1 Result for "

TNIK-IN-10

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "TNIK-IN-10" in MCE Product Catalog:

Cat. No.: HY-181930
CAS No.: 3112758-72-9
Target:  

Wnt c-Myc Apoptosis

Research Areas:  

Cancer

TNIK-IN-10 (Compound N15) is a TNIK inhibitor with an IC50 of 0.49 nM against human TNIK. TNIK-IN-10 inhibits the enzymatic activity of TNIK, downregulates the expression of Wnt pathway target genes c-Myc and AXIN2, and reduces the protein expression of LRP5 and LRP6. TNIK-IN-10 induces apoptosis. TNIK-IN-10 exhibits anticancer activity against colorectal cancer. TNIK-IN-10 can be used in the research of colorectal cancer .
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