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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
13 Results for "
Prolyl Endopeptidase (PREP)
" in MedChemExpress (MCE) Product Catalog:
Products (13)
13 Results for "Prolyl Endopeptidase (PREP)" in MCE Product Catalog:
1
1 Cited Publications
Target:
Research Areas:
Suc-Gly-Pro-AMC is a fluorescent substrate. Suc-Gly-Pro-AMC is a fibroblast activation protein (FAP) specific substrate. Suc-Gly-Pro-AMC reacts with recombinant porcine prolyl oligopeptidase. Suc-Gly-Pro-AMC can be used to study the activity of FAP, prolyl endopeptidase (PREP). Suc-Gly-Pro-AMC is used in glioma research .
Cat. No.: HY-17455
CAS No.: 68497-62-1
Synonyms: CI-879 free base
Target:
Research Areas:
Pramiracetam (CI-879 free base) is a PREP (prolyl endopeptidase) inhibitor. Pramiracetam improves cognitive impairment caused by traumatic brain injury. Pramiracetam can be used in the study of neurodegenerative diseases .
Cat. No.: HY-W001273
CAS No.: 72869-16-0
Synonyms: CI-879 sulfate
Target:
Research Areas:
Pramiracetam (CI-879) sulfate Pramiracetam is a PREP (prolyl endopeptidase) inhibitor. Pramiracetam sulfate improves cognitive impairment caused by traumatic brain injury. Pramiracetam sulfate can be used in the study of neurodegenerative diseases .
Cat. No.: HY-15113A
CAS No.: 143984-17-2
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Y-29794 tosylate is a selective, orally active inhibitor for non-peptide prolyl endopeptidase (PREP), with an IC50 of 3 nM and a Ki of 0.95 nM. Y-29794 tosylate enhances the effect of thyrotropin-releasing hormone (TRH) on the release of ACh in the rat hippocampus, exhibits potential neuroprotective efficacy. Y-29794 tosylate exhibits anticancer activity through inhibition of the IRS1-AKT-mTORC1 pathway. Y-29794 tosylate penetrates the brain-blood barrier (BBB) .
Cat. No.: HY-134454A
CAS No.: 88795-32-8
Synonyms: N-Benzyloxycarbonyl-L-Prolyl-L-prolinal
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Z-Pro-prolinal (N-Benzyloxycarbonyl-L-prolyl-L-prolinal) is a specific, orally active prolyl endopeptidase (PREP) inhibitor with an IC50 of 0.4 nM for porcine PREP .
Cat. No.: HY-P4308
CAS No.: 170116-63-9
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Cat. No.: HY-15112
CAS No.: 162203-65-8
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Research Areas:
JTP-4819 is a potent and specific inhibitor of prolyl endopeptidase (PREP) with IC50s of 0.83 nM (in rat brain supernatant) and 5.43 nM (in Flavobacterium meningosepticum). JTP-4819 has blood-brain penetration, also improves the retention time of amnesia rats induced by Scopolamine (HY-N2096) .
Cat. No.: HY-17455R
CAS No.: 68497-62-1
Synonyms: CI-879 free base (Standard)
Research Areas:
Pramiracetam (Standard) is the analytical standard of Pramiracetam. This product is intended for research and analytical applications. Pramiracetam (CI-879 free base) is a PREP (prolyl endopeptidase) inhibitor. Pramiracetam improves cognitive impairment caused by traumatic brain injury. Pramiracetam can be used in the study of neurodegenerative diseases .
Cat. No.: HY-15113
CAS No.: 129184-48-1
Target:
Research Areas:
Y-29794 is a selective, orally active inhibitor for non-peptide prolyl endopeptidase (PREP), with an IC50 of 3 nM and a Ki of 0.95 nM. Y-29794 enhances the effect of thyrotropin-releasing hormone (TRH) on the release of ACh in the rat hippocampus, exhibits potential neuroprotective efficacy. Y-29794 exhibits anticancer activity through inhibition of the IRS1-AKT-mTORC1 pathway. Y-29794 penetrates the brain-blood barrier (BBB) .
Cat. No.: HY-P703584
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PREP; PEP; Prolyl Endopeptidase; PE; Post-Proline Cleaving Enzyme; DJ355L5.1 (Prolyl Endopeptidase); Prolyl Oligopeptidase
Species:
Human
Source:
E. coli
Cat. No.: HY-181070
Target:
Research Areas:
PREP-IN-2 is an irreversible and selective prolyl endopeptidase (PREP) inhibitor with an IC50 of 0.53 μM and a Ki of 0.62 μM. PREP-IN-2 can be used in research related to neurodegenerative diseases and triple-negative breast cancer .
Cat. No.: HY-106021
CAS No.: 192658-64-3
Synonyms: ILX651 free base
Research Areas:
Tasidotin (ILX651 free base) is a tubulin inhibitor and competitive Prolyl Endopeptidase (PREP) inhibitor, with an IC50 of 10 μM against bovine tubulin. Tasidotin exhibits high cerebrospinal fluid penetration in non-human primates. Tasidotin antagonizes microtubule assembly and induces an extended assembly lag phase, thereby inhibiting mitosis and cell proliferation, and exerts cytotoxic and oncolytic effects on cancer cells. Tasidotin is metabolized into polypeptides and proline inside cells, and its in vivo metabolism is mediated by prolyl endopeptidase. Tasidotin can be applied in research related to Burkitt's lymphoma, breast cancer, leukemia, melanoma, central nervous system malignancies and various solid tumors .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
