Search Result

Results for "

Plasminogen Activator

" in MedChemExpress (MCE) Product Catalog:

By Targets:	PAI-1 (44) Plasminogen/Plasmin (2) Akt (1) Amino Acid Derivatives (1) AMPK (3) Amyloid-β (1) Androgen Receptor (1) Annexin A (2) Antibiotic (1) Apoptosis (17) Autophagy (1) Bacterial (1) Biochemical Assay Reagents (6) COX (1) Drug Intermediate (1) Drug Isomer (1) Endogenous Metabolite (1) ERK (3) Factor Xa (2) Fluorescent Dye (1) HSP (1) IGF-1R (3) Integrin (1) Interleukin Related (1) Isotope-Labeled Compounds (4) JNK (3) Mitophagy (3) MMP (8) Potassium Channel (2) Progesterone Receptor (1) PROTAC Linkers (1) Proteasome (1) Radionuclide-Drug Conjugates (RDCs) (1) Reactive Oxygen Species (ROS) (1) Reference Standards (8) Ser/Thr Protease (24) Sodium Channel (9) TGF-beta/Smad (1) Thrombin (4) Transmembrane Glycoprotein (3) TRP Channel (8)
By Research Areas:	Cancer (34) Cardiovascular Disease (40) Endocrinology (1) Infection (3) Inflammation/Immunology (16) Metabolic Disease (13) Neurological Disease (11)

By Targets:

PAI-1 (44)

Plasminogen/Plasmin (2)

Akt (1)

Amino Acid Derivatives (1)

AMPK (3)

Amyloid-β (1)

Androgen Receptor (1)

Annexin A (2)

Antibiotic (1)

Apoptosis (17)

Autophagy (1)

Bacterial (1)

Biochemical Assay Reagents (6)

COX (1)

Drug Intermediate (1)

Drug Isomer (1)

Endogenous Metabolite (1)

ERK (3)

Factor Xa (2)

Fluorescent Dye (1)

HSP (1)

IGF-1R (3)

Integrin (1)

Interleukin Related (1)

Isotope-Labeled Compounds (4)

JNK (3)

Mitophagy (3)

MMP (8)

Potassium Channel (2)

Progesterone Receptor (1)

PROTAC Linkers (1)

Proteasome (1)

Radionuclide-Drug Conjugates (RDCs) (1)

Reactive Oxygen Species (ROS) (1)

Reference Standards (8)

Ser/Thr Protease (24)

Sodium Channel (9)

TGF-beta/Smad (1)

Thrombin (4)

Transmembrane Glycoprotein (3)

TRP Channel (8)

By Research Areas:

Cancer (34)

Cardiovascular Disease (40)

Endocrinology (1)

Infection (3)

Inflammation/Immunology (16)

Metabolic Disease (13)

Neurological Disease (11)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Targets Recommended: Plasminogen/Plasmin PAI-1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0099

Edaravone 40+ Cited Publications MCI-186	MMP Apoptosis	Neurological Disease
Edaravone is a strong novel free radical scavenger, and inhibits MMP-9-related brain hemorrhage in rats treated with tissue plasminogen activator.

HY-B0285

Amiloride Maximum Cited Publications 62 Publications Verification MK-870	Sodium Channel TRP Channel Apoptosis	Cardiovascular Disease Metabolic Disease
Amiloride (MK-870) is an inhibitor of both epithelial sodium channel (ENaC ) and urokinase-type plasminogen activator receptor (uTPA ). Amiloride is a blocker of polycystin-2 (PC2; TRPP2 ) channel.

HY-15253

Tiplaxtinin 10+ Cited Publications PAI-039; Tiplasinin	PAI-1 Apoptosis	Metabolic Disease Cancer
Tiplaxtinin is a selective and orally efficacious inhibitor of plasminogen activator inhibitor-1 (PAI-1) with IC₅₀ of 2.7 μM .

HY-B0285A

Amiloride hydrochloride Maximum Cited Publications 62 Publications Verification MK-870 hydrochloride	Sodium Channel TRP Channel Apoptosis	Cardiovascular Disease Metabolic Disease
Amiloride hydrochloride (MK-870 hydrochloride) is an inhibitor of both epithelial sodium channel (ENaC ) and urokinase-type plasminogen activator receptor (uTPA ). Amiloride hydrochloride is a blocker of polycystin-2 (PC2; TRPP2 ) channel.

HY-B0149

Tranexamic acid 1 Publications Verification cyclocapron	IGF-1R AMPK MMP Mitophagy PROTAC Linkers	Cardiovascular Disease Neurological Disease Cancer
Tranexamic acid (cyclocapron), a cyclic analog of lysine, is an orally active antifibrinolytic agent. Tranexamic acid attenuates the effects of severe trauma, inhibits urokinase plasminogen activator and ameliorates dry wrinkles. Tranexamic acid can used for the research of hemostasis. Tranexamic acid is a PROTAC linker. Tranexamic acid is used to synthesize PROTACs (e.g. LZ-07 (HY-172590)) .

HY-108865

Alteplase Actilyse; Activase	Ser/Thr Protease	Cardiovascular Disease Cancer
Alteplase (Actilyse; Activase), a tissue plasminogen activator prepared by recombination, is a thrombolytic agent that play important roles in acute ischemic stroke, pulmonary embolism, acute myocardial infarction, and occluded catheters . The product size below only indicate the effective content of Alteplase. The ratio of Alteplase effective content : total content = 1:46-1:50. The actual ratio depends on the batch.)

HY-101761

TM5441 5+ Cited Publications	PAI-1 Apoptosis	Cardiovascular Disease Cancer
TM5441 is an orally bioavailable inhibitor of plasminogen activator inhibitor-1 (PAI-1), has IC₅₀ values between 13.9 and 51.1 μM and induces intrinsic apoptosis in several human cancer cell lines. TM5441 attenuates Nω-nitro-l-arginine methyl ester-induced cardiac hypertension and vascular senescence .

HY-P2824

Streptokinase, β-hemolytic streptococcus (Lancefield Group C) 1 Publications Verification	Bacterial	Cardiovascular Disease
Streptokinase, β-hemolytic streptococcus (Lancefield Group C) is a bacteria-derived protein and a plasminogen activator. Streptokinase is widely used for the research of the blood-clotting disorders. Streptokinase improves reperfusion blood flow after coronary artery occlusion .

HY-B0111

Drospirenone 1 Publications Verification Dihydrospirorenone	Progesterone Receptor Androgen Receptor	Endocrinology Cancer
Drospirenone (Dihydrospirorenone) is an orally active fourth-generation progestin that interacts with the progesterone receptor (PR) and androgen receptor (AR). Drospirenone significantly decreases both plasminogen activator inhibitor-1 (PAI-1) and tissue plasminogen activator (tPA) via the AR. Drospirenone can produce DNA damage in bone marrow cells of female mice. .

HY-P2333

LCKLSL Maximum Cited Publications 8 Publications Verification	Annexin A	Cardiovascular Disease
LCKLSL is a N-terminal hexapeptide and a competitive annexin A2 (AnxA2) inhibitor. LCKLSL potently inhibits the *binding of tissue plasminogen* activator (tPA) to AnxA2**. LCKLSL also inhibits the generation of plasmin and has anti-angiogenic roles .

HY-111056

UK122 TFA 1 Publications Verification	Ser/Thr Protease	Cancer
UK122 is a potent and selective *urokinase-type plasminogen* activator (uPA) inhibitor with an IC₅₀** of 0.2 μM. UK122 shows no or little inhibition of tissue-type PA (tPA), plasmin, thrombin, and trypsin (all IC₅₀>100 μM). UK122, 4-oxazolidinone analogue, is an anticancer agent and inhibits cancer cell migration and invasion .

HY-100897

Sulodexide	Thrombin	Cardiovascular Disease
Sulodexide is a mixture of glycosaminoglycans available in soft capsule form for oral administration. It is composed of low molecular weight heparin (80%) and dermatan sulfate (20%). Sulodexide exhibits antithrombotic activity through interaction with antithrombin III (AT III) and heparin cofactor II (HC II), and inhibition of thrombin formation. Sulodexide exhibits profibrinolytic activity through release of tissue plasminogen activator (tPA). Sulodexide exhibits endothelial protective and anti-inflammatory effect, ameliorates chronic venous disease . Sulodexide is a glycosaminoglycan mixture available in soft gelatin capsule form for oral administration.

HY-P2230

Angstrom6 1 Publications Verification A6 Peptide	PAI-1	Cancer
Angstrom6 (A6 Peptide) is an 8 amino-acid peptide derived from single-chain urokinase plasminogen activator (scuPA) and interferes with the uPA/uPAR cascade and abrogates downstream effects. Angstrom6 binds to CD44 resulting in the inhibition of migration, invasion, and metastasis of tumor cells, and the modulation of CD44-mediated cell signaling .

HY-16511

Upamostat 1 Publications Verification WX-671	PAI-1 Ser/Thr Protease	Infection Cancer
Upamostat (WX-671), a prodrug of WX-UK1, is an orally active serine protease inhibitor. Upamostat inhibits the urokinase-type plasminogen activator (uPA) system, blocking the plasminogen activation process mediated by it, thereby suppressing the invasion, migration and metastasis of tumor cells. Upamostat can be used in the research of metastatic breast cancer and locally advanced pancreatic cancer .

HY-B0285B

Amiloride hydrochloride dihydrate Maximum Cited Publications 62 Publications Verification MK-870 hydrochloride dihydrate	Sodium Channel Apoptosis TRP Channel	Cardiovascular Disease Metabolic Disease
Amiloride hydrochloride dihydrate (MK-870 hydrochloride dihydrate) is an inhibitor of both epithelial sodium channel (ENaC ) and urokinase-type plasminogen activator receptor (uTPA ). Amiloride hydrochloride dihydrate is a blocker of polycystin-2 (PC2; TRPP2 ) channel.

HY-B0099R

Edaravone (Standard) MCI-186 (Standard)	Reference Standards MMP Apoptosis	Neurological Disease
Edaravone (Standard) is the analytical standard of Edaravone. This product is intended for research and analytical applications. Edaravone is a strong novel free radical scavenger, and inhibits MMP-9-related brain hemorrhage in rats treated with tissue plasminogen activator.

HY-P2333A

LCKLSL hydrochloride Maximum Cited Publications 8 Publications Verification	Annexin A	Cardiovascular Disease
LCKLSL hydrochloride is a N-terminal hexapeptide and a competitive annexin A2 (AnxA2) inhibitor. LCKLSL hydrochloride potently inhibits the *binding of tissue plasminogen* activator (tPA) to AnxA2**. LCKLSL hydrochloride also inhibits the generation of plasmin and has anti-angiogenic roles .

HY-N1504

Loureirin B 4 Publications Verification	PAI-1 Potassium Channel ERK JNK	Metabolic Disease
Loureirin B, a flavonoid extracted from Dracaena cochinchinensis, is an inhibitor of plasminogen activator inhibitor-1 (PAI-1), with an IC₅₀ of 26.10 μM; Loureirin B also inhibits K_ATP, the phosphorylation of ERK and JNK, and has anti-diabetic activity.

HY-W018723

4-Aminobenzamidine dihydrochloride 1 Publications Verification p-Aminobenzamidine dihydrochloride	Ser/Thr Protease PAI-1	Cardiovascular Disease Cancer
4-Aminobenzamidine (p-Aminobenzamidine) dihydrochloride is a strong trypsin inhibitor. 4-Aminobenzamidine dihydrochloride acts as an orally active *urokinase type plasminogen* activator (uPA) inhibitor (K_i**=82 μM). 4-Aminobenzamidine dihydrochloride can be used for cardiovascular diseases and anti-tumor study .

HY-108845

Tenecteplase TNK-tPA	Ser/Thr Protease	Cardiovascular Disease
Tenecteplase (TNK-tPA) is a modified tissue plasminogen activator. Tenecteplase is a recombinant human tissue plasminogen activator (rt-PA) that has been bioengineered to produce mutations in three gene loci. Tenecteplase (TNK-tPA) can be used in the study of acute ischemic stroke .

HY-101214

UK-371804	PAI-1	Inflammation/Immunology
UK-371804 is a urokinase-type plasminogen activator (uPA) inhibitor with a K_i of 10 nM.

HY-P990552A

huATN-658	PAI-1 Integrin	Cancer
huATN-658 is an inhibitor that specifically targets the DIII domain of human urokinase plasminogen activator receptor (uPAR). huATN-658 neutralizes uPAR function by blocking the interaction between uPAR and integrins, without interfering with the binding of uPA or vitronectin to uPAR. huATN-658 inhibits the proliferation and invasion of breast cancer cells, slows the growth of primary breast tumors, reduces breast cancer-induced bone lesions and decreases osteoclast activity. huATN-658 also alters the gene expression of the TGF-β receptor complex signaling pathway. huATN-658 exerts synergistic anticancer effects when combined with Zoledronic Acid (HY-13777), and does not cause physiological or behavioral abnormalities in immunodeficient mice. huATN-658 can be used in research related to breast cancer, metastatic breast cancer and breast cancer-induced bone disease .

HY-P11446

AE105	Transmembrane Glycoprotein	Cancer
AE105 is a 9-mer peptide probe targeting the urokinase-type plasminogen activator receptor (uPAR). AE105 binds tightly to the uPA-binding cavity of uPAR. AE105 can be used for the study of cancer .

HY-100415

UKI-1 WX-UK1; UKI-1C	PAI-1 Ser/Thr Protease	Cancer
UKI-1 (WX-UK1) is a potent *urokinase-type plasminogen* activator (uPA) inhibitor with a K_i of 0.41 μM. UKI-1 is also a low molecular weight serine protease** inhibitor. UKI-1 is a potent antimetastatic agent and inhibits the invasive capacity of carcinoma cells .

HY-14759

Aleplasinin PAZ-417	PAI-1 Amyloid-β	Neurological Disease
Aleplastinin (PAZ-417) is an orally active, blood-brain barrier permeable, selective SERPINE1 (PAI-1) inhibitor (IC₅₀=655 nM). Aleplastinin activates the *tissue type plasminogen* activator (tPA)/fibrinolysis cascade by inhibiting PAI-1, thereby promoting the degradation of amyloid-β** (Aβ) oligomers and monomers. Aleplastinin can significantly reduce plasma and brain Aβ levels, improve memory impairment, and reverse cognitive impairment. Aleplastinin can be used for research on Alzheimer's disease .

HY-100897A

Sulodexide solution	Thrombin	Cardiovascular Disease
Sulodexide solution is a mixture of glycosaminoglycans that can be administered by injection. It is composed of low molecular weight heparin (80%) and dermatan sulfate (20%). Sulodexide exhibits antithrombotic activity through interaction with antithrombin III (AT III) and heparin cofactor II (HC II), and inhibition of thrombin formation. Sulodexide exhibits profibrinolytic activity through release of tissue plasminogen activator (tPA). Sulodexide exhibits endothelial protective and anti-inflammatory effect, ameliorates chronic venous disease.

HY-P5018

NOTA-AE105	Radionuclide-Drug Conjugates (RDCs) Ser/Thr Protease	Cancer
NOTA-AE105 is a PET ligand for the urokinase-type plasminogen activator receptor (uPAR). NOTA-AE105 can be radiolabeled with ⁶⁴Cu and ⁶⁸Ga. Images of 68Ga-NOTA-AE105 and 64Cu-NOTA-AE105 demonstrate high contrast and clear tumor delineation. NOTA-AE105 can be used in the synthesis of radionuclide-conjugated compounds (RDCs) .

HY-122098

Diaplasinin PAI-749	PAI-1	Cardiovascular Disease
Diaplasinin (PAI-749) is a plasminogen activator inhibitor-1 (PAI-1) inhibitor with IC₅₀ of 295 nM. Diaplasinin has antithrombotic efficacy .

HY-122311

Orniplabin SMTP-7	Reactive Oxygen Species (ROS)	Neurological Disease Inflammation/Immunology
Orniplabin (SMTP-7) is a low-molecular-weight compound that enhances plasminogen–fibrin binding, urokinase-catalyzed activation of plasminogen, and urokinase and plasminogen-mediated fibrin degradation. Orniplabin shows potential thrombolytic and anti-inflammatory effects. Orniplabin inhibits ROS .

HY-P4338

Glutaryl-Gly-Arg-AMC	PAI-1	Others
Glutaryl-Gly-Arg-AMC is a peptide substrate of urokinase plasminogen activator (uPA) .

HY-P1615

Cenupatide	Transmembrane Glycoprotein	Cancer
Cenupatide (UPARANT) is a *Urokinase-type plasminogen* activator receptor (uPAR) inhibitor. Cenupatide has anti-angiogenic and anti-inflammatory** efficacy .

HY-N0518

Toddalolactone 1 Publications Verification	PAI-1	Cardiovascular Disease
Toddalolactone, a main component of Toddalia asiatica, inhibits the activity of recombinant *human plasminogen* activator inhibitor-1 (PAI-1)**, with an IC₅₀ value of 37.31 μM .

HY-122714

SK-216	PAI-1	Cancer
SK-216 is a plasminogen activator inhibitor-1 (PAI-1) inhibitor that acts as an anti-metastatic agent for human osteosarcoma and inhibits lung metastasis of human osteosarcoma .

HY-N2082

Isorhamnetin 3-O-galactoside 1 Publications Verification Cacticin	Thrombin COX ERK JNK Factor Xa	Cardiovascular Disease Inflammation/Immunology
Isorhamnetin 3-O-galactoside (Cacticin) is a flavonoid glycoside that can be isolated from Oenanthe javanica, with antithrombotic and profibrinolytic activities. Isorhamnetin 3-O-galactoside inhibits the activities of thrombin and factor Xa (FXa) and reduces thrombin-catalyzed fibrin polymerization maximum rate. Isorhamnetin 3-O-galactoside suppresses TNF-α-induced PAI-1 secretion, decreases the PAI-1/tissue-type plasminogen activator (t-PA) ratio, and inhibits FXa production and FVa/FXa-mediated thrombin generation. Isorhamnetin 3-O-galactoside exerts protective effects against Carbon tetrachloride (CCl4) (HY-Y0298)-induced hepatic injury in mice. Isorhamnetin 3-O-galactoside can be used for the study of liver injury-related diseases and thrombotic vascular diseases .

HY-114330A

ZK824859 hydrochloride	PAI-1 Ser/Thr Protease	Inflammation/Immunology
ZK824859 hydrochloride is an oral available and selective urokinase plasminogen activator (uPA) inhibitor with IC₅₀s of 79 nM, 1580 nM and 1330 nM for human uPA, tPA, and plasmin, respectively .

HY-W008753

Z-L-Val-OH N-Cbz-L-valine	Biochemical Assay Reagents Drug Intermediate Amino Acid Derivatives	Infection
Z-L-Val-OH (N-Cbz-L-valine) is an amino acid derivative and key intermediate in organic synthesis. Z-L-Val-OH can be used in the synthesis of anti-cytomegalovirus compounds and peptide inhibitors of human spleen plasminogen activator (SFP) and human leukocyte elastase-like protease (ELP) .

HY-B0285AR

Amiloride hydrochloride (Standard) 15+ Cited Publications MK-870 hydrochloride (Standard)	Reference Standards Sodium Channel TRP Channel Apoptosis	Cardiovascular Disease Metabolic Disease
Amiloride (hydrochloride) (Standard) is the analytical standard of Amiloride (hydrochloride). This product is intended for research and analytical applications. Amiloride hydrochloride (MK-870 hydrochloride) is an inhibitor of both epithelial sodium channel (ENaC ) and urokinase-type plasminogen activator receptor (uTPA ). Amiloride hydrochloride is a blocker of polycystin-2 (PC2; TRPP2 ) channel.

HY-P4254

H-Gly-Glu-pNA	PAI-1 Ser/Thr Protease	Others
H-Gly-Glu-pNA is a chromogenic peptide substrate that can be widely used in enzymatic analysis, including trypsin and urokinase-type plasminogen activator (uPA) .

HY-117724

AZ3976	PAI-1	Cardiovascular Disease
AZ3976 is a potent plasminogen activator inhibitor type 1 (PAI-1) inhibitor with an IC₅₀ value of 26 μM in an enzymatic chromogenic assay. AZ3976 is active with an IC₅₀ of 16 μM in a plasma clot lysis assay. AZ3976 does not bind to active PAI-1 but bound reversibly to latent PAI-1. AZ3976 inhibits PAI-1 by enhancing the latency transition of active PAI-1. AZ3976 displays profibrinolytic activities in a human plasma clot lysis assay .

HY-137837

D-Ile-Pro-Arg p-nitroanilide dihydrochloride 1 Publications Verification	Biochemical Assay Reagents	Others
D-Ile-Pro-Arg p-nitroanilide dihydrochloride is a chromogenic peptide substrate of tissue plasminogen activator (tPA) .

HY-126361A

ZK824190 hydrochloride 1 Publications Verification	Ser/Thr Protease PAI-1	Inflammation/Immunology
ZK824190 hydrochloride is an orally available and selective urokinase plasminogen activator (uPA) inhibitor as a potential treatment for multiple sclerosis. IC₅₀s of 237, 1600 and 1850 nM for uPA, tPA, and Plasmin, respectively .

HY-126361

ZK824190	Ser/Thr Protease PAI-1	Inflammation/Immunology
ZK824190 is an orally available and selective urokinase plasminogen activator (uPA) inhibitor as a potential treatment for multiple sclerosis. IC₅₀s of 237, 1600 and 1850 nM for uPA, tPA, and Plasmin, respectively .

HY-173272

BT-114143	PAI-1	Cardiovascular Disease
BT-114143 is a *plasminogen* activation inhibitor, with an IC₅₀ of 8.42 μM. BT-114143 can be used in the research of hemorrhagic diseases caused by hyperfibrinolysis, such as traumatic bleeding, severe menstrual bleeding, postpartum hemorrhage, and complications of hemophilia .

HY-116868

Anecortave acetate Anecortave	PAI-1	Cardiovascular Disease
Anecortave acetate is a potent ocular angiostatic agent. Anecortave acetate inhibits neovascularization which is induced by many different angiogenic factors, and increases plasminogen activator inhibitor-1 (PAI-1) mRNA expression. Anecortave acetate can be used to research ocular neovascular diseases .

HY-100939

4-Chlorophenylguanidine hydrochloride	Sodium Channel	Neurological Disease
4-Chlorophenylguanidine hydrochloride is an urokinase-type plasminogen activator inhibitor. 4-Chlorophenylguanidine hydrochloride is a potent ASIC3 positive allosteric modulator and reverses the effects of ASIC3 desensitization. 4-Chlorophenylguanidine hydrochloride influences ASIC3 activity through directly activating the channel and increasing proton sensitivity. 4-Chlorophenylguanidine hydrochloride offers a chemical backbone for the design of new ASIC3 ligands to study ASIC3 in vivo .

HY-B0149R

Tranexamic acid (Standard) cyclocapron (Standard)	Reference Standards IGF-1R AMPK MMP Mitophagy	Cardiovascular Disease Neurological Disease Cancer
Tranexamic acid (Standard) is the analytical standard of Tranexamic acid. This product is intended for research and analytical applications. Tranexamic acid (cyclocapron), a cyclic analog of lysine, is an orally active antifibrinolytic agent. Tranexamic acid attenuates the effects of severe trauma, inhibits urokinase plasminogen activator and ameliorates dry wrinkles. Tranexamic acid can used for the research of hemostasis .

HY-N10227

Geodin	PAI-1 Antibiotic	Infection Inflammation/Immunology
Geodin, a fungal metabolite, shows antibacterial activity. Geodin also is an inhibitor of plasminogen activator inhibitor- 1 (PAI-1) .

HY-114150

D-Val-Leu-Arg-pNA	PAI-1	Others
D-Val-Leu-Arg-pNA is a glandular kininoreleasing enzyme substrate that also acts as a substrate for tissue-type plasminogen activator (t-PA) with no apparent affinity for fibrin .

HY-P10877

Bicyclic UK18	PAI-1	Cancer
Bicyclic UK18 is a competitive inhibitor for human urokinase-type plasminogen activator (uPA) with a K_i of 53 nM .

HY-P5355

Z-Gly-Gly-Arg-AFC	Fluorescent Dye	Others
Z-Gly-Gly-Arg-AFC is a biological active peptide. (Plasminogen Activator Acrosine Substrate, fluorescent Z-Gly-Gly-Arg-AFC)

Cat. No.	Product Name	Target	Research Area

HY-P2333

LCKLSL Maximum Cited Publications 8 Publications Verification	Annexin A	Cardiovascular Disease
LCKLSL is a N-terminal hexapeptide and a competitive annexin A2 (AnxA2) inhibitor. LCKLSL potently inhibits the *binding of tissue plasminogen* activator (tPA) to AnxA2**. LCKLSL also inhibits the generation of plasmin and has anti-angiogenic roles .

HY-P2230

Angstrom6 1 Publications Verification A6 Peptide	PAI-1	Cancer
Angstrom6 (A6 Peptide) is an 8 amino-acid peptide derived from single-chain urokinase plasminogen activator (scuPA) and interferes with the uPA/uPAR cascade and abrogates downstream effects. Angstrom6 binds to CD44 resulting in the inhibition of migration, invasion, and metastasis of tumor cells, and the modulation of CD44-mediated cell signaling .

HY-P2333A

LCKLSL hydrochloride Maximum Cited Publications 8 Publications Verification	Annexin A	Cardiovascular Disease
LCKLSL hydrochloride is a N-terminal hexapeptide and a competitive annexin A2 (AnxA2) inhibitor. LCKLSL hydrochloride potently inhibits the *binding of tissue plasminogen* activator (tPA) to AnxA2**. LCKLSL hydrochloride also inhibits the generation of plasmin and has anti-angiogenic roles .

HY-P11446

AE105	Transmembrane Glycoprotein	Cancer
AE105 is a 9-mer peptide probe targeting the urokinase-type plasminogen activator receptor (uPAR). AE105 binds tightly to the uPA-binding cavity of uPAR. AE105 can be used for the study of cancer .

HY-P5018

NOTA-AE105	Radionuclide-Drug Conjugates (RDCs) Ser/Thr Protease	Cancer
NOTA-AE105 is a PET ligand for the urokinase-type plasminogen activator receptor (uPAR). NOTA-AE105 can be radiolabeled with ⁶⁴Cu and ⁶⁸Ga. Images of 68Ga-NOTA-AE105 and 64Cu-NOTA-AE105 demonstrate high contrast and clear tumor delineation. NOTA-AE105 can be used in the synthesis of radionuclide-conjugated compounds (RDCs) .

HY-P4338

Glutaryl-Gly-Arg-AMC	PAI-1	Others
Glutaryl-Gly-Arg-AMC is a peptide substrate of urokinase plasminogen activator (uPA) .

HY-P1615

Cenupatide	Transmembrane Glycoprotein	Cancer
Cenupatide (UPARANT) is a *Urokinase-type plasminogen* activator receptor (uPAR) inhibitor. Cenupatide has anti-angiogenic and anti-inflammatory** efficacy .

HY-P4254

H-Gly-Glu-pNA	PAI-1 Ser/Thr Protease	Others
H-Gly-Glu-pNA is a chromogenic peptide substrate that can be widely used in enzymatic analysis, including trypsin and urokinase-type plasminogen activator (uPA) .

HY-P11009

SA-21	Peptides	Others
SA-21 is a 21-amino acid polymer peptide (Ac-RLIEDICLPRWGCLWEDD-NH2) that binds to ligands of urokinase-type plasminogen activator, Fab antibody fragments, and small proteins. SA-21 can be used to purify albumin (K_i=1.9 μM) .

HY-114150

D-Val-Leu-Arg-pNA	PAI-1	Others
D-Val-Leu-Arg-pNA is a glandular kininoreleasing enzyme substrate that also acts as a substrate for tissue-type plasminogen activator (t-PA) with no apparent affinity for fibrin .

HY-P11023

E16-uPA24	Peptides	Metabolic Disease Inflammation/Immunology Cancer
E16-uPA24 is a chimeric peptide targeting *urokinase-type plasminogen* activator receptor (uPAR)**. E16-uPA24 modifies senescent cells surface with polyglutamic acid, promoting immune cell-mediated responses through glutamate recognition. E16-uPA24 induces immune clearance of senescent cells and restores tissue homeostasis by enhancing immune cells recruitment and directly coupling senescent cells and immune cells. E16-uPA24 can be used for tissue degeneration, chronic inflammatory disease and age-related tumorigenesis research .

HY-P10877

Bicyclic UK18	PAI-1	Cancer
Bicyclic UK18 is a competitive inhibitor for human urokinase-type plasminogen activator (uPA) with a K_i of 53 nM .

HY-P5355

Z-Gly-Gly-Arg-AFC	Fluorescent Dye	Others
Z-Gly-Gly-Arg-AFC is a biological active peptide. (Plasminogen Activator Acrosine Substrate, fluorescent Z-Gly-Gly-Arg-AFC)

HY-P11413

PAI-1	Ser/Thr Protease	Cardiovascular Disease
PAI-1 is a plasminogen activator inhibitor. PAI-1 is a member of the Ser Protease inhibitor superfamily with antiprotease activity. PAI-1 is the main physiological inhibitor of tissue-type (tPA) and urokinase-type (uPA) plasminogen activators (PAs) .

HY-P11446A

AE105 TFA	Transmembrane Glycoprotein	Cancer
AE105 TFA is a 9-mer peptide probe targeting the urokinase-type plasminogen activator receptor (uPAR). AE105 TFA binds tightly to the uPA-binding cavity of uPAR. AE105 TFA can be used for the study of cancer .

HY-P5981

Chromozym t-PA	Biochemical Assay Reagents	Others
Chromozym t-PA can be used for determination of t-PA (tissue plasminogen activator) concentration

HY-137495

GGACK	PAI-1 Ser/Thr Protease	Cancer
GGACK (H-Glu-Gly-Arg-CMK) is an irreversible substrate-like *serine protease urokinase-type plasminogen* activator (uPA)** inhibitor .

HY-137495A

GGACK hydrochloride	PAI-1 Ser/Thr Protease	Cancer
GGACK (H-Glu-Gly-Arg-CMK) hydrochloride is an irreversible substrate-like *serine protease urokinase-type plasminogen* activator (uPA)** inhibitor .

HY-P10878

UK140	PAI-1	Cancer
UK140 is the inhibitor for urokinase-type plasminogen activator (uPA) with K_i of 0.20 µM and 2.79 µM for huPA anf muPA. UK140 can be used in metastasis-related research .

HY-P10005

D-Val-Gly-Arg-pNA	Ser/Thr Protease Plasminogen/Plasmin	Cardiovascular Disease
D-Val-Gly-Arg-pNA is a chromogenic substrate of TPA (tissue plasminogen activator). D-Val-Gly-Arg-pNA can be used to detect the amidolytic activity of TPA I and TPA II .

HY-P10059

Boc-Val-Gly-Arg-βNA	Peptides	Others
Boc-Val-Gly-Arg-βNA is a colorimetric substrate for plasminogen activator .

HY-P10005A

D-Val-Gly-Arg-pNA acetate	Ser/Thr Protease Plasminogen/Plasmin	Cardiovascular Disease
D-Val-Gly-Arg-pNA acetate is a chromogenic substrate of TPA (tissue plasminogen activator). D-Val-Gly-Arg-pNA can be used to detect the amidolytic activity of TPA I and TPA II .

Cat. No.	Product Name	Target	Research Area	Image

HY-P990552A

huATN-658	PAI-1 Integrin	Cancer
huATN-658 is an inhibitor that specifically targets the DIII domain of human urokinase plasminogen activator receptor (uPAR). huATN-658 neutralizes uPAR function by blocking the interaction between uPAR and integrins, without interfering with the binding of uPA or vitronectin to uPAR. huATN-658 inhibits the proliferation and invasion of breast cancer cells, slows the growth of primary breast tumors, reduces breast cancer-induced bone lesions and decreases osteoclast activity. huATN-658 also alters the gene expression of the TGF-β receptor complex signaling pathway. huATN-658 exerts synergistic anticancer effects when combined with Zoledronic Acid (HY-13777), and does not cause physiological or behavioral abnormalities in immunodeficient mice. huATN-658 can be used in research related to breast cancer, metastatic breast cancer and breast cancer-induced bone disease .

HY-P990239

Anti-Human/Mouse GRP78 Antibody (N88)	HSP Akt Interleukin Related	Inflammation/Immunology Cancer
Anti-Human/Mouse GRP78 Antibody (N88) is an anti-human/mouse GRP78 IgG1 monoclonal antibody. Anti-Human/Mouse GRP78 Antibody (N88) can activate the Akt signaling pathway. Anti-Human/Mouse GRP78 Antibody (N88) can inhibit the expression of inflammatory factors and plasminogen activator inhibitors induced by TLR agonists. Anti-Human/Mouse GRP78 Antibody (N88) can be used for research on inflammation conditions. Anti-Human/Mouse GRP78 Antibody (N88) can be used for immunoprecipitation .

HY-P992313

AS3288802	PAI-1	Cardiovascular Disease
AS3288802, a highly selective active plasminogen activator inhibitor-1 (PAI-1) antibody, is a PAI-1 inhibitor with a human IC₅₀ and EC₅₀ values of 4.2 ng/mL. AS3288802 can be used for the research of thrombosis and fibrosis-related diseases .

HY-P992410

MEDI-579	PAI-1 TGF-beta/Smad	Inflammation/Immunology
MEDI-579 is a fully human monoclonal antibody against PAI-1, with a K_D value of 6 pM for human PAI-1 and 105 pM for rat PAI-1. MEDI-579 restores renal plasmin activity and inhibits PAI-1-mediated intracellular signal transduction. MEDI-579 reduces albuminuria, glomerulosclerosis severity, TGF-β1 expression level, and phosphorylated Smad2 level induced in diabetic mice. MEDI-579 decreases the levels of active PAI-1 in plasma and kidneys, and increases plasma plasmin level in a mouse model of lupus nephritis. MEDI-579 can be used in research related to diabetic nephropathy and lupus nephritis. The recommended isotype control is human IgG1 kappa (HY-P99001) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N1504

Loureirin B 4 Publications Verification	Dracaena cochinchinensis (Lour.) S. C. Chen Monophenols Flavonoids Classification of Application Fields Phenols Metabolic Disease Agavaceae Plants Dihydrochalcones Disease Research Fields Source Classification	PAI-1 Potassium Channel ERK JNK
Loureirin B, a flavonoid extracted from Dracaena cochinchinensis, is an inhibitor of plasminogen activator inhibitor-1 (PAI-1), with an IC₅₀ of 26.10 μM; Loureirin B also inhibits K_ATP, the phosphorylation of ERK and JNK, and has anti-diabetic activity.

HY-N0518

Toddalolactone 1 Publications Verification	Toddalia asiatica (L.) Lam. Cardiovascular Disease Classification of Application Fields Rutaceae Coumarins Phenylpropanoids Plants Disease Research Fields Source Classification	PAI-1
Toddalolactone, a main component of Toddalia asiatica, inhibits the activity of recombinant *human plasminogen* activator inhibitor-1 (PAI-1)**, with an IC₅₀ value of 37.31 μM .

HY-N2082

Isorhamnetin 3-O-galactoside 1 Publications Verification Cacticin	Cardiovascular Disease Flavonols Flavonoids Typhaceae Classification of Application Fields Typha angustifolia L. Phenols Polyphenols Plants Disease Research Fields Source Classification	Thrombin COX ERK JNK Factor Xa
Isorhamnetin 3-O-galactoside (Cacticin) is a flavonoid glycoside that can be isolated from Oenanthe javanica, with antithrombotic and profibrinolytic activities. Isorhamnetin 3-O-galactoside inhibits the activities of thrombin and factor Xa (FXa) and reduces thrombin-catalyzed fibrin polymerization maximum rate. Isorhamnetin 3-O-galactoside suppresses TNF-α-induced PAI-1 secretion, decreases the PAI-1/tissue-type plasminogen activator (t-PA) ratio, and inhibits FXa production and FVa/FXa-mediated thrombin generation. Isorhamnetin 3-O-galactoside exerts protective effects against Carbon tetrachloride (CCl4) (HY-Y0298)-induced hepatic injury in mice. Isorhamnetin 3-O-galactoside can be used for the study of liver injury-related diseases and thrombotic vascular diseases .

HY-N10227

Geodin	Human Gut Microbiota Metabolites Monophenols Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Phenols Endogenous metabolite Disease Research Fields Inflammation/Immunology Source Classification	PAI-1 Antibiotic
Geodin, a fungal metabolite, shows antibacterial activity. Geodin also is an inhibitor of plasminogen activator inhibitor- 1 (PAI-1) .

HY-N1533

28-O-β-D-Glucopyranosyl pomolic acid	Triterpenes Classification of Application Fields Terpenoids Rosaceae Potentilla anserina Linn. Plants Inflammation/Immunology Disease Research Fields Source Classification	PAI-1
28-O-β-D-Glucopyranosyl pomolic acid is a urokinase plasminogen activator inhibitor with IC₅₀ at 37.82 μM .

HY-N0518R

Toddalolactone (Standard)	Toddalia asiatica (L.) Lam. Structural Classification Rutaceae Coumarins Phenylpropanoids Plants Source Classification	Reference Standards PAI-1
Toddalolactone (Standard) is the analytical standard of Toddalolactone. This product is intended for research and analytical applications. Toddalolactone, a main component of Toddalia asiatica, inhibits the activity of recombinant human plasminogen activator inhibitor-1 (PAI-1), with an IC50 value of 37.31 μM .

HY-N1504R

Loureirin B (Standard)	Dracaena cochinchinensis (Lour.) S. C. Chen Structural Classification Monophenols Flavonoids Phenols Agavaceae Plants Dihydrochalcones Source Classification	Reference Standards PAI-1 Potassium Channel ERK JNK
Loureirin B (Standard) is the analytical standard of Loureirin B. This product is intended for research and analytical applications. Loureirin B, a flavonoid extracted from Dracaena cochinchinensis, is an inhibitor of plasminogen activator inhibitor-1 (PAI-1), with an IC₅₀ of 26.10 μM; Loureirin B also inhibits KATP, the phosphorylation of ERK and JNK, and has anti-diabetic activity.

Species:	Human (13) Rat (4) Mouse (6)
Tag:	His (17) Tag Free (3) Avi (1) GST (1) Fc (3)
Source:	HEK293 (18) Sf9 insect cells (1) E. coli (4)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P73451

	T-PA Protein, Human (HEK293) T-PA; TPA; t-Plasminogen Activator; Tissue Plasminogen Activator	Human	HEK293
	The T-PA protein encoded by this gene is a secreted serine protease that converts plasminogen into plasmin, a key enzyme involved in tissue remodeling and cell migration. The proteolytic process produces heavy and light chains, forming heterodimeric enzymes. T-PA Protein, Human (HEK293) is the recombinant human-derived T-PA protein, expressed by HEK293 , with tag free.

HY-P71051

	T-PA Protein, Human (HEK293, His) 4 Publications Verification T-PA; TPA; t-Plasminogen Activator; Tissue Plasminogen Activator;	Human	HEK293
	T-PA is a key proteolytic enzyme that coordinates the conversion of the abundant but inactive zymogen plasminogen to its active form plasmin via hydrolysis of a single Arg-Val bond. This enzymatic conversion helps regulate plasmin-mediated proteolysis, a key process in tissue remodeling, degradation, and various pathophysiological events. T-PA Protein, Human (HEK293, His) is the recombinant human-derived T-PA protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P71050

	PLAU/uPA Protein, Human (HEK293, His, solution) 1 Publications Verification Urokinase-Type Plasminogen Activator; U-Plasminogen Activator; uPA; PLAU	Human	HEK293
	uPA chain A Protein, a key player in the plasminogen activation system, selectively cleaves plasminogen, initiating fibrinolysis and contributing to tissue remodeling. Its precision underscores its role in regulating proteolytic activity, emphasizing its significance in the cascade of events leading to fibrinolysis and extracellular matrix remodeling in various physiological processes. PLAU/uPA Protein, Human (HEK293, His, solution) is the recombinant human-derived PLAU/uPA protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P71133

	Serpin E1 Protein, Mouse (HEK293, His) 1 Publications Verification Plasminogen Activator inhibitor 1; Endothelial Plasminogen Activator inhibitor; Serpin E1; Mr1; Pai1; Planh1;	Mouse	HEK293
	Serpin E1 protein is a serine protease inhibitor that regulates TMPRSS7 and is a major inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU).It can significantly downregulate fibrinolysis and control thrombus degradation.Serpin E1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Serpin E1 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P71077

	Serpin E1 Protein, Human (HEK293, His) 2 Publications Verification Plasminogen Activator Inhibitor 1; PAI; PAI-1; Endothelial Plasminogen Activator Inhibitor; Serpin E1; SERPINE1; PAI1; PLANH1	Human	HEK293
	Serpin E1 is a serine protease inhibitor that regulates various cellular processes by inhibiting TMPRSS7, tissue-type plasminogen activator (PLAT), and urokinase-type plasminogen activator (PLAU). During fibrinolysis, it downregulates PLAT to control thrombus degradation and acts as a PLAU inhibitor to regulate cell adhesion. Serpin E1 Protein, Human (HEK293, His) is the recombinant human-derived Serpin E1 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P73467

	PLAU/uPA Protein, Human (HEK293, His) Urokinase-type Plasminogen Activator; uPA; PLAU	Human	HEK293
	uPA chain A Protein, a key player in the plasminogen activation system, selectively cleaves plasminogen, initiating fibrinolysis and contributing to tissue remodeling. Its precision underscores its role in regulating proteolytic activity, emphasizing its significance in the cascade of events leading to fibrinolysis and extracellular matrix remodeling in various physiological processes. PLAU/uPA Protein, Human (HEK293, His) is the recombinant human-derived PLAU/uPA protein, expressed by HEK293 , with C-His labeled tag.

HY-P73561

	PLAU/uPA Protein, Rat (HEK293, His) Urokinase-type Plasminogen Activator; uPA; PLAU	Rat	HEK293
	PLAU/uPA proteins lack conserved residues critical for feature annotation propagation, suggesting potential differences in molecular interactions in plasminogen activation and fibrinolysis regulation. PLAU/uPA Protein, Rat (HEK293, His) is the recombinant rat-derived PLAU/uPA protein, expressed by HEK293 , with C-His labeled tag.

HY-P71921

	Serpin B2 Protein, Human HsT1201; Monocyte Arg serpin ; Monocyte Arg-serpin; Monocyte Arginine-serpin; Monocyte-derived Plasminogen Activator inhibitor; PAI; PAI-2; PAI2 ; PAI2_HUMAN; Placental Plasminogen Activator inhibitor; PLANH2 ; Plasminogen Activator inhibitor 2; Plasminogen Activator inhibitor; type 2; Plasminogen Activator inhibitor; type II arginine-serpin; ; serine or cysteine; proteinase inhibitor; clade B ovalbumin; ; member 2; Serpin B2; serpin peptidase inhibitor; clade B ovalbumin; ; member 2; Serpinb2; Urokinase inhibitor	Human	E. coli
	Serpin B2 inhibits urokinase-type plasminogen activator and contributes to fibrinolytic regulation. Monocyte-derived plasminogen activator inhibitor 2 (PAI-2) differs from endothelial cell-derived PAI-1, highlighting different cellular origins. Serpin B2 Protein, Human is the recombinant human-derived Serpin B2 protein, expressed by E. coli , with tag free. The total length of Serpin B2 Protein, Human is 415 a.a., with molecular weight of ~46.6 kDa.

HY-P705552

	Serpin B2 Protein, Human (HEK293, His) HsT1201; Monocyte Arg serpin ; Monocyte Arg-serpin; Monocyte Arginine-serpin; Monocyte-derived Plasminogen Activator inhibitor; PAI; PAI-2; PAI2 ; PAI2_HUMAN; Placental Plasminogen Activator inhibitor; PLANH2 ; Plasminogen Activator inhibitor 2; Plasminogen Activator inhibitor; type 2; Plasminogen Activator inhibitor; type II arginine-serpin; serine or cysteine; proteinase inhibitor; clade B ovalbumin; member 2; Serpin B2; serpin peptidase inhibitor; clade B ovalbumin; member 2; Serpinb2; Urokinase inhibitor	Human	HEK293

HY-P73583

	T-PA Protein, Mouse (HEK293, Fc) Tissue-type Plasminogen Activator; t-PA; Plat	Mouse	HEK293
	The T-PA protein converts the inactive plasminogen to active plasmin by hydrolyzing a single Arg-Val bond.This conversion regulates plasmin-mediated proteolysis and is involved in tissue remodeling, degradation, and cell migration.T-PA also contributes to the prevention of polyspermy during oocyte activation by participating in the cortical granule reaction.T-PA Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived T-PA protein, expressed by HEK293 , with N-hFc labeled tag.

HY-P701312

	T-PA Protein, Mouse (HEK293, His) Tissue-type Plasminogen Activator; t-PA; Plat	Mouse	HEK293
	The T-PA protein converts the inactive plasminogen to active plasmin by hydrolyzing a single Arg-Val bond.This conversion regulates plasmin-mediated proteolysis and is involved in tissue remodeling, degradation, and cell migration.T-PA also contributes to the prevention of polyspermy during oocyte activation by participating in the cortical granule reaction.T-PA Protein, Mouse (HEK293, His) is the recombinant mouse-derived T-PA protein, expressed by HEK293 , with C-His labeled tag.

HY-P702769

	uPAR Protein, Human (GST) Urokinase Plasminogen Activator surface receptor; U-PAR; CD87; PLAUR; MO3	Human	E. coli
	The uPAR protein is a receptor for urokinase plasminogen activator and actively localizes and promotes plasmin formation. It mediates proteolysis-independent signaling activated by U-PA and undergoes negative feedback regulation. uPAR Protein, Human (GST) is the recombinant human-derived uPAR protein, expressed by E. coli , with N-GST labeled tag.

HY-P703682

	uPAR/PLAUR Protein, Rat (HEK293, His, Avi) Urokinase Plasminogen Activator surface receptor; Plaur; U-PAR	Rat	HEK293
	uPAR/PLAUR Protein, Rat (HEK293, His, Avi) is the recombinant rat-derived uPAR/PLAUR protein, expressed by HEK293, with C-Avi & C-His tag.

HY-P72433

	uPAR Protein, Human (HEK293, His) Urokinase Plasminogen Activator surface receptor; U-PAR; CD87; PLAUR; MO3	Human	HEK293
	The uPAR protein is a receptor for urokinase plasminogen activator and actively localizes and promotes plasmin formation. It mediates proteolysis-independent signaling activated by U-PA and undergoes negative feedback regulation. uPAR Protein, Human (HEK293, His) is the recombinant human-derived uPAR protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P77276

	uPAR Protein, Mouse (HEK293, His) Urokinase Plasminogen Activator surface receptor; U-PAR; CD87; PLAUR; MO3	Mouse	HEK293
	The uPAR protein acts as a receptor for urokinase plasminogen activator, facilitating plasmin formation and signal transduction activation.It interacts with SRPX2 and forms a monomer.uPAR also interacts with MRC2 and SORL1, reducing PLAUR internalization.Additionally, the PLAUR-PLAU-SERPINE1 complex interacts with SORL1.uPAR Protein, Mouse (HEK293, His) is the recombinant mouse-derived uPAR protein, expressed by HEK293 , with C-His labeled tag.

HY-P77275

	uPAR Protein, Mouse (HEK293, His-Fc) Urokinase Plasminogen Activator surface receptor; U-PAR; CD87; PLAUR; MO3	Mouse	HEK293
	uPAR (urokinase plasminogen activator receptor) possesses enzyme, protein, and receptor binding activities.It regulates apoptotic signaling, epidermal growth factor signaling, and cytochrome c release.uPAR is widely expressed in structures like decidua and spleen.Its human ortholog, PLAUR, is linked to rheumatoid arthritis.Investigating uPAR can reveal its role in cellular processes and shed light on diseases like rheumatoid arthritis.uPAR Protein, Mouse (HEK293, His-Fc) is the recombinant mouse-derived uPAR protein, expressed by HEK293 , with C-hFc, C-His labeled tag.

HY-P73655

	Serpin E1 Protein, Rat (HEK293, His) Plasminogen Activator inhibitor 1; PAI-1; Serpin E1; Serpine1; Planh1	Rat	HEK293
	Serpin E1 Protein, Rat (HEK293, His) is one important member of the serine proteinase inhibitor E superfamily that plays a crucial role in the fibrinolytic system. The Serpin E1 protein is a single-chain glycoprotein composed of 379 amino acids. The active site of the protein is Arg346-Met347. SERPINE1 encodes plasminogen activator inhibitor type 1 (PAI-1), which serves as the primary inhibitor of urokinase plasminogen activator (uPA) and tissue-type plasminogen activator (tPA). The Serpin E1 protein can quickly inhibit the formation of plasmin. Serpin E1 can be transcribed through several signaling cascades, including pro-fibrogenic and pro-inflammatory pathways. Serpin E1 is a serine proteinase inhibitor, serves as an important regulator of extracellular matrix remodeling. Serpin E1 Protein, Rat (HEK293, His) is the recombinant rat-derived Serpin E1 protein, expressed by HEK293 , with C-His, C-10*His labeled tag.

HY-P73336

	Serpin E1 Protein, Rat (HEK293, Fc) Plasminogen Activator inhibitor 1; PAI-1; Serpin E1; Serpine1; Planh1	Rat	HEK293
	Serpin E1 is a serine protease inhibitor that regulates TMPRSS7 and inhibits tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU).It can significantly downregulate fibrinolysis and control thrombus degradation.Serpin E1 Protein, Rat (HEK293, Fc) is the recombinant rat-derived Serpin E1 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P72055

	Serpin A5 Protein, Mouse (sf9, His) Serpina5; Pci; Plasma serine protease inhibitor; Plasminogen Activator inhibitor 3; PAI-3; PAI3; Protein C inhibitor; PCI; Serpin A5	Mouse	Sf9 insect cells
	Serpin A5 protein is a heparin-dependent serine protease inhibitor that controls proteolytic activity in body fluids. It binds irreversibly to the serine activation site, inactivating serine proteases and regulating intravascular and extravascular proteolysis. Serpin A5 Protein, Mouse (sf9, His) is the recombinant mouse-derived Serpin A5 protein, expressed by sf9 insect cells , with N-10*His labeled tag.

HY-P700875

	MRC2 Protein, Human (HEK293, His) C-type lectin domain family 13 member E, Endocytic receptor 180, Macrophage mannose receptor 2, Urokinase-type Plasminogen Activator receptor-associated protein (UPAR-associated protein; Urokinase receptor-associated protein)	Human	HEK293
	The MRC2 protein may function as an endocytic lectin receptor with calcium-dependent lectin activity. It internalizes glycosylated ligands via clathrin-mediated endocytosis and releases them in endosomes. MRC2 Protein, Human (HEK293, His) is the recombinant human-derived MRC2 protein, expressed by HEK293 , with C-His labeled tag.

HY-P70975

	Serpin A5 Protein, Human (HEK293, His) 2 Publications Verification Plasma Serine Protease Inhibitor; Acrosomal Serine Protease Inhibitor; Plasminogen Activator Inhibitor 3; PAI-3; PAI3; Protein C Inhibitor; PCI; Serpin A5; SERPINA5; PCI; PLANH3; PROCI	Human	HEK293
	Plasma serine protease inhibitor (SERPINA5) is a glycoproteins that inhibit serine proteases. SERPINA5 is involved in the regulation of intravascular and extravascular proteolytic activities, controls the sperm motility and fertilization and protect components of the genital tract. SERPINA5 also inhibits urinary-type plasminogen activator-dependent tumor cell invasion and metastasis. Serpin A5 Protein, Human (HEK293, His) is the recombinant human-derived Serpin A5 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P701528

	HLTF Protein, Human HLTF; Helicase-like transcription factor; DNA-binding protein/Plasminogen Activator inhibitor 1 regulator; HIP116; RING finger protein 80; RING-type E3 ubiquitin transferase HLTF; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3; Sucrose nonfermenting protein 2-like 3	Human	E. coli
	HLTF protein has helicase and E3 ubiquitin ligase activities and has intrinsic ATP-dependent nucleosome remodeling ability. It is critical for the transcriptional regulation of specific promoters such as SERPINE1, HIV-1 and SV40. HLTF Protein, Human is the recombinant human-derived HLTF protein, expressed by E. coli , with tag free.

HY-P701529

	HLTF Protein, Human (His) HLTF; Helicase-like transcription factor; DNA-binding protein/Plasminogen Activator inhibitor 1 regulator; HIP116; RING finger protein 80; RING-type E3 ubiquitin transferase HLTF; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3; Sucrose nonfermenting protein 2-like 3	Human	E. coli
	HLTF protein has helicase and E3 ubiquitin ligase activities and has intrinsic ATP-dependent nucleosome remodeling ability. It is critical for the transcriptional regulation of specific promoters such as SERPINE1, HIV-1 and SV40. HLTF Protein, Human (His) is the recombinant human-derived HLTF protein, expressed by E. coli , with N-6*His labeled tag.

Compare Products


Products	In-stock - + Add to Cart
Cat. No.
Species
Source
Tag
Accession
Gene ID
Molecular Weight
Purity
Endotoxin Level
Biological Activity
Appearance
Formulation
Storage & Stability
Shipping
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Product Name	Chemical Structure

HY-B0099S

Edaravone-d5
Edaravone-d₅ is a deuterium labeled Edaravone. Edaravone is a strong novel free radical scavenger, and inhibits MMP-9-related brain hemorrhage in rats treated with tissue plasminogen activator .

HY-B0285AS

Amiloride-15N3 hydrochloride
Amiloride- ¹⁵N₃ (hydrochloride) is the ¹⁵N labeled Amiloride hydrochloride . Amiloride hydrochloride (MK-870 hydrochloride) is an inhibitor of both epithelial sodium channel (ENaC ) and urokinase-type plasminogen activator receptor (uTPA ). Amiloride hydrochloride is a blocker of polycystin-2 (PC2;TRPP2 ) channel.

HY-B0149S2

Tranexamic acid-13C6
Tranexamic acid- ¹³C₆ (Cyclocapron- ¹³C₆) is ¹³C labeled Tranexamic acid. Tranexamic acid (cyclocapron), a cyclic analog of lysine, is an orally active antifibrinolytic agent. Tranexamic acid attenuates the effects of severe trauma, inhibits urokinase plasminogen activator and ameliorates dry wrinkles. Tranexamic acid can used for the research of hemostasis .

HY-B0285S

Amiloride-15N3
Amiloride- ¹⁵N₃ (MK-870- ¹⁵N₃) is ¹⁵N labeled Amiloride. Amiloride (MK-870) is an inhibitor of both epithelial sodium channel (ENaC ) and urokinase-type plasminogen activator receptor (uTPA ). Amiloride is a blocker of polycystin-2 (PC2; TRPP2 ) channel.

HY-W801479S

Edaravone sulfate-d5
Edaravone sulfate-d₅ is the deuterium labeled Edaravone sulfate. Edaravone is a strong novel free radical scavenger, and inhibits MMP-9-related brain hemorrhage in rats treated with tissue plasminogen activator.

Host:	Rabbit (5)
Reactivity:	Human (5) Rat (3) Mouse (5)
Application:	IHC-P (3) WB (5)
Isotype:	IgG (5)
Conjugation:	Non-conjugated (5)
Clonality:	Monoclonal (3) Recombinant (3)
Modification:	Unmodified (3)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P83503

	uPA Antibody (YA3248) Urokinase-type Plasminogen Activator; U-Plasminogen Activator; Upa; PLAU; ATF uPA	WB, IHC-P	Human, Mouse, Rat
	uPA Antibody (YA3248) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to uPA.

HY-P83461

	*Tissue Type Plasminogen* Activator Antibody (YA3206)** TPA; T-PA; TPA1; PLAT; Tissue Plasminogen Activator	WB, IHC-P	Human, Mouse, Rat
	Tissue Type Plasminogen Activator Antibody (YA3206) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Tissue Type Plasminogen Activator.

HY-P83503A

	uPA Antibody (YA3248)(PBS only) Urokinase-type Plasminogen Activator; U-Plasminogen Activator; Upa; PLAU; ATF uPA	WB, IHC-P	Human, Mouse, Rat
	uPA Antibody (YA3248) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to uPA.

HY-P81779

	PAI1 Antibody (YA1524) SERPINE1; PAI1; PLANH1; Plasminogen Activator inhibitor 1; PAI; PAI-1; Endothelial Plasminogen Activator inhibitor; Serpin E1	WB	Human, Mouse
	PAI1 Antibody (YA1524) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PAI1.

HY-P81779A

	PAI1 Antibody (YA1524)(PBS only) SERPINE1; PAI1; PLANH1; Plasminogen Activator inhibitor 1; PAI; PAI-1; Endothelial Plasminogen Activator inhibitor; Serpin E1	WB	Human, Mouse
	PAI1 Antibody (YA1524) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PAI1.