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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
34 Results for "
folate synthesis
" in MedChemExpress (MCE) Product Catalog:
Products (34)
34 Results for "folate synthesis" in MCE Product Catalog:
4
4 Cited Publications
Synonyms: 4,4′-Diaminodiphenyl sulfone; DDS
Research Areas:
Dapsone (4,4′-Diaminodiphenyl sulfone) is an orally active and blood-brain penetrant sulfonamide antibiotic with bacteriostatic, antimycobacterial and antiprotozoal activities . Dapsone?exerts effective antileprosy activity?and inhibits folate synthesis in cell extracts of?M. leprae. Dapsone is used for dermatologic disorder research, including leprosy, dermatitis herpetiformis, acne vulgaris et al .
3
3 Cited Publications
Synonyms: Chlorguanide triazine hydrochloride
Target:
Cycloguanil (Chlorguanide triazine) hydrochloride is a dihydrofolate reductase (DHFR) inhibitor with an IC50 of 10.8 μM against human DHFR. Cycloguanil hydrochloride blocks the folate metabolic pathway, thereby affecting nucleotide synthesis and interfering with DNA replication. Cycloguanil inhibits DHFR in Plasmodium and is thus used in malaria research. Cycloguanil hydrochloride also potently inhibits DHFR in human cancer cells and blocks the transcriptional activity of STAT3, thereby exhibiting anticancer activity .
1
1 Cited Publications
Cat. No.: HY-P2048
CAS No.: 1627580-64-6
Research Areas:
Neurological Disease Metabolic Disease Inflammation/Immunology Endocrinology
1
Research Areas:
Succinylsulfathiazole (Succinylsulphathiazole) is a long-acting sulfonamide antibiotic with localized gut-specific antibacterial activity and is orally active. Succinylsulfathiazole inhibits bacterial folate synthesis, reduces coliform counts, suppresses intestinal bacterial growth and vitamin biosynthesis, and depletes gut folate-producing bacteria. Succinylsulfathiazole modulates hepatic mTOR signaling, diminishes cecal fermentation, decreases hepatic folate levels and total folate excretion, elevates nitrogen excretion and reduces the fermentability of certain dietary fibers. Succinylsulfathiazole induces folate deficiency and triggers biotin- and folate-related nutritional deficiency symptoms in rats and C57BL/6 mice .
1
1 Cited Publications
Cat. No.: HY-W006064
CAS No.: 23235-01-0
Synonyms: (S)-2-Aminopent-4-ynoic acid
Target:
Research Areas:
1
Target:
Research Areas:
Silver sulfadiazine (AgSD), a sulfonamide antibiotic, effects a dual inhibitory action on bacterial growth by its sulfa moiety (SD-SDZ) that prevents bacterial folate absorption and subsequent DNA synthesis. The silver that is released from Silver sulfadiazine binds and disrupts the DNA structure, precluding bacterial DNA replication .
1
1 Cited Publications
Cat. No.: HY-P2048A
Research Areas:
Neurological Disease Metabolic Disease Inflammation/Immunology Endocrinology
1
1 Cited Publications
Synonyms: Chlorguanide triazine-d6
Cat. No.: HY-B1008S
CAS No.: 350820-01-8
Synonyms: PABA-d4; Vitamin Bx-d4; Vitamin H1-d4; p-Aminobenzoic acid-d4
Cat. No.: HY-133493
Target:
Research Areas:
Folate-PEG3-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
Cat. No.: HY-133494
CAS No.: 2743004-48-8
Target:
Research Areas:
Folate-PEG1-mal is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
Cat. No.: HY-B0688S2
CAS No.: 1632119-29-9
Synonyms: 4,4′-Diaminodiphenyl sulfone-13C12; DDS-13C12
Cat. No.: HY-133496
CAS No.: 1245285-73-7
Target:
Research Areas:
Folate-PEG3-alkyne is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Folate-PEG3-alkyne is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Cat. No.: HY-B0688S
CAS No.: 557794-38-4
Synonyms: 4,4′-Diaminodiphenyl sulfone-d8; DDS-d8
Cat. No.: HY-W115607
CAS No.: 24991-53-5
Synonyms: Poly(ethylene glycol)-bis-amine 4000
Target:
Research Areas:
Sulfaproxyline (Sulfaproxylin; Sulfaproxyline) is a sulfonamide antibiotic that inhibits bacterial dihydropteroate synthase, thereby blocking folate biosynthesis required for nucleic acid production. Sulfaproxyline shows antimicrobial activity primarily against Staphylococcus species and common uropathogens. Sulfaproxyline reduces bacterial growth by impairing DNA and protein synthesis. Sulfaproxyline can be used for research of staphylococcal and urinary tract infections .
Cat. No.: HY-133495
CAS No.: 1099829-15-8
Target:
Research Areas:
Folate-PEG2-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
Target:
Research Areas:
Folate-PEG3-amine is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .
Cat. No.: HY-126733
CAS No.: 73951-54-9
Synonyms: (6R)-Folinic acid
Target:
Research Areas:
(6R)-Leucovorin is a derivative of Folic Acid, a vitamin that plays a crucial role in DNA synthesis, DNA repair, and DNA methylation, and also serves as a cofactor in biological reactions involving folate .
Cat. No.: HY-B0688S1
CAS No.: 1346602-12-7
Synonyms: 4,4′-Diaminodiphenyl sulfone-d4; DDS-d4
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
