1. PROTAC
    Epigenetics
  2. SNIPER
    Epigenetic Reader Domain
  3. SNIPER(BRD)-1

SNIPER(BRD)-1 

Cat. No.: HY-111875
Handling Instructions

SNIPER(BRD)-1, consists of an IAP antagonist LCL-161 derivative and a BET inhibitor, (+)-JQ-1, connected by a linker. SNIPER(BRD)-1 induces the degradation of BRD4 via the ubiquitin-proteasome pathway. SNIPER(BRD)-1 also degrades cIAP1 , cIAP2 and XIAP with IC50s of 6.8 nM, 17 nM, and 49nM, respectively.

For research use only. We do not sell to patients.

SNIPER(BRD)-1 Chemical Structure

SNIPER(BRD)-1 Chemical Structure

CAS No. : 2095244-54-3

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Description

SNIPER(BRD)-1, consists of an IAP antagonist LCL-161 derivative and a BET inhibitor, (+)-JQ-1, connected by a linker. SNIPER(BRD)-1 induces the degradation of BRD4 via the ubiquitin-proteasome pathway. SNIPER(BRD)-1 also degrades cIAP1 , cIAP2 and XIAP with IC50s of 6.8 nM, 17 nM, and 49nM, respectively[1].

IC50 & Target[1]

BRD4

 

cIAP1

6.8 nM (IC50)

cIAP2

17 nM (IC50)

XIAP

49 nM (Ki)

SNIPER

 

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Molecular Weight

1056.73

Formula

C₅₃H₆₆ClN₉O₈S₂

CAS No.

2095244-54-3

SMILES

O=C(C[[email protected]]1C2=NN=C(C)N2C(SC(C)=C3C)=C3C(C4=CC=C(Cl)C=C4)=N1)NCCOCCOCCOCCOC5=CC(C(C6=CSC([[email protected]]7N(C([[email protected]@H](NC([[email protected]](C)NC)=O)C8CCCCC8)=O)CCC7)=N6)=O)=CC=C5

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
SNIPER(BRD)-1
Cat. No.:
HY-111875
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SNIPER(BRD)-1

Cat. No.: HY-111875