17440-83-4
17440-83-4
Chemical Structure
Amiloride hydrochloride dihydrate
Synonym(s): MK-870 hydrochloride dihydrate
- CAS No.: 17440-83-4
- Formula:C6H13Cl2N7O3
- Molecular Weight:302.12
IUPAC Name: 3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-carboxamide hydrochloride dihydrate
InChIKey: LTKVFMLMEYCWMK-UHFFFAOYSA-N
SMILES: O=C(C1=NC(Cl)=C(N)N=C1N)NC(N)=N.[H]Cl.O.O
Biological Activity: Amiloride hydrochloride dihydrate (MK-870 hydrochloride dihydrate) is an inhibitor of both epithelial sodium channel (ENaC[1]) and urokinase-type plasminogen activator receptor (uTPA[2]). Amiloride hydrochloride dihydrate is a blocker of polycystin-2 (PC2; TRPP2[3]) channel.
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Amiloride hydrochloride dihydrate | 99.88% | Amiloride hydrochloride dihydrate (MK-870 hydrochloride dihydrate) is an inhibitor of both epithelial sodium channel (ENaC) and urokinase-type plasminogen activator receptor (uTPA). Amiloride hydrochloride dihydrate is a blocker of polycystin-2 (PC2; TRPP2) channel. | ||||||||||||||||||||
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Amiloride hydrochloride dihydrate (Standard) | ≥98% | Amiloride hydrochloride dihydrate (Standard) is the analytical standard of Amiloride hydrochloride dihydrate. This product is intended for research and analytical applications. Amiloride hydrochloride dihydrate (MK-870 hydrochloride dihydrate) is an inhibitor of both epithelial sodium channel (ENaC) and urokinase-type plasminogen activator receptor (uTPA). Amiloride hydrochloride dihydrate is a blocker of polycystin-2 (PC2; TRPP2) channel. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.97
HY-B0285ARAmiloride hydrochloride (Standard) -
Similarity Score 0.97
HY-B0285ASAmiloride-15N3 hydrochloride -
Similarity Score 0.80
HY-132181Dimethylamiloride hydrochloride -
Similarity Score 0.79
HY-138866Dimethylamiloride -
Similarity Score 0.75
HY-123685UCD74A (hydrochloride) -
Similarity Score 0.73
HY-101840AREIPA hydrochloride (Standard) -
Similarity Score 0.72
HY-101840REIPA (Standard) -
Similarity Score 0.70
HY-B1546ABenzamil hydrochloride -
Similarity Score 0.69
HY-B1546Benzamil -
Explore the MedChemAI to find more analogs
References
- [1]. Miller RL, et al. Blockade of ENaCs by amiloride induces c-Fos activation of the area postrema. Brain Res. 2015 Mar 19;1601:40-51. [Content Brief]
- [2]. Xu LB, et al. Amiloride, a urokinase-type plasminogen activator receptor (uTPA) inhibitor, reduces proteinurea in podocytes. Genet Mol Res. 2015 Aug 14;14(3):9518-29. [Content Brief]
- [3]. Giamarchi A, et al. A polycystin-2 (TRPP2) dimerization domain essential for the function of heteromeric polycystin complexes. EMBO J. 2010 Apr 7;29(7):1176-91. [Content Brief]
