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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
32 Results for "
RON
" in MedChemExpress (MCE) Product Catalog:
Products (32)
32 Results for "RON" in MCE Product Catalog:
15
15 Publications Verification
Target:
Áreas de investigación:
BMS-754807 is a potent and reversible IGF-1R/IR inhibitor (IC50=1.8 and 1.7 nM, respectively; Ki=<2 nM for both). BMS-754807 also shows potent activities against Met, RON, TrkA, TrkB, AurA, and AurB with IC50 values of 6, 44, 7, 4, 9, and 25 nM, respectively .
13
13 Cited Publications
Synonyms: BMS 817378
Target:
Áreas de investigación:
BMS 777607 (BMS 817378) is a Met-related inhibitor for c-Met, Axl, Ron and Tyro3 with IC50s of 3.9 nM, 1.1 nM, 1.8 nM and 4.3 nM, respectively, and 40-fold more selective for Met-related targets than Lck, VEGFR-2, and TrkA/B, with more than 500-fold greater selectivity versus all other receptor and non receptor kinases .
3
3 Cited Publications
Target:
Áreas de investigación:
MK-8033 is an orally active ATP competitive c-Met/Ron dual inhibitor (IC50s: 1 nM (c-Met),7 nM (Ron)), with preferential binding to the activated kinase conformation. MK-8033 can be used in the research of cancers, such as breast and bladder cancers, non-small cell lung cancers (NSCLCs) .
3
3 Cited Publications
Target:
Áreas de investigación:
MK-8033 hydrochloride is an orally active ATP competitive c-Met/Ron dual inhibitor (IC50s: 1 nM (c-Met),7 nM (Ron)), with preferential binding to the activated kinase conformation. MK-8033 hydrochloride can be used in the research of cancers, such as breast and bladder cancers, non-small cell lung cancers (NSCLCs) .
2
2 Cited Publications
Synonyms: GumaRONtinib; SCC244
Target:
Áreas de investigación:
Glumetinib (SCC244) is a highly selective, orally bioavailable, ATP-competitive c-Met inhibitor with an IC50 of 0.42 nM. Glumetinib has greater than 2400-fold selectivity for c-Met over those 312 kinases evaluated, including the c-Met family member RON and highly homologous kinases Axl, Mer, TyrO3. Antitumor activity .
1
1 Cited Publications
Target:
Áreas de investigación:
AMG-208 is an orally active c-Met/RON dual selective inhibitor with an IC50 of 9 nM for c-Met. AMG-208 is a CYP3A4 inhibitor with an IC50 of 32 μM. AMG-208 has anti-cancer activity .
1
1 Cited Publications
Referencia número: HY-50703
No. CAS: 917879-39-1
Target:
Áreas de investigación:
MK-2461 is an ATP-competitive, selective and orally active wild-type and mutant c-Met inhibitor (IC50s: 0.4-2.5 nM). MK-2461 also inhibits Ron (IC50 of 7 nM) and Flt1 (IC50 of 10 nM), MK-2461 shows selective for c-MET over other kinases (lC50s = 22-7800 nM). MK-2461 can be used for the study of cancer, such as gastric cancer .
Referencia número: HY-P99375
No. CAS: 1188275-92-4
Synonyms: IMC-RON8; LY3012219; Anti-MSPR/RON/CD136 Reference Antibody (narnatumab)
Target:
Áreas de investigación:
NCGC00262650 is a potent apical membrane antigen 1-rhoptry neck protein 2 (AMA1-RON2) interaction inhibitor. NCGC00262650 can block entry of merozoites into red blood cells with an IC50 of 9.8 μM .
Referencia número: HY-18307
No. CAS: 913376-84-8
Target:
Áreas de investigación:
SYN1143 is a potent, selective and orally active dual inhibitor of c-Met/RON, with IC50s of 4 and 9 nM, respectively. SYN1143 has weak inhibitory activity on Lck, Tie2, Src, and BTK with IC50s ranging from 160 to 710 nM. SYN1143 can be used for the research of cancers that RON and c-Met are activated .
Referencia número: HY-123262
No. CAS: 669764-17-4
Target:
Áreas de investigación:
SU11606 is a Met inhibitor, with an average IC50 of 0.17 μM. SU11606 shows inhibitory activity on Ron, FLK-1, with IC50s of 2.5 μM and 0.18 μM, respectively. SU11606 can be used in the research of tumors .
Referencia número: HY-P990471
Target:
Áreas de investigación:
Referencia número: HY-P990472
Synonyms: H5B14
Target:
Áreas de investigación:
Referencia número: HY-155812
No. CAS: 2377507-01-0
Target:
Áreas de investigación:
Tyrosine kinase-IN-6 is a potent and promising RON splice variants inhibitor with anti-cancer and o?antineoplastic effects .
Referencia número: HY-118269
No. CAS: 1175296-94-2
Target:
Áreas de investigación:
OSI-296 is a potent, oral and selective inhibitor of cMET and RON kinases. OSI-296 shows in vivo efficacy in MKN45 tumor xenografts models and well tolerated .
Referencia número: HY-123225
No. CAS: 1229611-73-7
Target:
Áreas de investigación:
LCRF-0004 is a potent inhibitor of RON kinase, with the IC50 value of 10 nM. and a surprising result is also obtained regarding its c-Met inhibitory activity, with the IC50 value of 12 nM. LCRF-0004 plays an important role in cancer research .
Referencia número: HY-RS08730
Target:
Áreas de investigación:
MST1R Human Pre-designed siRNA Set A contains three designed siRNAs for MST1R gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Referencia número: HY-RS18291
Target:
Áreas de investigación:
Mst1r Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mst1r gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Referencia número: HY-123237
No. CAS: 1146944-35-5
Target:
Áreas de investigación:
KRC-108, an aminopyridine, is an orally active multiple kinase inhibitor with IC50s of 80 nM, 23 nM, 3 nM, 70 nM, 30 nM, 39 nM for c-Met, c-Met M1250T, c-Met Y1230D, Ron, Flt3 and TrkA, respectively. KRC-108 induces cell cycle arrest, apoptotic cell death, and autophagy. KRC-108 exhibits anti-tumor activity in vivo in HT29 colorectal cancer, NCI-H441 lung cancer xenograft models in athymic BALB/c nu/nu mice .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
