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Pathways Recommended:	Antibody-drug Conjugate/ADC Related

Results for "

conjugates

" in MedChemExpress (MCE) Product Catalog:

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VEGFR (4) Virus Protease (1) WDR5 (1) Wee1 (1) Wnt (1) YAP (5) YTHDF (1) β-catenin (1)
By Research Areas:	Cancer (3010) Cardiovascular Disease (44) Endocrinology (8) Infection (115) Inflammation/Immunology (322) Metabolic Disease (115) Neurological Disease (90)
Click Chemistry:	ADC Synthesis (245) TCO (16) Labeling and Fluorescence Imaging (5) DBCO (83) PROTAC Synthesis (63) BCN (22) Azide (154) Tetrazine (35) Alkynes (77)
Oligonucleotides:	Nucleotide Analogs (4) Phospholipids (6) siRNA drugs (10) Other Phosphoramidite (2) Antisense Oligonucleotides (11) Cholesterol (7) siRNAs (11) Fluorescent Lipids (12) Pegylated Lipids (76) Guanine Nucleotide (2) Aptamers (3) Cationic Lipids (2) Polymers (12) Phosphoramidites (2)

4233

Inhibitors & Agonists

Screening Libraries

188

Fluorescent Dye

543

Biochemical Assay Reagents

198

Peptides

MCE Kits

106

Inhibitory Antibodies

100

Natural
Products

Isotope-Labeled Compounds

382

Click Chemistry

133

Oligonucleotides

GMP Molecules

Targets Recommended: Antibody-Drug Conjugates (ADCs) Target Protein Ligand-Linker Conjugates Peptide-Drug Conjugates (PDCs) PROTAC-Linker Conjugates for PAC Radionuclide-Drug Conjugates (RDCs) Drug-Linker Conjugates for ADC Antibody-Oligonucleotide Conjugates (AOCs) E3 Ligase Ligand-Linker Conjugates ADC Linker

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-103602

(S,R,S)-AHPC-PEG3-NH2 hydrochloride VH032-PEG3-NH2 hydrochloride; VHL Ligand-Linker conjugates 1 hydrochloride; E3 ligase Ligand-Linker conjugates 5	E3 Ligase Ligand-Linker Conjugates	Cancer
(S,R,S)-AHPC-PEG3-NH2 (VH032-PEG3-NH2) hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 3-unit PEG linker used in PROTAC technology.

HY-103604

(S,R,S)-AHPC-PEG4-NH2 hydrochloride 2 Publications Verification VH032-PEG4-NH2 hydrochloride; VHL Ligand-Linker conjugates 4 hydrochloride; E3 ligase Ligand-Linker conjugates 7	E3 Ligase Ligand-Linker Conjugates	Cancer
(S,R,S)-AHPC-PEG4-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 4-unit PEG linker used in PROTAC technology.

HY-103603

(S,R,S)-AHPC-PEG2-NH2 hydrochloride VH032-PEG2-NH2 hydrochloride; VHL Ligand-Linker conjugates 3 hydrochloride; E3 ligase Ligand-Linker conjugates 6	E3 Ligase Ligand-Linker Conjugates	Cancer
(S,R,S)-AHPC-PEG2-NH2 hydrochloride (VH032-PEG2-NH2 hydrochloride) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker used in the synthesis of PROTACs .

HY-128716B

Pomalidomide-PEG3-C2-NH2 hydrochloride Cereblon Ligand-Linker conjugates 5 hydrochloride; E3 ligase Ligand-Linker conjugates 30 hydrochloride	E3 Ligase Ligand-Linker Conjugates	Cancer
Pomalidomide-PEG3-C2-NH2 (Cereblon Ligand-Linker Conjugates 5) hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology .

HY-103601

(S,R,S)-AHPC-PEG4-N3 1 Publications Verification VH032-PEG4-N3; VHL Ligand-Linker conjugates 5; E3 ligase Ligand-Linker conjugates 4	E3 Ligase Ligand-Linker Conjugates	Others
(S,R,S)-AHPC-PEG4-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 4-unit PEG linker used in PROTAC technology. (S,R,S)-AHPC-PEG4-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-103598

(S,R,S)-AHPC-PEG3-N3 VH032-PEG3-N3; VHL Ligand-Linker conjugates 8; E3 ligase Ligand-Linker conjugates 12	E3 Ligase Ligand-Linker Conjugates	Cancer
(S,R,S)-AHPC-PEG3-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 3-unit PEG linker used in PROTAC technology. (S,R,S)-AHPC-PEG3-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-103600

(S,R,S)-AHPC-PEG1-N3 VH032-PEG1-N3; VHL Ligand-Linker conjugates 9; E3 ligase Ligand-Linker conjugates 3	E3 Ligase Ligand-Linker Conjugates	Cancer
(S,R,S)-AHPC-PEG1-N3 (VH032-PEG1-N3) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 1-unit PEG linker used in PROTAC technology. (S,R,S)-AHPC-PEG1-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-175360

*USP7 Ligand-Linker Conjugates* 1**	Target Protein Ligand-Linker Conjugates Deubiquitinase	Cancer
USP7 Ligand-Linker Conjugates 1 is an Target Protein Ligand-Linker Conjugate that incorporates a ligand for USP7 (HY-175359) and a PROTAC linker, which recruits E3 ligases. USP7 Ligand-Linker Conjugates 1 can be used for synthesis of PROTAC USP7 Degrader-1 (HY-175358) .

HY-21930

Pomalidomide-PEG4-C-COOH Cereblon Ligand -Linker conjugates 1; E3 Ligase Ligand-Linker conjugates 1	E3 Ligase Ligand-Linker Conjugates	Cancer
Pomalidomide-PEG4-C-COOH (Cereblon Ligand -Linker Conjugate 1) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 4-unit PEG linker used in PROTAC technology.

HY-103614

Thalidomide-O-amido-C8-NH2 TFA 1 Publications Verification Cereblon Ligand -Linker conjugates 2 TFA; E3 Ligase Ligand-Linker conjugates 20 TFA	E3 Ligase Ligand-Linker Conjugates Autophagy Apoptosis	Cancer
Thalidomide-O-amido-C8-NH2 TFA (Cereblon Ligand -Linker Conjugates 2 TFA) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.

HY-103615

Thalidomide-O-amido-C4-N3 1 Publications Verification Cereblon Ligand-Linker conjugates 4; E3 ligase Ligand-Linker conjugates 18	E3 Ligase Ligand-Linker Conjugates	Others
Thalidomide-O-amido-C4-N3 is a synthetic E3 ligase ligand-linker conjugate, consisting of a cereblon ligand based on Thalidomide (HY-14658) and a linker .

HY-103604A

(S,R,S)-AHPC-PEG4-NH2 2 Publications Verification VH032-PEG4-NH2; VHL Ligand-Linker conjugates 4 ; E3 ligase Ligand-Linker conjugates 7 Free Base	E3 Ligase Ligand-Linker Conjugates	Cancer
(S,R,S)-AHPC-PEG4-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 4-unit PEG linker used in PROTAC technology.

HY-125843

Pomalidomide-PEG1-C2-N3 Cereblon Ligand-Linker conjugates 13; E3 ligase Ligand-Linker conjugates 50	E3 Ligase Ligand-Linker Conjugates	Cancer
Pomalidomide-PEG1-C2-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 1-unit PEG linker used in PROTAC technology. Pomalidomide-PEG1-C2-N3 can be used to design a selective CDK6 PROTAC degrader CP-10. CP-10 induces the degradation of CDK6 with an DC₅₀ of 2.1 nM . Pomalidomide-PEG1-C2-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-128832

Nutlin-C1-amido-PEG4-C2-N3 MDM2 Ligand-Linker conjugates 1; E3 ligase Ligand-Linker conjugates 48	E3 Ligase Ligand-Linker Conjugates	Cancer
Nutlin-C1-amido-PEG4-C2-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Nutlin 3 based MDM2 ligand and 4-unit PEG linker used in PROTAC technology. Nutlin-C1-amido-PEG4-C2-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-103611

Thalidomide-O-amido-PEG3-C2-NH2 TFA Cereblon Ligand-Linker conjugates 3 TFA; E3 ligase Ligand-Linker conjugates 14 TFA	E3 Ligase Ligand-Linker Conjugates Autophagy Apoptosis	Cancer
Thalidomide-O-amido-PEG3-C2-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology.

HY-130271

(S,R,S)-AHPC-PEG5-COOH VH032-PEG5-COOH; VHL Ligand-Linker conjugates 16; E3 Ligase Ligand-Linker conjugates 58	E3 Ligase Ligand-Linker Conjugates	Cancer
(S,R,S)-AHPC-PEG5-COOH (VH032-PEG5-COOH) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 5-unit PEG linker used in PROTAC technology .

HY-103603A

(S,R,S)-AHPC-PEG2-NH2 VH032-PEG2-NH2 ; VHL Ligand-Linker conjugates 3 ; E3 ligase Ligand-Linker conjugates 6 Free Base	E3 Ligase Ligand-Linker Conjugates	Cancer
(S,R,S)-AHPC-PEG2-NH2 (VH032-PEG2-NH2) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker used in the synthesis of PROTACs .

HY-103599

(S,R,S)-AHPC-PEG2-N3 1 Publications Verification VH032-PEG2-N3; VHL Ligand-Linker conjugates 6; E3 ligase Ligand-Linker conjugates 13	E3 Ligase Ligand-Linker Conjugates	Cancer
(S,R,S)-AHPC-PEG2-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker. (S,R,S)-AHPC-PEG2-N3 can be used for the synthesis of PROTACs .

HY-128846A

Pomalidomide-C2-NH2 hydrochloride Cereblon Ligand-Linker conjugates 15 hydrochloride	E3 Ligase Ligand-Linker Conjugates	Cancer
Pomalidomide-C2-NH2 (Cereblon Ligand-Linker Conjugate 15) hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology.

HY-126458

Thalidomide-O-PEG2-propargyl E3 ligase Ligand-Linker conjugates 32	E3 Ligase Ligand-Linker Conjugates Autophagy Apoptosis	Cancer
Thalidomide-O-PEG2-propargyl (E3 ligase Ligand-Linker Conjugates 32) is an E3 ligase ligand-linker conjugate. Thalidomide-O-PEG2-propargyl is also a click chemistry reagent containing an alkyne group, which can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAC) with molecules bearing an azide group .

HY-103606

(S,R,S)-AHPC-PEG6-C4-Cl VH032-PEG6-C4-Cl; VHL Ligand-Linker conjugates 10; E3 ligase Ligand-Linker conjugates 9	E3 Ligase Ligand-Linker Conjugates	Cancer
(S,R,S)-AHPC-PEG6-C4-Cl is a conjugate of ligands for E3 and 25-atom-length linker. The connector of linker is Halogen group. (S,R,S)-AHPC-PEG6-C4-Cl incorporates the (S,R,S)-AHPC based VHL ligand and 6-unit PEG linker. (S,R,S)-AHPC-PEG6-C4-Cl is capable of inducing the degradation of GFP-HaloTag7 in cell-based assays .

HY-147225

*TSPO Ligand-Linker Conjugates* 1**	AUTACs Mitophagy	Neurological Disease Metabolic Disease Cancer
TSPO Ligand-Linker Conjugates 1 contains a ligand for translocator protein (TSPO) and a linker, which is used for the synthesis of mitochondria-targeting autophagy-targeting chimera (AUTAC). AUTAC can bind the TSPO on the outer mitochondrial membrane (OMM) of mitochondria and degrades impaired mitochondria and proteins via mitophagy, and improves mitochondrial activity. TSPO Ligand-Linker Conjugates 1 can be used in mitochondrial dysfunction related research, including neurodegenerative diseases, cancer, and diabetes .

HY-103613

Thalidomide-O-amido-C4-NH2 TFA Cereblon Ligand-Linker conjugates 6 TFA; E3 ligase Ligand-Linker conjugates 19 TFA	E3 Ligase Ligand-Linker Conjugates Autophagy Apoptosis	Others
Thalidomide-O-amido-C4-NH2 TFA (Cereblon Ligand-Linker Conjugates 6 TFA) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.

HY-128716A

Pomalidomide-PEG3-C2-NH2 TFA Cereblon Ligand-Linker conjugates 5 TFA ; E3 ligase Ligand-Linker conjugates 30 TFA	E3 Ligase Ligand-Linker Conjugates	Cancer
Pomalidomide-PEG3-C2-NH2 TFA (Cereblon Ligand-Linker Conjugates 5 (TFA)) is a synthetic E3 ligase ligand-linker conjugate comprising a Pomalidomide (HY-10984)-based cereblon ligand and a 3-unit PEG linker. Pomalidomide-PEG3-C2-NH2 TFA can be used for the synthesis of PROTACs .

HY-112599

Pomalidomide-PEG4-C2-NH2 Cereblon Ligand-Linker conjugates 8; E3 Ligase Ligand-Linker conjugates 22	E3 Ligase Ligand-Linker Conjugates	Cancer
Pomalidomide-PEG4-C2-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 4-unit PEG linker used in PROTAC technology.

HY-133046

*VHL Ligand-Linker Conjugates* 17**	E3 Ligase Ligand-Linker Conjugates	Cancer
VHL Ligand-Linker Conjugates 17 incorporates a VHL ligand for the E3 ubiquitin ligase, and a PROTAC linker. VHL Ligand-Linker Conjugates 17 can be used in the synthesis of a series of PROTACs, such as ARD-266 (HY-133020). ARD-266 is a highly potent androgen receptor (AR) PROTAC degrader . VHL Ligand-Linker Conjugates 17 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-112618A

Thalidomide-O-amido-C6-NH2 TFA Cereblon Ligand-Linker conjugates 11 TFA; E3 Ligase Ligand-Linker conjugates 25 TFA	E3 Ligase Ligand-Linker Conjugates Autophagy Apoptosis	Cancer
Thalidomide-O-amido-C6-NH2 TFA (Cereblon Ligand-Linker Conjugates 11 TFA), a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs .

HY-103612

Thalidomide-O-amido-C3-COOH Cereblon Ligand-Linker conjugates 7; E3 ligase Ligand-Linker conjugates 15	E3 Ligase Ligand-Linker Conjugates Autophagy Apoptosis	Cancer
Thalidomide-O-amido-C3-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.

HY-41549

Pomalidomide-PEG4-Ph-NH2 Cereblon Ligand-Linker conjugates 9; E3 Ligase Ligand-Linker conjugates 2	E3 Ligase Ligand-Linker Conjugates	Cancer
Pomalidomide-PEG4-Ph-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 4-unit PEG linker used in PROTAC technology.

HY-128848

Pomalidomide-C2-amido-(C1-O-C5-O-C1)2-COOH Cereblon Ligand-Linker conjugates 14; E3 ligase Ligand-Linker conjugates 49	E3 Ligase Ligand-Linker Conjugates	Cancer
Pomalidomide-C2-amido-(C1-O-C5-O-C1)2-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology.

HY-103607

(S,R,S)-AHPC-PEG2-C4-Cl 1 Publications Verification VH032-PEG2-C4-Cl; VHL Ligand-Linker conjugates 7; E3 ligase Ligand-Linker conjugates 10	E3 Ligase Ligand-Linker Conjugates	Cancer
(S,R,S)-AHPC-PEG2-C4-Cl (VH032-PEG2-C4-Cl) is a conjugate of ligands for E3 and 13-atom-length linker. The connector of linker is Halogen group. (S,R,S)-AHPC-PEG2-C4-Cl incorporates the (S,R,S)-AHPC based VHL ligand and an alkyl/ether-based linker. (S,R,S)-AHPC-PEG2-C4-Cl is capable of inducing the degradation of GFP-HaloTag7 in cell-based assays .

HY-175726

*BRAF ligand-Linker Conjugate* 1**	Target Protein Ligand-Linker Conjugates	Cancer
BRAF ligand-Linker Conjugate 1 is a target protein ligand-linker conjugate that can be used to synthesize PROTAC CST905(HY-175435) .

HY-D2262

*BODIPY-cholesterol conjugate-2*	Fluorescent Dye	Metabolic Disease
BODIPY-cholesterol conjugate-2 (compound 6) is a BODIPY-cholesterol conjugate. BODIPY-cholesterol conjugate-2 is a useful probe for simultaneous visualization of intracellular cholesterol pools and for monitoring cholesterol efflux from cells to extracellular acceptors. (λex=589 nm, λem=638 nm) .

HY-176788

*EGFR Ligand-Linker Conjugates* 1**	Target Protein Ligand-Linker Conjugates EGFR	Cancer
EGFR Ligand-Linker Conjugates 1 is an Target Protein Ligand-Linker Conjugate that incorporates a ligand for EGFR (HY-150905) and a PROTAC linker, which recruits E3 ligases. EGFR Ligand-Linker Conjugates 1 can be used for synthesis of PROTAC EGFR degrader 3 (HY-144605) .

HY-176791

*CDK12-Cyclin K Ligand-Linker Conjugates* 1**	Target Protein Ligand-Linker Conjugates CDK	Cancer
CDK12-Cyclin K Ligand-Linker Conjugates 1 is an Target Protein Ligand-Linker Conjugate that incorporates a ligand for CDK12-Cyclin K (HY-176790) and a PROTAC linker (HY-W244922), which recruits E3 ligases. CDK12-Cyclin K Ligand-Linker Conjugates 1 can be used for synthesis of PROTAC PP-C8 (HY-144691) .

HY-178311

*EGFR Ligand-Linker Conjugates* 4**	Target Protein Ligand-Linker Conjugates EGFR	Cancer
EGFR Ligand-Linker Conjugates 4 is a conjugate of the EGFR ligand (HY-178313) and the linker. EGFR Ligand-Linker Conjugates 4 can be used for synthesizing PROTAC EGFR degrader 16 (HY-178242) .

HY-125906

*VHL Ligand-Linker Conjugates* 15** E3 Ligase Ligand-Linker conjugates 56	E3 Ligase Ligand-Linker Conjugates	Cancer
VHL Ligand-Linker Conjugates 15 incorporates an VHL ligand for the E3 ubiquitin ligase, and a PROTAC linker. VHL Ligand-Linker Conjugates 15 can be used to design PROTACs .

HY-128818

*cIAP1 Ligand-Linker Conjugates* 5** E3 ligase Ligand-Linker conjugates 39	E3 Ligase Ligand-Linker Conjugates	Cancer
cIAP1 Ligand-Linker Conjugates 5 incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. cIAP1 Ligand-Linker Conjugates 5 can be used to design SNIPERs .

HY-176787

*KRAS G12C Ligand-Linker Conjugates* 1**	Target Protein Ligand-Linker Conjugates Ras	Cancer
KRAS G12C Ligand-Linker Conjugates 1 is a conjugate of KRAS ^G12C ligand and linker, which can be used in the synthesis of PROTAC YF135 (HY-144323) .

HY-107438

Thalidomide-O-amido-C4-NH2 Cereblon Ligand-Linker conjugates 6; E3 Ligase Ligand-Linker conjugates 19	E3 Ligase Ligand-Linker Conjugates Autophagy Apoptosis	Cancer
Thalidomide-O-amido-C4-NH2 (Cereblon Ligand-Linker Conjugates 6), a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs .

HY-130521

Pomalidomide-amido-PEG3-C2-NH2 Cereblon Ligand-Linker conjugates 22; E3 ligase Ligand-Linker conjugates 55	E3 Ligase Ligand-Linker Conjugates	Cancer
Pomalidomide-amido-PEG3-C2-NH2 (Cereblon Ligand-Linker Conjugates 22) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology .

HY-128716

Pomalidomide-PEG3-C2-NH2 Cereblon Ligand-Linker conjugates 5; E3 ligase Ligand-Linker conjugates 30	E3 Ligase Ligand-Linker Conjugates	Cancer
Pomalidomide-PEG3-C2-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology.

HY-115560A

Thalidomide-O-amido-C3-NH2 TFA Cereblon Ligand-Linker conjugates 16 TFA; E3 Ligase Ligand-Linker conjugates 52 TFA	E3 Ligase Ligand-Linker Conjugates Autophagy Apoptosis	Cancer
Thalidomide-O-amido-C3-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.

HY-128846

Pomalidomide-C2-NH2 Cereblon Ligand-Linker conjugates 15	E3 Ligase Ligand-Linker Conjugates	Cancer
Pomalidomide-C2-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a PEG linker used in PROTAC technology.

HY-112599A

Pomalidomide-PEG4-C2-NH2 TFA Cereblon Ligand-Linker conjugates 8 TFA; E3 Ligase Ligand-Linker conjugates 22 TFA	E3 Ligase Ligand-Linker Conjugates	Cancer
Pomalidomide-PEG4-C2-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 4-unit PEG linker used in PROTAC technology.

HY-112617A

Thalidomide-O-amido-PEG2-C2-NH2 TFA Cereblon Ligand-Linker conjugates 10 TFA; E3 Ligase Ligand-Linker conjugates 24 TFA	E3 Ligase Ligand-Linker Conjugates Autophagy Apoptosis	Inflammation/Immunology Cancer
Thalidomide-O-amido-PEG2-C2-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 2-unit PEG linker used in PROTAC technology.

HY-114176

(S,R,S)-AHPC-C4-NH2 hydrochloride VH032-C4-NH2 hydrochloride; VHL Ligand-Linker conjugates 13; E3 ligase Ligand-Linker conjugates 28	E3 Ligase Ligand-Linker Conjugates	Cancer
(S,R,S)-AHPC-C4-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and a linker used for EED-Targeted PROTAC .

HY-103602A

(S,R,S)-AHPC-PEG3-NH2 VH032-PEG3-NH2; VHL Ligand-Linker conjugates 1; E3 ligase Ligand-Linker conjugates 5 Free Base	E3 Ligase Ligand-Linker Conjugates	Cancer
(S,R,S)-AHPC-PEG3-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 3-unit PEG linker used in PROTAC technology.

HY-130270

*AhR Ligand-Linker Conjugates* 1** E3 Ligase Ligand-Linker conjugates 57	E3 Ligase Ligand-Linker Conjugates	Cancer
AhR Ligand-Linker Conjugates 1 (E3 Ligase Ligand-Linker Conjugates 57) incorporates an IAP ligand for the E3 ubiquitin ligase, and a SNIPER linker. AhR Ligand-Linker Conjugates 1 can be used to design SNIPER .

HY-128822

*cIAP1 Ligand-Linker Conjugates* 13** E3 ligase Ligand-Linker conjugates 43	E3 Ligase Ligand-Linker Conjugates	Cancer
cIAP1 Ligand-Linker Conjugates 13 incorporates an IAP ligand for the E3 ubiquitin ligase, and a PROTAC linker. cIAP1 Ligand-Linker Conjugates 13 can be used to design SNIPERs .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0324

Cholic acid 15+ Cited Publications	Human Gut Microbiota Metabolites Microorganisms Other disease Classification of Application Fields Disease markers Metabolic Disease Endogenous metabolite Disease Research Fields Steroids Source Classification	Endogenous Metabolite
Cholic acid is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion. Cholic acid is orally active .

HY-N1424

Glycoursodeoxycholic acid 3 Publications Verification GUDCA; Ursodeoxycholylglycine	Structural Classification Endogenous metabolite Steroids Source Classification	Endogenous Metabolite
Glycoursodeoxycholic acid, a acyl glycine and a bile acid-glycine conjugate, is a metabolite of ursodeoxycholic acid.

HY-112942A

CMP-Sialic acid sodium salt 4 Publications Verification CMP-Neu5Ac sodium salt	Natural Products Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
CMP-Sialic acid (CMP-Neu5Ac) sodium salt is an allosteric inhibitor of UDP-GlcNAc 2-epimerase. CMP-Sialic acid sodium salt provides a substrate for Golgi sialyltransferases. CMP-Sialic acid sodium salt is an important sugar nucleotide for biosynthesis of sialic acid and its conjugates .

HY-Y1055

Guanine 3 Publications Verification	Structural Classification Natural Products Microorganisms Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification Cancer	DNA/RNA Synthesis Endogenous Metabolite
Guanine is one of the fundamental components of nucleic acids (DNA and RNA). Guanine is a purine derivative, consisting of a fused pyrimidine-imidazole ring system with conjugated double bonds. Guanine has the potential to serve as a large-capacity N pool. Guanine has cytotoxic, antinociceptive and neuroprotective effects .

HY-116374

Glycolithocholic acid 2 Publications Verification Lithocholylglycine	Human Gut Microbiota Metabolites Classification of Application Fields Endogenous metabolite Inflammation/Immunology Disease Research Fields Steroids Source Classification	Endogenous Metabolite
Glycolithocholic acid (Lithocholylglycine), an endogenous metabolite, is a glycine-conjugated secondary bile acid. Glycolithocholic acid can be used to diagnose ulcerative colitis (UC), non-alcoholic steatohepatitis (NASH) and primary sclerosing cholangitis (PSC) .

HY-101884

Biocytin 4 Publications Verification (+)-Biocytin	Human Gut Microbiota Metabolites Neurological Disease Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Biocytin is a conjugate of _D-biotin and _L-lysine, where the carboxylate of _D-biotin is coupled with the -amine of _L-lysine via a secondary amide bond. Biocytin is a classical neuroanatomical tracer commonly used to map brain connectivity. Biocytin is used as a versatile marker in anterograde, retrograde and intracellular neuroanatomical investigations and in biotinidase assays .

HY-N11420

Coronatine	Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Other Diseases Disease Research Fields Source Classification Agricultural Research	Bacterial Phytohormone
Coronatine is a plant growth regulator that mimicks the jasmonic acid-isoleucine conjugate (JA-Ile), targets the jasmonic acid receptor COI1, activates the jasmonic acid signaling pathway, thereby inhibiting salicylic acid (SA)-dependent defense responses. Coronatine antagonizes the stomatal closure, induces plant cell necrosis and chlorosis, interfers with plant hormone balance, thereby promoting pathogen infection .

HY-N0324A

Cholic acid sodium 15+ Cited Publications Sodium cholate	Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Steroids Source Classification	Endogenous Metabolite
Cholic acid sodium is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion. Cholic acid sodium is orally active .

HY-126995

Glycohyodeoxycholic acid	Structural Classification Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Steroids Source Classification	Endogenous Metabolite
Glycohyodeoxycholic acid is a glycine-conjugated bile acid and also a metabolite of Hyodeoxycholic acid (HY-N0169). The serum level of Glycohyodeoxycholic acid is negatively correlated with the severity of non-alcoholic fatty liver disease. Glycohyodeoxycholic acid can be used in research related to non-alcoholic fatty liver disease .

HY-117371

Hemiasterlin (-)-Hemiasterlin; Milnamide B	Alkaloids Animals Classification of Application Fields Marine natural products Sponge Disease Research Fields Indole Alkaloids Cancer	ADC Payload
Hemiasterlin ((-)-Hemiasterlin) is an antimitotic marine natural product with potent anticancer effects. Hemiasterlin can be used as a cytotoxic payload (ADC Cytotoxin) in antibody-drug conjugates (ADCs) .

HY-122141

Glycohyocholic acid GHCA	Structural Classification Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Steroids Source Classification	Endogenous Metabolite
Glycohyocholic acid (GHCA) is a primary conjugated bile acid formed by the conjugation of Hyocholic acid (HY-121238) and Glycine (HY-Y0966). Glycohyocholic acid can be used as a biomarker in the study of hepatitis C-related cirrhosis and diabetes .

HY-125934

Allocholic acid	Microorganisms Animals Classification of Application Fields Disease Research Fields Steroids Source Classification Cancer	Endogenous Metabolite
Allocholic acid is a typically fetal bile acid found in vertebrates and reappears during liver regeneration and carcinogenesis, besides it is also a conjugate acid of allocholate and an isomer of cholic acid. Allocholic acid is a potent and specific stimulant of the adult olfactory system, it has a role as a marine metabolite, a rat metabolite and a human metabolite .

HY-77641

Cinnamoylglycine	Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Cinnamoylglycine is a human urinary metabolite and PPG analog. Cinnamoylglycine is a conjugate of cinnamic acid and glycine. Cinnamoylglycine is used as a urine marker. Cinnamoylglycine can be used in adipogenic differentiation studies .

HY-N15721

Tryptophan-cholic acid Trp-CA	Triterpenes Structural Classification Terpenoids Endogenous metabolite Source Classification	Orphan GPCR GLP Receptor
Tryptophan-cholic acid (Trp-CA) is a microbial *amino acid-conjugated* bile acid that acts as an endogenous ligand and agonist (EC₅₀=9.6 μM) for the orphan G protein-coupled receptor (GPCR) MRGPRE (Mas-related G protein-coupled receptor family member E). Tryptophan-cholic acid is orally effective but has poor oral absorption and does not cross the blood-brain barrier. Tryptophan-cholic acid promotes the secretion of glucagon-like peptide GLP-1**, thereby improving glucose tolerance in diabetic mice. Tryptophan-cholic acid improves glucose tolerance, promotes insulin secretion, and alleviates high-fat diet-induced hepatic steatosis without causing pruritus side effects. Tryptophan-cholic acid is primarily used in research on type 2 diabetes (T2D) .

HY-W007324

Maleimide	Alkaloids Microorganisms Pyrrole Alkaloids Other Alkaloids Endogenous metabolite Disease Research Fields Source Classification Cancer	ADC Linker Biochemical Assay Reagents
Maleimide can be used for production of antibody-drug conjugate (ADC) which is used in cancer research. Maleimide also be leveraged for the preparation of fluorogenic probe, which is mainly used for the specific detection of thiol analytes .

HY-133890

Tauro-α-muricholic acid 2 Publications Verification T-α-MCA	Structural Classification Human Gut Microbiota Metabolites Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Endogenous Metabolite FXR
Tauro-α-muricholic acid (T-α-MCA) is a Taurine (HY-B0351)-conjugated primary Bile acid. Tauro-α-muricholic acid is a FXR antagonist with an IC₅₀ of 28 µM. Tauro-α-muricholic acid attenuates other bile acid-activated FXR signaling. Tauro-α-muricholic acid can be used in the research of Alzheimer's disease, glucose metabolism, and lipid metabolism .

HY-113427

trans-Vaccenic acid 1 Publications Verification	Animals Classification of Application Fields Ketones, Aldehydes, Acids Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite Bcl-2 Family Apoptosis
trans-Vaccenic acid is a naturally occurring trans fatty acid (TFA). trans-Vaccenic acid inhibits nasopharyngeal carcinoma (NPC) cell growth and induces apoptosis through the inhibition of Bad/Akt phosphorylation. trans-Vaccenic acid is a precursor for the synthesis of saturated fatty acid in the rumen and of conjugated Linoleic acid (CLA) at the tissue level. trans-Vaccenic acid exerts hypolipidemic effects in a rat model of obesity .

HY-19696B

Tauroursodeoxycholate dihydrate Maximum Cited Publications 104 Publications Verification Tauroursodeoxycholic acid dihydrate; TUDCA dihydrate; UR 906 dihydrate	Classification of Application Fields Endogenous metabolite Disease Research Fields Steroids Source Classification Cancer	Caspase Apoptosis Endogenous Metabolite IRE1 NF-κB JNK Reactive Oxygen Species (ROS) Akt
Tauroursodeoxycholate dehydrate is an orally active taurine conjugate of Ursodeoxycholic acid (HY-13771). Tauroursodeoxycholate dehydrate inhibits caspase-3/7, Apoptosis, IRE1α/TRAF2/NF-κB, prevents JNK phosphorylation, inhibits ROS generation, and activates Akt signaling. Tauroursodeoxycholate dehydrate prevents cataract formation, reduces renal tubular damage in type 2 diabetic mice, reduces I/R injury in liver, and inhibits intestinal inflammation and barrier disruption in nonalcoholic fatty liver disease .

HY-W008646

7,8-Dihydro-L-biopterin 1 Publications Verification	Structural Classification Natural Products Human Gut Microbiota Metabolites Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Source Classification	SOD Apoptosis NO Synthase
7,8-Dihydro-L-biopterin is a NOS uncoupling inducer with blood-brain barrier permeability, and it is a reduced non-conjugated pteridine. 7,8-Dihydro-L-biopterin is the main metabolite of 4-amino-tetrahydro-L-biopterin, and it undergoes photooxidation to form biopterin. 7,8-Dihydro-L-biopterin promotes the conversion of nitric oxide synthase to a superoxide-producing form, thereby increasing oxidative stress levels in the renal outer medulla and inducing apoptosis. 7,8-Dihydro-L-biopterin is sensitive to the inhibitory effect of SOD, and it can be applied to research related to salt-sensitive hypertension, moderate to severe traumatic brain injury, and neurodegenerative diseases .

HY-N9459

2-Amino-2-deoxyglucose hydrochloride D-Glucosamine Hydrochloride	Structural Classification Microorganisms Classification of Application Fields Other Diseases Disease Research Fields Saccharides Source Classification	GLUT
2-Amino-2-deoxyglucose hydrochloride (D-Glucosamine Hydrochloride) is a glucose analog that is specifically recognized and transported by the cell membrane GLUT1. 2-Amino-2-deoxyglucose hydrochloride acts as a tumor-targeting ligand and a guiding molecule for the synthesis of prodrug conjugates, thus delivering drugs precisely to tumor cells. 2-Amino-2-deoxyglucose hydrochloride is applicable to diagnostic imaging and therapeutic efficacy monitoring of solid tumors and various cancers (e.g., breast cancer, glioblastoma). 2-Amino-2-deoxyglucose hydrochloride also helps bacteria resist lysozyme digestion by integrating into the non-N-acetylated residues of Streptococcus pneumoniae peptidoglycan. 2-Amino-2-deoxyglucose hydrochloride is used in studies on tumor metabolism and the exploration of bacterial drug resistance mechanisms .

HY-112942

CMP-Sialic acid CMP-Neu5Ac	Natural Products Human Gut Microbiota Metabolites Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
CMP-Sialic acid (CMP-Neu5Ac) is an allosteric inhibitor of UDP-GlcNAc 2-epimerase. CMP-Sialic acid provides a substrate for Golgi sialyltransferases. CMP-Sialic acid is an important sugar nucleotide for biosynthesis of sialic acid and its conjugates .

HY-135072

N,N',N''-Triacetylchitotriose	Infection Structural Classification Polysaccharides Microorganisms Animals Classification of Application Fields Disease Research Fields Saccharides Source Classification	Bacterial Liposome
N,N',N''-Triacetylchitotriose is a competitive Lysozyme inhibitor. N,N',N''-Triacetylchitotriose inhibits the activity of lysozyme. N,N',N''-Triacetylchitotriose reduces the fusion rate between *lysozyme*-conjugated liposomes and erythrocyte ghosts, and decreases the equilibrium fusion rate .

HY-W041019

5-Hydroxytryptophol 1 Publications Verification	Natural Products Monophenols Classification of Application Fields Other Diseases Phenols Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
5-Hydroxytryptophol is a mammalian serotonin metabolite that can be used as a sensitive biomarker for recent alcohol intake. 5-Hydroxytryptophol is formed by alcohol-induced changes in the serotonin metabolic pathway and is excreted in the urine as a glucuronic acid conjugate. 5-Hydroxytryptophol is elevated in urine excretion and can be used clinically to monitor alcohol intake in scenarios such as alcohol relapse .

HY-111974

β-D-Glucopyranosyl abscisate ABA-GE; (S)-cis,trans-Abscisic acid glucosyl ester	other families Classification of Application Fields Terpenoids Sesquiterpenes Abscisic acid Plants Phytohormone Disease Research Fields Endocrinology Source Classification Agricultural Research	Proton Pump
β-D-Glucopyranosyl abscisate (ABA-GE) is a hydrolyzable abscisic acid (ABA) conjugate that accumulates in the vacuole and presumably also in the endoplasmic reticulum. The deconjugation of β-D-Glucopyranosyl abscisate allows the rapid formation of free ABA in response to abiotic stress conditions such as dehydration and salt stress. β-D-Glucopyranosyl abscisate contributes to the maintenance of ABA homeostasis .

HY-P2031

Phallacidin	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Other Diseases Disease Research Fields Source Classification	Arp2/3 Complex
Phallacidin is a natural bicyclic heptapeptide derived from the poisonous mushroom Amanita phalloides. Phallacidin binds to filamentous actin specifically with high affinity, with a K_d of 20 nM. After binding to F-actin, Phallacidin strongly inhibits its depolymerization, stabilizes microfilament structures, and prevents their disruption by drugs such as cytochalasins. When conjugated with a fluorophore, Phallacidin serves as a specific fluorescent probe for F-actin, which is used to clearly visualize the distribution of actin in the cytoskeleton (e.g., stress fibers, cortical peripheral bands) under fluorescence microscopy .

HY-113469

Cyclic GMP 1 Publications Verification	Natural Products Human Gut Microbiota Metabolites Microorganisms Endogenous metabolite Source Classification	Endogenous Metabolite
Cyclic GMP (cGMP), an important second messenger, is a major intracellular mediator of extracellular signals such as nitric oxide (NO) and natriuretic peptides (NPs). Effects of Cyclic GMP occur through three main groups of cellular targets: cGMP-dependent protein kinases (PKGs), cGMP-gated cation channels, and PDEs. Cyclic GMP can inhibit both platelet adhesion and aggregation. cGAMP (Cyclic-GMP-AMP) (HY-12512), a conjugate of Cyclic GMP and AMP, can induce IRF3 phosphorylation and nuclear translocation, enhancing antiviral immune responses .

HY-139066

Punicic acid 1 Publications Verification Trichosanic acid	Structural Classification Punica granatum L. Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Punicaceae Plants Disease Research Fields Source Classification	TNF Receptor GLUT Proteasome Tau Protein PKC
Punicic acid is a bioactive compound of pomegranate seed oil. Punicic acid is an isomer of conjugated α-linolenic acid and ω-5 polyunsaturated fatty acids. Punicic acid has anti-inflammatory and antioxidant activities and can inhibit the expression of inflammatory mediators such as tumor necrosis factor α (TNF-α). Punicic acid can also reduce the formation of β-amyloid deposits and hyperphosphorylation of tau by increasing the expression of GLUT4 protein and inhibiting the overactivation of calpain, and is used to prevent and treat neurodegenerative diseases. In addition, punicic acid also has breast cancer inhibitor properties that depend on lipid peroxidation and PKC pathways .

HY-W399297

Isodeoxycholic acid 1 Publications Verification 7α,12α-Dihydroxycholanoic acid	Structural Classification Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Steroids Source Classification	Endogenous Metabolite
Isodeoxycholic acid (7α,12α-Dihydroxycholanoic acid) is a 3β-hydroxylated secondary bile acid. Isodeoxycholic acid is produced by epimerization of deoxycholic acid by intestinal bacteria. Isodeoxycholic acid is detectable in feces, mainly existing as saponifiable conjugates with long-chain fatty acids. Isodeoxycholic acid participates in the regulation of intestinal physiology .

HY-W034595

Eicosanedioic acid	Microorganisms Source Classification	ADC Linker PROTAC Linkers
Eicosanedioic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Eicosanedioic acid is also a alkyl chain-based PROTAC linker that can be used in the synthesis

HY-N11424

Bilirubin diglucuronide	Structural Classification Natural Products Endogenous metabolite Source Classification	Drug Metabolite Glycosyltransferase
Bilirubin diglucuronide is a bilirubin glycoside conjugate with a 1-O-acyl β-D-glucuronide structure. Bilirubin diglucuronide is the major conjugated bilirubin (HY-N0323) and predominant pigment excreted in the bile of adult humans, rats, dogs and cats. Bilirubin diglucuronide is mainly synthesized via UDP-glucuronosyltransferase-mediated transfer of glucuronic acid from UDP-glucuronic acid to bilirubin monoglucuronide, or via enzymatic disproportionation of two moles of bilirubin monoglucuronide (predominantly producing the IXα configuration). In addition, Bilirubin diglucuronide can also be synthesized from bilirubin or its monoglucuronide in a UDP-glucuronic acid-dependent manner. Pretreatment with phenobarbital significantly enhances the formation process of Bilirubin diglucuronide .

HY-141793

ATRA-biotin Biotin-ATRA-conjugate	Alkaloids Classification of Application Fields Other Alkaloids Endogenous metabolite Disease Research Fields Source Classification Cancer	RAR/RXR PPAR Endogenous Metabolite Autophagy
ATRA-biotin (Biotin-ATRA-conjugate) is a biotin-conjugated ATRA. ATRA-biotin can be used to track ATRA in cells or a given tissue .

HY-133890A

Tauro-α-muricholic acid sodium 2 Publications Verification T-α-MCA sodium	Structural Classification Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Steroids Source Classification	Endogenous Metabolite FXR
Tauro-α-muricholic acid sodium (T-α-MCA sodium) is a Taurine (HY-B0351)-conjugated primary Bile acid. Tauro-α-muricholic acid sodium is a FXR antagonist with an IC₅₀ of 28 µM. Tauro-α-muricholic acid sodium attenuates other bile acid-activated FXR signaling. Tauro-α-muricholic acid sodium can be used in the research of Alzheimer's disease, glucose metabolism, and lipid metabolism .

HY-N0324R

Cholic acid (Standard) 15+ Cited Publications	Structural Classification Human Gut Microbiota Metabolites Microorganisms Other disease Classification of Application Fields Disease markers Metabolic Disease Endogenous metabolite Disease Research Fields Steroids Source Classification	Reference Standards Endogenous Metabolite
Cholic acid (Standard) is the analytical standard of Cholic acid. This product is intended for research and analytical applications. Cholic acid is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion. Cholic acid is orally active .

HY-113003

H-γ-Glu-Gln-OH γ-Glutamylglutamine; γ-Glu-Gln	Animals Classification of Application Fields Ketones, Aldehydes, Acids Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Others
H-γ-Glu-Gln-OH is a hydrophilic peptide and can be conjugated to drugs. The carrier composed of H-γ-Glu-Gln-OH has the characteristics of high water solubility and drug-loading capacity, good biocompatibility, low toxicity, improved tumor targeting ability, and anti-tumor efficacy .

HY-113469A

Cyclic GMP sodium 1 Publications Verification	Natural Products Classification of Application Fields Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	Endogenous Metabolite
Cyclic GMP (cGMP) sodium, an important second messenger, is a major intracellular mediator of extracellular signals such as nitric oxide (NO) and natriuretic peptides (NPs). Effects of Cyclic GMP sodium occur through three main groups of cellular targets: cGMP-dependent protein kinases (PKGs), cGMP-gated cation channels, and PDEs. Cyclic GMP can inhibit both platelet adhesion and aggregation. cGAMP (Cyclic-GMP-AMP) (HY-12512), a conjugate of Cyclic GMP and AMP, can induce IRF3 phosphorylation and nuclear translocation, enhancing antiviral immune responses .

HY-124422

Pentacosanoic acid	other families Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Plants Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Pentacosanoic acid is a 25-carbon long-chain saturated fatty acid. Pentacosanoic is a conjugate acid of a pentacosanoate .

HY-113095

γ-CEHC 1 Publications Verification	Monophenols Classification of Application Fields Ketones, Aldehydes, Acids Other Diseases Phenols Endogenous metabolite Disease Research Fields Source Classification	Drug Metabolite Endogenous Metabolite
γ-CEHC is a γ-tocopherol (HY-N7148) metabolite. γ-CEHC is mainly excreted into the urine rather than into the bile. γ-CEHC is present in conjugated form in human urine, mainly as glucuronide .

HY-118667

Dehydroergosterol 1 Publications Verification	Microorganisms Source Classification	Liposome
Dehydroergosterolis a naturally occurring fluorescent sterol analog (Ex/Em=325/375 nm), which mimics the properties of cholesterol in cell membranes. DehydroergosterolEasily conjugated by cholesterol-binding proteins for real-time imaging in live cells. DehydroergosterolThe sterol environment and intracellular sterol transport in vivo can be probed/elucidated in real time .

HY-Y1055R

Guanine (Standard)	Structural Classification Natural Products Microorganisms Endogenous metabolite Source Classification	Reference Standards DNA/RNA Synthesis Endogenous Metabolite
Guanine (Standard) is the analytical standard of Guanine (HY-Y1055). This product is intended for research and analytical applications. Guanine is one of the fundamental components of nucleic acids (DNA and RNA). Guanine is a purine derivative, consisting of a fused pyrimidine-imidazole ring system with conjugated double bonds. Guanine has the potential to serve as a large-capacity N pool. Guanine has cytotoxic, antinociceptive and neuroprotective effects .

HY-N1424R

Glycoursodeoxycholic acid (Standard) GUDCA (Standard); Ursodeoxycholylglycine (Standard)	Structural Classification Microorganisms Endogenous metabolite Steroids Source Classification	Reference Standards Endogenous Metabolite
Glycoursodeoxycholic acid (Standard) is the analytical standard of Glycoursodeoxycholic acid. This product is intended for research and analytical applications. Glycoursodeoxycholic acid, a acyl glycine and a bile acid-glycine conjugate, is a metabolite of ursodeoxycholic acid.

HY-W034918

Docosanedioic acid	other families Classification of Application Fields Ketones, Aldehydes, Acids Plants Disease Research Fields Source Classification Cancer	ADC Linker PROTAC Linkers
Docosanedioic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Docosanedioic acid is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-131663

L-Lysinamide	Microorganisms Amino acids Source Classification	Amino Acid Derivatives
L-Lysinamide is an amide form of L-Lysine (HY-N0469). L-Lysinamide can be conjugated with Cholesterol (HY-N0322) and L-ornithinamide for use as a DNA delivery agent .

HY-N6740

Beta-Zearalanol	Microorganisms Macrolide Antibiotics Classification of Application Fields Antibiotics Phenols Polyphenols Metabolic Disease Antibacterial Disease Research Disease Research Fields Source Classification	Apoptosis
Beta-Zearalenol is an mycotoxin produced by Fusarium spp, which causes apoptosis and oxidative stress in mammalian reproductive cells . Beta-Zearalenol is the derivative of zearalenone (ZEA) which can conjugate with glucuronic acid .

HY-N16321

C18:0 DG-PEG2K-triGalNAc	Lipid	Biochemical Assay Reagents
C18:0 DG-PEG2K-triGalNAc is a functionalized PEG lipid that consists of a C18:0 DG unit conjugated to a triGalNAc. C18:0 DG-PEG2K-triGalNAc can be used to prepare lipid nanoparticles for drug delivery.

HY-126995R

Glycohyodeoxycholic acid (Standard)	Structural Classification Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Steroids Source Classification	Reference Standards Endogenous Metabolite
Glycohyodeoxycholic acid (Standard) is the analytical standard of Glycohyodeoxycholic acid. This product is intended for research and analytical applications. Glycohyodeoxycholic acid is a glycine-conjugated bile acid and also a metabolite of Hyodeoxycholic acid (HY-N0169). The serum level of Glycohyodeoxycholic acid is negatively correlated with the severity of non-alcoholic fatty liver disease. Glycohyodeoxycholic acid can be used in research related to non-alcoholic fatty liver disease.

HY-W004260R

Arachidic acid (Standard) 3 Publications Verification Eicosanoic acid (Standard)	Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Reference Standards Endogenous Metabolite
Arachidic acid (Standard) is the analytical standard of Arachidic acid (HY-W004260). This product is intended for research and analytical applications. Arachidic acid (Eicosanoic acid) is a long-chain saturated fatty acid. Arachidic acid can be found in the human organism from the plasma phospholipid, fish, cannabis and other plant oils. Arachidic acid conjugated with Chitosan oligosaccharide (HY-112108) can be used for anti-cancer drug delivery research .

HY-113469R

Cyclic GMP (Standard)	Structural Classification Natural Products Human Gut Microbiota Metabolites Microorganisms Endogenous metabolite Source Classification	Endogenous Metabolite Reference Standards
Cyclic GMP (Standard) is the analytical standard of Cyclic GMP (HY-113469). This product is intended for research and analytical applications. Cyclic GMP (cGMP), an important second messenger, is a major intracellular mediator of extracellular signals such as nitric oxide (NO) and natriuretic peptides (NPs). Effects of Cyclic GMP occur through three main groups of cellular targets: cGMP-dependent protein kinases (PKGs), cGMP-gated cation channels, and PDEs. Cyclic GMP can inhibit both platelet adhesion and aggregation. cGAMP (Cyclic-GMP-AMP) (HY-12512), a conjugate of Cyclic GMP and AMP, can induce IRF3 phosphorylation and nuclear translocation, enhancing antiviral immune responses .

HY-W008646R

7,8-Dihydro-L-biopterin (Standard)	Structural Classification Natural Products Human Gut Microbiota Metabolites Microorganisms Endogenous metabolite Source Classification	Reference Standards SOD Apoptosis NO Synthase
NADH (disodium salt) (Standard) is the analytical standard of NADH (disodium salt). This product is intended for research and analytical applications. 7,8-Dihydro-L-biopterin is a NOS uncoupling inducer with blood-brain barrier permeability, and it is a reduced non-conjugated pteridine. 7,8-Dihydro-L-biopterin is the main metabolite of 4-amino-tetrahydro-L-biopterin, and it undergoes photooxidation to form biopterin. 7,8-Dihydro-L-biopterin promotes the conversion of nitric oxide synthase to a superoxide-producing form, thereby increasing oxidative stress levels in the renal outer medulla and inducing apoptosis. 7,8-Dihydro-L-biopterin is sensitive to the inhibitory effect of SOD, and it can be applied to research related to salt-sensitive hypertension, moderate to severe traumatic brain injury, and neurodegenerative diseases .

HY-W751418

N-Nervonoyl taurine (Z)-2-tetracos-15-enamidoethanesulfonic acid	Natural Products Endogenous metabolite Source Classification	FAAH
N-Nervonoyl taurine ((Z)-2-tetracos-15-enamidoethanesulfonic acid) is a fatty acid-taurine conjugate derived from nervonic acid. N-Nervonoyl taurine is a substrate of fatty acid amide hydrolase (FAAH) discovered during metabolite profiling .

HY-N7497

Protoescigenin	Triterpenes other families Classification of Application Fields Terpenoids Other Diseases Plants Disease Research Fields Source Classification	Others
Protoescigenin is the main aglycone of horse chestnut saponin mixture known as escin. Protoescigenin is selected as substrate for exploratory chemistry towards selective protection, followed by propargyl ether formation and subsequent condensation with azido-monosaccharides, to obtain novel triazole linked conjugates of the triterpene .

Cat. No.	Product Name	Chemical Structure

HY-N0324S

Cholic acid-d4 3 Publications Verification
Cholic acid-d₄ is the deuterium labeled Cholic acid. Cholic acid is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion.

HY-13631DS

DXd-d5
DXd-d₅ is a deuterium labeled DXd. DXd is a potent DNA topoisomerase I inhibitor, with an IC₅₀ of 0.31 μM, used as a conjugated drug of HER2-targeting ADC (DS-8201a) .

HY-18569S

3-Indoleacetic acid-d5 2 Publications Verification
3-Indoleacetic acid-d₅ is the deuterium labeled 3-Indoleacetic acid (HY-18569). 3-Indoleacetic acid-d₅ can be used as internal standard for assay of IAA releases by alkaline hydrolysis of ester and amide conjugates .

HY-13631ES4

Deruxtecan-d5
Deruxtecan-d₅ is deuterium labeled Deruxtecan (HY-13631E). Deruxtecan is an ADC drug-linker conjugate composed of an DX-8951 derivative (DXd) and a maleimide-GGFG peptide linker, used for synthesizing DS-8201 and U3-1402.

HY-15575S

VcMMAE-d8
VcMMAE-d8 is an isotope of VcMMAE (HY-15575). VcMMAE-d8 is a *agent-linker conjugate* for ADC** with potent antitumor activity by using the anti-mitotic agent, monomethyl auristatin E (MMAE, a tubulin inhibitor), linked via the lysosomally cleavable dipeptide, valine-citrulline (vc) .

HY-N0324S2

Cholic acid-13C
Cholic acid- ¹³C is the ¹³C-labeled Cholic acid. Cholic acid is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion.

HY-W041895S1

DL-Glutamic acid-d3
DL-Glutamic acid-d₃ is the deuterium labeled DL-Glutamic acid. DL-Glutamic acid is the conjugate acid of Glutamic acid, which acts as a fundamental metabolite. Comparing with the second phase of polymorphs α and β L-Glutamic acid, DL-Glutamic acid presents better stability .

HY-N0324S1

Cholic acid-d5
Cholic acid-d₅ is the deuterium labeled Cholic acid. Cholic acid is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion.

HY-N1424S

Glycoursodeoxycholic acid-d4
Glycoursodeoxycholic acid-d₄ (Ursodeoxycholylglycine-d₄) is the deuterium labeled Glycoursodeoxycholic acid. Glycoursodeoxycholic acid, a acyl glycine and a bile acid-glycine conjugate, is a metabolite of ursodeoxycholic acid .

HY-12454S

DM4-d6
DM4-d₆ is deuterium labeled DM4. DM4 is is an antitubulin agent that inhibit cell division. DM4 can be used in the preparation of antibody agent conjugate.

HY-13631ES3

Deruxtecan-d2
Deruxtecan-d₂ is the deuterium labeled Deruxtecan (HY-13631E) . Deruxtecan is an ADC drug-linker conjugate composed of an DX-8951 derivative (DXd) and a maleimide-GGFG peptide linker, used for synthesizing DS-8201 and U3-1402.

HY-N6740S

β-Zearalanol-d4
β-Zearalanol-d₄ is a deuterium labeled Beta-Zearalanol (HY-N6740） . Beta-Zearalenol is an mycotoxin produced by Fusarium spp, which causes apoptosis and oxidative stress in mammalian reproductive cells . Beta-Zearalenol is the derivative of zearalenone (ZEA) which can conjugate with glucuronic acid .

HY-W004260S1

Arachidic acid-d39
Arachidic acid-d₃₉ is the deuterium labeled Arachidic acid (HY-W004260). Arachidic acid (Eicosanoic acid) is a long-chain saturated fatty acid. Arachidic acid can be found in the human organism from the plasma phospholipid, fish, cannabis and other plant oils. Arachidic acid conjugated with Chitosan oligosaccharide (HY-112108) can be used for anti-cancer drug delivery research .

HY-Y1055S3

Guanine-15N5
Guanine- ¹⁵N₅ is ¹⁵N labeled Guanine (HY-Y1055). Guanine is one of the fundamental components of nucleic acids (DNA and RNA). Guanine is a purine derivative, consisting of a fused pyrimidine-imidazole ring system with conjugated double bonds. Guanine has the potential to serve as a large-capacity N pool. Guanine has cytotoxic, antinociceptive and neuroprotective effects .

HY-Y1055S

Guanine-13C
Guanine- ¹³C is the ¹³C labeled Guanine (HY-Y1055) . Guanine is one of the fundamental components of nucleic acids (DNA and RNA). Guanine is a purine derivative, consisting of a fused pyrimidine-imidazole ring system with conjugated double bonds. Guanine has the potential to serve as a large-capacity N pool. Guanine has cytotoxic, antinociceptive and neuroprotective effects .

HY-15582S

Auristatin E-d8

Auristatin E-d₈ is the deuterium labeled Auristatin E (HY-15582). Auristatin E is a cytotoxic microtubule polymerization inhibitor with potent and selective antitumor activity. Auristatin E is a cytotoxin in antibody-drug conjugates (ADC). Auristatin E inhibits cell division by blocking the polymerisation of tubulin, promising for research in B-cell malignancies. Auristatin E, a synthetic analogue of the Dolastatin 10 (HY-15580), is linear peptides comprised of four amino acids .

HY-W041895S

DL-Glutamic acid-d5
DL-Glutamic acid-d₅ is the deuterium labeled DL-Glutamic acid. DL-Glutamic acid is the conjugate acid of Glutamic acid, which acts as a fundamental metabolite. Comparing with the second phase of polymorphs α and β L-Glutamic acid, DL-Glutamic acid presents better stability .

HY-116374S

Glycolithocholic acid-d4
Glycolithocholic acid-d₄ is the deuterium labeled Glycolithocholic acid. Glycolithocholic acid, an endogenous metabolite, is a glycine-conjugated secondary bile acid and can be used to diagnose ulcerative colitis (UC), non-alcoholic steatohepatitis (NASH) and primary sclerosing cholangitis (PSC) .

HY-13631ES

Deruxtecan-d4
Deruxtecan-d₄ is deuterium labeled Deruxtecan (HY-13631E). Deruxtecan is an ADC drug-linker conjugate composed of an DX-8951 derivative (DXd) and a maleimide-GGFG peptide linker, used for synthesizing DS-8201 and U3-1402.

HY-Y1055S1

Guanine-13C,15N2

Guanine- ¹³C, ¹⁵N₂ is the ¹³C and ¹⁵N labeled Guanine (HY-Y1055) . Guanine is one of the fundamental components of nucleic acids (DNA and RNA). Guanine is a purine derivative, consisting of a fused pyrimidine-imidazole ring system with conjugated double bonds. Guanine has the potential to serve as a large-capacity N pool. Guanine has cytotoxic, antinociceptive and neuroprotective effects .

HY-161022S1

FL118-C3-O-C-amide-C-NH2-d5 formate
FL118-C3-O-C-amide-C-NH2-d5 formate is a deuterium labeled FL118-C3-O-C-amide-C-NH2 formate. FL118-C3-O-C-amide-C-NH2 formate is an ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .

HY-N1420AS

Rhamnose-13C monohydrate
Rhamnose- ¹³C (monohydrate) is the ¹³C labeled Rhamnose monohydrate. Rhamnose monohydrate (L-Rhamnose monohydrate) is a monosaccharide found in plants and bacteria. Rhamnose monohydrate-conjugated immunogens is used in immunotherapies. Rhamnose monohydrate c

HY-N1420AS2

Rhamnose-13C-2 monohydrate
Rhamnose- ¹³C-2 (monohydrate) is the ¹³C labeled Rhamnose monohydrate. Rhamnose monohydrate (L-Rhamnose monohydrate) is a monosaccharide found in plants and bacteria. Rhamnose monohydrate-conjugated immunogens is used in immunotherapies. Rhamnose monohydrate

HY-77641S

Cinnamoylglycine-d2
Cinnamoylglycine-d₂ is the deuterium labeled Cinnamoylglycine. Cinnamoylglycine is a glycine conjugate of cinnamic acid and a urinary metabolite in human. Cinnamoylglycine is used as a potential urinary biomarker indicating intact or disrupted colonization resistance during and after antibiotic treatment .

HY-13631ES2

Deruxtecan-d4-1
Deruxtecan-d₄-1 is the deuterium labeled Adenosine Deruxtecan (HY-13631E) . Deruxtecan is an ADC drug-linker conjugate composed of an DX-8951 derivative (DXd) and a maleimide-GGFG peptide linker, used for synthesizing DS-8201 and U3-1402.

HY-W004260S4

Arachidic acid-d4
Arachidic acid-d₄ is the deuterium labeled Arachidic acid (HY-W004260). Arachidic acid (Eicosanoic acid) is a long-chain saturated fatty acid. Arachidic acid can be found in the human organism from the plasma phospholipid, fish, cannabis and other plant oils. Arachidic acid conjugated with Chitosan oligosaccharide (HY-112108) can be used for anti-cancer drug delivery research .

HY-14532S

Brincidofovir-d6

Brincidofovir-d₆ (CMX001-d₆) is the deuterium labeled Brincidofovir (HY-14532). Brincidofovir (CMX001), the lipid-conjugated prodrug of Cidofovir (HY-17438), is an orally available, long-acting antiviral. Brincidofovir shows activity against a broad spectrum of DNA viruses including cytomegalovirus (CMV), adenovirus (ADV), varicella zoster virus, herpes simplex virus, polyomaviruses, papillomaviruses, poxviruses, and mixed double-stranded DNA virus infections. Brincidofovir, an oral antiviral in late stage development, has proven effective against orthopoxviruses in vitro and in vivo. .

HY-176415S

Cys-MC-GGFG-Dxd-d5
Cys-MC-GGFG-Dxd-d₅ is the deuterium labeled Cys-MC-GGFG-Dxd (HY-176415). Cys-MC-GGFG-Dxd is a conjugate of Cys and Deruxtecan (HY-13631E). Cys-MC-GGFG-Dxd is a linker-toxin building block in antibody-drug conjugates (ADCs) used to link antibody Cys residues to cytotoxic drugs. Cys-MC-GGFG-Dxd can be used in cancer research .

HY-W777809

Guanine-13C2,15N

Guanine- ¹³C₂, ¹⁵N is the ¹³C- and ¹⁵N-labeled Guanine (HY-Y1055). Guanine is one of the fundamental components of nucleic acids (DNA and RNA). Guanine is a purine derivative, consisting of a fused pyrimidine-imidazole ring system with conjugated double bonds. Guanine has the potential to serve as a large-capacity N pool. Guanine has cytotoxic, antinociceptive and neuroprotective effects .

HY-113427S

trans-Vaccenic acid-d13

trans-Vaccenic acid-d₁₃ is deuterium labeled trans-Vaccenic acid (HY-113427). trans-Vaccenic acid is a naturally occurring trans fatty acid (TFA). trans-Vaccenic acid inhibits nasopharyngeal carcinoma (NPC) cell growth and induces apoptosis through the inhibition of Bad/Akt phosphorylation. trans-Vaccenic acid is a precursor for the synthesis of saturated fatty acid in the rumen and of conjugated Linoleic acid (CLA) at the tissue level. trans-Vaccenic acid exerts hypolipidemic effects in a rat model of obesity .

HY-137522S

Zidovudine O-β-D-glucuronide-d3 sodium

Zidovudine O-β-D-glucuronide-d₃ sodium (3'-Azido-3'-deoxythymidine β-D-glucuronide-d₃ sodium) is a deuterium labeled Zidovudine O-β-D-glucuronide sodium (HY-137522). Zidovudine O-β-D-glucuronide (3'-Azido-3'-deoxythymidine β-D-glucuronide) sodium is the glucuronide conjugate and metabolite of Zidovudine (HY-17413), which can be used to detect UGT2B7 activity. As a substrate, Zidovudine O-β-D-glucuronide sodium undergoes deconjugation via hydrolysis by immobilized β-glucuronidase to produce Zidovudine .

HY-W767865

Cyclic GMP sodium-13C5

Cyclic GMP sodium- ¹³C₅ is the ¹³C-labeled Cyclic GMP sodium (HY-113469A). Cyclic GMP (cGMP) sodium, an important second messenger, is a major intracellular mediator of extracellular signals such as nitric oxide (NO) and natriuretic peptides (NPs). Effects of Cyclic GMP sodium occur through three main groups of cellular targets: cGMP-dependent protein kinases (PKGs), cGMP-gated cation channels, and PDEs. Cyclic GMP can inhibit both platelet adhesion and aggregation. cGAMP (Cyclic-GMP-AMP) (HY-12512), a conjugate of Cyclic GMP and AMP, can induce IRF3 phosphorylation and nuclear translocation, enhancing antiviral immune responses .

HY-15583S

Auristatin F-d8
Auristatin F-d₈ is deuterium labeled Auristatin F (HY-15583). Auristatin F is a potent cytotoxin in antibo-conjugated agents and an analogue of MMAF. Auristatin F is a potent microtubule inhibitor and vascular damaging agent (VDA). Auristatin F inhibits cell division by preventing tubulin aggregation.Auristatin F can be used in antibody-drug conjugates (ADC) .

HY-145989S

Aminobenzenesulfonic auristatin E-d8
Aminobenzenesulfonic auristatin E-d₈ is the deuterium labeled Aminobenzenesulfonic auristatin E. Aminobenzenesulfonic auristatin E is a drug-linker conjugate for ADC. Aminobenzenesulfonic auristatin E has potent antitumor activity by using Auristatin E (a cytotoxic tubulin modifier), linked via the ADC linker Aminobenzenesulfonic .

HY-145399S

AZ14170133-d5
AZ14170133-d₅ (SG 3932-d₅) is the deuterium labeled AZ14170133 (HY-145399). AZ14170133 (SG 3932) is a Drug-Linker Conjugates for ADC, which comprises a topoisomerase inhibitor and a linker for ligand unit connecting. AZ14170133 can be used to synthesis antibody-drug conjugate (ADC) .

HY-133890AS

Tauro-α-muricholic acid-d4 sodium

Tauro-α-muricholic acid-d₄ (sodium) is the deuterium labeled Tauro-α-muricholic acid sodium (HY-133890A). Tauro-α-muricholic acid sodium (T-α-MCA sodium) is a Taurine (HY-B0351)-conjugated primary Bile acid. Tauro-α-muricholic acid sodium is a FXR antagonist with an IC₅₀ of 28 µM. Tauro-α-muricholic acid sodium attenuates other bile acid-activated FXR signaling. Tauro-α-muricholic acid sodium can be used in the research of Alzheimer's disease, glucose metabolism, and lipid metabolism .

HY-W653947

Glycoursodeoxycholic acid-d5
Glycoursodeoxycholic acid-d₅ (Ursodeoxycholylglycine-d₅) is the deuterium labeled Glycoursodeoxycholic acid (HY-N1424). Glycoursodeoxycholic acid, a acyl glycine and a bile acid-glycine conjugate, is a metabolite of ursodeoxycholic acid.

HY-W019776

Sudan I-d5
Sudan I-d₅ is a the deuterated Sudan I. Sudan I is a diazo-conjugate red dye and can be used as an additive to products such as oils, solvents or polishes. Sudan I inhibits growth of bacterial strains Clostridium perfringens and L. rhamnosus .

HY-I1129

Fmoc-3VVD-OH-d8
Fmoc-3VVD-OH-d₈ is a deuterium labeled Fmoc-3VVD-OH (HY-78921). Fmoc-3VVD-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .

HY-114360AS1

Taurohyodeoxycholic acid-d4 sodium
Taurohyodeoxycholic acid-d4 (sodium) is a deuterated labeled Taurohyodeoxycholic acid (sodium) . Taurohyodeoxycholic acid (THDCA) sodium is the taurine-conjugated form of the secondary bile acid hyodeoxycholic acid. Taurohyodeoxycholic acid can also reduce the activity and expression of myeloperoxidase TNF-α and IL-6, as well as colonic damage in TNBS-induced ulcerative colitis mouse model.

HY-W750488

Glycolithocholic acid-d5
Glycolithocholic acid-d₅ (Lithocholylglycine-d₅) is the deuterium labeled Glycolithocholic acid (HY-116374). Glycolithocholic acid (Lithocholylglycine), an endogenous metabolite, is a glycine-conjugated secondary bile acid. Glycolithocholic acid can be used to diagnose ulcerative colitis (UC), non-alcoholic steatohepatitis (NASH) and primary sclerosing cholangitis (PSC) .

HY-122141S

Glycohyocholic acid-d4
Glycohyocholic acid-d₄ is the deuterium labeled Glycohyocholic acid (HY-122141). Glycohyocholic acid (GHCA) is a primary conjugated bile acid formed by the conjugation of Cholic acid (HY-N0324) and Glycine (HY-Y0966). Glycohyocholic acid can be used in the study of hepatitis C-related cirrhosis and diabetes mellitus .

HY-N6740S2

Beta-Zearalanol-d5
Beta-Zearalanol-d₅ is the deuterium labeled Beta-Zearalanol (HY-N6740). Beta-Zearalenol is an mycotoxin produced by Fusarium spp, which causes apoptosis and oxidative stress in mammalian reproductive cells . Beta-Zearalenol is the derivative of Zearalenone (HY-103447) which can conjugate with glucuronic acid .

HY-145397S

(4-NH2)-Exatecan-d5
(4-NH2)-Exatecan-d5 is a deuterated labeled (4-NH2)-Exatecan . (4-NH2)-Exatecan (compound A), a topoisomerase inhibitor, is a derivative of Exatecan. (4-NH2)-Exatecan can be used in the synthesis of antibody-drug conjugates (ADCs) .

HY-150159S

Cotinine-d3 N-β-D-Glucuronide
Cotinine-d₃ N-β-D-Glucuronide is the deuterium labeled Cotinine N-β-D-Glucuronide (HY-W588194). Cotinine N-β-D-Glucuronide is a glucuronide conjugate of the tobacco metabolite Cotinine (HY-B1178). Cotinine N-β-D-Glucuronide is promising for research of tobacco carcinogen metabolism and cognitive function .

HY-W004260S2

Arachidic acid-d3
Arachidic acid-d₃ is the deuterium labeled Arachidic acid (HY-W004260). Arachidic acid (Eicosanoic acid) is a long-chain saturated fatty acid. Arachidic acid can be found in the human organism from the plasma phospholipid, fish, cannabis and other plant oils. Arachidic acid conjugated with Chitosan oligosaccharide (HY-112108) can be used for anti-cancer drug delivery research .

HY-W004260S

Arachidic acid-d2
Arachidic acid-d₂ is the deuterium labeled Arachidic acid (HY-W004260). Arachidic acid (Eicosanoic acid) is a long-chain saturated fatty acid. Arachidic acid can be found in the human organism from the plasma phospholipid, fish, cannabis and other plant oils. Arachidic acid conjugated with Chitosan oligosaccharide (HY-112108) can be used for anti-cancer drug delivery research .

HY-Y1055S4

Guanine-13C5
Guanine- ¹³C₅ is ¹³C-labeled Guanine (HY-Y1055). Guanine is one of the fundamental components of nucleic acids (DNA and RNA). Guanine is a purine derivative, consisting of a fused pyrimidine-imidazole ring system with conjugated double bonds. Guanine has the potential to serve as a large-capacity N pool. Guanine has cytotoxic, antinociceptive and neuroprotective effects .

HY-W778114

Guanine-13C2,7-15N

HY-Y1055S2

Guanine-13C5,15N5

Guanine- ¹³C₅, ¹⁵N₅ is ¹³C and ¹⁵N-labeled Guanine (HY-Y1055). Guanine is one of the fundamental components of nucleic acids (DNA and RNA). Guanine is a purine derivative, consisting of a fused pyrimidine-imidazole ring system with conjugated double bonds. Guanine has the potential to serve as a large-capacity N pool. Guanine has cytotoxic, antinociceptive and neuroprotective effects .

Targets Recommended: Antibody-Drug Conjugates (ADCs) Target Protein Ligand-Linker Conjugates Peptide-Drug Conjugates (PDCs) PROTAC-Linker Conjugates for PAC Radionuclide-Drug Conjugates (RDCs) Drug-Linker Conjugates for ADC Antibody-Oligonucleotide Conjugates (AOCs) E3 Ligase Ligand-Linker Conjugates ADC Linker

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-138300GL

ALC-0159 (GMP Like)	Liposome	Inflammation/Immunology
ALC-0159 (GMP Like) is the GMP Like class ALC-0159 (HY-138300). GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. ALC-0159, a polyethylene glycol (PEG) lipid conjugate, could be used as vaccine excipient .

HY-W000423G

DBCO-amine	Biochemical Assay Reagents	Cancer
DBCO-amine (GMP) is a GMP grade DBCO-amine (HY-W000423). DBCO-amine is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. DBCO-amine is used in the synthesis of antibody-drug conjugates (ADCs) .

HY-15578G

McMMAF Maleimidocaproyl monomethylauristatin F	Drug-Linker Conjugates for ADC	Cancer
McMMAF GMP is a GMP grade McMMAF (HY-15578). McMMAF is a protective group (maleimidocaproyl)-conjugated MMAF, which is a potent tubulin polymerization inhibitor. McMMAF can be used as a agent-linker for *antibody-drug conjugates* (ADC)**. McMMAF is uncleavable, and must be internalized and degraded within a cell, releasing cysteine-McMMAF as the active agent .

HY-78921AG

Fmoc-3VVD-OH	ADC Linker	Cancer
Fmoc-3VVD-OH (GMP) is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .

HY-15575G

VcMMAE MC-Val-Cit-PAB-MMAE; mc-vc-PAB-MMAE	Drug-Linker Conjugates for ADC	Cancer
VcMMAE (MC-Val-Cit-PAB-MMAE) (GMP) is VcMMAE (HY-15575) produced by using GMP guidelines. VcMMAE is a drug-linker conjugate for ADC .

HY-78932G

Dap-NE hydrochloride	ADC Linker	Cancer
Dap-NE hydrochloride (GMP) is Dap-NE hydrochloride (HY-78932A) produced by using GMP guidelines. Dap-NE hydrochloride is an intermediate used in the synthesis of antibody-drug conjugates (ADCs) .

HY-19318G

Fmoc-Val-Cit-PAB	ADC Linker	Cancer
Fmoc-Val-Cit-PAB GMP is a GMP grade Fmoc-Val-Cit-PAB (HY-19318). Fmoc-Val-Cit-PAB is a cleavable antibody-conjugated active molecule (ADC) commonly used linker.

HY-45672G

Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH	ADC Linker	Cancer
Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH GMP is a GMP grade Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH (HY-45672). Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH is an ADC Linker that can be used to synthesize Drug-Linker Conjugates for ADC. Especially for the synthesis of Deruxtecan (HY-13631E), a toxic drug-linker conjugate .

HY-131833G

Fmoc-Gly-Gly-Phe-OH	ADC Linker	Cancer
Fmoc-Gly-Gly-Phe-OH GMP is a GMP grade Fmoc-Gly-Gly-Phe-OH (HY-131833). Fmoc-Gly-Gly-Phe-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .

HY-133540G

Maleimide-DOTA Maleimido-mono-amide-DOTA	ADC Linker	Inflammation/Immunology Cancer
Maleimide-DOTA (Maleimido-mono-amide-DOTA) (GMP) is Maleimide-DOTA (HY-133540) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Maleimide-DOTA is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .

HY-78738G

MC-Val-Cit-PAB	ADC Linker	Cancer
MC-Val-Cit-PAB GMP is a GMP grade MC-Val-Cit-PAB (HY-78738). MC-Val-Cit-PAB is an intermediate in the synthesis of VcMMAE (HY-15575), which is a Drug-Linker Conjugates for ADC. Monomethyl auristatin E can be used to inhibit Microtubule/Tubulin as ADC Cytotoxin.

HY-15579BG

MMAF sodium Monomethylauristatin F sodium	Microtubule/Tubulin ADC Payload	Cancer
MMAF sodium GMP is a GMP grade MMAF (sodium) (HY-15579B). MMAF sodium (Monomethylauristatin F sodium) is a potent tubulin polymerization inhibitor and is used as a antitumor agent. MMAF sodium (Monomethylauristatin F sodium) is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) such as Vorsetuzumab mafodotin and SGN-CD19A .

HY-78931G

Boc-Dap-NE	ADC Linker	Cancer
Boc-Dap-NE (GMP) is Boc-Dap-NE (HY-78931) produced by using GMP guidelines. Boc-Dap-NE is an intermediate in the synthesis of Monomethyl auristatin E (HY-15162), which is an inhibitor of tubulin polymerization. Monomethyl auristatin E can be used to synthesize Antibody-Drug Conjugates (ADCs) as ADC Cytotoxin.

HY-100374G

Val-Cit-PAB-MMAE	Drug-Linker Conjugates for ADC	Cancer
Val-Cit-PAB-MMAE GMP is a GMP grade Val-Cit-PAB-MMAE (HY-100374). Val-Cit-PAB-MMAE is a agent-linker conjugate for ADC. Val-Cit-PAB-MMAE contains the ADCs linker (peptide Val-Cit-PAB) and a potent tubulin inhibitor MMAE (HY-15162). MMAE a potent mitotic inhibitor by inhibiting tubulin polymerization.

HY-20336G

Mc-Val-Cit-PABC-PNP	ADC Linker	Cancer
Mc-Val-Cit-PABC-PNP GMP is a GMP grade Mc-Val-Cit-PABC-PNP (HY-20336). GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Mc-Val-Cit-PABC-PNP is a cathepsin cleavable ADC linker. Mc-Val-Cit-PABC-PNP can be used in the synthesis of antibody-drug conjugates (ADCs) .

HY-44980G

Fmoc-Gly-NH-CH2-acetyloxy	ADC Linker	Cancer
Fmoc-Gly-NH-CH2-acetyloxy GMP is a GMP grade Fmoc-Gly-NH-CH2-acetyloxy (HY-44980). GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Fmoc-Gly-NH-CH2-acetyloxy is a cleavable linker that can be used to synthesize antiboy-drug Conjugates (ADCs).

HY-15579G

MMAF Monomethylauristatin F	Microtubule/Tubulin ADC Payload	Cancer
MMAF (Monomethylauristatin F) GMP is a GMP grade MMAF (HY-15579). GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. MMAF (Monomethylauristatin F) is a potent tubulin polymerization inhibitor and is used as a antitumor agent. MMAF (Monomethylauristatin F) is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) such as vorsetuzumab mafodotin and SGN-CD19A .

HY-13631EG

Deruxtecan MC-GGFG-DXD	Drug-Linker Conjugates for ADC	Cancer
Deruxtecan (GMP) (MC-GGFG-DXD (GMP)) is Deruxtecan (HY-13631E) in GMP grade. GMP-grade small molecules can be used as auxiliary reagents in cell therapy. Deruxtecan is an ADC drug-linker conjugate composed of an DX-8951 derivative (DXd) and a maleimide-GGFG peptide linker, used for synthesizing Trastuzumab deruxtecan (HY-138298A) and Patritumab deruxtecan (HY-P99813) .

HY-42972G

DBCO-acid	Biochemical Assay Reagents	Cancer
DBCO-acid GMP is a GMP grade DBCO-acid (HY-42972). DBCO-acid is a click chemistry reagent used in the synthesis of ADC linker DBCO-NHS ester ((HY-115524) and (HY-115545)), and agent-linker conjugates DBCO-PEG-MMAE (HY-111012 and HY-126690). DBCO-acid contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups .

HY-42360G

SMCC	ADC Linker	Inflammation/Immunology Cancer
SMCC (GMP) is the GMP level of SMCC (HY-42360). GMP guidelines are used to produce SMCC (HY-42360) (GMP). GMP small molecules works appropriately as an auxiliary reagent for cell research manufacture. SMCC (GMP) is a protein crosslinker. SMCC (GMP) contains an amine-reactive N-hydroxysuccinimide ester and a sulfhydryl-reactive maleimide group that can be used in the conjugation of proteins. SMCC-conjugated antigen coupled spleen cells to induce antigen-specific immune responses.

HY-131990G

MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH	ADC Linker	Cancer
MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH GMP is a GMP grade MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH (HY-131990). MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .

HY-W087187G

DOTAGA-anhydride	Radionuclide-Drug Conjugates (RDCs)	Cancer
DOTAGA-anhydride (GMP) is DOTAGA-anhydride (HY-W087187) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. DOTAGA-anhydride is a DOTA-based metal chelator that can bind to radionuclides and is used to prepare radionuclide drug conjugates (RDCs). DOTAGA-anhydride has been successfully used for labeling antibodies (e.g., Trastuzumab (HY-P9907)). DOTAGA-anhydride can be used for the synthesis of a bimodal tag for Single-photon emission computed tomography (SPECT) or PET/optical imaging .

HY-128952G

Tesirine SG3249	Drug-Linker Conjugates for ADC DNA Alkylator/Crosslinker	Cancer
Tesirine (GMP) (SG3249 (GMP)) is Tesirine (HY-128952) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Tesirine (SG3249) is an antibody-drug conjugate (ADC) pyrrolobenzodiazepine (PBD) dimer payload. Tesirine combines potent antitumor activity with desirable physicochemical properties such as favorable hydrophobicity and improved conjugation characteristics. SG3199 (HY-101161) is the released warhead component of the ADC payload Tesirine. SG3199 retains picomolar activity in a panel of cancer cell lines. PBD dimers are highly efficient DNA minor groove cross-linking agents with potent cytotoxicity .

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