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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
18 Results for "
antidementia
" in MedChemExpress (MCE) Product Catalog:
Products (18)
18 Results for "antidementia" in MCE Product Catalog:
10
10 Publications Verification
Cat. No.: HY-B0763
CAS No.: 50847-11-5
Synonyms: KC-404; AV-411; MN-166
Target:
Research Areas:
Ibudilast (KC-404; AV-411; MN-166) is a cyclic AMP phosphodiesterase (PDE) inhibitor. Ibudilast has platelet anti-aggregatory effects. Ibudilast can be used for the research of asthma for its inhibitory effects on tracheal smooth muscle contractility. Ibudilast may be a useful neuroprotective and anti-dementia agent counteracting neurotoxicity in activated microglia .
6
6 Cited Publications
Cat. No.: HY-16969
CAS No.: 1401708-83-5
Synonyms: PNB-0408; N-hexanoic-Try-Ile-(6)-amino hexanoic amide; Hexanoyl-Tyr-Ile-Ahx-NH2
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Dihexa, an oligopeptide drug, is an orally active and blood-brain barrier-permeable angiotensin IV analog. Dihexa binds to hepatocyte growth factor (HGF) with high affinity (Kd=65 pM) and potentiates its activity at its receptor, c-Met. Dihexa exhibits excellent antidementia activity and improves cognitive function in animal models. Dihexa may have therapeutic potential as a treatment Alzheimer’s disease .
3
3 Cited Publications
Synonyms: Hyperforin DCHA
Target:
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1
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Tenilsetam (CAS 997) is an antidementia compound. Tenilsetam is an advanced glycation end product (AGE) inhibitor. Tenilsetam inhibits early retinopathy in experimental diabetes rats .
Cat. No.: HY-116330
CAS No.: 11079-53-1
Category:
Anti-inflammation/Immunoregulatory Antibiotics Guttiferae Hyperlcurn perforatum L. Plants Disease Research Anticancer
Target:
Target:
Research Areas:
FK962 is an enhancer of somatostatin release, exerts cognitive-enhancing actions. Anti-dementia properties .
Cat. No.: HY-19225A
CAS No.: 155773-59-4
Synonyms: KA-672; Anseculin
Research Areas:
Ensaculin free base (KA-672) is a NMDA antagonist and have high affinities to serotonergic 5-HT1A and 5-HT7 receptors, adrenergic α1, and dopaminergic D2 and D3 receptors. Ensaculin free base is a memory-enhancing agent. Ensaculin free base has the potential as an antidementia agent acting on various transmitter systems .
Cat. No.: HY-105435
CAS No.: 133920-65-7
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FR121196 is a cognitive enhancer, and ameliorates Scopolamine (HY-N0296)-induced memory deficit. FR121196 is an antidementia compound .
Cat. No.: HY-19225
CAS No.: 209969-60-8
Synonyms: KA-672 hydrochloride; Anseculin hydrochloride
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Research Areas:
Ensaculin is an NMDA receptor channel blocker. Ensaculin has neuroprotective effects in NMDA toxicity models and promotes neuronal growth in primary cultures of rat brain cells. Ensaculin has the potential to be developed as an anti-dementia drug that acts on various neurotransmitter systems .
Cat. No.: HY-100618R
CAS No.: 555-55-5
Cat. No.: HY-B0763S1
CAS No.: 2713301-45-0
Cat. No.: HY-B0763R
CAS No.: 50847-11-5
Synonyms: KC-404 (Standard); AV-411 (Standard); MN-166 (Standard)
Research Areas:
Ibudilast (Standard) is the analytical standard of Ibudilast. This product is intended for research and analytical applications. Ibudilast (KC-404; AV-411; MN-166) is a cyclic AMP phosphodiesterase (PDE) inhibitor. Ibudilast has platelet anti-aggregatory effects. Ibudilast can be used for the research of asthma for its inhibitory effects on tracheal smooth muscle contractility. Ibudilast may be a useful neuroprotective and anti-dementia agent counteracting neurotoxicity in activated microglia .
Cat. No.: HY-B0763S
CAS No.: 102064-45-9
Cat. No.: HY-B0763S2
CAS No.: 1204192-90-4
Synonyms: KC-404-d7-1; AV-411-d7-1; MN-166-d7-1
Cat. No.: HY-15116
CAS No.: 117427-00-6
Target:
Research Areas:
ONO 1603, a novel prolyl endopeptidase inhibitor investigated as a potential antidementia drug, demonstrated neuroprotective and neurotrophic effects in cerebellar granule cells similar to tetrahydroaminoacridine (THA). At a concentration of 0.03 microM, ONO 1603 promoted neuronal survival, enhanced neurite outgrowth, increased m3-muscarinic acetylcholine receptor (mAChR) mRNA levels, and stimulated mAChR-mediated signaling pathways. These findings suggest that ONO 1603 shares pharmacological similarities with THA, indicating its potential as a therapeutic agent for Alzheimer's disease by enhancing cholinergic neurotransmission and neuronal function .
Cat. No.: HY-118275
CAS No.: 133920-70-4
Target:
Research Areas:
FK960 is a potential anti-dementia agent that reverses the reduction in cerebral blood flow (rCBF) caused by sensory stimulation by enhancing cholinergic neurotransmission. In macaque experiments, physostigmine (AChE inhibitor; HY-N6608) was able to completely eliminate the rCBF in the sensory cortex increased by vibrotactile stimulation. FK960 (1-1000 μg/kg) can restore the eliminated rCBF response, and the action time can last for 1 hour. However, FK960 cannot restore the rCBF response eliminated by HA-966 (NMDA modulator; HY-100822), indicating that its function is not dependent on non-glutamatergic neurotransmission.
Cat. No.: HY-116330AR
CAS No.: 238074-03-8
Synonyms: Hyperforin DCHA (Standard)
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
