73951-54-9
73951-54-9
Chemical Structure
(6R)-Leucovorin
Synonym(s): (6R)-Folinic acid
- CAS No.: 73951-54-9
- Formula:C20H23N7O7
- Molecular Weight:473.44
IUPAC Name: (4-((((R)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl)methyl)amino)benzoyl)-L-glutamic acid
InChIKey: VVIAGPKUTFNRDU-OLZOCXBDSA-N
SMILES: O=C(CC[C@H](NC(C1=CC=C(C=C1)NC[C@H]2N(C3=C(NC2)NC(N)=NC3=O)C=O)=O)C(O)=O)O
Biological Activity: (6R)-Leucovorin is a derivative of Folic Acid, a vitamin that plays a crucial role in DNA synthesis, DNA repair, and DNA methylation, and also serves as a cofactor in biological reactions involving folate[1][2].
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(6R)-Leucovorin | (6R)-Leucovorin is a derivative of Folic Acid, a vitamin that plays a crucial role in DNA synthesis, DNA repair, and DNA methylation, and also serves as a cofactor in biological reactions involving folate. | |||||||||||||||||||||
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References
- [1]. Zittoun J, et al. Comparative effect of 6S, 6R and 6RS leucovorin on methotrexate rescue and on modulation of 5-fluorouracil. Br J Cancer. 1991 Jun;63(6):885-8. [Content Brief]
- [2]. Liu K, et al. Simultaneous determination of 6R-leucovorin, 6S-leucovorin and 5-methyltetrahydrofolate in human plasma using solid phase extraction and chiral liquid chromatography-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Apr 1;877(10):902-10. [Content Brief]
