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Solanum nigrum

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (3) Apoptosis (3) Autophagy (2) Biochemical Assay Reagents (1) COX (2) EGFR (1) Endogenous Metabolite (1) ERK (1) GSK-3 (1) Hedgehog (2) MMP (2) mTOR (2) NF-κB (2) NO Synthase (3) Reference Standards (2)
By Research Areas:	Cancer (8) Inflammation/Immunology (3) Metabolic Disease (1)

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Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N6602

α-Solanine 3 Publications Verification	Apoptosis Autophagy Akt mTOR MMP NO Synthase COX NF-κB	Inflammation/Immunology Cancer
α-solanine, a bioactive component and one of the major steroidal glycoalkaloids in Solanum nigrum, has been observed to inhibit growth and induce apoptosis in cancer cells .

HY-N2322

Khasianine 3 Publications Verification	Others	Cancer
Khasianine is a steroidal glycoalkaloid which is obtained from black nightshade (Solanum Nigrum L.), which displays antitumor activity.

HY-N1917

alpha-Solamarine	Others	Metabolic Disease
Alpha-Solamarine is a glycoalkaloid isolated from Solanum nigrum .

HY-N6602R

α-Solanine (Standard)	Reference Standards Apoptosis Akt mTOR MMP NO Synthase COX NF-κB Autophagy	Inflammation/Immunology Cancer
α-Solanine (Standard) is the analytical standard of α-Solanine. This product is intended for research and analytical applications. α-solanine, a bioactive component and one of the major steroidal glycoalkaloids in Solanum nigrum, has been observed to inhibit growth and induce apoptosis in cancer cells .

HY-N11912

Soladulcoside A	Biochemical Assay Reagents	Cancer
Soladulcoside A is a steroidal glycoside and antineoplastic agent that can be obtained from the whole plant of Solanum nigrum. Soladulcoside A can inhibit A549 cells and has the potential to study cancers such as non-small cell lung cancer (NSCLC) .

HY-N2322R

Khasianine (Standard)	Reference Standards Others	Cancer
Khasianine (Standard) is the analytical standard of Khasianine. This product is intended for research and analytical applications. Khasianine is a steroidal glycoalkaloid which is obtained from black nightshade (Solanum Nigrum L.), which displays antitumor activity.

HY-N8270

Physalin H	Hedgehog Endogenous Metabolite	Cancer
Physalin H is a natural product that can be isolated from Solanum nigrum. Physalin H is an inhibitor of Hedgehog (Hh) signaling and it disrupts GLI1-DNA-complex formation. Physalin H inhibits GLI1 transcription with an IC₅₀ value of 0.7 μM. Physalin H shows cytotoxicity to PANC1 and DU145 cells with IC₅₀ values of 5.7 and 6.8 μM, respectively .

HY-N19427

25S-Anguivioside XV	NO Synthase	Inflammation/Immunology Cancer
25S-Anguivioside XV (Compound 8) is a steroidal glycoside. 25S-Anguivioside XV is isolated from the unripe berries of Solanum nigrum L. 25S-Anguivioside XV inhibits LPS-induced NO production with an IC₅₀ of 49.35 μM. 25S-Anguivioside XV exhibits antiproliferative activity against hepatoma cells .

HY-N9684

Degalactotigonin	EGFR GSK-3 Hedgehog Akt ERK Apoptosis	Cancer
Degalactotigonin is a saponin-selective inhibitor targeting the EGFR, GSK3β and Hedgehog/Gli1 pathways and can be isolated from Solanum nigrum (Solanum nigrum). Degalactotigonin inhibits EGFR phosphorylation and the downstream Akt/ERK signaling pathway, and at the same time inhibits the Hedgehog/Gli1 pathway through GSK3β inactivation, thereby inducing cancer cell apoptosis, arresting the cell cycle, and inhibiting migration and invasion. Degalactotigonin can be used in targeted research on malignant tumors such as pancreatic cancer and osteosarcoma .

α-Solanine 3 Publications Verification	Classification of Application Fields Solanum nigrum Linn. Solanaceae Plants Disease Research Fields Steroids Source Classification Cancer	Apoptosis Autophagy Akt mTOR MMP NO Synthase COX NF-κB
α-solanine, a bioactive component and one of the major steroidal glycoalkaloids in Solanum nigrum, has been observed to inhibit growth and induce apoptosis in cancer cells .

Khasianine 3 Publications Verification	Alkaloids Piperidine Alkaloids Classification of Application Fields Solanum nigrum Linn. Solanaceae Plants Disease Research Fields Source Classification Cancer	Others
Khasianine is a steroidal glycoalkaloid which is obtained from black nightshade (Solanum Nigrum L.), which displays antitumor activity.

alpha-Solamarine	Alkaloids Piperidine Alkaloids Structural Classification Classification of Application Fields Solanum nigrum Linn. Metabolic Disease Solanaceae Plants Disease Research Fields Source Classification	Others
Alpha-Solamarine is a glycoalkaloid isolated from Solanum nigrum .

α-Solanine (Standard)	Structural Classification Solanum nigrum Linn. Solanaceae Plants Steroids Source Classification	Reference Standards Apoptosis Akt mTOR MMP NO Synthase COX NF-κB Autophagy
α-Solanine (Standard) is the analytical standard of α-Solanine. This product is intended for research and analytical applications. α-solanine, a bioactive component and one of the major steroidal glycoalkaloids in Solanum nigrum, has been observed to inhibit growth and induce apoptosis in cancer cells .

Soladulcoside A	Solanum nigrum Linn. Plants Solanaceae Steroids Source Classification	Biochemical Assay Reagents
Soladulcoside A is a steroidal glycoside and antineoplastic agent that can be obtained from the whole plant of Solanum nigrum. Soladulcoside A can inhibit A549 cells and has the potential to study cancers such as non-small cell lung cancer (NSCLC) .

Khasianine (Standard)	Alkaloids Piperidine Alkaloids Solanum nigrum Linn. Solanaceae Plants Source Classification	Reference Standards Others
Khasianine (Standard) is the analytical standard of Khasianine. This product is intended for research and analytical applications. Khasianine is a steroidal glycoalkaloid which is obtained from black nightshade (Solanum Nigrum L.), which displays antitumor activity.

Physalin H	Cardiacglycosides Solanum nigrum Linn. Plants Solanaceae Steroids Source Classification	Hedgehog Endogenous Metabolite
Physalin H is a natural product that can be isolated from Solanum nigrum. Physalin H is an inhibitor of Hedgehog (Hh) signaling and it disrupts GLI1-DNA-complex formation. Physalin H inhibits GLI1 transcription with an IC₅₀ value of 0.7 μM. Physalin H shows cytotoxicity to PANC1 and DU145 cells with IC₅₀ values of 5.7 and 6.8 μM, respectively .

25S-Anguivioside XV	Structural Classification Solanum nigrum Linn. Solanaceae Plants Steroids Source Classification	NO Synthase
25S-Anguivioside XV (Compound 8) is a steroidal glycoside. 25S-Anguivioside XV is isolated from the unripe berries of Solanum nigrum L. 25S-Anguivioside XV inhibits LPS-induced NO production with an IC₅₀ of 49.35 μM. 25S-Anguivioside XV exhibits antiproliferative activity against hepatoma cells .

Degalactotigonin	Plantaginaceae Digitalis purpurea L. Structural Classification Natural Products Plants Source Classification	EGFR GSK-3 Hedgehog Akt ERK Apoptosis
Degalactotigonin is a saponin-selective inhibitor targeting the EGFR, GSK3β and Hedgehog/Gli1 pathways and can be isolated from Solanum nigrum (Solanum nigrum). Degalactotigonin inhibits EGFR phosphorylation and the downstream Akt/ERK signaling pathway, and at the same time inhibits the Hedgehog/Gli1 pathway through GSK3β inactivation, thereby inducing cancer cell apoptosis, arresting the cell cycle, and inhibiting migration and invasion. Degalactotigonin can be used in targeted research on malignant tumors such as pancreatic cancer and osteosarcoma .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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Solanum nigrum

Inhibitors & Agonists

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Natural
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