1025720-94-8
Chemical Structure
BMS 777607
Synonym(s): BMS 817378
- CAS No.: 1025720-94-8
- Formula:C25H19ClF2N4O4
- Molecular Weight:512.89
IUPAC Name: N-(4-((2-amino-3-chloropyridin-4-yl)oxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide
InChIKey: VNBRGSXVFBYQNN-UHFFFAOYSA-N
SMILES: O=C(NC1=CC=C(C(F)=C1)OC2=C(C(N)=NC=C2)Cl)C3=C(C=CN(C3=O)C4=CC=C(C=C4)F)OCC
Biological Activity: BMS 777607 (BMS 817378) is a Met-related inhibitor for c-Met, Axl, Ron and Tyro3 with IC50s of 3.9 nM, 1.1 nM, 1.8 nM and 4.3 nM, respectively, and 40-fold more selective for Met-related targets than Lck, VEGFR-2, and TrkA/B, with more than 500-fold greater selectivity versus all other receptor and non receptor kinases[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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BMS 777607 | 99.36% | BMS 777607 (BMS 817378) is a Met-related inhibitor for c-Met, Axl, Ron and Tyro3 with IC50s of 3.9 nM, 1.1 nM, 1.8 nM and 4.3 nM, respectively, and 40-fold more selective for Met-related targets than Lck, VEGFR-2, and TrkA/B, with more than 500-fold greater selectivity versus all other receptor and non receptor kinases. | ||||||||||||||||||||
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Similarity Score 0.65
HY-10497RBMS-794833 (Standard) -
Similarity Score 0.64
HY-18309MET kinase-IN-4 -
Similarity Score 0.63
HY-18711SCR-1481B1 -
Similarity Score 0.62
HY-155812Tyrosine kinase-IN-6 -
Similarity Score 0.56
HY-131064RIPK3-IN-1 -
Similarity Score 0.55
HY-100946RCEP-40783 (Standard) -
Similarity Score 0.55
HY-146884MET kinase-IN-3 -
Similarity Score 0.55
HY-114356BPI-9016M -
Similarity Score 0.55
HY-15514Merestinib -
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References
- [1]. Schroeder GM, et al. Discovery of N-(4-(2-amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide (BMS-777607), a selective and orally efficacious inhibitor of the Met kinase superfamily. J Med Chem. 2009 Mar 12;52(5):1251-4. [Content Brief]
