibiotic from Streptomyces alanosinicus, has antineoplastic activity. L-Alanosine (NSC-153353) inhibits adenylosuccinate synthetase, which converts inosine monophospate (IMP) into adenylosuccinate. L-Alanosine is the inhibitor for methylthioadenosine phosphorylase (MTAP) .

HY-W039442

2′-Deoxy-2′-fluoroadenosine 1 Publications Verification	Nucleoside Antimetabolite/Analog	Infection Cancer
2′-Deoxy-2′-fluoroadenosine is a fluorinated deoxyadenosine with antitumor and antiviral activity, able to interfere with viral or cancer cell replication by being incorporated into DNA. 2′-Deoxy-2′-fluoroadenosine can be used for the synthesis of 2′-Deoxy-2′-fluoro-modified oligonucleotides hybridized with RNA. 2′-Deoxy-2′-fluoroadenosine can be cleaved efficiently by E. coli purine nucleoside phosphorylase (PNP) to the toxic agent 2-fluoroadenine (FAde). 2′-Deoxy-2′-fluoroadenosine shows excellent in vivo activity against tumors expressing E. coli PNP .

HY-127018

Maltoheptaose	Biochemical Assay Reagents	Others
Maltoheptaose is a linear oligosaccharide composed of seven glucose units and belongs to the class of malto-oligosaccharides .

HY-113291

5'-Deoxyadenosine 2 Publications Verification	Nucleoside Antimetabolite/Analog Phosphorylase	Others
5'-Deoxyadenosine is a 5'-methylthioadenosine phosphorylase substrate and deoxyadenosine. 5'-Deoxyadenosine serves as a non-metabolizable substrate for nucleoside transport assays only in cells lacking 5'-methylthioadenosine phosphorylase .

HY-136648A

2'-Deoxyadenosine-5'-triphosphate trisodium dATP trisodium	Endogenous Metabolite DNA/RNA Synthesis	Cancer
2'-Deoxyadenosine-5'-triphosphate (dATP) trisodium is a nucleotide used in cells for DNA synthesis (or replication), as a substrate of DNA polymerase. 2'-Deoxyadenosine-5'-triphosphate is promising for research of genetic immunodeficiency diseases adenosine deaminase deficiency and purine nucleotide phosphorylase deficiency .

HY-19396

Ingliforib 2 Publications Verification CP 368296; GPi 296	Phosphorylase	Cardiovascular Disease
Ingliforib (CP 368296) is a glycogen phosphorylase inhibitor, with IC₅₀s of 52, 352 and 150 nM for liver, muscle and brain glycogen phosphorylase, and has cardioprotective activity.

HY-108615

CP-316819 GPi 819	Phosphorylase	Cardiovascular Disease Neurological Disease Metabolic Disease
CP-316819 (GPi 819) is a blood-brain barrier permeable glycogen phosphorylase inhibitor. CP-316819 inhibits hepatic glycogenolysis, safely reduces blood glucose in type 2 diabetes, and rarely induces hypoglycemia. CP-316819 increases brain glycogen reserves, protects neurons, alleviates hypoglycemic brain injury, and inhibits excessive platelet activation, exerting both neuroprotective and vasculoprotective effects. CP-316819 can be used in research related to hypoglycemia, thrombosis, autoimmune inflammatory diseases, and type 2 diabetes .

HY-19480

Ulodesine 1 Publications Verification BCX4208	Endogenous Metabolite	Metabolic Disease
Ulodesine is a *purine nucleoside phosphorylase* (PNP) inhibitor. Ulodesine inhibits PNP with IC₅₀** value of 2.293 nM/L. Ulodesine can be used for the research of hyporucicemia .

HY-134529A

D-Ribofuranose1-dihydrogenphosphate dicyclohexanamine 1 Publications Verification Ribose 1-phosphate dicyclohexanamine	Endogenous Metabolite	Others
D-Ribofuranose1-dihydrogenphosphate dicyclohexanamine, also known as ribose 1-phosphate, is the material for the synthesis of 5-fluorouracil (FUra) by uridine phosphorylase .

HY-41121

Boc-L-Ala-OH 1 Publications Verification Boc-Ala-OH	Amino Acid Derivatives	Cancer
Boc-L-Ala-OH (Boc-Ala-OH) is a single N-protected amino acid ligand and a protected L-alanine derivative. Boc-L-Ala-OH promotes Pd (II)-catalyzed enantioselective C-H alkenylation and kinetic resolution. Boc-L-Ala-OH serves as a coupling reagent for the synthesis of liver-targeted glycogen phosphorylase inhibitors and P6A metabolites, and also acts as a negative control in synthesis studies of betulinic acid amino acid esters. Boc-L-Ala-OH is applicable to research on epidermoid squamous cell carcinoma .

HY-113468

3-O-Methyl-DL-DOPA 3-Methoxytyrosine	Endogenous Metabolite	Neurological Disease
3-O-Methyl-DL-DOPA is an endogenous metabolite present in Cerebrospinal_Fluid that can be used for the research of Epilepsy, Purine Nucleoside Phosphorylase Deficiency and Aromatic L Amino Acid Decarboxylase Deficiency .

HY-W008638

2'-Deoxyinosine 2 Publications Verification	Endogenous Metabolite	Metabolic Disease Cancer
2'-Deoxyinosine is the major product of 2'-deoxyadenosine in the absence of deoxycoformycin. 2'-Deoxyinosine is found to be associated with purine nucleoside phosphorylase (PNP) deficiency .

HY-I0210

4-Iodoaniline, 98%	Biochemical Assay Reagents Drug Intermediate	Cardiovascular Disease Cancer
4-Iodoaniline is a potent methemoglobin former. 4-Iodoaniline is also an intermediate. 4-Iodoaniline can be used to synthesize glycogen phosphorylase inhibitors. 4-Iodoaniline is used in the research of liver cancer and blood diseases .

HY-E70373

λ Protein phosphatase	Biochemical Assay Reagents	Others
λ Protein phosphatase is a serine/threonine phosphatase encoded by bacteriophage Lambda. λ Protein phosphatase is activated with requirement for divalent cations, such as Mn ²⁺. λ Protein phosphatase is able to dephosphorylate casein, adenovirus E1A protein, and the α subunit of phosphorylase kinase

HY-P2757

Phosphorylase kinase PhK	Others	Others
Phosphorylase kinase relies on Ca ²⁺ to exert its activity. Phosphorylase kinase’s sensitivity to Ca ²⁺ is influenced by its activation state and pH. Phosphorylase kinase can be activated by adrenaline .

HY-P2724

*Purine nucleoside phosphorylase, Microorganism* PNP	Endogenous Metabolite	Metabolic Disease
Purine nucleoside phosphorylase, Microorganism (PNP) is a key enzyme in purine metabolism, which is involved in the purine rescue pathway. The deficiency of Purine nucleoside phosphorylase resulted in impaired T cell function. In the presence of inorganic orthophosphate as the second substrate, Purine nucleoside phosphorylase catalyzes the breaking of the glycosidic bond between ribose and deoxyribonucleoside to generate purine base and ribose (deoxyribose) -1-phosphate .

HY-N1932

Bayogenin	Phosphorylase	Metabolic Disease
Bayogenin is a triterpenoid saponin and one of the main components of Medicago sativa saponins. Bayogenin is an inhibitor of glycogen phosphorylase .

HY-W013330

3′-Deoxyguanosine Guanosine, 3'-deoxy-	Nucleoside Antimetabolite/Analog Drug Derivative	Metabolic Disease
3′-Deoxyguanosine (Guanosine, 3'-deoxy-) is a derivative of Guanosine (HY-N0097). 3′-Deoxyguanosine interacts with human purine nucleoside phosphorylase via hydrogen bonding with residues such as Glu201 and Asn243. 3′-Deoxyguanosine exhibits moderate displacement activity for [ ³H]-guanosine in rat meninges. 3′-Deoxyguanosine is useful for studying the mechanism of guanosine receptors and purine metabolism .

HY-B0016S

Capecitabine-d11	Isotope-Labeled Compounds DNA/RNA Synthesis Nucleoside Antimetabolite/Analog Apoptosis	Cancer
Capecitabine-d₁₁ is the deuterium labeled Capecitabine. Capecitabine is an oral proagent that is converted to its active metabolite, 5-FU, by thymidine phosphorylase .

HY-B0016R

Capecitabine (Standard)	Reference Standards DNA/RNA Synthesis Nucleoside Antimetabolite/Analog Apoptosis	Cancer
Capecitabine (Standard) is the analytical standard of Capecitabine. This product is intended for research and analytical applications. Capecitabine is an oral proagent that is converted to its active metabolite, 5-FU, by thymidine phosphorylase.

HY-W010854

*2'-Deoxyadenosine 5'-di-phos-phate disodium* dADP disodium	DNA/RNA Synthesis	Others
2'-Deoxyadenosine 5'-di-phos-phate disodium (dADP disodium) is an inhibitor of bacterial poly(A) polymerase. It can be used to synthesize deoxyadenosine oligonucleotides with Escherichia coli polynucleotide phosphorylase and other enzymes .

HY-P2741

Maltose phosphorylase E.C. 2.4.1.8	Endogenous Metabolite	Metabolic Disease
Maltose phosphorylase is a dimerase which catalyzes the transformation of maltose and inorganic phosphate into β-D-glucose-1-phosphate and glucose. Maltose phosphorylases have been classified in family 65 of the glycoside hydrolases .

HY-106934A

Peldesine dihydrochloride 1 Publications Verification BCX 34 dihydrochloride	Nucleoside Antimetabolite/Analog HIV	Infection Inflammation/Immunology Cancer
Peldesine (BCX 34) dihydrochloride is a potent, competitive, reversible and orally active *purine nucleoside phosphorylase* (PNP) inhibitor with IC₅₀s of 36 nM, 5 nM, and 32 nM for human, rat, and mouse red blood cell (RBC) PNP, respectively. Peldesine dihydrochloride is also a T-cell proliferation inhibitor with an IC₅₀ of 800 nM. Peldesine dihydrochloride has the potential for cutaneous T-cell lymphoma, psoriasis and HIV** infection research .

HY-P2734

Phosphorylase a, rabbit muscle	Phosphatase	Others
Phosphorylase a, rabbit muscle is glycogen phosphorylase isolated from rabbit muscle. Phosphorylase a, rabbit muscle catalyzes glycogenolysis, converting glycogen and inorganic phosphate into glucose-1-phosphate to supply energy for muscle contraction .

HY-121106

9-Deazaguanine 1 Publications Verification	DNA/RNA Synthesis	Others
9-Deazaguanine is a nucleoside analog with potent inhibitory activity against purine nucleoside phosphorylase (PNP) .

HY-77537

7-Deazaxanthine 7DX	Thymidylate Synthase	Cardiovascular Disease
7-Deazaxanthine (7DX) is an inhibitor of thymidine phosphorylase (TPase). 7-Deazaxanthine inhibits TPase reaction in a concentration-dependent manner with an IC₅₀ value of 40 μM. 7-Deazaxanthine also has a significant angiogenesis inhibitory effect .

HY-P1821A

Myelin basic protein (4-14) TFA 2 Publications Verification MHP4-14 TFA	PKC	Neurological Disease
Myelin Basic Protein (MHP4-14) TFA, a synthetic peptide comprising residues 4-14 of myelin basic protein, is a very selective PKC substrate (K_m=7 μM). Myelin Basic Protein TFA is not phosphorylated by cyclic AMP-dependent protein kinase, casein kinases I and II, Ca ²⁺/calmodulin-dependent protein kinase II, or phosphorylase kinase, and can be routinely used for the assay of protein kinase C with low background in the crude tissue extracts .

HY-139037

8-Aminoguanine	Endogenous Metabolite	Metabolic Disease
8-Aminoguanine is a endogenous purine. 8-Aminoguanine inhibits PNPase (purine nucleoside phosphorylase). 8-Aminoguanine induces diuresis/natriuresis/glucosuria .

HY-15424R

5-Iodotubercidin (Standard) NSC 113939 (Standard); 5-ITu (Standard)	Adenosine Kinase Reference Standards	Cancer
5-Iodotubercidin (Standard) is the analytical standard of 5-Iodotubercidin. This product is intended for research and analytical applications. 5-Iodotubercidin (NSC 113939), an ATP mimetic, is a potent adenosine kinase inhibitor with an IC50 of 26 nM. 5-Iodotubercidin (NSC 113939) initiates glycogen synthesis in isolated hepatocytes by causing inactivation of phosphorylase and activation of glycogen synthase. 5-Iodotubercidin (NSC 113939) also inhibits CK1, insulin receptor tyrosine kinase, phosphorylase kinase, PKA, CK2, PKC and Haspin .

HY-113585

1,4-Dideoxy-1,4-imino-D-arabinitol hydrochloride	Endogenous Metabolite	Others
1,4-Dideoxy-1,4-imino-D-arabinitol hydrochloride is a naturally occurring pyrrolidine alkaloid that acts as an inhibitor of glycogen phosphorylase and α-glucosidases, and is sourced from Arachniodes standishii and Angylocalyx boutiqueanus.

HY-W008638R

2'-Deoxyinosine (Standard)	Reference Standards Endogenous Metabolite	Metabolic Disease Cancer
2'-Deoxyinosine (Standard) is the analytical standard of 2'-Deoxyinosine (HY-W008638). This product is intended for research and analytical applications. 2'-Deoxyinosine is the major product of 2'-deoxyadenosine in the absence of deoxycoformycin. 2'-Deoxyinosine is found to be associated with purine nucleoside phosphorylase (PNP) deficiency .

HY-106934

Peldesine BCX 34	Nucleoside Antimetabolite/Analog HIV	Infection Inflammation/Immunology Cancer
Peldesine (BCX 34) is a potent, competitive, reversible and orally active *purine nucleoside phosphorylase* (PNP) inhibitor with IC₅₀s of 36 nM, 5 nM, and 32 nM for human, rat, and mouse red blood cell (RBC) PNP, respectively. Peldesine is also a T-cell proliferation inhibitor with an IC₅₀ of 800 nM. Peldesine has the potential for cutaneous T-cell lymphoma, psoriasis and HIV** infection research .

HY-W400427

α-D-Glucose-1-phosphate	Biochemical Assay Reagents	Others
α-D-Glucose-1-phosphate is an important intermediate in sugar metabolism, functioning as a glycosyl donor in glycosyl transfer reactions and participating in glycogen synthesis and degradation through the action of phosphorylases .

HY-111627

5-Aza-7-deazaguanine 1 Publications Verification	Nucleoside Antimetabolite/Analog	Cancer
5-Aza-7-deazaguanine is a substrate for wild-type (WT) E. coli purine nucleoside phosphorylase and its Ser90Ala mutant in the synthesis of base-modified nucleosides .

HY-P2735

Phosphorylase b	Phosphorylase	Metabolic Disease
Phosphorylase b is one of the two forms of phosphorylase present in skeletal muscle. The other is Phosphorylase a, which can be transformed into one another. The conversion process requires the addition of divalent metal ions and ATP .

HY-128029

*Glycogen phosphorylase-IN-1*	Phosphorylase	Metabolic Disease
Glycogen phosphorylase-IN-1 (Compound 42) is an inhibitor for human liver glycogen phosphorylase (hlGPa) and hepatocyte glycogen-derived glucose production with IC₅₀s of 53 and 380 nM, respectively. Glycogen phosphorylase-IN-1 reveals efficacy towards type 2 diabetes .

Cat. No.	Product Name

HY-L044

Nucleotide Compound Library

572 compounds

Nucleoside and nucleotide analogues are synthetic, chemically modified compounds that have been developed to mimic their physiological counterparts in order to exploit cellular metabolism and subsequently be incorporated into DNA and RNA to inhibit cellular division and viral replication. In addition to their incorporation into nucleic acids, nucleoside and nucleotide analogues can interact with and inhibit essential enzymes such as human and viral polymerases (that is, DNA-dependent DNA polymerases, RNA-dependent DNA polymerases or RNA-dependent RNA polymerases), kinases, ribonucleotide reductase, DNA methyltransferases, purine and pyrimidine nucleoside phosphorylase and thymidylate synthase. These actions of nucleoside and nucleotide analogues have potential therapeutic benefits — for example, in the inhibition of cancer cell growth, the inhibition of viral replication as well as other indications.

MCE offers a unique collection of 572 nucleotide compounds including nucleotide, nucleoside and their structural analogues. MCE Nucleotide Compound Library is a useful tool to discover anti-cancer and antiviral drugs for high throughput screening (HTS) and high content screening (HCS).

Cat. No.	Product Name	Type

HY-D0995

7-Methyl-6-thioguanosine 2 Publications Verification MESG	Fluorescent Dyes
7-Methyl-6-thioguanosine (MESG) is a chromogenic substrate that can be converted to 7-methyl-6-thioguanine in the presence of purine nucleoside phosphorylase and inorganic phosphate. 7-Methyl-6-thioguanosine can be used to quantify inorganic phosphate. 7-Methyl-6-thioguanosine can also be used to determine the activities of purine nucleoside phosphorylase and protein phosphatases .

Cat. No.	Product Name	Type

HY-136648A

2'-Deoxyadenosine-5'-triphosphate trisodium dATP trisodium	Biochemical Assay Reagents
2'-Deoxyadenosine-5'-triphosphate (dATP) trisodium is a nucleotide used in cells for DNA synthesis (or replication), as a substrate of DNA polymerase. 2'-Deoxyadenosine-5'-triphosphate is promising for research of genetic immunodeficiency diseases adenosine deaminase deficiency and purine nucleotide phosphorylase deficiency .

HY-I0210

4-Iodoaniline, 98%	Biochemical Assay Reagents
4-Iodoaniline is a potent methemoglobin former. 4-Iodoaniline is also an intermediate. 4-Iodoaniline can be used to synthesize glycogen phosphorylase inhibitors. 4-Iodoaniline is used in the research of liver cancer and blood diseases .

HY-W010854

*2'-Deoxyadenosine 5'-di-phos-phate disodium* dADP disodium	Biochemical Assay Reagents
2'-Deoxyadenosine 5'-di-phos-phate disodium (dADP disodium) is an inhibitor of bacterial poly(A) polymerase. It can be used to synthesize deoxyadenosine oligonucleotides with Escherichia coli polynucleotide phosphorylase and other enzymes .

HY-W012670

2-Deoxy-L-ribose	Biochemical Assay Reagents
2-Deoxy-L-ribose is a stereoisomer of 2-Deoxy-d-ribose that inhibits 2-Deoxy-d-ribose anti-apoptotic effects. 2-Deoxy-L-ribose suppresses metastasis of tumor cells overexpressing thymidine phosphorylase .

HY-W008907

5'-O-Tritylthymidine 5-OTT	Biochemical Assay Reagents
5'-O-Tritylthymidine is an inhibitor of TK-2 and inhibits angiogenesis . 5'-O-Tritylthymidine targets FAK-Mdm-2 interactions, decreasing cell viability and increasing apoptosis.

Cat. No.	Product Name	Target	Research Area

HY-P1821

Myelin Basic Protein 2 Publications Verification MHP4-14	PKC	Neurological Disease
Myelin Basic Protein (MHP4-14), a synthetic peptide comprising residues 4-14 of myelin basic protein, is a very selective PKC substrate (K_m=7 μM). Myelin Basic Protein is not phosphorylated by cyclic AMP-dependent protein kinase, casein kinases I and II, Ca ²⁺/calmodulin-dependent protein kinase II, or phosphorylase kinase, and can be routinely used for the assay of protein kinase C with low background in the crude tissue extracts .

HY-41121

Boc-L-Ala-OH 1 Publications Verification Boc-Ala-OH	Amino Acid Derivatives	Cancer
Boc-L-Ala-OH (Boc-Ala-OH) is a single N-protected amino acid ligand and a protected L-alanine derivative. Boc-L-Ala-OH promotes Pd (II)-catalyzed enantioselective C-H alkenylation and kinetic resolution. Boc-L-Ala-OH serves as a coupling reagent for the synthesis of liver-targeted glycogen phosphorylase inhibitors and P6A metabolites, and also acts as a negative control in synthesis studies of betulinic acid amino acid esters. Boc-L-Ala-OH is applicable to research on epidermoid squamous cell carcinoma .

HY-P1597

Malantide 1 Publications Verification	PKA PKC	Cancer
Malantide is a synthetic dodecapeptide derived from the site phosphorylated by cAMP-dependent protein kinase (PKA) on the β-subunit of phosphorylase kinase. Malantide is a highly specific substrate for PKA with a K_m of 15 μM and shows protein inhibitor (PKI) inhibition >90% substrate phosphorylation in various rat tissue extracts . Malantide is also an efficient substrate for PKC with a K_m of 16 μM .

HY-P3570

Adipokinetic hormone II (Locusta migratoria) Lom-AKH-II	Endogenous Metabolite	Metabolic Disease
Adipokinetic hormone II (Locusta migratoria) (Lom-AKH-II) is a insect adipokinetic hormone (AKH), enhances fat body cAMP levels in vitro. Insect adipokinetic hormones (AKHs) controls flight-directed mobilization of carbohydrate and lipid from fat body stores, which depends on AKH receptor(s) coupling to cAMP formation and glycogen phosphorylase activation via the stimulatory guanine nucleotide-binding protein (Gs) .

HY-P1821A

Myelin basic protein (4-14) TFA 2 Publications Verification MHP4-14 TFA	PKC	Neurological Disease
Myelin Basic Protein (MHP4-14) TFA, a synthetic peptide comprising residues 4-14 of myelin basic protein, is a very selective PKC substrate (K_m=7 μM). Myelin Basic Protein TFA is not phosphorylated by cyclic AMP-dependent protein kinase, casein kinases I and II, Ca ²⁺/calmodulin-dependent protein kinase II, or phosphorylase kinase, and can be routinely used for the assay of protein kinase C with low background in the crude tissue extracts .

HY-P3572

Adipokinetic hormone I (Locusta migratoria) Lom-AKH-I	Endogenous Metabolite	Endocrinology
Adipokinetic hormone I (Locusta migratoria) (Lom-AKH-I) is a insect adipokinetic hormone (AKH), enhances fat body cAMP levels in vitro. Insect adipokinetic hormones (AKHs) controls flight-directed mobilization of carbohydrate and lipid from fat body stores, which depends on AKH receptor(s) coupling to cAMP formation and glycogen phosphorylase activation via the stimulatory guanine nucleotide-binding protein (Gs) .

HY-P1873

Phosphorylase Kinase β-Subunit Fragment (420-436)	Ser/Thr Protease	Endocrinology
Phosphorylase Kinase β-Subunit Fragment (420-436) is the β-Subunit fragment (peptide 430-436) of phosphorylase kinase. Phosphorylase kinase is a serine/threonine-specific protein kinase which activates glycogen phosphorylase to release glucose-1-phosphate from glycogen .

HY-P1597A

Malantide TFA	PKA PKC	Cancer
Malantide TFA is a synthetic dodecapeptide derived from the site phosphorylated by cAMP-dependent protein kinase (PKA) on the β-subunit of phosphorylase kinase. Malantide TFA is a highly specific substrate for PKA with a K_m of 15 μM and shows protein inhibitor (PKI) inhibition >90% substrate phosphorylation in various rat tissue extracts . Malantide TFA is also an efficient substrate for PKC with a K_m of 16 μM .

HY-P1873B

Phosphorylase Kinase β-Subunit Fragment (420-436) acetate	Ser/Thr Protease	Metabolic Disease
Phosphorylase Kinase β-Subunit Fragment (420-436) acetate is the β-Subunit fragment (peptide 430-436) of phosphorylase kinase. Phosphorylase kinase is a serine/threonine-specific protein kinase which activates glycogen phosphorylase to release glucose-1-phosphate from glycogen .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-15141

Staurosporine Maximum Cited Publications 207 Publications Verification Antibiotic AM-2282; STS; AM-2282	Infection Structural Classification Alkaloids Microorganisms Classification of Application Fields Marine natural products Marine microorganism Disease Research Fields Indole Alkaloids Source Classification	PKC PKA Apoptosis Bacterial Fungal Antibiotic
Staurosporine is a potent, ATP-competitive and non-selective inhibitor of protein kinases with IC₅₀s of 6 nM, 15 nM, 2 nM, and 3 nM for PKC, PKA, c-Fgr, and Phosphorylase kinase respectively. Staurosporine also inhibits TAOK2 with an IC₅₀ of 3 μM. Staurosporine is an apoptosis inducer .

HY-N6732

K-252a 25+ Cited Publications SF2370; Antibiotic K 252a; Antibiotic SF 2370	Alkaloids Structural Classification Microorganisms Classification of Application Fields Inflammation/Immunology Disease Research Fields Indole Alkaloids Source Classification	Autophagy PKA PKC Trk Receptor CaMK
K-252a, a staurosporine analog, inhibits protein kinase, with IC₅₀ values of 470 nM, 140 nM, 270 nM, and 1.7 nM for PKC, PKA, Ca ²⁺/calmodulin-dependent kinase type II, and phosphorylase kinase, respectively . K-252a is a potent inhibitor (IC₅₀ of 3 nM) of the tyrosine protein kinase (TRK) activity of the NGF receptor gp140trk, the product of the trk protooncogene .

HY-100126

Tubercidin 5+ Cited Publications 7-Deazaadenosine	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Antiviral Antibacterial Disease Research Disease Research Fields Other Antibiotics Source Classification	Bacterial DNA/RNA Synthesis Influenza Virus Antibiotic
Tubercidin (7-Deazaadenosine) is an antibiotic obtained from Streptomyces tubercidicus. Tubercidin inhibits the growth of Streptococcus faecalis (8043) with an IC₅₀ of 0.02 μM . Tubercidin inhibits polymerases by incorporating DNA or RNA, thereby inhibiting DNA replication, RNA and protein synthesis . Tubercidin is a weak inhibitor of adenosine phosphorylase, and interferes with the phosphorylation of adenosine and AMP . Tubercidin has antiviral activity .

HY-42680

D-Tagatose D-(-)-Tagatose	Structural Classification Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Sweeteners Saccharides Monosaccharides Source Classification Food Research	Endogenous Metabolite
D-Tagatose (D-(-)-Tagatose) is a natural low-calorie rare sugar. D-Tagatose inhibits the activities of sucrase, maltase and intestinal disaccharidases, reduces the digestion of sucrose and starch, and blocks the absorption of sucrose, maltose and glucose. D-Tagatose promotes glucokinase activity and inhibits glycogen phosphorylase activity via tagatose-1-phosphate, regulates the synthesis and decomposition of hepatic glycogen, reduces postprandial and fasting blood glucose levels, and improves hyperinsulinemia. D-Tagatose regulates lipid profiles, stimulates GLP-1 secretion, and exhibits prebiotic effects. D-Tagatose is a bulking sweetener. D-Tagatose can be used in research related to diabetes, hyperlipidemia, dental caries, atherosclerosis and type 2 diabetes .

HY-127018

Maltoheptaose	Human Gut Microbiota Metabolites Microorganisms Endogenous metabolite Source Classification	Biochemical Assay Reagents
Maltoheptaose is a linear oligosaccharide composed of seven glucose units and belongs to the class of malto-oligosaccharides .

HY-113291

5'-Deoxyadenosine 2 Publications Verification	Structural Classification Natural Products Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Nucleoside Antimetabolite/Analog Phosphorylase
5'-Deoxyadenosine is a 5'-methylthioadenosine phosphorylase substrate and deoxyadenosine. 5'-Deoxyadenosine serves as a non-metabolizable substrate for nucleoside transport assays only in cells lacking 5'-methylthioadenosine phosphorylase .

HY-136648A

2'-Deoxyadenosine-5'-triphosphate trisodium dATP trisodium	Alkaloids Structural Classification Classification of Application Fields Other Alkaloids Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite DNA/RNA Synthesis
2'-Deoxyadenosine-5'-triphosphate (dATP) trisodium is a nucleotide used in cells for DNA synthesis (or replication), as a substrate of DNA polymerase. 2'-Deoxyadenosine-5'-triphosphate is promising for research of genetic immunodeficiency diseases adenosine deaminase deficiency and purine nucleotide phosphorylase deficiency .

HY-19480

Ulodesine 1 Publications Verification BCX4208	Natural Products Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Ulodesine is a *purine nucleoside phosphorylase* (PNP) inhibitor. Ulodesine inhibits PNP with IC₅₀** value of 2.293 nM/L. Ulodesine can be used for the research of hyporucicemia .

HY-134529A

D-Ribofuranose1-dihydrogenphosphate dicyclohexanamine 1 Publications Verification Ribose 1-phosphate dicyclohexanamine	Natural Products Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
D-Ribofuranose1-dihydrogenphosphate dicyclohexanamine, also known as ribose 1-phosphate, is the material for the synthesis of 5-fluorouracil (FUra) by uridine phosphorylase .

HY-113468

3-O-Methyl-DL-DOPA 3-Methoxytyrosine	Monophenols Neurological Disease Classification of Application Fields Phenols Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
3-O-Methyl-DL-DOPA is an endogenous metabolite present in Cerebrospinal_Fluid that can be used for the research of Epilepsy, Purine Nucleoside Phosphorylase Deficiency and Aromatic L Amino Acid Decarboxylase Deficiency .

HY-128747A

α-D-Glucose-1-phosphate disodium hydrate	Cardiovascular Disease Structural Classification Classification of Application Fields Endogenous metabolite Inflammation/Immunology Disease Research Fields Saccharides Monosaccharides Source Classification	Drug Derivative Drug Intermediate Antibiotic
α-D-Glucose-1-phosphate disodium hydrate is a derivative of D-glucose (HY-B0389). α-D-Glucose-1-phosphate disodium hydrate serves as a starting material for glucuronic acid synthesis. Glucuronic acid acts as a Ca ²⁺ chelator and also functions as a biosynthetic substrate for the production of linear maltooligosaccharides or α,α-trehalose. α-D-Glucose-1-phosphate disodium hydrate can be used as a cytostatic compound, Antibiotic, and immunosuppressant essential for heart disease management. α-D-Glucose-1-phosphate disodium hydrate is applicable to the research of heart disease .

HY-N1932

Bayogenin	Triterpenes Classification of Application Fields Terpenoids Cucurbitaceae Metabolic Disease Plants Bolbostemma paniculaum (Maxim)Franguet Disease Research Fields Source Classification	Phosphorylase
Bayogenin is a triterpenoid saponin and one of the main components of Medicago sativa saponins. Bayogenin is an inhibitor of glycogen phosphorylase .

HY-15141R

Staurosporine (Standard) Antibiotic AM-2282 (Standard); STS (Standard); AM-2282 (Standard)	Alkaloids Structural Classification Microorganisms Marine natural products Marine microorganism Indole Alkaloids Source Classification	Reference Standards PKC PKA Apoptosis Bacterial Fungal Antibiotic
Staurosporine (Standard) is the analytical standard of Staurosporine. This product is intended for research and analytical applications. Staurosporine is a potent, ATP-competitive and non-selective inhibitor of protein kinases with IC50s of 6 nM, 15 nM, 2 nM, and 3 nM for PKC, PKA, c-Fgr, and Phosphorylase kinase respectively. Staurosporine also inhibits TAOK2 with an IC50 of 3 μM. Staurosporine is an apoptosis inducer[1][2][3][4][5].

HY-W008638R

2'-Deoxyinosine (Standard)	Structural Classification Natural Products Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite
2'-Deoxyinosine (Standard) is the analytical standard of 2'-Deoxyinosine (HY-W008638). This product is intended for research and analytical applications. 2'-Deoxyinosine is the major product of 2'-deoxyadenosine in the absence of deoxycoformycin. 2'-Deoxyinosine is found to be associated with purine nucleoside phosphorylase (PNP) deficiency .

HY-113468R

3-O-Methyl-DL-DOPA (Standard) 3-Methoxytyrosine (Standard)	Structural Classification Monophenols Phenols Endogenous metabolite Source Classification	Endogenous Metabolite Reference Standards
3-O-Methyl-DL-DOPA (Standard) is the analytical standard of 3-O-Methyl-DL-DOPA. This product is intended for research and analytical applications. 3-O-Methyl-DL-DOPA is an endogenous metabolite present in Cerebrospinal_Fluid that can be used for the research of Epilepsy, Purine Nucleoside Phosphorylase Deficiency and Aromatic L Amino Acid Decarboxylase Deficiency [4].

HY-D0843R

N-Ethylmaleimide (Standard) NEM (Standard)	Microorganisms Source Classification	Reference Standards Cathepsin Deubiquitinase Apoptosis
Bayogenin (Standard) is the analytical standard of Bayogenin. This product is intended for research and analytical applications. Bayogenin is an alfalfa saponin, shows moderate potency of glycogen phosphorylase inhibition .

HY-154871

α-D-Glucosamine 1-phosphate	Structural Classification Natural Products Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Drug Derivative Biochemical Assay Reagents
α-D-Glucosamine 1-phosphate is a glycosyl donor analog of Glc-1-P. α-D-Glucosamine 1-phosphate acts as a glycosyl donor to produce α(1→4)-linked glucosamine chains in the enzyme-catalyzed polymerization reaction mediated by thermostable α-glucan phosphorylase. α-D-Glucosamine 1-phosphate serves as a glycosyl donor analog to generate a pentasaccharide with a glucosamine residue at the non-reducing end in the maltotetraose glucosamination reaction catalyzed by potato α-glucan phosphorylase. α-D-Glucosamine 1-phosphate is used for the synthesis of amphiphilic block polysaccharides with pH-responsive assembly/disassembly properties .

HY-N1932R

Bayogenin (Standard)	Triterpenes Structural Classification Terpenoids Cucurbitaceae Plants Bolbostemma paniculaum (Maxim)Franguet Source Classification	Reference Standards Phosphorylase
Bayogenin (Standard) is the analytical standard of Bayogenin (HY-N1932). This product is intended for research and analytical applications. Bayogenin is a triterpenoid saponin and one of the main components of Medicago sativa saponins. Bayogenin is an inhibitor of glycogen phosphorylase .

HY-100126R

Tubercidin (Standard) 7-Deazaadenosine (Standard)	Structural Classification Microorganisms Antibiotics Antiviral Antibacterial Disease Research Other Antibiotics Source Classification	Reference Standards Bacterial DNA/RNA Synthesis Influenza Virus Antibiotic
Tubercidin (Standard) is the analytical standard of Tubercidin. This product is intended for research and analytical applications. Tubercidin (7-Deazaadenosine) is an antibiotic obtained from Streptomyces tubercidicus. Tubercidin inhibits the growth of Streptococcus faecalis (8043) with an IC50 of 0.02 μM[1]. Tubercidin inhibits polymerases by incorporating DNA or RNA, thereby inhibiting DNA replication, RNA and protein synthesis[2]. Tubercidin is a weak inhibitor of adenosine phosphorylase, and interferes with the phosphorylation of adenosine and AMP[1]. Tubercidin has antiviral activity[2].

HY-42680R

D-Tagatose (Standard) D-(-)-Tagatose (Standard)	Structural Classification Microorganisms Endogenous metabolite Saccharides Monosaccharides Source Classification	Reference Standards Endogenous Metabolite
D-Tagatose (Standard) is the analytical standard of D-Tagatose (HY-42680). This product is intended for research and analytical applications. D-Tagatose (D-(-)-Tagatose) is a natural low-calorie rare sugar. D-Tagatose inhibits the activities of sucrase, maltase and intestinal disaccharidases, reduces the digestion of sucrose and starch, and blocks the absorption of sucrose, maltose and glucose. D-Tagatose promotes glucokinase activity and inhibits glycogen phosphorylase activity via tagatose-1-phosphate, regulates the synthesis and decomposition of hepatic glycogen, reduces postprandial and fasting blood glucose levels, and improves hyperinsulinemia. D-Tagatose regulates lipid profiles, stimulates GLP-1 secretion, and exhibits prebiotic effects. D-Tagatose is a bulking sweetener. D-Tagatose can be used in research related to diabetes, hyperlipidemia, dental caries, atherosclerosis and type 2 diabetes.

HY-126756

Amorphin	Structural Classification Leguminosae Coumarins Amorpha fruticosaL. Phenylpropanoids Plants Source Classification	Phosphorylase
Amorphin is a phosphorylase b with glycogen metabolism activity. Amorphin binds directly to alpha-actinin, with alpha-actinin mediating its binding to actin filaments. Amorphin can be used for the research of McArdle’s disease and breast cancer .

Species:	Human (4)
Tag:	His (4) Tag Free (2) GST (2)
Source:	Sf9 insect cells (1) E. coli (7)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P701897

	*glycogen phosphorylase* Protein, Pyrococcus furiosus** Glycogen Phosphorylase	Others	E. coli
	glycogen phosphorylase Protein, Pyrococcus furiosus is the recombinant glycogen phosphorylase protein, expressed by E. coli, with tag free.

HY-P74665

	*Nucleoside phosphorylase/PNP Protein, Human (His)* Purine nucleoside Phosphorylase; PNP; Inosine Phosphorylase; NP	Human	E. coli
	Nucleoside phosphorylase/PNP proteins play a vital role in cellular processes by catalyzing the phosphate breakdown of β-(deoxy)ribonucleosides, preferably 6-oxopurine nucleosides, such as inosine and guanosine. This enzymatic activity results in the formation of free purine bases and pentose 1-phosphate, highlighting the importance of this protein in regulating nucleoside degradation. Nucleoside phosphorylase/PNP Protein, Human (His) is the recombinant human-derived Nucleoside phosphorylase/PNP protein, expressed by E. coli , with C-10*His labeled tag.

HY-P701898

	*glycogen phosphorylase* Protein, Pyrococcus furiosus (His)** Glycogen Phosphorylase	Others	E. coli
	glycogen phosphorylase Protein, Pyrococcus furiosus (His) is the recombinant glycogen phosphorylase protein, expressed by E. coli, with N-6*His labeled tag.

HY-P701869

	*Purine nucleoside phosphorylase* Protein, Thermus thermophilus** Purine nucleoside Phosphorylase	Others	E. coli
	Purine nucleoside phosphorylase Protein, Thermus thermophilus is the recombinant Purine nucleoside phosphorylase protein, expressed by E. coli, with tag free.

HY-P701870

	*Purine nucleoside phosphorylase* Protein, Thermus thermophilus (His)** Purine nucleoside Phosphorylase	Others	E. coli
	Purine nucleoside phosphorylase Protein, Thermus thermophilus (His) is the recombinant Purine nucleoside phosphorylase protein, expressed by E. coli, with N-6*His labeled tag.

HY-P705722

	PYGL Protein, Human (GST) Glycogen Phosphorylase; Glycogen Phosphorylase L; Glycogen Phosphorylase liver; Glycogen Phosphorylase liver form; GSD6; Hers disease; glycogen storage disease type VI; liver form; OTTHUMP00000233649; OTTHUMP00000233651; Phosphorylase glycogen liver; Pygl; PYGL_HUMAN	Human	E. coli

HY-P71416

	UPP1 Protein, Human (His) 1 Publications Verification UPP1 Protein; Uridine Phosphorylase 1; UPP1	Human	E. coli
	UPP1 belongs to the family of pentosyltransferases. UPP1 is expressed in the cytosol of most tissues and is important for the homeostatic regulation of intracellular and plasma uridine concentrations. UPP1 elevates its expression levels in many tumors. UPP1 Protein, Human (His) is a recombinant human UPP1 protein expressed by E. coli, with an N-6*His tag, consisting of 173 amino acids (M1-A173).

HY-P702665

	PHKG1 Protein, Human (Active, sf9, GST) PHKG1; Phosphorylase kinase, gamma 1 (muscle); Phosphorylase kinase, gamma 1 (muscle); Phosphorylase b kinase gamma catalytic chain, skeletal muscle isoform; Phosphorylase kinase gamma; Phosphorylase kinase subunit gamma-1; EC 2.7.11.19	Human	Sf9 insect cells
	PHKG1 is the catalytic subunit of phosphorylase b kinase (PHK), which plays a key role in the neural and hormonal regulation of glycogenolysis (glycogen breakdown) by phosphorylating and activating glycogen phosphorylase. PHKG1 Protein, Human (Active, sf9, GST) is the recombinant human-derived PHKG1, expressed by Sf9 insect cells, with GST labeled tag.

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Source
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Cat. No.	Product Name	Chemical Structure

HY-B0016S

Capecitabine-d11
Capecitabine-d₁₁ is the deuterium labeled Capecitabine. Capecitabine is an oral proagent that is converted to its active metabolite, 5-FU, by thymidine phosphorylase .

HY-I0210S

4-Iodoaniline-13C6
4-Iodoaniline- ¹³C₆ is the ¹³C labeled 4-Iodoaniline (HY-I0210). 4-Iodoaniline is a potent methemoglobin former. 4-Iodoaniline is also an intermediate. 4-Iodoaniline can be used to synthesize glycogen phosphorylase inhibitors. 4-Iodoaniline is used in the research of liver cancer and blood diseases .

HY-B0021S

Doxifluridine-d2
Doxifluridine-d₂ is the deuterium labeled Doxifluridine . Doxifluridine is a thymidine phosphorylase activator for PC9-DPE2 cells with IC₅₀ of 0.62 μM.

HY-W771063

8-Aminoguanine-13C2,15N
8-Aminoguanine- ¹³C₂, ¹⁵N is the ¹³C- and ¹⁵N-labeled 8-Aminoguanine (HY-139037). 8-Aminoguanine is a endogenous purine. 8-Aminoguanine inhibits PNPase (purine nucleoside phosphorylase). 8-Aminoguanine induces diuresis/natriuresis/glucosuria .

HY-42680S1

D-Tagatose-13C-1

D-Tagatose- ¹³C-1 is the ¹³C labeled D-Tagatose (HY-42680). D-Tagatose (D-(-)-Tagatose) is a natural low-calorie rare sugar. D-Tagatose inhibits the activities of sucrase, maltase and intestinal disaccharidases, reduces the digestion of sucrose and starch, and blocks the absorption of sucrose, maltose and glucose. D-Tagatose promotes glucokinase activity and inhibits glycogen phosphorylase activity via tagatose-1-phosphate, regulates the synthesis and decomposition of hepatic glycogen, reduces postprandial and fasting blood glucose levels, and improves hyperinsulinemia. D-Tagatose regulates lipid profiles, stimulates GLP-1 secretion, and exhibits prebiotic effects. D-Tagatose is a bulking sweetener. D-Tagatose can be used in research related to diabetes, hyperlipidemia, dental caries, atherosclerosis and type 2 diabetes.

HY-42680S

D-Tagatose-13C

D-Tagatose- ¹³C is the ¹³C labeled D-Tagatose (HY-42680). D-Tagatose (D-(-)-Tagatose) is a natural low-calorie rare sugar. D-Tagatose inhibits the activities of sucrase, maltase and intestinal disaccharidases, reduces the digestion of sucrose and starch, and blocks the absorption of sucrose, maltose and glucose. D-Tagatose promotes glucokinase activity and inhibits glycogen phosphorylase activity via tagatose-1-phosphate, regulates the synthesis and decomposition of hepatic glycogen, reduces postprandial and fasting blood glucose levels, and improves hyperinsulinemia. D-Tagatose regulates lipid profiles, stimulates GLP-1 secretion, and exhibits prebiotic effects. D-Tagatose is a bulking sweetener. D-Tagatose can be used in research related to diabetes, hyperlipidemia, dental caries, atherosclerosis and type 2 diabetes.

HY-W009538S

5'-Deoxy-5-fluorocytidine-d3

5'-Deoxy-5-fluorocytidine-d₃ is deuterated labeled 5'-Deoxy-5-fluorocytidine (HY-W009538). 5'-Deoxy-5-fluorocytidine (5-Fluoro-5'-deoxycytidine) is a cytidine analog and metabolite of Capecitabine (HY-B0016). 5'-Deoxy-5-fluorocytidine is converted from Capecitabine by carboxylesterase in the liver. 5'-Deoxy-5-fluorocytidine is deaminated by cytidine deaminase to generate 5'-deoxy-5-fluorouridine, which is finally converted into 5-fluorouracil (HY-90006) by thymidine phosphorylase in tumor tissues to exert anti-tumor effects. 5'-Deoxy-5-fluorocytidine is used in the researches for solid tumors such as colorectal cancer, non-small cell lung cancer and breast cancer .

HY-W009538S1

5'-Deoxy-5-fluorocytidine-13C5

5'-Deoxy-5-fluorocytidine-13C5 is the ¹³C labeled isotope of 5'-Deoxy-5-fluorocytidine (HY-W009538). 5'-Deoxy-5-fluorocytidine (5-Fluoro-5'-deoxycytidine) is a cytidine analog and metabolite of Capecitabine (HY-B0016). 5'-Deoxy-5-fluorocytidine is converted from Capecitabine by carboxylesterase in the liver. 5'-Deoxy-5-fluorocytidine is deaminated by cytidine deaminase to generate 5'-deoxy-5-fluorouridine, which is finally converted into 5-fluorouracil (HY-90006) by thymidine phosphorylase in tumor tissues to exert anti-tumor effects. 5'-Deoxy-5-fluorocytidine is used in the researches for solid tumors such as colorectal cancer, non-small cell lung cancer and breast cancer .

Host:	Mouse (5) Rabbit (2)
Reactivity:	Human (7) Rat (6) Mouse (6)
Application:	IHC-P (6) ICC/IF (1) WB (5) FC (1)
Isotype:	IgG (2) IgG1 (4) IgG2a (1)
Conjugation:	Non-conjugated (7)
Clonality:	Monoclonal (3) Recombinant (2)
Modification:	Unmodified (3)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P810675

	*Nucleoside Phosphorylase* Antibody** FLJ94043; FLJ97288; FLJ97312; Inosine Phosphorylase; Inosine-guanosine Phosphorylase; MGC117396; MGC125915; MGC125916; NP; Np1	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
	Nucleoside Phosphorylase Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to Nucleoside Phosphorylase.

HY-P87137

	*Uridine Phosphorylase* 1 Antibody (YA6830)** UDRPASE antibody; UP antibody; UPase 1 antibody; UPASE antibody; UPP antibody; Upp1 antibody; UPP1_HUMAN antibody; UrdPase 1 antibody; Uridine Phosphorylase 1 antibody;	WB	Human, Mouse, Rat
	Uridine Phosphorylase 1 Antibody (YA6830) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Uridine Phosphorylase 1.

HY-P88302

	PYGM Antibody (YA7986) glycogen; glycogen Phosphorylase; glycogen storage disease type V; glycogen storage disease type V); McArdle syndrome; muscle; muscle (McArdle syndrome; myoPhosphorylase; Phosphorylase	IHC-P	Human, Rat, Mouse
	PYGM Antibody (YA7986) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to PYGM.

HY-P88302A

	PYGM Antibody (YA7986)(PBS only) glycogen; glycogen Phosphorylase; glycogen storage disease type V; glycogen storage disease type V); McArdle syndrome; muscle; muscle (McArdle syndrome; myoPhosphorylase; Phosphorylase	IHC-P	Human, Rat, Mouse
	PYGM Antibody (YA7986) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to PYGM.

HY-P810616

	*Thymidine Phosphorylase* Antibody (YA9878)** ECGF 1; ECGF; ECGF1; Endothelial cell growth factor 1; Endothelial cell growth factor 1 platelet derived; Endothelial cell growth factor, platelet-derived; Gliostatin; hPD ECGF; MEDPS1; MNGIE; ECGF 1; ECGF; ECGF1; Endothelial cell growth factor 1; Endothelial cell growth factor 1 platelet derived; Endothelial cell growth factor, platelet-derived; Gliostatin; hPD ECGF; MEDPS1; MNGIE; MTDPS1; PD ECGF; PD-ECGF; PDECGF; PDEGF; Platelet derived endothelial cell growth factor; Platelet derived endothelial growth factor; Platelet-derived endothelial cell growth factor; TdRPase; Thymidine Phosphorylase; TP; Tymp; TYPH_HUMAN	WB, IHC-P	Human
	Thymidine Phosphorylase Antibody (YA9878) is a Mouse-derived and non-conjugated IgG1 Monoclonal antibody, targeting to Thymidine Phosphorylase.

HY-P810617

	*Thymidine Phosphorylase* Antibody (YA9879)** ECGF 1; ECGF; ECGF1; Endothelial cell growth factor 1; Endothelial cell growth factor 1 platelet derived; Endothelial cell growth factor, platelet-derived; Gliostatin; hPD ECGF; MEDPS1; MNGIE; ECGF 1; ECGF; ECGF1; Endothelial cell growth factor 1; Endothelial cell growth factor 1 platelet derived; Endothelial cell growth factor, platelet-derived; Gliostatin; hPD ECGF; MEDPS1; MNGIE; MTDPS1; PD ECGF; PD-ECGF; PDECGF; PDEGF; Platelet derived endothelial cell growth factor; Platelet derived endothelial growth factor; Platelet-derived endothelial cell growth factor; TdRPase; Thymidine Phosphorylase; TP; Tymp; TYPH_HUMAN	WB, IHC-P	Human, Mouse, Rat
	Thymidine Phosphorylase Antibody (YA9879) is a Mouse-derived and non-conjugated IgG2a Monoclonal antibody, targeting to Thymidine Phosphorylase.

HY-P87125

	*Thymidine Phosphorylase* Antibody (YA6818)** ECGF 1 antibody; ECGF antibody; ECGF1 antibody; Endothelial cell growth factor 1 antibody; Endothelial cell growth factor 1 platelet derived antibody; Endothelial cell growth factor, platelet-derived antibody; Gliostatin antibody; hPD ECGF antibody; MEDPS1 antibody; MNGIE antibody; ECGF 1 antibody; ECGF antibody; ECGF1 antibody; Endothelial cell growth factor 1 antibody; Endothelial cell growth factor 1 platelet derived antibody; Endothelial cell growth factor, platelet-derived antibody; Gliostatin antibody; hPD ECGF antibody; MEDPS1 antibody; MNGIE antibody; MTDPS1 antibody; PD ECGF antibody; PD-ECGF antibody; PDECGF antibody; PDEGF antibody; Platelet derived endothelial cell growth factor antibody; Platelet derived endothelial growth factor antibody; Platelet-derived endothelial cell growth factor antibody; TdRPase antibody; Thymidine Phosphorylase antibody; TP antibody; Tymp antibody; TYPH_HUMAN antibody;	WB, IHC-P	Human, Mouse, Rat
	Thymidine Phosphorylase Antibody (YA6818) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Thymidine Phosphorylase.

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Cat. No.	Product Name		Classification

HY-D0995

7-Methyl-6-thioguanosine 2 Publications Verification MESG		Nucleoside Analogs Guanosine
7-Methyl-6-thioguanosine (MESG) is a chromogenic substrate that can be converted to 7-methyl-6-thioguanine in the presence of purine nucleoside phosphorylase and inorganic phosphate. 7-Methyl-6-thioguanosine can be used to quantify inorganic phosphate. 7-Methyl-6-thioguanosine can also be used to determine the activities of purine nucleoside phosphorylase and protein phosphatases .

HY-W039442

2′-Deoxy-2′-fluoroadenosine 1 Publications Verification		Nucleoside Analogs Adenosine
2′-Deoxy-2′-fluoroadenosine is a fluorinated deoxyadenosine with antitumor and antiviral activity, able to interfere with viral or cancer cell replication by being incorporated into DNA. 2′-Deoxy-2′-fluoroadenosine can be used for the synthesis of 2′-Deoxy-2′-fluoro-modified oligonucleotides hybridized with RNA. 2′-Deoxy-2′-fluoroadenosine can be cleaved efficiently by E. coli purine nucleoside phosphorylase (PNP) to the toxic agent 2-fluoroadenine (FAde). 2′-Deoxy-2′-fluoroadenosine shows excellent in vivo activity against tumors expressing E. coli PNP .

HY-136648A

2'-Deoxyadenosine-5'-triphosphate trisodium dATP trisodium		Nucleotide Analogs
2'-Deoxyadenosine-5'-triphosphate (dATP) trisodium is a nucleotide used in cells for DNA synthesis (or replication), as a substrate of DNA polymerase. 2'-Deoxyadenosine-5'-triphosphate is promising for research of genetic immunodeficiency diseases adenosine deaminase deficiency and purine nucleotide phosphorylase deficiency .

HY-W009538

5'-Deoxy-5-fluorocytidine 5-Fluoro-5'-deoxycytidine		Nucleoside Analogs Cytidine
5'-Deoxy-5-fluorocytidine (5-Fluoro-5'-deoxycytidine) is a cytidine analog and metabolite of Capecitabine (HY-B0016). 5'-Deoxy-5-fluorocytidine is converted from Capecitabine by carboxylesterase in the liver. 5'-Deoxy-5-fluorocytidine is deaminated by cytidine deaminase to generate 5'-deoxy-5-fluorouridine, which is finally converted into 5-fluorouracil (HY-90006) by thymidine phosphorylase in tumor tissues to exert anti-tumor effects. 5'-Deoxy-5-fluorocytidine is used in the researches for solid tumors such as colorectal cancer, non-small cell lung cancer and breast cancer .

HY-W008638

2'-Deoxyinosine 2 Publications Verification		Nucleoside Analogs Inosine
2'-Deoxyinosine is the major product of 2'-deoxyadenosine in the absence of deoxycoformycin. 2'-Deoxyinosine is found to be associated with purine nucleoside phosphorylase (PNP) deficiency .

HY-W013330

3′-Deoxyguanosine Guanosine, 3'-deoxy-		Nucleoside Analogs Guanosine
3′-Deoxyguanosine (Guanosine, 3'-deoxy-) is a derivative of Guanosine (HY-N0097). 3′-Deoxyguanosine interacts with human purine nucleoside phosphorylase via hydrogen bonding with residues such as Glu201 and Asn243. 3′-Deoxyguanosine exhibits moderate displacement activity for [ ³H]-guanosine in rat meninges. 3′-Deoxyguanosine is useful for studying the mechanism of guanosine receptors and purine metabolism .

HY-W010854

*2'-Deoxyadenosine 5'-di-phos-phate disodium* dADP disodium		Nucleotide Analogs Adenine Nucleotide
2'-Deoxyadenosine 5'-di-phos-phate disodium (dADP disodium) is an inhibitor of bacterial poly(A) polymerase. It can be used to synthesize deoxyadenosine oligonucleotides with Escherichia coli polynucleotide phosphorylase and other enzymes .

HY-111627

5-Aza-7-deazaguanine 1 Publications Verification		Nucleoside Analogs Guanosine
5-Aza-7-deazaguanine is a substrate for wild-type (WT) E. coli purine nucleoside phosphorylase and its Ser90Ala mutant in the synthesis of base-modified nucleosides .

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