5 Results for "

c-fos/NFATc1 signaling pathway

" in MedChemExpress (MCE) Product Catalog:
Products (5)

5 Results for "c-fos/NFATc1 signaling pathway" in MCE Product Catalog:

2
Bavachalcone
Bavachalcone
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2 Cited Publications
Cat. No.: HY-N0231
CAS No.: 28448-85-3
Synonyms: Broussochalcone B
Category:  

Infection Flavonoids Chalcones Leguminosae Phenols Polyphenols Psoralea corylifolia L. Plants Disease Research Fields

Target:  

Bacterial Antibiotic NF-κB PERK Akt Autophagy Apoptosis

Bavachalcone is a potent inducer of apoptosis. Bavachalcone exerts anticancer activity by promoting autophagy and apoptosis in HepG2 cells. Bavachalcone acts as an anti-neuroinflammatory and antidepressant through the NF-κB pathway. Bavachalcone inhibits osteoclasts by interfering with ERK and Akt signaling pathways and the expression of c-Fos and NFATc1. Bavachalcone exhibits a significant inhibitory effect on baculovirus-expressed BACE-1 in vitro .
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Ganomycin I
Ganomycin I
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Cat. No.: HY-N10076
CAS No.: 1191255-15-8
Category:  

Microorganisms Phenols Polyphenols

Target:  

HMG-CoA Reductase (HMGCR) Glycosidase HIV Protease

Ganomycin I is a non-competitive dual inhibitor of α-glucosidase and HMG-CoA reductase, with IC50 values of 0.3 μM and 12.3 μM, respectively. Ganomycin I inhibits HIV-1 protease, with an IC50 of 7.5 μg/mL. Ganomycin I also suppresses RANKL-induced osteoclast differentiation and bone resorption by inhibiting the activation of ERK, JNK and p38 MAPK, as well as downregulating the c-Fos/NFATc1 signaling pathway. Ganomycin I exhibits antibacterial activity against Gram-positive bacteria, and shows weak activity against Mycobacterium tuberculosis H37Ra. It can be used in research related to metabolic diseases, bone metabolism and anti-infection .
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Bavachalcone (Standard)
Bavachalcone (Standard)
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Cat. No.: HY-N0231R
CAS No.: 28448-85-3
Synonyms: Broussochalcone B (Standard)
Category:  

Flavonoids Chalcones Leguminosae Phenols Polyphenols Psoralea corylifolia L. Plants

Target:  

Reference Standards Bacterial Antibiotic NF-κB PERK Apoptosis Autophagy

Bavachalcone (Standard) is the analytical standard of Bavachalcone. This product is intended for research and analytical applications. Bavachalcone is a potent inducer of apoptosis. Bavachalcone exerts anticancer activity by promoting autophagy and apoptosis in HepG2 cells. Bavachalcone acts as an anti-neuroinflammatory and antidepressant through the NF-κB pathway. Bavachalcone inhibits osteoclasts by interfering with ERK and Akt signaling pathways and the expression of c-Fos and NFATc1. Bavachalcone exhibits a significant inhibitory effect on baculovirus-expressed BACE-1 in vitro .
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CLP-d2
CLP-d2
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Cat. No.: HY-P11617
Target:  

NF-κB ERK JNK p38 MAPK Interleukin Related

Research Areas:  

Inflammation/Immunology

CLP-d2 is a multi-target anti-inflammatory agent, osteoclastogenesis inhibitor and immunomodulator with superior pharmacokinetic properties to Daptomycin (HY-B0108) and good safety profiles. CLP-d2 inhibits the NF-κB and MAPK signaling pathways by reducing the expression levels of c-Fos and NFATc1, and decreasing the phosphorylation levels of IκBα, p65, ERK and JNK, thereby reducing the secretion of pro-inflammatory cytokines such as IL-6, TNF-α and IL-1β to exert anti-inflammatory activity. CLP-d2 inhibits intra-articular osteoclastogenesis in mice, alleviates bone erosion and joint swelling, reduces synovial hyperplasia and inflammatory cell infiltration, and decreases serum rheumatoid factor (RF) levels. CLP-d2 is applicable to related research on rheumatoid arthritis .
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Y1693
Y1693
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Cat. No.: HY-182757
CAS No.: 2812381-74-9
Target:  

RANKL/RANK Nuclear Factor of activated T Cells (NFAT) Cathepsin

Research Areas:  

Metabolic Disease Inflammation/Immunology

Y1693 is an orally active RANKL inhibitor with a Kd of 5.03 μM for hRANKL. Y1693 inhibits the activation of the downstream c-fos/NFATc1 signaling pathway by blocking its interaction with RANK. Y1693 significantly inhibits RANKL-induced osteoclast differentiation, F-actin ring formation and bone resorptive activity, while downregulating the mRNA and protein expressions of TRAP, cathepsin K, c-fos and NFATc1. Y1693 shows no obvious cytotoxicity to bone marrow-derived macrophages and osteoclast precursor cells, and exhibits favorable ADME properties. Y1693 improves ovariectomy-induced osteoporosis in mice and reverses ligation-induced periodontal alveolar bone loss. Y1693 is applicable to research related to osteoporosis and periodontal diseases .
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