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Cat. No.: HY-118269

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OSI-296

OSI-296 is a potent, oral and selective inhibitor of cMET and RON kinases. OSI-296 shows in vivo efficacy in MKN45 tumor xenografts models and well tolerated.

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CAS No.: 1175296-94-2
Formule: C₂₁H₁₉Cl₂FN₄O₃
Masse moléculaire:465.30

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

OSI-296 Chemical Structure

CAS No.: 1175296-94-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

OSI-296 is a potent, oral and selective inhibitor of cMET and RON kinases. OSI-296 shows in vivo efficacy in MKN45 tumor xenografts models and well tolerated^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HeLa	IC₅₀	0.2 μM Compound: 6, OSI-296	Inhibition of short-form RON (unknown origin) expressed in human HeLa cells assessed as phosphorylated RON levels after 4 hrs Inhibition of short-form RON (unknown origin) expressed in human HeLa cells assessed as phosphorylated RON levels after 4 hrs	[PMID: 23773865]
HT-29	IC₅₀	>10 μM Compound: 6, OSI-296	Inhibition of aurora-B in human HT-29 cells assessed as phosphorylation of histone H3 at Ser10 in presence of mouse plasma Inhibition of aurora-B in human HT-29 cells assessed as phosphorylation of histone H3 at Ser10 in presence of mouse plasma	[PMID: 23773865]
HT-29	IC₅₀	1 μM Compound: 6, OSI-296	Inhibition of aurora-B in human HT-29 cells assessed as phosphorylation of histone H3 at Ser10 Inhibition of aurora-B in human HT-29 cells assessed as phosphorylation of histone H3 at Ser10	[PMID: 23773865]
HUVEC	IC₅₀	6.1 μM Compound: 6, OSI-296	Inhibition of KDR autophosphorylation in HUVEC Inhibition of KDR autophosphorylation in HUVEC	[PMID: 23773865]
KARPAS-299	IC₅₀	0.5 μM Compound: 6, OSI-296	Inhibition of ALK autophosphorylation in human Karpas-299 cells Inhibition of ALK autophosphorylation in human Karpas-299 cells	[PMID: 23773865]
MKN-45	ED₅₀	50 mg/kg Compound: 6, OSI-296	Antitumor activity against human MKN45 cells xenografted in po dosed nu/nu CD1 mouse model assessed as tumor growth inhibition administered qd for 14 days Antitumor activity against human MKN45 cells xenografted in po dosed nu/nu CD1 mouse model assessed as tumor growth inhibition administered qd for 14 days	[PMID: 23773865]
MKN-45	IC₅₀	0.042 μM Compound: 6, OSI-296	Inhibition of cMET in human MKN45 cells assessed as phosphorylated MET levels after 4 hrs Inhibition of cMET in human MKN45 cells assessed as phosphorylated MET levels after 4 hrs	[PMID: 23773865]
MKN-45	IC₅₀	0.13 μM Compound: 6, OSI-296	Antiproliferative activity against human MKN45 cells after 3 days by CellTiter-Glo assay Antiproliferative activity against human MKN45 cells after 3 days by CellTiter-Glo assay	[PMID: 23773865]
MKN-45	IC₅₀	0.6 μM Compound: 6, OSI-296	Inhibition of cMET in human MKN45 cells assessed as phosphorylated MET levels after 4 hrs in presence of mouse plasma Inhibition of cMET in human MKN45 cells assessed as phosphorylated MET levels after 4 hrs in presence of mouse plasma	[PMID: 23773865]

Chemical Information

CAS No. 1175296-94-2
Masse moléculaire 465.30
Formule C₂₁H₁₉Cl₂FN₄O₃
SMILES

O=C(N)N1CC=C(CC1)C2=COC3=C2C=NC(N)=C3O[C@H](C)C4=C(C=CC(F)=C4Cl)Cl
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Steinig AG, et al. Novel 6-aminofuro[3,2-c]pyridines as potent, orally efficacious inhibitors of cMET and RON kinases. Bioorg Med Chem Lett. 2013;23(15):4381-4387. [Content Brief]

Calculators

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Molecular Weight Molecular Weight

Calculateur de dilution

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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