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製品番号: HY-118269

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OSI-296

OSI-296 is a potent, oral and selective inhibitor of cMET and RON kinases. OSI-296 shows in vivo efficacy in MKN45 tumor xenografts models and well tolerated.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 1175296-94-2
分子式: C₂₁H₁₉Cl₂FN₄O₃
分子量:465.30

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

OSI-296 構造式

CAS 番号: 1175296-94-2

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

OSI-296 is a potent, oral and selective inhibitor of cMET and RON kinases. OSI-296 shows in vivo efficacy in MKN45 tumor xenografts models and well tolerated^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HeLa	IC₅₀	0.2 μM Compound: 6, OSI-296	Inhibition of short-form RON (unknown origin) expressed in human HeLa cells assessed as phosphorylated RON levels after 4 hrs Inhibition of short-form RON (unknown origin) expressed in human HeLa cells assessed as phosphorylated RON levels after 4 hrs	[PMID: 23773865]
HT-29	IC₅₀	>10 μM Compound: 6, OSI-296	Inhibition of aurora-B in human HT-29 cells assessed as phosphorylation of histone H3 at Ser10 in presence of mouse plasma Inhibition of aurora-B in human HT-29 cells assessed as phosphorylation of histone H3 at Ser10 in presence of mouse plasma	[PMID: 23773865]
HT-29	IC₅₀	1 μM Compound: 6, OSI-296	Inhibition of aurora-B in human HT-29 cells assessed as phosphorylation of histone H3 at Ser10 Inhibition of aurora-B in human HT-29 cells assessed as phosphorylation of histone H3 at Ser10	[PMID: 23773865]
HUVEC	IC₅₀	6.1 μM Compound: 6, OSI-296	Inhibition of KDR autophosphorylation in HUVEC Inhibition of KDR autophosphorylation in HUVEC	[PMID: 23773865]
KARPAS-299	IC₅₀	0.5 μM Compound: 6, OSI-296	Inhibition of ALK autophosphorylation in human Karpas-299 cells Inhibition of ALK autophosphorylation in human Karpas-299 cells	[PMID: 23773865]
MKN-45	ED₅₀	50 mg/kg Compound: 6, OSI-296	Antitumor activity against human MKN45 cells xenografted in po dosed nu/nu CD1 mouse model assessed as tumor growth inhibition administered qd for 14 days Antitumor activity against human MKN45 cells xenografted in po dosed nu/nu CD1 mouse model assessed as tumor growth inhibition administered qd for 14 days	[PMID: 23773865]
MKN-45	IC₅₀	0.042 μM Compound: 6, OSI-296	Inhibition of cMET in human MKN45 cells assessed as phosphorylated MET levels after 4 hrs Inhibition of cMET in human MKN45 cells assessed as phosphorylated MET levels after 4 hrs	[PMID: 23773865]
MKN-45	IC₅₀	0.13 μM Compound: 6, OSI-296	Antiproliferative activity against human MKN45 cells after 3 days by CellTiter-Glo assay Antiproliferative activity against human MKN45 cells after 3 days by CellTiter-Glo assay	[PMID: 23773865]
MKN-45	IC₅₀	0.6 μM Compound: 6, OSI-296	Inhibition of cMET in human MKN45 cells assessed as phosphorylated MET levels after 4 hrs in presence of mouse plasma Inhibition of cMET in human MKN45 cells assessed as phosphorylated MET levels after 4 hrs in presence of mouse plasma	[PMID: 23773865]

化学情報

CAS 番号 1175296-94-2
分子量 465.30
分子式 C₂₁H₁₉Cl₂FN₄O₃
SMILES

O=C(N)N1CC=C(CC1)C2=COC3=C2C=NC(N)=C3O[C@H](C)C4=C(C=CC(F)=C4Cl)Cl
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (269 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Steinig AG, et al. Novel 6-aminofuro[3,2-c]pyridines as potent, orally efficacious inhibitors of cMET and RON kinases. Bioorg Med Chem Lett. 2013;23(15):4381-4387. [Content Brief]

Calculators

モル濃度計算機

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分子量分子量

希釈計算機

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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