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Isoforms Recommended:	cIAP-1 cIAP1 cIAP1 IAP

Results for "

cIAP1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (2) Androgen Receptor (2) Apoptosis (16) Autophagy (2) Bacterial (2) Bcr-Abl (1) Caspase (4) E3 Ligase Ligand-Linker Conjugates (19) Epigenetic Reader Domain (1) Estrogen Receptor/ERR (2) HIV (2) IAP (37) JAK (2) Ligands for E3 Ligase (6) Ligands for Target Protein for PROTAC (3) NF-κB (5) NOD-like Receptor (NLR) (1) PANoptosis (1) PARP (1) PROTACs (10) Proteasome (1) RAR/RXR (1) Reference Standards (1) RIP kinase (2) Small Interfering RNA (siRNA) (3) SNIPERs (11) TGF-beta/Smad (2) TNF Receptor (1) YAP (5)
By Research Areas:	Cancer (67) Infection (3) Inflammation/Immunology (4) Metabolic Disease (1)
Click Chemistry:	PROTAC Synthesis (2) Alkynes (1)
Oligonucleotides:	Mouse Pre-designed siRNA Sets (2) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

Natural
Products

Antibodies

Click Chemistry

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-16591

Birinapant Maximum Cited Publications 42 Publications Verification TL32711	IAP Apoptosis HIV	Cancer
Birinapant (TL32711), a bivalent Smac mimetic, is a potent antagonist for XIAP and *cIAP1* with K_ds of 45 nM and less than 1 nM, respectively. Birinapant (TL32711) induces the autoubiquitylation and proteasomal degradation of cIAP1 and cIAP2 in intact cells, which results in formation of a RIPK1: caspase-8 complex, caspase-8 activation, and induction of tumor cell death. Birinapant (TL32711) targets TRAF2-associated cIAPs and abrogates TNF-induced NF-κB activation.

HY-15454

Xevinapant 10+ Cited Publications AT-406; Debio 1143; SM-406	IAP Apoptosis	Cancer
Xevinapant (AT-406) is a potent and orally bioavailable Smac mimetic and an antagonist of IAPs, and it binds to XIAP, cIAP1, and cIAP2 proteins with K_i of 66.4, 1.9, and 5.1 nM, respectively.

HY-16701

BV6 20+ Cited Publications	IAP	Cancer
BV6 is an antagonist of *cIAP1* and XIAP, members of the inhibitors of apoptosis (IAP) family. BV6 shows an IC₅₀ of 7.2 μM in MTS assays in HCC193 cells. BV6 can be used in the research of endometrial cancer and endometriosis ^[1] .

HY-15518

LCL161 40+ Cited Publications	IAP	Cancer
LCL161 is a IAP inhibitor which inhibits XIAP in HEK293 cell and *cIAP1* in MDA-MB-231 cell with IC₅₀s of 35 and 0.4 nM, respectively.

HY-12600

AZD5582 15+ Cited Publications	IAP Apoptosis	Cancer
AZD5582 is an antagonist of the inhibitor of apoptosis proteins (IAPs), which binds to the BIR3 domains cIAP1, cIAP2, and XIAP with IC₅₀s of 15, 21, and 15 nM, respectively. AZD5582 induces apoptosis ^[1].

HY-N0732

Jolkinolide B 1 Publications Verification	IAP Akt Caspase NF-κB TGF-beta/Smad JAK Bacterial Apoptosis	Infection Metabolic Disease Inflammation/Immunology Cancer
Jolkinolide B is a bioactive diterpene isolated from the roots of Euphorbia fischeriana Steud with oral activity. Jolkinolide B downregulates XIAP, *cIAP1, cIAP2, and phosphorylated Akt, upregulates Smac, activates caspase-3* and caspase-9, and inhibits NF-κB, TGFβ/smad3 and JAK/STAT3 pathways. Jolkinolide B exerts comprehensive biological effects including inducing cancer cell apoptosis, suppressing inflammatory responses, improving lung function, alleviating hepatic steatosis and eliminating intracellular Mycobacterium tuberculosis. Jolkinolide B can be used for the research of leukemia, histiocytic lymphoma, asthma, metabolic dysfunction-associated steatotic liver disease and tuberculosis ^[1] .

HY-125593

Dasminapant APG-1387	IAP Apoptosis	Cancer
Dasminapant (APG-1387), a bivalent SMAC mimetic and an IAP antagonist, blocks the activity of IAPs family proteins (XIAP, cIAP-1, cIAP-2, and ML-IAP). Dasminapant induces degradation of cIAP-1 and XIAP proteins, as well as caspase-3 activation and PARP cleavage, which leads to apoptosis. Dasminapant can be used for the research of hepatocellular carcinoma, ovarian cancer, and nasopharyngeal carcinoma ^[1] .

HY-13208

Xevinapant hydrochloride 10+ Cited Publications AT-406 hydrochloride; Debio 1143 hydrochloride; SM-406 hydrochloride	IAP Apoptosis	Cancer
Xevinapant (AT-406) hydrochloride is a potent and orally bioavailable Smac mimetic and an antagonist of the inhibitor of apoptosis proteins (IAPs). Xevinapant hydrochloride binds to XIAP, cIAP1, and cIAP2 proteins with K_is of 66.4, 1.9, and 5.1 nM, respectively. Xevinapant hydrochloride effectively antagonizes XIAP BIR3 protein in a cell-free functional assay, induces rapid degradation of cellular cIAP1 protein, and inhibits cancer cell growth in various human cancer cell lines. Xevinapant hydrochloride is highly effective in induction of apoptosis in xenograft tumors ^[1] .

HY-13638

GDC-0152 10+ Cited Publications	IAP	Cancer
GDC-0152 is a potent IAPs inhibitor, and binds to the BIR3 domains of XIAP, *cIAP1, cIAP2* and the BIR domain of ML-IAP with K_i values of 28 nM, 17 nM, 43 nM and 14 nM, respectively.

HY-128808

cIAP1 ligand 1 E3 ligase Ligand 12	Ligands for E3 Ligase	Cancer
cIAP1 ligand 1 is the LCL161 derivative based IAP ligand. cIAP1 ligand 1 can be connected to the ABL ligand for protein by a linker to form SNIPER. cIAP1 ligand 1 can be used in prostate cancer research ^[1].

HY-111875

SNIPER(BRD)-1	SNIPERs PROTACs Epigenetic Reader Domain	Cancer
SNIPER(BRD)-1 is a SNIPER degrader of BRD4, *cIAP1* and XIAP. SNIPER(BRD)-1 has IC₅₀ values of 6.8 nM, 17 nM and 49 nM for *cIAP1, cIAP2* and XIAP, respectively. SNIPER(BRD)-1 can be used for cancer research ^[1]. (Blue: LCL161 (HY-15518); Black: linker (HY-W008005); Pink: (+)-JQ-1 (HY-13030))

HY-138779

ICCB-19 hydrochloride 1 Publications Verification	Autophagy RIP kinase Apoptosis	Inflammation/Immunology
ICCB-19 hydrochloride is a TRADD (TNFRSF1A associated via death domain) inhibitor. ICCB-19 hydrochloride binds with N-terminal domain of TRADD (TRADD-N), disrupting its binding to both TRADD-C and TRAF2. ICCB-19 hydrochloride is indirect inhibitor of RIPK1 kinase activity. ICCB-19 hydrochloride effectively induces autophagy and the degradation of long-lived proteins ^[1].

HY-N6064

Polygalacin D 3 Publications Verification	Apoptosis IAP	Cancer
Polygalacin D (PGD) is a bioactive compound isolated from Platycodon grandiflorum with anticancer and anti-proliferative properties. PGD suppresses the expression of the IAP family of proteins including survivin, cIAP-1 and cIAP-2 and blocks the PI3K/Akt pathway by inhibiting the phosphorylation of GSK3β, Akt and the expression of PI3K. Polygalacin D induces apoptosis ^[1]

HY-102051

*XIAP/cIAP1* antagonist-1**	IAP	Cancer
XIAP/cIAP1 antagonist-1 is a potent and orally active *XIAP/cIAP1* antagonist with EC₅₀s of 5.1 nM and 0.32 nM for XIAP and cIAP1, respectively. XIAP/cIAP1 antagonist-1 inhibits the tumor growth in dose-dependent manner in vivo ^[1].

HY-128809

cIAP1 ligand 2 E3 ligase Ligand 11	Ligands for E3 Ligase	Cancer
cIAP1 ligand 2 is the LCL161 derivative based IAP ligand. cIAP1 ligand 2 can be connected to the ABL ligand for protein by a linker to form SNIPER.

HY-110346

AZD5582 dihydrochloride 15+ Cited Publications	IAP Apoptosis	Cancer
AZD5582 dihydrochloride is an antagonist of the inhibitor of apoptosis proteins (IAPs), which binds to the BIR3 domains cIAP1, cIAP2, and XIAP with IC₅₀s of 15, 21, and 15 nM, respectively. AZD5582 induces apoptosis ^[1].

HY-149924

CST626	PROTACs IAP	Cancer
CST626 (Compound 9) is a pan-IAP degrader PROTAC. CST626 degrades XIAP, cIAP1 and cIAP2 with DC₅₀s of 0.7, 2.4, and 6.2 nM in MM.1S cells, respectively ^[1].

HY-124181

SM-1295	IAP Apoptosis	Cancer
SM-1295 is an inhibitor of apoptosis protein (IAP) antagonist, with K_d values of 3077 nM, 3.2 nM and 9.5 nM for XIAP-BIR3, c-IAP1-BIR3 and c-IAP2-BIR3, respectively ^[1] .

HY-151966

TD1092	PROTACs IAP Caspase PANoptosis	Cancer
TD1092 is a pan-IAP degrader, degrades *cIAP1, cIAP2, and XIAP. TD1092 activates Caspase* 3/7, and promotes cancer cells apoptosis via IAP degradation. TD1092 inhibits TNFα mediated NF-κB pathway and reduces the phosphorylation of IKK, IkBα, p65, and p38. TD1092 can act as PROTAC, and is used for cancer research ^[1].

HY-128818

cIAP1 Ligand-Linker Conjugates 5 E3 ligase Ligand-Linker Conjugates 39	E3 Ligase Ligand-Linker Conjugates	Cancer
cIAP1 Ligand-Linker Conjugates 5 incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. cIAP1 Ligand-Linker Conjugates 5 can be used to design SNIPERs ^[1].

HY-139656

cIAP1 ligand 4	Ligands for E3 Ligase	Cancer
cIAP1 ligand 4 is a ligand for E3 ligase that can be used in the synthesis of PROTACs.

HY-120434

AEG40826 HGS1029	IAP	Cancer
AEG40826 (HGS1029), a second mitochondria-derived activator of caspases (SMAC) mimetic, is an inhibitor of apoptosis (IAP) inhibitor. AEG40826 degrades cellular IAP1 (cIAP1) and blocks TNF-α pro-survival signaling. AEG40826 can be used for cancer research ^[1].

HY-139655

cIAP1 Ligand-Linker Conjugates 16	E3 Ligase Ligand-Linker Conjugates	Cancer
cIAP1 Ligand-Linker Conjugates 16 is an E3 ligase ligand-linker conjugate that can be used in the synthesis of PROTACs.

HY-128822

cIAP1 Ligand-Linker Conjugates 13 E3 ligase Ligand-Linker Conjugates 43	E3 Ligase Ligand-Linker Conjugates	Cancer
cIAP1 Ligand-Linker Conjugates 13 incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. cIAP1 Ligand-Linker Conjugates 13 can be used to design SNIPERs ^[1].

HY-128813A

cIAP1 Ligand-Linker Conjugates 15 hydrochloride E3 ligase Ligand-Linker Conjugates 34 hydrochloride	E3 Ligase Ligand-Linker Conjugates	Cancer
cIAP1 Ligand-Linker Conjugates 15 hydrochloride incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. cIAP1 Ligand-Linker Conjugates 15 hydrochloride can be used to design SNIPERs ^[1].

HY-128815

cIAP1 Ligand-Linker Conjugates 14 E3 ligase Ligand-Linker Conjugates 36	E3 Ligase Ligand-Linker Conjugates	Cancer
cIAP1 Ligand-Linker Conjugates 14 incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. cIAP1 Ligand-Linker Conjugates 14 can be used to design SNIPERs ^[1].

HY-128816A

cIAP1 Ligand-Linker Conjugates 2 Hydrochloride E3 ligase Ligand-Linker Conjugates 37 Hydrochloride	E3 Ligase Ligand-Linker Conjugates	Cancer
cIAP1 Ligand-Linker Conjugates 2 Hydrochloride incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. cIAP1 Ligand-Linker Conjugates 2 Hydrochloride can be used to design SNIPERs ^[1].

HY-128820

cIAP1 Ligand-Linker Conjugates 1 E3 ligase Ligand-Linker Conjugates 41	E3 Ligase Ligand-Linker Conjugates	Cancer
cIAP1 Ligand-Linker Conjugates 1 incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. cIAP1 Ligand-Linker Conjugates 1 can be used to design SNIPERs ^[1].

HY-128819

cIAP1 Ligand-Linker Conjugates 3 E3 ligase Ligand-Linker Conjugates 40	E3 Ligase Ligand-Linker Conjugates	Cancer
cIAP1 Ligand-Linker Conjugates 3 incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. cIAP1 Ligand-Linker Conjugates 3 can be used to design SNIPERs ^[1].

HY-128813

cIAP1 Ligand-Linker Conjugates 15 E3 ligase Ligand-Linker Conjugates 34	E3 Ligase Ligand-Linker Conjugates	Cancer
cIAP1 Ligand-Linker Conjugates 15 incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. cIAP1 Ligand-Linker Conjugates 15 can be used to design SNIPERs ^[1].

HY-128824

cIAP1 Ligand-Linker Conjugates 9 E3 ligase Ligand-Linker Conjugates 45	E3 Ligase Ligand-Linker Conjugates	Cancer
cIAP1 Ligand-Linker Conjugates 9 incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. cIAP1 Ligand-Linker Conjugates 9 can be used to design SNIPERs ^[1].

HY-128812

cIAP1 Ligand-Linker Conjugates 11 E3 ligase Ligand-Linker Conjugates 33	E3 Ligase Ligand-Linker Conjugates	Cancer
cIAP1 Ligand-Linker Conjugates 11 incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. cIAP1 Ligand-Linker Conjugates 11 can be used to design SNIPERs ^[1].

HY-128817

cIAP1 Ligand-Linker Conjugates 12 E3 ligase Ligand-Linker Conjugates 38	E3 Ligase Ligand-Linker Conjugates	Cancer
cIAP1 Ligand-Linker Conjugates 12 incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. cIAP1 Ligand-Linker Conjugates 12 can be used to design SNIPERs ^[1].

HY-128812A

cIAP1 Ligand-Linker Conjugates 11 Hydrochloride E3 ligase Ligand-Linker Conjugates 33 Hydrochloride	E3 Ligase Ligand-Linker Conjugates	Cancer
cIAP1 Ligand-Linker Conjugates 11 Hydrochloride incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. cIAP1 Ligand-Linker Conjugates 11 Hydrochloride can be used to design SNIPERs ^[1].

HY-128826

cIAP1 Ligand-Linker Conjugates 10 E3 ligase Ligand-Linker Conjugates 47	E3 Ligase Ligand-Linker Conjugates	Cancer
cIAP1 Ligand-Linker Conjugates 10 incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. cIAP1 Ligand-Linker Conjugates 10 can be used to design SNIPERs ^[1].

HY-128825

cIAP1 Ligand-Linker Conjugates 8 E3 ligase Ligand-Linker Conjugates 46	E3 Ligase Ligand-Linker Conjugates	Cancer
cIAP1 Ligand-Linker Conjugates 8 incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. cIAP1 Ligand-Linker Conjugates 8 can be used to design SNIPERs ^[1].

HY-128823

cIAP1 Ligand-Linker Conjugates 7 E3 ligase Ligand-Linker Conjugates 44	E3 Ligase Ligand-Linker Conjugates	Cancer
cIAP1 Ligand-Linker Conjugates 7 incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. cIAP1 Ligand-Linker Conjugates 7 can be used to design SNIPERs ^[1].

HY-128821

cIAP1 Ligand-Linker Conjugates 4 E3 ligase Ligand-Linker Conjugates 42	E3 Ligase Ligand-Linker Conjugates	Cancer
cIAP1 Ligand-Linker Conjugates 4 incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. cIAP1 Ligand-Linker Conjugates 4 can be used to design SNIPERs ^[1].

HY-128816

cIAP1 Ligand-Linker Conjugates 2 E3 ligase Ligand-Linker Conjugates 37	E3 Ligase Ligand-Linker Conjugates	Cancer
cIAP1 Ligand-Linker Conjugates 2 incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. cIAP1 Ligand-Linker Conjugates 2 can be used to design SNIPERs ^[1].

HY-128814

cIAP1 Ligand-Linker Conjugates 6 hydrochloride E3 ligase Ligand-Linker Conjugates 35 hydrochloride	E3 Ligase Ligand-Linker Conjugates	Cancer
cIAP1 Ligand-Linker Conjugates 6 hydrochloride incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. cIAP1 Ligand-Linker Conjugates 6 hydrochloride can be used to design SNIPERs ^[1].

HY-111848A

PROTAC AR Degrader-4 TFA	SNIPERs PROTACs Androgen Receptor	Cancer
PROTAC AR Degrader-4 comprises a IAP ligand binding group, a linker and an Androgen Receptor (AR) binding group. PROTAC AR Degrader-4 is an AR degrader. Degradation inducers based on cIAP1 are called specific and non-genetic IAP-dependent protein erasers (SNIPERs) ^[1].

HY-150825

CST530	IAP Ligands for E3 Ligase	Cancer
CST530 is an inhibitor of apoptosis protein (IAP) antagonist. CST530 is an IAP-type Ligands for E3 Ligase. CST530 binds to the BIR3 domain of IAP and interferes with its function, thereby promoting the ubiquitination and degradation of cIAP1. CST530 can be used to prepare PROTACs ^[1].

HY-111848

PROTAC AR Degrader-4	SNIPERs PROTACs Androgen Receptor	Cancer
PROTAC AR Degrader-4 comprises a IAP ligand binding group, a linker and an Androgen Receptor (AR) binding group. PROTAC AR Degrader-4 is an AR degrader. Degradation inducers based on cIAP1 are called specific and non-genetic IAP-dependent protein erasers (SNIPERs) ^[1].

HY-155019

Anticancer agent 128	IAP	Cancer
Anticancer agent 128 (compound 1) is an IAP inhibitor that covalently targets the BIR3 domains of XIAP, cIAP1, and cIAP2. Anticancer agent 128 targets the BIR3 domains of XIAP, cIAP1, and cIAP2 with IC₅₀s of 24.9 nM, 19.3 nM, and 10.3 nM, respectively ^[1].

HY-155018

Anticancer agent 127	IAP	Cancer
Anticancer agent 127 (142D6) is an IAP inhibitor that covalently targets the BIR3 domains of XIAP, cIAP1, and cIAP2. Anticancer agent 127 targets the BIR3 domains of XIAP, cIAP1, and cIAP2 with IC₅₀s of 12 nM, 14 nM, and 9 nM, respectively. Anticancer agent 127 has anticancer effects ^[1].

HY-16701A

BV6 TFA 20+ Cited Publications	IAP	Cancer
BV6 TFA is an antagonist of *cIAP1* and XIAP, members of the inhibitors of apoptosis (IAP) family. BV6 TFA shows an IC₅₀ of 7.2 μM in MTS assays in HCC193 cells. BV6 TFA can be used in the research of endometrial cancer and endometriosis ^[1] .

HY-111878

BzNH-BS	SNIPERs	Cancer
BzNH-BS contains two different ligands, methyl-bestatin (MeBS) for cIAP1 and benzoyl-amide, which are connected by linkers. MeBS as a ligand for cellular inhibitor of apoptosis protein 1 (cIAP1) ubiquitin ligase ^[1].

HY-100682

T-3256336	IAP	Cancer
T-3256336 is a potent and orally active *cIAP1* and XIAP inhibitor with IC₅₀s of 1.3, 200 nM, respectively. T-3256336 shows anti-tumor activity ^[1].

HY-111874

SNIPER(ABL)-039	SNIPERs Bcr-Abl	Cancer
SNIPER(ABL)-039, conjugating Dasatinib (ABL inhibitor) to LCL161 derivative (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC₅₀ of 10 nM. IC₅₀s are 0.54 nM, 10 nM, 12 nM, and 50 nM for ABL, cIAP1, cIAP2, XIAP, respectively ^[1].

HY-111886

KHS108-MV1	SNIPERs IAP	Cancer
KHS108-MV1 is a conjugate of KHS108 and MV1. KHS108 is a ligand for TACC3. MV1 is an IAP antagonist that binds to cIAP1, cIAP2, and XIAP. KHS108-MV1 can be used in the research of breast cancer and fibrosarcoma ^[1].

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0732

Jolkinolide B 1 Publications Verification	Structural Classification Euphorbia fischeriana Steud. Classification of Application Fields Terpenoids Diterpenoids Euphorbiaceae Plants Disease Research Fields Cancer	IAP Akt Caspase NF-κB TGF-beta/Smad JAK Bacterial Apoptosis
Jolkinolide B is a bioactive diterpene isolated from the roots of Euphorbia fischeriana Steud with oral activity. Jolkinolide B downregulates XIAP, *cIAP1, cIAP2, and phosphorylated Akt, upregulates Smac, activates caspase-3* and caspase-9, and inhibits NF-κB, TGFβ/smad3 and JAK/STAT3 pathways. Jolkinolide B exerts comprehensive biological effects including inducing cancer cell apoptosis, suppressing inflammatory responses, improving lung function, alleviating hepatic steatosis and eliminating intracellular Mycobacterium tuberculosis. Jolkinolide B can be used for the research of leukemia, histiocytic lymphoma, asthma, metabolic dysfunction-associated steatotic liver disease and tuberculosis ^[1] .

HY-N6064

Polygalacin D 3 Publications Verification	Triterpenes Classification of Application Fields Terpenoids Platycodon grandiflorus (Jacq.) A. DC. Campanulaceae Plants Disease Research Fields Cancer Source Classification	Apoptosis IAP
Polygalacin D (PGD) is a bioactive compound isolated from Platycodon grandiflorum with anticancer and anti-proliferative properties. PGD suppresses the expression of the IAP family of proteins including survivin, cIAP-1 and cIAP-2 and blocks the PI3K/Akt pathway by inhibiting the phosphorylation of GSK3β, Akt and the expression of PI3K. Polygalacin D induces apoptosis ^[1]

HY-N0732R

Jolkinolide B (Standard)	Structural Classification Euphorbia fischeriana Steud. Terpenoids Diterpenoids Euphorbiaceae Plants	Reference Standards IAP Akt Caspase NF-κB TGF-beta/Smad JAK Bacterial Apoptosis
Jolkinolide B (Standard) is the analytical standard of Jolkinolide B (HY-N0732). This product is intended for research and analytical applications. Jolkinolide B is a bioactive diterpene isolated from the roots of Euphorbia fischeriana Steud with oral activity. Jolkinolide B downregulates XIAP, *cIAP1, cIAP2, and phosphorylated Akt, upregulates Smac, activates caspase-3* and caspase-9, and inhibits NF-κB, TGFβ/smad3 and JAK/STAT3 pathways. Jolkinolide B exerts comprehensive biological effects including inducing cancer cell apoptosis, suppressing inflammatory responses, improving lung function, alleviating hepatic steatosis and eliminating intracellular Mycobacterium tuberculosis. Jolkinolide B can be used for the research of leukemia, histiocytic lymphoma, asthma, metabolic dysfunction-associated steatotic liver disease and tuberculosis ^[1] .

Host:	Rabbit (2)
Reactivity:	Human (2)
Application:	ICC/IF (2) WB (2)
Isotype:	IgG (2)
Conjugation:	Non-conjugated (2)
Clonality:	Monoclonal (1) Recombinant (1)
Modification:	Unmodified (1)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P82755

	cIAP1 Antibody (YA2500) cIAP1; C-IAP1; IAP homolog B; Inhibitor of apoptosis protein 2; IAP-2; hIAP-2; hIAP2; API1; IAP2; MIHB; RNF48	WB, ICC/IF	Human
	cIAP1 Antibody (YA2500) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to cIAP1.

HY-P82755A

	cIAP1 Antibody (YA2500)(PBS only) cIAP1; C-IAP1; IAP homolog B; Inhibitor of apoptosis protein 2; IAP-2; hIAP-2; hIAP2; API1; IAP2; MIHB; RNF48	WB, ICC/IF	Human
	cIAP1 Antibody (YA2500) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to cIAP1.

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HY-181534

PROTAC TEAD1/IAP degrader-1		PROTAC Synthesis
PROTAC TEAD1/IAP degrader-1 (Compound A232) is a selective *TEAD1* and *cIAP1* PROTAC degrader, with DC₅₀ values of 14 nM and 270 nM, respectively. PROTAC TEAD1/IAP degrader-1 promotes the ubiquitination and degradation of TEAD1 and cIAP1. PROTAC TEAD1/IAP degrader-1 downregulates the expression of the TEAD-dependent gene CTGF. PROTAC TEAD1/IAP degrader-1 exhibits anticancer activity against mesothelioma ^[1].

HY-160601

Anticancer agent 294		Alkynes
Anticancer agent 294 (Example 2) is an anticancer agent that has inhibitory activity against apoptosis inhibitor protein 1 (cIAP1) with an IC₅₀ of 15 nM ^[1].

HY-181530

IAP ligand 6		PROTAC Synthesis
IAP ligand 6 (A250) is an IAP ligand with a K_a value of 0.1 μM for the human XIAP BIR3 domain. IAP ligand 6 binds to the XIAP BIR3 domain and serves as an alkynylpyridine scaffold for the preparation of TEAD degraders that recruit IAP. IAP ligand 6 is applicable to research related to mesothelioma ^[1].

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