1. Metabolic Enzyme/Protease
  2. PAI-1
  3. Angstrom6

Angstrom6 (Synonyms: A6 Peptide)

Cat. No.: HY-P2230 Purity: 99.70%
Handling Instructions

Angstrom6 (A6 Peptide) is an 8 amino-acid peptide derived from single-chain urokinase plasminogen activator (scuPA) and interferes with the uPA/uPAR cascade and abrogates downstream effects. Angstrom6 binds to CD44 resulting in the inhibition of migration, invasion, and metastasis of tumor cells, and the modulation of CD44-mediated cell signaling.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Angstrom6 Chemical Structure

Angstrom6 Chemical Structure

CAS No. : 220334-14-5

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5 mg USD 205 In-stock
Estimated Time of Arrival: December 31
10 mg USD 350 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Angstrom6 (A6 Peptide) is an 8 amino-acid peptide derived from single-chain urokinase plasminogen activator (scuPA) and interferes with the uPA/uPAR cascade and abrogates downstream effects. Angstrom6 binds to CD44 resulting in the inhibition of migration, invasion, and metastasis of tumor cells, and the modulation of CD44-mediated cell signaling[1][2].

In Vitro

Angstrom6 is effective at blocking the migration of the OVCAR8, OVCAR3, ES2, IGROV-1, MDA-MB-468, and MDA-MB361 cells with IC50s in the range of 10 to 100 nM[3].
Angstrom6 potentiates the CD44-dependent adhesion of cancer cells to hyaluronic acid and activated CD44-mediated signaling, as evidenced by focal adhesion kinase and MAP/ERK kinase phosphorylation[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Angstrom6 (100 mg/kg; s.c. twice daily) reduces the number of lung foci generated by the i.v. injection of B16-F10 melanoma cells by 50%[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57Bl/6 mice (bearing B16-F10 cells)[3]
Dosage: 100 mg/kg
Administration: S.c.; twice a day for 11 days
Result: Reduced the number of lung nodules and reduced the number of lung metastases to 50% of control.
Molecular Weight

910.97

Formula

C₃₉H₆₂N₁₀O₁₅

CAS No.

220334-14-5

Sequence

Ac-Lys-Pro-Ser-Ser-Pro-Pro-Glu-Glu-NH2

Sequence Shortening

Ac-KPSSPPEE-NH2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -80°C 2 years
-20°C 1 year
In solvent -80°C 6 months
-20°C 1 month
References
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Keywords:

Angstrom6A6 PeptideAngstrom 6Angstrom-6PAI-1Plasminogen activator inhibitor-1single-chainurokinaseplasminogenactivatorCD44migrationinvasionmetastasiscancerInhibitorinhibitorinhibit

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Angstrom6
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HY-P2230
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