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Results for "

RON

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (1) Autophagy (1) c-Met/HGFR (14) Cytochrome P450 (1) FLT3 (1) IGF-1R (2) Insulin Receptor (2) Parasite (1) Reference Standards (1) Small Interfering RNA (siRNA) (3) TAM Receptor (2) Trk Receptor (1) Tyrosinase (2) VEGFR (1)
By Research Areas:	Cancer (16) Endocrinology (2) Infection (1) Inflammation/Immunology (2)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

Inhibitory Antibodies

Recombinant Proteins

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-10200

BMS-754807 Maximum Cited Publications 14 Publications Verification	IGF-1R Insulin Receptor	Endocrinology Cancer
BMS-754807 is a potent and reversible IGF-1R/IR inhibitor (IC₅₀=1.8 and 1.7 nM, respectively; K_i=<2 nM for both). BMS-754807 also shows potent activities against Met, RON, TrkA, TrkB, AurA, and AurB with IC₅₀ values of 6, 44, 7, 4, 9, and 25 nM, respectively .

HY-12076

BMS 777607 10+ Cited Publications BMS 817378	c-Met/HGFR TAM Receptor	Cancer
BMS 777607 (BMS 817378) is a Met-related inhibitor for c-Met, Axl, *Ron* and Tyro3 with IC₅₀s of 3.9 nM, 1.1 nM, 1.8 nM and 4.3 nM, respectively, and 40-fold more selective for Met-related targets than Lck, VEGFR-2, and TrkA/B, with more than 500-fold greater selectivity versus all other receptor and non receptor kinases .

HY-P99375

Narnatumab IMC-RON8; LY3012219; Anti-MSPR/RON/CD136 Reference Antibody (narnatumab)	Tyrosinase c-Met/HGFR	Cancer
Narnatumab (IMC-RON8) is a neutralizing human monoclonal antibody that blocks *RON* binding to its ligand, macrophage-stimulating protein (MSP), with a K_d of 32 pM. Narnatumab can be used for the research of cancer .

HY-13299

MK-8033 3 Publications Verification	c-Met/HGFR	Cancer
MK-8033 is an orally active ATP competitive *c-Met/Ron* dual inhibitor (IC₅₀s: 1 nM (c-Met),7 nM (Ron)), with preferential binding to the activated kinase conformation. MK-8033 can be used in the research of cancers, such as breast and bladder cancers, non-small cell lung cancers (NSCLCs) .

HY-116000

Glumetinib 2 Publications Verification GumaRONtinib; SCC244	c-Met/HGFR	Cancer
Glumetinib (SCC244) is a highly selective, orally bioavailable, ATP-competitive c-Met inhibitor with an IC₅₀ of 0.42 nM. Glumetinib has greater than 2400-fold selectivity for c-Met over those 312 kinases evaluated, including the c-Met family member RON and highly homologous kinases Axl, Mer, TyrO3. Antitumor activity .

HY-12035

AMG-208 1 Publications Verification	c-Met/HGFR Cytochrome P450	Cancer
AMG-208 is an orally active *c-Met/RON* dual selective inhibitor with an IC₅₀ of 9 nM for c-Met. AMG-208 is a CYP3A4 inhibitor with an IC₅₀ of 32 μM. AMG-208 has anti-cancer activity .

HY-50703

MK-2461 1 Publications Verification	c-Met/HGFR	Cancer
MK-2461 is an ATP-competitive, selective and orally active wild-type and mutant c-Met inhibitor (IC₅₀s: 0.4-2.5 nM). MK-2461 also inhibits Ron (IC₅₀ of 7 nM) and Flt1 (IC₅₀ of 10 nM), MK-2461 shows selective for c-MET over other kinases (lC₅₀s = 22-7800 nM). MK-2461 can be used for the study of cancer, such as gastric cancer .

HY-18307

SYN1143	c-Met/HGFR	Cancer
SYN1143 is a potent, selective and orally active dual inhibitor of *c-Met/RON, with IC₅₀s of 4 and 9 nM, respectively. SYN1143 has weak inhibitory activity on Lck, Tie2, Src, and BTK* with IC₅₀s ranging from 160 to 710 nM. SYN1143 can be used for the research of cancers that RON and c-Met are activated .

HY-126425

NCGC00262650	Parasite	Infection
NCGC00262650 is a potent *apical membrane antigen 1-rhoptry neck protein 2 (AMA1-RON2) interaction* inhibitor. NCGC00262650 can block entry of merozoites into red blood cells with an IC₅₀ of 9.8 μM .

HY-13299A

MK-8033 hydrochloride 3 Publications Verification	c-Met/HGFR	Cancer
MK-8033 hydrochloride is an orally active ATP competitive *c-Met/Ron* dual inhibitor (IC₅₀s: 1 nM (c-Met),7 nM (Ron)), with preferential binding to the activated kinase conformation. MK-8033 hydrochloride can be used in the research of cancers, such as breast and bladder cancers, non-small cell lung cancers (NSCLCs) .

HY-123262

SU11606	c-Met/HGFR VEGFR	Cancer
SU11606 is a Met inhibitor, with an average IC₅₀ of 0.17 μM. SU11606 shows inhibitory activity on *Ron, FLK-1, with IC₅₀*s of 2.5 μM and 0.18 μM, respectively. SU11606 can be used in the research of tumors .

HY-P990471

*Anti-MSPR/RON/CD136 Antibody*	Tyrosinase	Inflammation/Immunology
The Anti-MSPR/RON/CD136 Antibody is a human antibody expressed in CHO, targeting *MSPR/RON/CD136. The Anti-MSPR/RON/CD136 Antibody is equipped with huIgG1 heavy chain and huκ light chain, with a predicted molecular weight (MW) of 145.74 kDa. The isotype control for the Anti-MSPR/RON*/CD136 Antibody can refer to Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P990472

*Anti-MSPR/RON/CD136 Antibody (H5B14)* H5B14	c-Met/HGFR	Inflammation/Immunology
Anti-MSPR/RON/CD136 Antibody (H5B14) is a humanized antibody expressed in CHO cells, targeting *MSPR/RON/CD136. Anti-MSPR/RON/CD136 Antibody (H5B14) has a huIgG1 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 156.7 kDa. The isotype control for Anti-MSPR/RON*/CD136 Antibody (H5B14) can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).

HY-155812

Tyrosine kinase-IN-6	c-Met/HGFR	Cancer
Tyrosine kinase-IN-6 is a potent and promising RON splice variants inhibitor with anti-cancer and o?antineoplastic effects .

HY-118269

OSI-296	c-Met/HGFR	Cancer
OSI-296 is a potent, oral and selective inhibitor of cMET and *RON* kinases. OSI-296 shows in vivo efficacy in MKN45 tumor xenografts models and well tolerated .

HY-123225

LCRF-0004	c-Met/HGFR	Cancer
LCRF-0004 is a potent inhibitor of RON kinase, with the IC₅₀ value of 10 nM. and a surprising result is also obtained regarding its c-Met inhibitory activity, with the IC₅₀ value of 12 nM. LCRF-0004 plays an important role in cancer research .

HY-RS08730

MST1R Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
MST1R Human Pre-designed siRNA Set A contains three designed siRNAs for MST1R gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

MST1R Human Pre-designed siRNA Set A MST1R Human Pre-designed siRNA Set A

HY-RS18291

Mst1r Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Mst1r Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mst1r gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Mst1r Mouse Pre-designed siRNA Set A Mst1r Mouse Pre-designed siRNA Set A

HY-162085

Axl-IN-17	TAM Receptor	Cancer
Axl-IN-17 (compound 13c) is an orally active, selective AXL inhibitor with an IC₅₀ value of 3.2 nM. Axl-IN-17 reveals antitumor efficacy .

HY-123237

KRC-108	c-Met/HGFR FLT3 Trk Receptor Apoptosis Autophagy	Cancer
KRC-108, an aminopyridine, is an orally active multiple kinase inhibitor with IC₅₀s of 80 nM, 23 nM, 3 nM, 70 nM, 30 nM, 39 nM for c-Met, c-Met M1250T, c-Met Y1230D, *Ron, Flt3* and TrkA, respectively. KRC-108 induces cell cycle arrest, apoptotic cell death, and autophagy. KRC-108 exhibits anti-tumor activity in vivo in HT29 colorectal cancer, NCI-H441 lung cancer xenograft models in athymic BALB/c nu/nu mice .

HY-RS24769

Mst1r Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Mst1r Rat Pre-designed siRNA Set A contains three designed siRNAs for Mst1r gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Mst1r Rat Pre-designed siRNA Set A Mst1r Rat Pre-designed siRNA Set A

HY-10200R

BMS-754807 (Standard)	Reference Standards IGF-1R Insulin Receptor	Endocrinology Cancer
BMS-754807 (Standard) is the analytical standard of BMS-754807 (HY-10200). This product is intended for research and analytical applications. BMS-754807 is a potent and reversible IGF-1R/IR inhibitor (IC₅₀=1.8 and 1.7 nM, respectively; Ki=<2 nM for both). BMS-754807 also shows potent activities against Met, RON, TrkA, TrkB, AurA, and AurB with IC₅₀ values of 6, 44, 7, 4, 9, and 25 nM, respectively .

Cat. No.	Product Name	Target	Research Area	Image

HY-P99375

Narnatumab IMC-RON8; LY3012219; Anti-MSPR/RON/CD136 Reference Antibody (narnatumab)	Tyrosinase c-Met/HGFR	Cancer
Narnatumab (IMC-RON8) is a neutralizing human monoclonal antibody that blocks *RON* binding to its ligand, macrophage-stimulating protein (MSP), with a K_d of 32 pM. Narnatumab can be used for the research of cancer .

HY-P990471

*Anti-MSPR/RON/CD136 Antibody*	Tyrosinase	Inflammation/Immunology
The Anti-MSPR/RON/CD136 Antibody is a human antibody expressed in CHO, targeting *MSPR/RON/CD136. The Anti-MSPR/RON/CD136 Antibody is equipped with huIgG1 heavy chain and huκ light chain, with a predicted molecular weight (MW) of 145.74 kDa. The isotype control for the Anti-MSPR/RON*/CD136 Antibody can refer to Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P990472

*Anti-MSPR/RON/CD136 Antibody (H5B14)* H5B14	c-Met/HGFR	Inflammation/Immunology
Anti-MSPR/RON/CD136 Antibody (H5B14) is a humanized antibody expressed in CHO cells, targeting *MSPR/RON/CD136. Anti-MSPR/RON/CD136 Antibody (H5B14) has a huIgG1 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 156.7 kDa. The isotype control for Anti-MSPR/RON*/CD136 Antibody (H5B14) can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).

Species:	Human (4)
Tag:	His (2) Tag Free (1) GST (1)
Source:	HEK293 (2) sf9 insect cells (1) Sf9 insect cells (1)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P77180

	RON/MSPR Protein, Human (HEK293, His, solution) Macrophage-stimulating protein receptor; p185-RON; MST1R; PTK8	Human	HEK293
	RON/MSPR protein is a receptor tyrosine kinase that transduces signals by binding to MST1 ligand and regulates cell survival, migration, and differentiation. Ligand binding induces RON autophosphorylation, creating docking sites for downstream molecules. RON/MSPR Protein, Human (HEK293, His, solution) is the recombinant human-derived RON/MSPR protein, expressed by HEK293 , with C-His labeled tag.

HY-P705876

	RON/MSPR Protein, Human (sf9) Macrophage-stimulating protein receptor; p185-RON; MST1R; PTK8	Human	sf9 insect cells

HY-P77180A

	RON/MSPR Protein, Human (HEK293, C-His) Macrophage-stimulating protein receptor; p185-RON; MST1R; PTK8	Human	HEK293
	RON/MSPR protein is a receptor tyrosine kinase that transduces signals by binding to MST1 ligand and regulates cell survival, migration, and differentiation. Ligand binding induces RON autophosphorylation, creating docking sites for downstream molecules. RON/MSPR Protein, Human (HEK293, C-His) is the recombinant human-derived RON/MSPR, expressed by HEK293, with C-10*His labeled tag.

HY-P705604

	RON/MSPR Protein, Human (Active, sf9, GST) Macrophage-stimulating protein receptor; p185-RON; MST1R; PTK8	Human	Sf9 insect cells

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Host:	Mouse (2) Rabbit (5)
Reactivity:	Human (6) E.coli (1)
Application:	IHC-P (4) ICC/IF (2) IF-Tissue (1) IP (3) WB (5) FC (1) ELISA (2)
Isotype:	IgG (5) IgG1 (2)
Conjugation:	Non-conjugated (7)
Clonality:	Monoclonal (4) Monoclonal Antibody (1) Recombinant (4)
Modification:	Unmodified (5)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P85354

	Ron Antibody (YA5046) MST1R; PTK8; RON; Macrophage-stimulating protein receptor; MSP receptor; CDw136; Protein-tyrosine kinase 8; p185-RON; CD antigen CD136	WB, IHC-P, ICC/IF, IP, IF-Tissue	Human
	Ron Antibody (YA5046) is a Rabbit-derived and non-conjugated monoclonal antibody, targeting to Ron.

HY-P82658

	RNA Polymerase beta Antibody (YA2403) gRON; nitB; rif; RNA pol beta; RNA polymerase subunit beta; RON; rpoB; stl; stv; tabD; Transcriptase subunit beta	WB, IP	E.coli
	RNA Polymerase beta Antibody (YA2403) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to RNA Polymerase beta.

HY-P81384

	RON Antibody (YA1129) MST1R; PTK8; RON; Macrophage-stimulating protein receptor; MSP receptor; CDw136; Protein-tyrosine kinase 8; p185-RON; CD136	IHC-P	Human
	RON Antibody (YA1129) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to RON.

HY-P810691

	RON Antibody (YA9944) MST1R; PTK8; RON; Macrophage-stimulating protein receptor; MSP receptor; CDw136; Protein-tyrosine kinase 8; p185-RON; CD136	WB, IHC-P, ICC/IF, IP, FC	Human
	RON Antibody (YA1129) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to RON.

HY-P81384A

	RON Antibody (YA1129)(PBS only) MST1R; PTK8; RON; Macrophage-stimulating protein receptor; MSP receptor; CDw136; Protein-tyrosine kinase 8; p185-RON; CD136	IHC-P	Human
	RON Antibody (YA1129) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to RON.

HY-P84486

	RON Antibody (YA4183) PTK8; CD136; CDw136; MST1R	WB, ELISA	Human
	RON Antibody (YA4183) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to RON.

HY-P84486A

	RON Antibody (YA4183)(PBS only) PTK8; CD136; CDw136; MST1R	WB, ELISA	Human
	RON Antibody (YA4183) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to RON.

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Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Product Name		Classification

HY-RS08730

MST1R Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
MST1R Human Pre-designed siRNA Set A contains three designed siRNAs for MST1R gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS18291

Mst1r Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Mst1r Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mst1r gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS24769

Mst1r Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Mst1r Rat Pre-designed siRNA Set A contains three designed siRNAs for Mst1r gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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