Biliverdin hydrochloride
Based on 1 publication(s) in Google Scholar
Biliverdin hydrochloride, a tetrapyrrolic pigment, is a product of heme catabolism. Heme is broken down into Biliverdin and carbon monoxide and iron by heme oxidase. Biliverdin hydrochloride is then quickly broken down to bilirubin by Biliverdin reductase. Biliverdin hydrochloride is anti-mutagenic, an antioxidant, anti-inflammatory, and immunosuppressant.
For research use only. We do not sell to patients.
- Purity: 99.3%
- CAS No.: 856699-18-8
- Formula: C33H35ClN4O6
- Molecular Weight:619.11
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Biliverdin hydrochloride
MoreAll Endogenous Metabolite Isoforms
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Biological Activity
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Human Endogenous Metabolite |
Biliverdin hydrochloride is considered a waste product of heme degradation. When red blood cells lyse, either due to hemolytic diseases or by natural apoptosis, heme get released. The heme is metabolized by heme oxygenase using three molecules of oxygen and seven electrons and producing Biliverdin IX-alpha, carbon monoxide, and ferrous iron. The Biliverdin IX-alpha undergoes metabolism to bilirubin IX-alpha via NADPH-dependent Biliverdin reductase[1].
The buildup of Biliverdin hydrochloride has been shown to upregulate the activity of Biliverdin hydrochloride reductase, an enzyme that is a regulator of the innate immune system[1].
Biliverdin hydrochloride downregulates the proliferation of vascular smooth muscle cells and demonstrate an antioxidant effect in the damaged blood vessels. This decreases the formation of the tunica intima of blood vessels and blocks neovascularization and angiogenesis[1].
Biliverdin hydrochloride decreases inflammation by downregulating pro-inflammatory cytokines such as TLR-4 and by stimulating the production of anti-inflammatory cytokines such as IL-10[1].
Biliverdin hydrochloride is a scavenger of hydroxyl peroxide groups showing the antioxidant effects of Biliverdin[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 856699-18-8
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Appearance Solid
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Molecular Weight 619.11
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Formula C33H35ClN4O6
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Color Green to dark green
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SMILES
OC(CCC1=C(C)C(/C=C(N2)/C(C=C)=C(C)C2=O)=N/C1=C\C3=C(C(C)=C(/C=C(N4)/C(C)=C(C=C)C4=O)N3)CCC(O)=O)=O.Cl
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
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J Virol
Seneca Valley virus 3C protease targets the Nrf2/HO-1 pathway to antagonize its antiviral activity. [Abstract]2026 Feb 17;100(2):e0165625. PMID: 41489372
Solvent & Solubility
DMSO : 20 mg/mL (32.30 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : < 0.1 mg/mL (insoluble)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (282 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.6152 mL | 8.0761 mL | 16.1522 mL | 40.3805 mL |
| 5 mM | 0.3230 mL | 1.6152 mL | 3.2304 mL | 8.0761 mL | |
| 10 mM | 0.1615 mL | 0.8076 mL | 1.6152 mL | 4.0381 mL | |
| 15 mM | 0.1077 mL | 0.5384 mL | 1.0768 mL | 2.6920 mL | |
| 20 mM | 0.0808 mL | 0.4038 mL | 0.8076 mL | 2.0190 mL | |
| 25 mM | 0.0646 mL | 0.3230 mL | 0.6461 mL | 1.6152 mL | |
| 30 mM | 0.0538 mL | 0.2692 mL | 0.5384 mL | 1.3460 mL |
Biliverdin hydrochloride Related Classifications
HY-135005 Related Classifications
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