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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
7 Results for "
autophagy monitoring
" in MedChemExpress (MCE) Product Catalog:
Products (7)
7 Results for "autophagy monitoring" in MCE Product Catalog:
4
4 Cited Publications
CA-5f is a potent late-stage macroautophagy/autophagy inhibitor via inhibiting autophagosome-lysosome fusion. CA-5f increases LC3B-II (a marker to monitor autophagy) and SQSTM1 protein, and also increases ROS production. Anti-tumor activity .
Cat. No.: HY-D2971
CAS No.: 2781892-92-8
Cat. No.: HY-D3005
Cat. No.: HY-151536
CAS No.: 2922973-15-5
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Research Areas:
meso-Benzothiazole-BODIPY 505/515 is a boron dipyrromethenes (BODIPY) -based fluorescent probemonitor cellular viscosity changes and autophagy. meso-Benzothiazole-BODIPY 505/515 can be used for the research of Alzheimer’s diseases, lysosomal storage diseases and neural degeneration diseases .
Cat. No.: HY-D3131
CAS No.: 2243068-74-6
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Research Areas:
Lyso-MPCB is a two-photon fluorescent probe used for lysosomal pH detection and autophagy monitoring. Lyso-MPCB integrates a benzimidazole pH-responsive group and a morpholine lysosome-targeting group, enabling specific localization to lysosomes. The fluorescence properties of Lyso-MPCB change with protonation, exhibiting blue fluorescence under alkaline conditions and green fluorescence under acidic conditions .
Cat. No.: HY-D3109
CAS No.: 148043-22-5
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pH-Ap-1 is a fluorescent probe used for ratiometric monitoring of pH fluctuations during autophagy in living cells, and it can detect intracellular pH changes in the autophagy process. For fluorescence detection of pH-Ap-1, its excitation wavelength is 475 nm, with an emission wavelength of 538 nm under alkaline conditions and 645 nm under acidic conditions. For intracellular imaging, excitation is performed at 488 nm: the emission light ranging from 500-550 nm is collected via the green channel corresponding to 538 nm, while the emission light ranging from 625-750 nm is collected via the red channel corresponding to 645 nm. pH-Ap-1 exhibits excellent photostability and chemical stability .
Cat. No.: HY-D3087
CAS No.: 1966158-27-9
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Research Areas:
Lyso-OC is a two-photon fluorescent probe that enables real-time monitoring of autophagy through ultrasensitive detection of lysosomal polarity changes. Lyso-OC possesses a coumarin (HY-N0709) solvatochromic group and a morpholine lysosome-targeting group, allowing selective lysosomal localization in living cells. Lyso-OC emits strong fluorescence in low-polarity lysosomes, whereas in high-polarity autolysosomes formed during autophagy, its fluorescence intensity decreases and the emission peak shifts by approximately 30 nm. For two-photon detection, the excitation/emission wavelengths of Lyso-OC are 760/490-550 nm, and its one-photon excitation wavelength is 375 nm. Lyso-OC can be used in cancer-related research .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
