DPPD
Based on 1 Customer Validation
DPPD (N,N′-Diphenyl-p-phenylenediamine) is an orally active antioxidant. DPPD also acts as a toxic substance and pregnancy disruptor.
For research use only. We do not sell to patients.
- Purity: 98.02%
- CAS No.: 74-31-7
- Formula: C18H16N2
- Molecular Weight:260.33
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HT-22 | EC50 |
7.7 nM
Compound: Fig6, R1C1
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Neuroprotective activity in mouse HT22 cells assessed as protection against glutamate-induced oxidative damage after 24 hrs by MTT assay
Neuroprotective activity in mouse HT22 cells assessed as protection against glutamate-induced oxidative damage after 24 hrs by MTT assay
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[PMID: 24602904] |
DPPD (0.001-1 mg/mL; 0.1 mg/mL with rat liver S9 mix) interferes with bilirubin measurements via the diazo method in male rat serum in a concentration-dependent manner, and this interference is not eliminated by rat liver S9 metabolism[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
DPPD (8-300 mg/kg bw/day; p.o.; daily; 42 days (males); 42-46 days (females)) significantly prolongs gestation length at doses of 50 and 300 mg/kg bw/day in female [Crl:CD(SD)] SPF rats, with the reproductive/developmental NOAEL established at 8 mg/kg bw/day[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Crl:CD(SD) SPF rats (male and female; males 5 weeks old, 152-172 g; females 5 weeks old, 130-147 g)[1]
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Dosage:100 mg/kg bw/day; 300 mg/kg bw/day; 1000 mg/kg bw/day
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Administration:p.o.; daily; 28 days
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Result:Decreased food consumption significantly in the fourth week at 300 and 1000 mg/kg bw/day in male rats.
Decreased food consumption significantly in the third week at 1000 mg/kg bw/day in male rats.
Increased total bilirubin levels significantly at all doses in male rats at the end of dosing period, which resolved during recovery.
Decreased γ-GTP to 0.63 IU/L at 1000 mg/kg bw/day in female rats, within normal background range.
Showed no significant dose-related effects in clinical signs, sensory/motor function, body weight, hematology, urine parameters, organ weights, or histopathology.
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Animal Model:Crl:CD(SD) SPF rats (male and female; males 10 weeks old, 370.2-446.9 g; females 10 weeks old, 220.4-265.2 g, 4-5 day estrous cycles)[1]
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Dosage:8 mg/kg bw/day; 50 mg/kg bw/day; 300 mg/kg bw/day
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Administration:p.o.; daily; 42 days (males); 42-46 days (females)
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Result:Caused piloerection, hypothermia, pale skin, dystocia, and litter loss in some female rats at 300 mg/kg bw/day.
Prolonged gestation length significantly at 50 and 300 mg/kg bw/day (mean 23.0 days vs control 22.4 days).
Showed non-significant dose-dependent decrease in number of pups born, delivery index, number of live pups, birth index, live birth index (day 0 of lactation), number of live pups, and viability index (day 4 of lactation), most marked at 300 mg/kg bw/day.
Showed no effects in male fertility, estrous cycle length, implantation indices, pup body weights, or pup malformations.
Chemical Information
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CAS No. 74-31-7
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Appearance Solid
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Molecular Weight 260.33
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Formula C18H16N2
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Color Light brown to brown
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SMILES
C1(NC2=CC=CC=C2)=CC=C(NC3=CC=CC=C3)C=C1
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Synonyms
N,N′-Diphenyl-p-phenylenediamine
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 100 mg/mL (384.13 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.8413 mL | 19.2064 mL | 38.4128 mL | 96.0320 mL |
| 5 mM | 0.7683 mL | 3.8413 mL | 7.6826 mL | 19.2064 mL | |
| 10 mM | 0.3841 mL | 1.9206 mL | 3.8413 mL | 9.6032 mL | |
| 15 mM | 0.2561 mL | 1.2804 mL | 2.5609 mL | 6.4021 mL | |
| 20 mM | 0.1921 mL | 0.9603 mL | 1.9206 mL | 4.8016 mL | |
| 25 mM | 0.1537 mL | 0.7683 mL | 1.5365 mL | 3.8413 mL | |
| 30 mM | 0.1280 mL | 0.6402 mL | 1.2804 mL | 3.2011 mL | |
| 40 mM | 0.0960 mL | 0.4802 mL | 0.9603 mL | 2.4008 mL | |
| 50 mM | 0.0768 mL | 0.3841 mL | 0.7683 mL | 1.9206 mL | |
| 60 mM | 0.0640 mL | 0.3201 mL | 0.6402 mL | 1.6005 mL | |
| 80 mM | 0.0480 mL | 0.2401 mL | 0.4802 mL | 1.2004 mL | |
| 100 mM | 0.0384 mL | 0.1921 mL | 0.3841 mL | 0.9603 mL |
DPPD Related Classifications
HY-W011787 Related Classifications
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