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cisplatin-induced ototoxicity

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By Targets:	Apoptosis (1) Caspase (1) FOXO (1) HIF/HIF Prolyl-Hydroxylase (1) JNK (1) MDM-2/p53 (1) Mitochondrial Metabolism (2) Quinone Reductase (2) Reactive Oxygen Species (ROS) (1)
By Research Areas:	Cancer (2) Metabolic Disease (2) Neurological Disease (2)

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Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-128895

KL1333 1 Publications Verification	Quinone Reductase Mitochondrial Metabolism	Metabolic Disease
KL1333, a derivative of β-lapachone, is an orally available NAD+ modulator. KL1333 reacts with NAD(P)H:quinone oxidoreductase 1 (NQO1) as a substrate, resulting in increases in intracellular NAD+ levels via NADH oxidation. KL1333 improves energy metabolism and mitochondrial dysfunction in MELAS fibroblasts. KL1333 protects against Cisplatin-induced ototoxicity in mouse cochlear cultures .

HY-N4102

5,7-Dihydroxy-4-methylcoumarin	Apoptosis JNK FOXO Reactive Oxygen Species (ROS) Caspase	Neurological Disease
5,7-Dihydroxy-4-methylcoumarin is an antioxidant. 5,7-Dihydroxy-4-methylcoumarin protects mouse cochlear hair cells from Cisplatin-induced damage, enhances cell viability and inhibits apoptosis. 5,7-Dihydroxy-4-methylcoumarin downregulates phosphorylated JNK levels, increases the ratio of phosphorylated FoxO1 to total FoxO1, scavenges free radicals, reduces ROS accumulation, maintains mitochondrial membrane potential and alleviates mitochondrial dysfunction. 5,7-Dihydroxy-4-methylcoumarin downregulates the expression of caspase-3 and improves cell viability. 5,7-Dihydroxy-4-methylcoumarin can be used in studies related to ototoxicity .

HY-B0639C

Amifostine sodium WR2721 sodium	MDM-2/p53 HIF/HIF Prolyl-Hydroxylase	Neurological Disease
Amifostine sodium (WR2721 sodium) is a phosphorus sulfate with radioprotective activity. Amifostine sodium can cause splenic vasodilation and may block autonomic ganglia. Amifostine sodium is clinically used to prevent cisplatin-induced ototoxicity .

HY-128895A

KL1333 hydrochloride	Mitochondrial Metabolism Quinone Reductase	Metabolic Disease
KL1333 hydrochloride is an orally active NAD ⁺ modulator that reacts with NAD(P)H:quinone oxidoreductase 1 (NQO1) as a substrate, leading to increased intracellular NAD ⁺ levels through NADH oxidation. Elevated NAD ⁺ levels trigger activation of SIRT1 and AMPK, and subsequently activate PGC-1α. KL1333 hydrochloride improves energy metabolism and mitochondrial dysfunction in mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) fibroblasts. KL1333 hydrochloride protects against cisplatin-induced ototoxicity in mouse cochlear cultures .

Cat. No.	Product Name	Target	Research Area

HY-P11350

A666 peptide	Peptides	Cancer
A666 peptide is a highly selective prestin ligand. A666 peptide enables active drug delivery (e.g., dexamethasone) to outer hair cells (OHCs). A666 peptide is promising for research of cisplatin-induced ototoxicity protection and sensorineural hearing loss interventions .

HY-P11350A

A666 peptide TFA	Peptides	Cancer
A666 peptide TFA is a highly selective prestin ligand. A666 peptide TFA enables active drug delivery (e.g., dexamethasone) to outer hair cells (OHCs). A666 peptide TFA is promising for research of cisplatin-induced ototoxicity protection and sensorineural hearing loss interventions .

5,7-Dihydroxy-4-methylcoumarin	Infection Structural Classification other families Classification of Application Fields Coumarins Phenols Polyphenols Phenylpropanoids Plants Disease Research Fields Source Classification	Apoptosis JNK FOXO Reactive Oxygen Species (ROS) Caspase
5,7-Dihydroxy-4-methylcoumarin is an antioxidant. 5,7-Dihydroxy-4-methylcoumarin protects mouse cochlear hair cells from Cisplatin-induced damage, enhances cell viability and inhibits apoptosis. 5,7-Dihydroxy-4-methylcoumarin downregulates phosphorylated JNK levels, increases the ratio of phosphorylated FoxO1 to total FoxO1, scavenges free radicals, reduces ROS accumulation, maintains mitochondrial membrane potential and alleviates mitochondrial dysfunction. 5,7-Dihydroxy-4-methylcoumarin downregulates the expression of caspase-3 and improves cell viability. 5,7-Dihydroxy-4-methylcoumarin can be used in studies related to ototoxicity .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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cisplatin-induced ototoxicity

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