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FK962 

Cat. No.: HY-133025
Handling Instructions

FK962 is an enhancer of somatostatin release, exerts cognitive-enhancing actions. Anti-dementia properties.

For research use only. We do not sell to patients.

FK962 Chemical Structure

FK962 Chemical Structure

CAS No. : 283167-06-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 105 In-stock
Estimated Time of Arrival: December 31
5 mg USD 180 In-stock
Estimated Time of Arrival: December 31
10 mg USD 300 In-stock
Estimated Time of Arrival: December 31
25 mg USD 600 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

FK962 is an enhancer of somatostatin release, exerts cognitive-enhancing actions. Anti-dementia properties[1].

IC50 & Target

Somatostatin release[1]

In Vitro

FK962 (1 nM-1 μM) significantly enhances high K+-evoked somatostatin release from rat hippocampal slices. FK962 also significantly reduces somatostatin-induced inhibition of Ca2+ channels at 1-100 nM in single rat hippocampal neurons using whole-cell patch-clamp[1].

In Vivo

FK962 (0.1, 0.3 or 1.0 mg/kg; i.p.) and Donepezil (a single dose of 1 mg/kg) act synergistically to improve cognition in rats: as an add-on therapy for Alzheimer's disease[2].

Animal Model: Male Lister Hooded rats, weighing approximately 270-300[2]
Dosage: 0.1, 0.3 or 1.0 mg/kg; Donepezil was given as a single dose of 1 mg/kg
Administration: Administered i.p.
Result: Resulted in minimal cognition enhancement when given separately. Combination showed a significantly greater effect on cognition.
Molecular Weight

264.30

Formula

C₁₄H₁₇FN₂O₂

CAS No.

283167-06-6

SMILES

O=C(NC1CCN(C(C)=O)CC1)C2=CC=C(F)C=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

FK962FK 962FK-962OtherssomatostatincognitiveAlzheimerInhibitorinhibitorinhibit

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FK962
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