1. PROTAC
    Epigenetics
  2. SNIPER
    Epigenetic Reader Domain
  3. SNIPER(BRD)-1

SNIPER(BRD)-1 

Cat. No.: HY-111875
Handling Instructions

SNIPER(BRD)-1, consists of an IAP antagonist LCL-161 derivative and a BET inhibitor, (+)-JQ-1, connected by a linker. SNIPER(BRD)-1 induces the degradation of BRD4 via the ubiquitin-proteasome pathway. SNIPER(BRD)-1 also degrades cIAP1 , cIAP2 and XIAP with IC50s of 6.8 nM, 17 nM, and 49nM, respectively.

For research use only. We do not sell to patients.

SNIPER(BRD)-1 Chemical Structure

SNIPER(BRD)-1 Chemical Structure

CAS No. : 2095244-54-3

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Description

SNIPER(BRD)-1, consists of an IAP antagonist LCL-161 derivative and a BET inhibitor, (+)-JQ-1, connected by a linker. SNIPER(BRD)-1 induces the degradation of BRD4 via the ubiquitin-proteasome pathway. SNIPER(BRD)-1 also degrades cIAP1 , cIAP2 and XIAP with IC50s of 6.8 nM, 17 nM, and 49nM, respectively[1].

IC50 & Target

BRD4

 

cIAP1

6.8 nM (IC50)

cIAP2

17 nM (IC50)

XIAP

49 nM (Ki)

SNIPER

 

Molecular Weight

1056.73

Formula

C₅₃H₆₆ClN₉O₈S₂

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (94.63 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9463 mL 4.7316 mL 9.4632 mL
5 mM 0.1893 mL 0.9463 mL 1.8926 mL
10 mM 0.0946 mL 0.4732 mL 0.9463 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (2.37 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (2.37 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
SNIPER(BRD)-1
Cat. No.:
HY-111875
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