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Results for "

bilirubin

" in MedChemExpress (MCE) Product Catalog:

27

Inhibitors & Agonists

4

Biochemical Assay Reagents

9

Natural
Products

1

Isotope-Labeled Compounds

1

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-N0323
    Bilirubin
    Maximum Cited Publications
    6 Publications Verification

    		 Endogenous Metabolite Metabolic Disease
    Bilirubin is a yellow breakdown product of heme catabolism . Bilirubin exhibits antioxidant and antimutagenic effects .
    Bilirubin
  • HY-135005A
    Biliverdin
    1 Publications Verification

    		 Endogenous Metabolite Inflammation/Immunology
    Biliverdin, a tetrapyrrolic pigment, is a product of heme catabolism. Heme is broken down into Biliverdin and carbon monoxide and iron by heme oxidase. Biliverdin is then quickly broken down to bilirubin by Biliverdin reductase. Biliverdin can mediate the protective effects of HO-1 in many disease models including IRI and organ transplantation. Biliverdin exhibits anti-mutagenic, an antioxidant, anti-inflammatory, and immunosuppressant properties .
    Biliverdin
  • HY-135005
    Biliverdin hydrochloride
    1 Publications Verification

    		 Endogenous Metabolite Inflammation/Immunology
    Biliverdin hydrochloride, a tetrapyrrolic pigment, is a product of heme catabolism. Heme is broken down into Biliverdin and carbon monoxide and iron by heme oxidase. Biliverdin hydrochloride is then quickly broken down to bilirubin by Biliverdin reductase. Biliverdin hydrochloride is anti-mutagenic, an antioxidant, anti-inflammatory, and immunosuppressant .
    Biliverdin hydrochloride
  • HY-N8332
    Bile extract

    Ox bile extract

    		 Bacterial DNA/RNA Synthesis Infection
    Bile extract (Ox bile extract) is a complex mixture of substances, containing bile acids, cholesterol, and bilirubin. Bile extract has antimicrobial activity and can induce DNA damage and degrade viral and bacterial membranes. Bile extract can be used in bacterial culture media as a selective inhibitor for the isolation and identification of pathogens .
    Bile extract
  • HY-147041
    Selvigaltin
    1 Publications Verification

    GB1211

    		 Galectin Inflammation/Immunology Cancer
    Selvigaltin (GB1211) is an orally active galectin-3 small molecule inhibitor with an IC50 value of 12 nM in rabbits, showing anti-tumor activity. Selvigaltin decreases galectin-3 levels in the liver and reduces biomarkers of liver function (AST, ALT, bilirubin), inflammation (cells foci) and fibrosis (PSR, SHG), as well as decreasing the mRNA and protein expression of several key inflammation and fibrosis biomarkers (IL6, TGFβ3, SNAI2, collagen). Selvigaltin restores T-cell activity and induces less tumors and metastasis .
    Selvigaltin
  • HY-150097
    Recombinant Human Serum Albumin(rHSA)

    		Biochemical Assay Reagents Metabolic Disease Inflammation/Immunology Cancer
    Recombinant Human Serum Albumin (rHSA) is a non-glycosylated monomeric plasma protein that acts as a core factor for maintaining plasma colloid osmotic pressure. Recombinant Human Serum Albumin (rHSA) possesses multiple physiological functions including carrier, metabolic regulation, detoxification, antioxidation and enzyme mimicking. Recombinant Human Serum Albumin (rHSA) not only scavenges reactive oxygen and nitrogen species via specific residues and binds a variety of endogenous and exogenous compounds to maintain redox homeostasis, but also serves as a biomarker for multiple diseases such as cancer and inflammation. Recombinant Human Serum Albumin (rHSA) broadly supports the development of implantable materials, surgical adhesives and ligand capture, and can be used for research on critical illnesses including hypovolemia, liver failure, severe sepsis and various types of trauma resuscitation .
    Recombinant Human Serum Albumin(rHSA)
  • HY-N11424
    Bilirubin diglucuronide

    		Drug Metabolite Glycosyltransferase Metabolic Disease
    Bilirubin diglucuronide is a bilirubin glycoside conjugate with a 1-O-acyl β-D-glucuronide structure. Bilirubin diglucuronide is the major conjugated bilirubin (HY-N0323) and predominant pigment excreted in the bile of adult humans, rats, dogs and cats. Bilirubin diglucuronide is mainly synthesized via UDP-glucuronosyltransferase-mediated transfer of glucuronic acid from UDP-glucuronic acid to bilirubin monoglucuronide, or via enzymatic disproportionation of two moles of bilirubin monoglucuronide (predominantly producing the IXα configuration). In addition, Bilirubin diglucuronide can also be synthesized from bilirubin or its monoglucuronide in a UDP-glucuronic acid-dependent manner. Pretreatment with phenobarbital significantly enhances the formation process of Bilirubin diglucuronide .
    Bilirubin diglucuronide
  • HY-P2888
    Bilirubin oxidase

    BOD

    		 Biochemical Assay Reagents Metabolic Disease
    Bilirubin oxidase (BOD) is an electrocatalyst with oxygen removal activity. Bilirubin oxidase can catalyze the oxidation of bilirubin to biliverdin. Bilirubin oxidase participates in the metabolism of porphyrins and chlorophyll, and acts as a catalyst for oxygen reduction. Bilirubin oxidase can serve as a component of a single-enzyme oxygen removal system for reductase-based voltammetric biosensors .
    Bilirubin oxidase
  • HY-N5092
    7-Methylcoumarin

    		Reactive Oxygen Species (ROS) Cytochrome P450 Metabolic Disease
    7-Methylcoumarin is a coumarin derivative with potent hepatoprotective and antioxidant properties. 7-Methylcoumarin is a mechanism-based inhibitor for CYP2A6. 7-Methylcoumarin significantly decreases alanine aminotransferase (ALT), aspartate aminotransferase (AST), and serum bilirubin (TB) in rats with CCl4-induced liver damage, whilst restoring total protein (TP) and albumin (TA) levels in serum as well as preventing oxidative stress. 7-Methylcoumarin can decline mitotic activity of A. sativum promeristem .
    7-Methylcoumarin
  • HY-160250
    UGT1A1-IN-1

    		Fluorescent Dye UGT Metabolic Disease
    UGT1A1-IN-1 is a UGT1A1 inhibitor and fluorescent probe (Ex=370 nm, Em=520 nm), with an IC50 of 1.33 μM and a Ki of 5.02 μM. UGT1A1-IN-1 is selectively glucuronidated by UGT1A1 at the bilirubin homologous binding site, and its PET effect is blocked along with this reaction, triggering fluorescence changes. UGT1A1-IN-1 can serve as a substitute for bilirubin to detect UGT1A1 activity and perform high-throughput screening of UGT1A1 modulators .
    UGT1A1-IN-1
  • HY-129834
    Bilirubin Conjugate disodium

    		Drug Metabolite Metabolic Disease
    Bilirubin Conjugate disodium is a ditaurate derivative of Bilirubin. Bilirubin, a major end product of heme breakdown, is an important constituent of bile .
    Bilirubin Conjugate disodium
  • HY-W743522
    Bilirubin-d4 (Technical Grade)

    		Isotope-Labeled Compounds Others
    Bilirubin-d4 (Technical Grade) is the deuterium labeled Bilirubin.
    Bilirubin-d4 (Technical Grade)
  • HY-125954A
    Uridine diphosphate glucuronic acid ammonium

    UDP-α-D-glucuronic acid ammonium

    		 Endogenous Metabolite Metabolic Disease
    Uridine diphosphate glucuronic acid ammonium (UDP-α-D-glucuronic acid ammonium) is a glucuronic acid donor. Uridine diphosphate glucuronic acid ammonium transfers its glucuronic acid moiety to acceptor molecules, thereby forming "ether" glucuronides, while being converted into uridine 5'-pyrophosphate. Uridine diphosphate glucuronic acid ammonium serves as a substrate for Arabidopsis UDP-GlcA 4-epimerase 1, and undergoes reversible 4-epimerization to generate UDP-α-D-galacturonic acid .
    Uridine diphosphate glucuronic acid ammonium
  • HY-46846
    Styrene-divinylbenzene sulfonated copolymer

    		Environmental Pollutants Biochemical Assay Reagents Others
    Styrene-divinylbenzene sulfonated copolymer is a cation exchange resin prepared from sulfonic acid group-containing microporous styrene/divinylbenzene (DVB) copolymer. Styrene-divinylbenzene sulfonated copolymer serves as the core matrix material for most bilirubin adsorbents. It also acts as a hydrophilic cell immobilization carrier, whose porous structure provides an ideal environment for microbial growth and biochemical reactions .
    Styrene-divinylbenzene sulfonated copolymer
  • HY-145728
    Alicaforsen

    ISIS-2302

    		 Integrin Inflammation/Immunology
    Alicaforsen is an oligonucleotide and immunostimulant targeting human ICAM-1 mRNA. Alicaforsen hybridizes to specific sites to reduce the expression level of ICAM-1. Alicaforsen is applicable to relevant research on psoriasis, rheumatoid arthritis and inflammatory bowel disease .
    Alicaforsen
  • HY-P2888A
    Bilirubin oxidase, bacillus cereus

    BOD, bacillus cereus

    		 Endogenous Metabolite Metabolic Disease
    Bilirubin oxidase, bacillus cereus is a multi-copper oxidase that catalyzes the oxidation of bilirubin into biliverdin, as well as other tetrapyrroles, phenols, and aryl diamines. Bilirubin oxidase, bacillus cereus can serve as a single-enzyme deoxygenator, catalyzing the direct reduction of oxygen to water in the presence of electron donor substrates, without releasing hydrogen peroxide. Bilirubin oxidase, bacillus cereus can be used to develop enzyme-based biosensors .
    Bilirubin oxidase, bacillus cereus
  • HY-P2888C
    Bilirubin oxidase, Bacillus pumilus

    BOD, Bacillus pumilus

    		 Endogenous Metabolite Metabolic Disease
    Bilirubin oxidase (BOD), Bacillus pumilus is a multicopper oxidase that catalyzes the oxidation of bilirubin to biliverdin, as well as other tetrapyrrole, phenols, and aryl diamines. Bilirubin oxidase, Bacillus pumilus can serve as a single-enzyme deoxygenator, catalyzing the direct reduction of oxygen to water in the presence of electron donor substrates, without releasing hydrogen peroxide. Bilirubin oxidase, Bacillus pumilus can be used to develop enzyme-based biosensors .
    Bilirubin oxidase, Bacillus pumilus
  • HY-P2888B
    Bilirubin oxidase, Magnaporthe oryzae

    BOD, Magnaporthe oryzae

    		 Endogenous Metabolite Metabolic Disease
    Bilirubin oxidase (BOD), Magnaporthe oryza is a multi-copper oxidase that catalyzes the oxidation of bilirubin to biliverdin and reduces molecular oxygen to water. Bilirubin oxidase, Magnaporthe oryzae can participate in the metabolism of porphyrin and chlorophyll, and is widely used in biochemical research as a catalyst for oxygen reduction .
    Bilirubin oxidase, Magnaporthe oryzae
  • HY-W721484
    Stercobilinogen

    		Endogenous Metabolite Metabolic Disease
    Stercobilinogen is a gut microorganisms' metabolite of bilirubin (HY-N0323). Stercobilinogen can be used for metabolic research .
    Stercobilinogen
  • HY-160800
    Bilirubin ditaurine

    BR-DT

    		 Drug Derivative Inflammation/Immunology
    Bilirubin ditaurine (BR-DT) is a mimetic compound of conjugated bilirubin. Bilirubin ditaurine can completely prevent the oxidation of phosphatidylcholine induced by reactive oxygen species in multilayer liposomes or micelles. Bilirubin ditaurine does not significantly decompose 18:2-OOH on its own, but it can greatly accelerate the decomposition of 18:2-OOH catalyzed by copper ions. Bilirubin ditaurine can be used to study the detoxification effect of conjugated bilirubin .
    Bilirubin ditaurine
  • HY-125129
    Carlinoside

    		Keap1-Nrf2 Others
    Carlinoside is a flavone glycoside with hepatoprotective efficiency. Carlinoside reduces hepatic bilirubin accumulation by stimulating bilirubin-UGT activity through Nrf2 gene expression. Carlinoside has the potential to intervene hyperbilirubinemia due to liver dysfunction .
    Carlinoside
  • HY-136973
    Biliverdin dihydrochloride

    		Biochemical Assay Reagents Inflammation/Immunology
    Biliverdin dihydrochloride, a tetrapyrrolic pigment, is a product of heme catabolism. Heme is broken down into Biliverdin dihydrochloride and carbon monoxide and iron by heme oxidase. Biliverdin dihydrochloride is then quickly broken down to bilirubin by Biliverdin hydrochloride reductase. Biliverdin hydrochloride is anti-mutagenic, an antioxidant, anti-inflammatory, and immunosuppressant .
    Biliverdin dihydrochloride
  • HY-135005R
    Biliverdin hydrochloride (Standard)

    		Endogenous Metabolite Inflammation/Immunology
    Biliverdin (hydrochloride) (Standard) is the analytical standard of Biliverdin (hydrochloride). This product is intended for research and analytical applications. Biliverdin hydrochloride, a tetrapyrrolic pigment, is a product of heme catabolism. Heme is broken down into Biliverdin and carbon monoxide and iron by heme oxidase. Biliverdin hydrochloride is then quickly broken down to bilirubin by Biliverdin reductase. Biliverdin hydrochloride is anti-mutagenic, an antioxidant, anti-inflammatory, and immunosuppressant .
    Biliverdin hydrochloride (Standard)
  • HY-P2888D
    Bilirubin Oxidase, Myrothecium verrucaria

    		Biochemical Assay Reagents Metabolic Disease
    Bilirubin Oxidase, Myrothecium verrucaria (EC 1.3.3.5) is a family of oxidoreductases that act on the CH-CH group as a donor and use oxygen as an acceptor. Bilirubin Oxidase, Myrothecium verrucaria (EC 1.3.3.5) is involved in the metabolism of porphyrins and chlorophyll. The two substrates of Bilirubin Oxidase, Myrothecium verrucaria (EC 1.3.3.5) are bilirubin and O2, while its two products are biliverdin and H2O.
    Bilirubin Oxidase, Myrothecium verrucaria
  • HY-N5092R
    7-Methylcoumarin (Standard)

    		Reference Standards Reactive Oxygen Species (ROS) Cytochrome P450 Metabolic Disease
    7-Methylcoumarin (Standard) is the analytical standard of 7-Methylcoumarin. This product is intended for research and analytical applications. 7-Methylcoumarin is a coumarin derivative with potent hepatoprotective and antioxidant properties. 7-Methylcoumarin is a mechanism-based inhibitor for CYP2A6. 7-Methylcoumarin significantly decreases alanine aminotransferase (ALT), aspartate aminotransferase (AST), and serum bilirubin (TB) in rats with CCl4-induced liver damage, whilst restoring total protein (TP) and albumin (TA) levels in serum as well as preventing oxidative stress. 7-Methylcoumarin can decline mitotic activity of A. sativum promeristem .
    7-Methylcoumarin (Standard)
  • HY-E70892
    β-D-Glucuronidase, Bacteria

    		Endogenous Metabolite Metabolic Disease
    β-D-Glucuronidase, Bacteria (EC 3.2.1.31) catalyzes the breakdown of complex carbohydrates. β-D-Glucuronidase, Bacteria (EC 3.2.1.31) converts conjugated bilirubin into the unconjugated form, making bilirubin suitable for reabsorption.
    β-D-Glucuronidase, Bacteria
  • HY-182824
    Sucrose dilaurate

    		Autophagy Others
    Sucrose dilaurate acts as an emulsifier, dispersant and stabilizer. Sucrose dilaurate reduces the release of HMGB1 from UVB-irradiated keratinocytes. Sucrose dilaurate inhibits melanogenesis and decreases bilirubin levels. Sucrose dilaurate induces autophagy in human epidermal keratinocytes, thereby reducing carboxymethyl lysine (CML) levels. Sucrose dilaurate reduces the secretion of insulin-like growth factor-binding protein 3 (IGFBP3) and nerve growth factor (NGF) by senescent keratinocytes. Sucrose dilaurate is investigated as an emulsifier, dispersant or stabilizer in the cosmetics, food and pharmaceutical industries .
    Sucrose dilaurate

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