Search Result

Results for "

fraction

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (1) Adenylate Cyclase (1) AMPK (1) Anaplastic lymphoma kinase (ALK) (1) Antibody-Drug Conjugates (ADCs) (1) Apoptosis (4) Autophagy (1) Bacterial (3) BCRP (2) Biochemical Assay Reagents (11) Cannabinoid Receptor (2) CCR (1) COX (1) Cytochrome P450 (3) DNA/RNA Synthesis (1) Drug Derivative (5) Drug Isomer (1) Drug Metabolite (3) E1/E2/E3 Enzyme (1) Endogenous Metabolite (12) Environmental Pollutants (1) Eukaryotic Initiation Factor (eIF) (2) FAP (1) Fungal (1) GABA Receptor (1) Glutathione Peroxidase (3) Guanylate Cyclase (1) Heme Oxygenase (HO) (1) Herbicide (2) HIV (1) HIV Protease (1) Interleukin Related (1) Isotope-Labeled Compounds (1) Leukotriene Receptor (2) Lipase (1) MMP (1) Monoamine Oxidase (2) Neuropeptide Y Receptor (2) Opioid Receptor (1) Parasite (2) PDHK (1) Phosphodiesterase (PDE) (3) Phospholipase (2) PKC (1) Platelet-activating Factor Receptor (PAFR) (1) Proteasome (1) Reactive Oxygen Species (ROS) (1) Reference Standards (6) ROR (1) SARS-CoV (2) Sodium Channel (2) Toll-like Receptor (TLR) (1) Transthyretin (TTR) (1) TRP Channel (1)
By Research Areas:	Cancer (14) Cardiovascular Disease (14) Endocrinology (4) Infection (11) Inflammation/Immunology (18) Metabolic Disease (20) Neurological Disease (13)
Click Chemistry:	Azide (1) Alkynes (1)

117

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Click Chemistry

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-Y1422D

Lipase,Candida antarctica (Immobilized)	Environmental Pollutants Lipase	Others
Lipase,Candida antarctica (Immobilized) is an immobilized lipase isolated from Candida antarctica fraction* B*. Lipase,Candida antarctica (Immobilized) features high stability and selectivity. Lipase,Candida antarctica (Immobilized) is widely used in fields such as chemical synthesis, food oil modification, and biodiesel production .

HY-112654

GCN2iB Maximum Cited Publications 60 Publications Verification	Eukaryotic Initiation Factor (eIF) Glutathione Peroxidase	Cardiovascular Disease Metabolic Disease Cancer
GCN2iB is an ATP-competitive, selective GCN2 inhibitor with an IC₅₀ of 2.4 nM. GCN2iB inhibits the activation of the GCN2 pathway and upregulates GPX4. GCN2iB enhances the anticancer effect of ASNase against acute lymphoblastic leukemia. GCN2iB increases left ventricular ejection fraction, while reducing fasting blood glucose and myocardial fibrosis. GCN2iB can be used in research related to acute lymphoblastic leukemia, acute myeloid leukemia and diabetic cardiomyopathy .

HY-W102714

1,2-Cyclohexylenedinitrilotetraacetic acid CDTA	Biochemical Assay Reagents	Neurological Disease
1,2-Cyclohexylenedinitrilotetraacetic acid (CDTA) is a chelating agent. 1,2-Cyclohexylenedinitrilotetraacetic acid has an ability to remove manganese from brain and liver (in vivo) and their sub-cellular fractions (in vitro), of rats pretreated with manganese sulphate .

HY-N0554

Escin IA 1 Publications Verification	HIV Protease Monoamine Oxidase	Infection Inflammation/Immunology Cancer
Escin IA is an oral LOXL2 inhibitor and EMT inhibitor, with selectivity for LOXL2-expressing cells. Escin IA suppresses invasion, migration, and metastasis of breast cancer cells, and acts as the primary anti-TNBC metastasis constituent of Aesculus chinensis Bunge fruit saponin fraction. Escin IA can be used for the research of triple-negative breast cancer, acute inflammation, and ethanol-induced gastric mucosal lesions .

HY-W004307

Octadecanal Stearyl aldehyde	Endogenous Metabolite	Others
Octadecanal (Stearyl aldehyde) is a long-chain aldehyde component. Octadecanal exists in the phospholipid fractions of thigh and breast muscles of broiler chickens .

HY-145581

Mitiperstat 1 Publications Verification AZD4831	Glutathione Peroxidase Cytochrome P450	Cardiovascular Disease Inflammation/Immunology
Mitiperstat (AZD4831) is an effective oral inhibitor of myeloperoxidase (MPO). Mitiperstat inhibits MPO and thyroid peroxidase (TPO) with IC₅₀s of 1.5 nM and 0.69 μM. Mitiperstat exhibits a weak inhibitory activity against CYP3A4 with an IC₅₀ of 6 μM. Mitiperstat can reduce inflammation and improve microvascular function, and it can be used in studies related to heart failure, preserved or mildly reduced ejection fraction, non-alcoholic fatty liver disease, and chronic obstructive pulmonary disease .

HY-164027

MyoMed 205	E1/E2/E3 Enzyme	Metabolic Disease Cancer
MyoMed 205 is an orally active muscle ring finger protein 1 (MuRF1) inhibitor. MyoMed-205 reduces ubiquitination and subsequent proteasomal degradation of muscle proteins by inhibiting MuRF1 activity. MyoMed 205 augments muscle performance, attenuates muscle weight loss and alleviates disease-induced weight loss. MyoMed 205 can be used for the research of cancer cachexia, type 2 diabetes mellitus, and heart failure with preserved ejection fraction .

HY-138877

Phosphoglycolic acid	Endogenous Metabolite	Infection
Phosphoglycolic acid is a metabolite and a bacterial cytoplasmic component. Phosphoglycolic acid acts as a by-product generated during the preparation of phosphoglycolohydroxamic acid via hydrolysis of ethyl phosphoglycolate. Phosphoglycolic acid also functions as an active component of postbiotics .

HY-109136

Runcaciguat 1 Publications Verification BAY 1101042	Guanylate Cyclase	Cardiovascular Disease Metabolic Disease
Runcaciguat (BAY 1101042) is a selective, orally active, allosteric activator of soluble guanylate cyclase (sGC) that specifically targets its oxidized and heme-free form. Runcaciguat binds to sGC in a histidine-dependent manner and restores cyclic guanosine monophosphate (cGMP) production under oxidative stress, independent of nitric oxide (NO) or heme. Runcaciguat exhibits renoprotective and cardioprotective activities, such as reduced proteinuria and improved renal function. Runcaciguat is primarily being studied in chronic kidney disease (CKD) associated with hypertension, diabetes, and metabolic disorders, as well as potential cardiovascular indications such as heart failure with preserved ejection fraction (HFpEF) .

HY-108693

β-Tocotrienol	Leukotriene Receptor Apoptosis	Inflammation/Immunology
β-Tocotrienol is an isomer of vitamin E. β-Tocotrienol is a less potent antioxidant than α-tocotrienol. β-Tocotrienol can be found in the tocotrienol-rich fraction (TRF) of palm oil, which possesses anti-carcinogenic effects in vitro on human colon carcinoma and prostate cancer cells. β-Tocotrienol inhibits the growth of A549 (GI₅₀ = 1.38 μM) and U87MG (GI₅₀ = 2.53 μM) cells. β-Tocotrienol also induces apoptosis in cancer cells. β-Tocotrienol can inhibit PD-L1 expression and mitigates PD-L1-mediated immune suppression in vitro and in vivo .

HY-138560

Cross-linked dextran G 50 2 Publications Verification	Biochemical Assay Reagents	Others
Cross-linked dextran G 50 is a gel filtration medium. Cross-linked dextran G 50 can be used in gel permeation chromatography for fractionation of the glycopeptide mixture (Sphere protein separation range: 1.5K-30K Da; Polysaccharide separation range: 500-10K Da) .

HY-137295

Ingenol 3,20-dibenzoate	PKC Apoptosis	Inflammation/Immunology
Ingenol 3,20-dibenzoate is a potent protein kinase C (PKC) isoform-selective agonist. Ingenol 3,20-dibenzoate induces selective translocation of nPKC-delta, -epsilon, and -theta and PKC-mu from the cytosolic fraction to the particulate fraction and induces morphologically typical apoptosis through de novo synthesis of macromolecules. Ingenol 3,20-dibenzoate increases the IFN-γ production and degranulation by NK cells, especially when NK cells are stimulated by NSCLC cells .

HY-P1604

ATX-II 1 Publications Verification	Sodium Channel	Cardiovascular Disease Inflammation/Immunology
ATX-II is a selective sodium channel modulator toxin. ATX-II enhances late sodium current, prevents full sodium channel inactivation, and generates persistent current fractions. ATX-II has pro-arrhythmic effect. ATX-II slows intrinsic heart rate, prolongs QT interval and sinus node recovery time, and causes sinus pauses and arrests. ATX-II can be used for the research of atrial fibrillation, long QT syndrome, and long QT3 syndrome .

HY-113020

21-Hydroxypregnenolone 1 Publications Verification	Endogenous Metabolite Cytochrome P450	Metabolic Disease
21-Hydroxypregnenolone is a CYP17 inhibitor. 21-Hydroxypregnenolone competitively inhibits CYP17-mediated 17α-hydroxylation activity of progesterone, with a Ki value of 36.4 μM .

HY-P1604A

ATX-II TFA 1 Publications Verification	Sodium Channel	Cardiovascular Disease Inflammation/Immunology
ATX-II TFA is a selective sodium channel modulator toxin. ATX-II TFA enhances late sodium current, prevents full sodium channel inactivation, and generates persistent current fractions. ATX-II TFA has pro-arrhythmic effect. ATX-II TFA slows intrinsic heart rate, prolongs QT interval and sinus node recovery time, and causes sinus pauses and arrests. ATX-II TFA can be used for the research of atrial fibrillation, long QT syndrome, and long QT3 syndrome .

HY-W250145

Acid Black 2 Nigrosine	Biochemical Assay Reagents	Others
Acid Black 2 (Nigrosine) is an alcohol-soluble absorber used to mimic skin pigmentation in tissue-mimicking phantoms. Acid Black 2 acts as an absorber in silicone-based thin tissue phantoms to simulate varying melanosome volume fractions in skin .

HY-N0860

Schisantherin E Schizantherin-E	Others	Inflammation/Immunology
Schisantherin E is a natural compound isolated from the active fraction of the fruits of Schisandra sphenanthera Rehd. et Wils.

HY-N0786

Ginkgolide J	Others	Neurological Disease
Ginkgolide J is a main constituent of the non-flavone fraction of Ginkgo biloba with an IC₅₀ range of 12-54 µM, has neuroprotective and anti neuronal apoptotic ability .

HY-N3433

Kaempferol 3-O-arabinoside 1 Publications Verification	Others	Others
Kaempferol 3-O-arabinoside is an antioxidant flavonoids isolated from ethyl acetate fraction (EAF) obtained from the leaves of Nectandra hihua. Kaempferol 3-O-arabinoside has good antioxidant capacity .

HY-N2018

α-D-Xylose α-D-Xylopyranose	Endogenous Metabolite	Metabolic Disease
α-D-Xylose (α-D-Xylopyranose) is a basic component of the five-carbon fraction of biomass and a precursor of hemicellulose. α-D-Xylose participates in a variety of enzyme-catalyzed reactions, which in turn participate in a variety of metabolic pathways. In addition, α-D-Xylose is also used in tanning, dyeing and as a diabetic food .

HY-W782122

Photoclick cholesterol	Biochemical Assay Reagents	Cancer
Photoclick cholesterol is a photoreactive cholesterol analog capable of undergoing click reactions. Photoclick cholesterol enables specific, saturable photoaffinity labeling of the mitochondrial translocator protein TSPO .

HY-125361

Ganosporeric acid A	Others	Others
Ganosporeric acid A, a natural product, is isolated from the ether-soluble fraction of the spores of Ganoderma lucidum. Ganosporeric acid A can be used for the research of liver injury .

HY-N3955

Alnusenone Glutinone; Glutinone	Others	Others
Alnusenone (Glutinone) is a stabilised intermediate int he biogenesis of friedelin (XV) from squalene. Alnusenone is the major natural compound in fractions .

HY-157538

PDK4-IN-2	PDHK	Cardiovascular Disease
PDK4-IN-2 (compound 8) is a pyruvate dehydrogenase kinase 4 (PDK4) inhibitor with an IC₅₀ of 46 µM. PDK4-IN-2 improves ejection fraction of failing hearts by regulating bioenergetics via activation of the tricarboxylic acid cycle .

HY-W283166

n-Undecyl β-D-maltopyranoside	Biochemical Assay Reagents	Others
n-Undecyl β-D-maltopyranoside is an n-alkyl β-D-maltopyranoside detergent that can be used for solubilization and structural determination of membrane proteins. n-Undecyl β-D-maltopyranoside effectively solubilizes CST from Golgi-enriched fractions of Pichia pastoris, but fails to maintain the functional activity of CST during subsequent partial purification and reconstitution into proteoliposomes. n-Undecyl β-D-maltopyranoside is more suitable for structural analysis studies of membrane proteins rather than functional reconstitution experiments .

HY-118852

Isoxaben	Herbicide	Others
Isoxaben, a herbicide, inhibits incorporation of radiolabeled glucose into an acid insoluble cell wall fraction. Isoxaben is also a specific inhibitor of cell wall biosynthesis .

HY-W709825

(-)-Cyperene	Others	Infection
(-)-Cyperene is a sesquiterpene hydrocarbon. (-)-Cyperene can be obtained from the n-hexane fraction of the smoke condensate of Goniothalamus andersonii. (-)-Cyperene can be used in the study of mosquitoes .

HY-W011120

Ethyl docosa-4,7,10,13,16,19-hexaenoate	Endogenous Metabolite	Metabolic Disease
Ethyl cis-4,7,10,13,16,19-Docosahexaenoate, the ethyl ester of Docosahexaenoate (DHA), is enriched in the ethyl ester fraction by the selective alcoholysis of fatty acid ethyl esters originating from tuna oil with lauryl alcohol.

HY-153168

Bemoradan	Phosphodiesterase (PDE)	Cardiovascular Disease
Bemoradan (compound 10a) is an orally active and selective canine Phosphodiesterase (PDE) fraction III inhibitor. Bemoradan is a long-acting, potent, inotropic vasodilator and a novel cardiotonic agent, and can be used in congestive heart failure research .

HY-N2203A

Vitexin2''-O-p-trans-coumarate	Others	Others
Vitexin2''-O-p-trans-coumarate is a flavonoid, can be isolated from the Et acetate-soluble fraction of the ethanolic extract of the seeds of Trigonella foenum-graecum. Vitexin2''-O-p-trans-coumarate strongly promotes 2BS cell proliferation induced by H₂O₂ .

HY-P11331

Az-NC-002	Proteasome	Others
Az-NC-002 is a Proteasome trypsin-like site (β2) and immunoproteasome β2i-specific active probe. Az-NC-002 has weak off-target effects with no significant inhibition for Cathepsin D (HY-P2750), but this inhibition reacts outside of the active site or influence on a small fraction of the enzyme .

HY-116547

Methylenephenanthrene 4,5-Methylenephenanthrene	Others	Others
Methylenephenanthrene (4,5-Methylenephenanthrene) can be isolated from the refined neutral fraction of anthracene oil

HY-N12039

Juniper camphor	Others	Others
Juniper camphor is a sesquiterpene compound isolated from camphor blue oil, the high-boiling fraction of camphor .

HY-P5700

*SAAP Fraction* 3**	Bacterial	Infection
SAAP Fraction 3 is an antimicrobial peptide. SAAP Fraction 3 is active against P. haemolytica in Zn-saline buffer .

HY-W009934

2-Phenyl-2-(2-pyridyl)acetonitrile α-Phenyl-2-pyridineacetonitrile	Drug Metabolite	Endocrinology
2-Phenyl-2-(2-pyridyl)acetonitrile is the major metabolite of SC 15396 metabolized by the supernatant fraction of rat liver homogenate. SC 15396 is an antigastrin that inhibits gastric secretion .

HY-116494

ML753286	BCRP	Cancer
ML753286 is an orally active and selective BCRP (Breast cancer resistance protein) inhibitor with an IC₅₀ of 0.6 μM. ML753286 has high permeability and low to medium clearance in rodent and human liver S9 fractions, and is stable in plasma cross species .

HY-125986

GK187	Phospholipase	Neurological Disease
GK187 is a potent and selective Group VIA calcium-independent phospholipase A₂ (GVIA iPLA₂) inhibitor with an X_I(50) value of 0.0001. GK187 can be used for researching various neurological disorders . ^{[The X_I(50) is the mole fraction of the inhibitor in the total substrate interface required to inhibit the enzyme by 50%.]}

HY-14240

PG 116800 PG 530742; PGE 530742; PGE 7113313	MMP	Cardiovascular Disease
PG 116800 (PGE 530742; PGE 7113313) is an orally active, selective and high-affinity inhibitor of MMP. PG 116800 acts as an inhibitor of ventricular remodeling, reduces left ventricular volumes and infarct zone collagen content, and improves ejection fraction. PG 116800 is generally well tolerated, but is associated with higher rates of arthralgia, joint stiffness, and dyspepsia. PG 116800 can be used for the research of myocardial infarction .

HY-W710399

2-Hydroxy-3-(palmitoyloxy)propyl stearate DG(16:0/0:0/18:0); 1-Palmitin-3-Stearin	Endogenous Metabolite	Metabolic Disease
1-Palmitoyl-3-stearoyl-rac-glycerol is a diacylglycerol that contains palmitic acid (HY-N0830) at the sn-1 position and stearic acid (HY-B2219) at the sn-3 position. It has been found in palm-based diacylglycerols produced from palm stearin, palm mid fraction, palm oil, and palm olein, as well as in wheat bran and brewer’s spent grain extracts.

HY-P10996

Corticostatin, human TFA Human Neutrophil Peptide-4 TFA	Bacterial SARS-CoV	Infection
Corticostatin, human (Human Neutrophil Peptide-4) TFA is an antimicrobial peptide with demonstrated antiviral activity. Corticostatin, human TFA can kill Escherichia coli, Streptococcus faecalis, and Candida albicans. Corticostatin, human (HNP-4) TFA is more bactericidal against Gram-negative bacteria than any of HNP-1-3. Corticostatin, human TFA can be isolated from the azurophil granule fraction of discontinuous Percoll gradients .

HY-138560A

Cross-linked dextran G 50, medium	Biochemical Assay Reagents	Others
Cross-linked dextran G 50, medium is a gel filtration medium. Cross-linked dextran G 50, medium can be used in gel permeation chromatography for fractionation of the glycopeptide mixture (Sphere protein separation range: 1.5K-30K Da; Polysaccharide separation range: 500-10K Da). Cross-linked dextran G 50, medium are microspheres with an average particle size of D50 = 220-250 μm .

HY-138560B

Cross-linked dextran G 50, fine	Biochemical Assay Reagents	Others
Cross-linked dextran G 50, fine is a gel filtration medium. Cross-linked dextran G 50, fine can be used in gel permeation chromatography for fractionation of the glycopeptide mixture (Sphere protein separation range: 1.5K-30K Da; Polysaccharide separation range: 500-10K Da). Cross-linked dextran G 50, fineThe average particle size is D50=110-130 μmof microspheres .

HY-N3621

Corchoionol C	Others	Others
Corchoionol C is a n-butanol-soluble fraction of the whole plant extract of Pulicaria undulate .

HY-160658

AZ760	CCR	Inflammation/Immunology
AZ760 is a CCR8 antagonist. AZ760 shows excellent potency, good lipophilicity and high free fraction in blood. AZ760 exhibits unacceptable hERG inhibition .

HY-N4245

Siegesmethyletheric acid	Others	Others
Siegesmethyletheric acid is isolated from the ethyl acetate fraction of Siegesbeckia orientalis L. (Asteraceae) .

HY-156980

Podilfen	Bacterial	Infection
Podilfen is an active fraction of Delftia strains 2189 with antimicrobial effects .

HY-167728

Taxusin	Others	Others
Taxusin is a natural product that can be isolated from the heartwood fraction of the yew tree (Taxus mairei) .

HY-133610

3,4,6-Trichlorocatechol	DNA/RNA Synthesis	Others
3,4,6-trichlorocatechol (TCC) is the metabolite produced by industrial pollutant through post-mitochondrial liver fraction from Aroclor-1254 induced rats .

HY-112738

AX048	Phospholipase	Inflammation/Immunology
AX048 is an inhibitor for calcium-dependent phospholipase A2 cPLA₂ with a X_I(50) of 0.022 mole fraction and reveals an antihyperalgesic efficacy .

HY-B1370E

(R)-Hydroxychloroquine phosphate (R)-HCQ phosphate	Parasite Toll-like Receptor (TLR) SARS-CoV Autophagy	Metabolic Disease
(R)-Hydroxychloroquine ((R)-HCQ) phosphate is a (R)-isomer of Hydroxychloroquine (HY-W031727). (R)-Hydroxychloroquine inhibits the insulin metabolizing enzyme of cytosolic fraction of liver homogenates in healthy and diabetic rats .

Cat. No.	Product Name	Type

HY-138877

Phosphoglycolic acid	Biochemical Assay Reagents
Phosphoglycolic acid is a metabolite and a bacterial cytoplasmic component. Phosphoglycolic acid acts as a by-product generated during the preparation of phosphoglycolohydroxamic acid via hydrolysis of ethyl phosphoglycolate. Phosphoglycolic acid also functions as an active component of postbiotics .

HY-138560

Cross-linked dextran G 50 2 Publications Verification	Biochemical Assay Reagents
Cross-linked dextran G 50 is a gel filtration medium. Cross-linked dextran G 50 can be used in gel permeation chromatography for fractionation of the glycopeptide mixture (Sphere protein separation range: 1.5K-30K Da; Polysaccharide separation range: 500-10K Da) .

HY-W283166

n-Undecyl β-D-maltopyranoside

Biochemical Assay Reagents

n-Undecyl β-D-maltopyranoside is an n-alkyl β-D-maltopyranoside detergent that can be used for solubilization and structural determination of membrane proteins. n-Undecyl β-D-maltopyranoside effectively solubilizes CST from Golgi-enriched fractions of Pichia pastoris, but fails to maintain the functional activity of CST during subsequent partial purification and reconstitution into proteoliposomes. n-Undecyl β-D-maltopyranoside is more suitable for structural analysis studies of membrane proteins rather than functional reconstitution experiments .

HY-124187

Pinolenic acid ethyl ester

Ethyl pinolenate

Biochemical Assay Reagents

Pinolenic acid is a polyunsaturated fatty acid found in the seed oils of red pine (Pinus orientalis) and maritime pine (Pinus pinaster). Both oils were found to have lipid-lowering properties. A diet containing marine pine nut oil (MPSO) reduces HDL and ApoA1 levels in transgenic mice expressing human ApoA1. MPSO was found to reduce cholesterol efflux in vitro. Korean pine nut oil supplements may help obesity by reducing appetite. People who take this oil experience an increase in the satiety hormones CCK and GLP-1 and a decrease in appetite. The activity of the oil is attributed to pinolenic acid. Pinolenic acid is not metabolized to arachidonic acid and can reduce the level of arachidonic acid in the phosphatidylinositol fraction of HepG2 cells from 15.9% to 7.0%. Pinolenic acid ethyl ester is a neutral, more lipophilic form of the free acid.

HY-138560A

Cross-linked dextran G 50, medium	Biochemical Assay Reagents
Cross-linked dextran G 50, medium is a gel filtration medium. Cross-linked dextran G 50, medium can be used in gel permeation chromatography for fractionation of the glycopeptide mixture (Sphere protein separation range: 1.5K-30K Da; Polysaccharide separation range: 500-10K Da). Cross-linked dextran G 50, medium are microspheres with an average particle size of D50 = 220-250 μm .

HY-138560B

Cross-linked dextran G 50, fine	Biochemical Assay Reagents
Cross-linked dextran G 50, fine is a gel filtration medium. Cross-linked dextran G 50, fine can be used in gel permeation chromatography for fractionation of the glycopeptide mixture (Sphere protein separation range: 1.5K-30K Da; Polysaccharide separation range: 500-10K Da). Cross-linked dextran G 50, fineThe average particle size is D50=110-130 μmof microspheres .

Cat. No.	Product Name	Target	Research Area

HY-P1604

ATX-II 1 Publications Verification	Sodium Channel	Cardiovascular Disease Inflammation/Immunology
ATX-II is a selective sodium channel modulator toxin. ATX-II enhances late sodium current, prevents full sodium channel inactivation, and generates persistent current fractions. ATX-II has pro-arrhythmic effect. ATX-II slows intrinsic heart rate, prolongs QT interval and sinus node recovery time, and causes sinus pauses and arrests. ATX-II can be used for the research of atrial fibrillation, long QT syndrome, and long QT3 syndrome .

HY-P1604A

ATX-II TFA 1 Publications Verification	Sodium Channel	Cardiovascular Disease Inflammation/Immunology
ATX-II TFA is a selective sodium channel modulator toxin. ATX-II TFA enhances late sodium current, prevents full sodium channel inactivation, and generates persistent current fractions. ATX-II TFA has pro-arrhythmic effect. ATX-II TFA slows intrinsic heart rate, prolongs QT interval and sinus node recovery time, and causes sinus pauses and arrests. ATX-II TFA can be used for the research of atrial fibrillation, long QT syndrome, and long QT3 syndrome .

HY-P11331

Az-NC-002	Proteasome	Others
Az-NC-002 is a Proteasome trypsin-like site (β2) and immunoproteasome β2i-specific active probe. Az-NC-002 has weak off-target effects with no significant inhibition for Cathepsin D (HY-P2750), but this inhibition reacts outside of the active site or influence on a small fraction of the enzyme .

HY-P5700

*SAAP Fraction* 3**	Bacterial	Infection
SAAP Fraction 3 is an antimicrobial peptide. SAAP Fraction 3 is active against P. haemolytica in Zn-saline buffer .

HY-P10996

Corticostatin, human TFA Human Neutrophil Peptide-4 TFA	Bacterial SARS-CoV	Infection
Corticostatin, human (Human Neutrophil Peptide-4) TFA is an antimicrobial peptide with demonstrated antiviral activity. Corticostatin, human TFA can kill Escherichia coli, Streptococcus faecalis, and Candida albicans. Corticostatin, human (HNP-4) TFA is more bactericidal against Gram-negative bacteria than any of HNP-1-3. Corticostatin, human TFA can be isolated from the azurophil granule fraction of discontinuous Percoll gradients .

HY-P1495

Small Cardioactive Peptide B (SCPB)	Adenylate Cyclase	Cardiovascular Disease Neurological Disease
Small Cardioactive Peptide B (SCP_B), a neurally active peptide, stimulates adenylate cyclase activity in particulate fractions of both heart and gill tissues with EC₅₀s of 0.1 and 1.0 μM, respectively.

HY-P1428A

RFRP-1(human) TFA	Neuropeptide Y Receptor	Cardiovascular Disease
RFRP-1(human) TFA is a potent endogenous NPFF receptor agonist (EC₅₀ values are 0.0011 and 29 nM for NPFF2 and NPFF1, respectively). Attenuates contractile function of isolated rat and rabbit cardiac myocytes. Reduces heart rate, stroke volume, ejection fraction and cardiac output, and increases plasma prolactin levels in rats.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0554

Escin IA 1 Publications Verification	Infection Triterpenes Structural Classification other families Classification of Application Fields Terpenoids Hippocastanaceae Aesculus hippocastanum Plants Disease Research Fields Source Classification Cancer	HIV Protease Monoamine Oxidase
Escin IA is an oral LOXL2 inhibitor and EMT inhibitor, with selectivity for LOXL2-expressing cells. Escin IA suppresses invasion, migration, and metastasis of breast cancer cells, and acts as the primary anti-TNBC metastasis constituent of Aesculus chinensis Bunge fruit saponin fraction. Escin IA can be used for the research of triple-negative breast cancer, acute inflammation, and ethanol-induced gastric mucosal lesions .

HY-W004307

Octadecanal Stearyl aldehyde	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Octadecanal (Stearyl aldehyde) is a long-chain aldehyde component. Octadecanal exists in the phospholipid fractions of thigh and breast muscles of broiler chickens .

HY-125954

Uridine diphosphate glucuronic acid UDP-α-D-glucuronic acid	Human Gut Microbiota Metabolites Microorganisms Endogenous metabolite Source Classification	Endogenous Metabolite
Uridine diphosphate glucuronic acid (UDP-α-D-glucuronic acid) is a glucuronic acid donor. Uridine diphosphate glucuronic acid transfers its glucuronic acid moiety to acceptor molecules, thereby forming "ether" glucuronides, while being converted into uridine 5'-pyrophosphate. Uridine diphosphate glucuronic acid serves as a substrate for Arabidopsis UDP-GlcA 4-epimerase 1, and undergoes reversible 4-epimerization to generate UDP-α-D-galacturonic acid .

HY-45609

L-Cysteine S-sulfate sodium hydrate	Structural Classification Natural Products Neurological Disease Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification	Drug Derivative
L-Cysteine S-sulfate sodium hydrate is an S-sulfated derivative of L-cysteine (HY-Y0337). L-Cysteine S-sulfate sodium hydrate is the substrate for cystine lyase, it can be used in mass spectrometry and chromatography analyses .

HY-137295

Ingenol 3,20-dibenzoate	Classification of Application Fields Terpenoids Diterpenoids Euphorbia esula L. Euphorbiaceae Plants Inflammation/Immunology Disease Research Fields Source Classification	PKC Apoptosis
Ingenol 3,20-dibenzoate is a potent protein kinase C (PKC) isoform-selective agonist. Ingenol 3,20-dibenzoate induces selective translocation of nPKC-delta, -epsilon, and -theta and PKC-mu from the cytosolic fraction to the particulate fraction and induces morphologically typical apoptosis through de novo synthesis of macromolecules. Ingenol 3,20-dibenzoate increases the IFN-γ production and degranulation by NK cells, especially when NK cells are stimulated by NSCLC cells .

HY-113020

21-Hydroxypregnenolone 1 Publications Verification	Structural Classification Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Steroids Source Classification	Endogenous Metabolite Cytochrome P450
21-Hydroxypregnenolone is a CYP17 inhibitor. 21-Hydroxypregnenolone competitively inhibits CYP17-mediated 17α-hydroxylation activity of progesterone, with a Ki value of 36.4 μM .

HY-N0860

Schisantherin E Schizantherin-E	Monophenols Classification of Application Fields Lignans Phenols Phenylpropanoids Plants Schisandraceae Disease Research Fields Inflammation/Immunology Schisandra chinensis (Turcz.) Baill. Source Classification	Others
Schisantherin E is a natural compound isolated from the active fraction of the fruits of Schisandra sphenanthera Rehd. et Wils.

HY-N0786

Ginkgolide J	Ginkgoaceae Terpenoids Diterpenoids Plants Ginkgo biloba Source Classification	Others
Ginkgolide J is a main constituent of the non-flavone fraction of Ginkgo biloba with an IC₅₀ range of 12-54 µM, has neuroprotective and anti neuronal apoptotic ability .

HY-N3433

Kaempferol 3-O-arabinoside 1 Publications Verification	Flavonols Flavonoids Classification of Application Fields Sauropus spatulifolius Beille Other Diseases Phenols Polyphenols Euphorbiaceae Plants Disease Research Fields Source Classification	Others
Kaempferol 3-O-arabinoside is an antioxidant flavonoids isolated from ethyl acetate fraction (EAF) obtained from the leaves of Nectandra hihua. Kaempferol 3-O-arabinoside has good antioxidant capacity .

HY-N2018

α-D-Xylose α-D-Xylopyranose	Plants Endogenous metabolite Saccharides Monosaccharides Source Classification	Endogenous Metabolite
α-D-Xylose (α-D-Xylopyranose) is a basic component of the five-carbon fraction of biomass and a precursor of hemicellulose. α-D-Xylose participates in a variety of enzyme-catalyzed reactions, which in turn participate in a variety of metabolic pathways. In addition, α-D-Xylose is also used in tanning, dyeing and as a diabetic food .

HY-125361

Ganosporeric acid A	Triterpenes Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Terpenoids Polyporaceae Other Diseases Plants Endogenous metabolite Disease Research Fields Source Classification	Others
Ganosporeric acid A, a natural product, is isolated from the ether-soluble fraction of the spores of Ganoderma lucidum. Ganosporeric acid A can be used for the research of liver injury .

HY-N3955

Alnusenone Glutinone; Glutinone	Triterpenes Terpenoids Polyporaceae Plants Source Classification	Others
Alnusenone (Glutinone) is a stabilised intermediate int he biogenesis of friedelin (XV) from squalene. Alnusenone is the major natural compound in fractions .

HY-W709825

(-)-Cyperene	Structural Classification Terpenoids Sesquiterpenes Plants Asparagaceae Juss. Source Classification	Others
(-)-Cyperene is a sesquiterpene hydrocarbon. (-)-Cyperene can be obtained from the n-hexane fraction of the smoke condensate of Goniothalamus andersonii. (-)-Cyperene can be used in the study of mosquitoes .

HY-N2203A

Vitexin2''-O-p-trans-coumarate	Flavonoids Flavones Leguminosae Plants Trigonella foenum-graecum Linn. Source Classification	Others
Vitexin2''-O-p-trans-coumarate is a flavonoid, can be isolated from the Et acetate-soluble fraction of the ethanolic extract of the seeds of Trigonella foenum-graecum. Vitexin2''-O-p-trans-coumarate strongly promotes 2BS cell proliferation induced by H₂O₂ .

HY-N12973

Peonidin 3-arabinoside	Structural Classification Phenols Polyphenols Ericaceae Plants Vaccinium uliginosum L. Source Classification	Anaplastic lymphoma kinase (ALK)
Peonidin 3-arabinoside is an anthocyanin found in vaccinium mytrillus. Peonidin 3-arabinoside binds to the ALK5 and has anticancer activity. Peonidin 3-arabinoside also has antioxidant, anti-inflammatory, and anti-urinary tract infection properties .

HY-N12039

Juniper camphor	Terpenoids Sesquiterpenes Plants Lauraceae Cinnamomum camphora Source Classification	Others
Juniper camphor is a sesquiterpene compound isolated from camphor blue oil, the high-boiling fraction of camphor .

HY-P5700

*SAAP Fraction* 3**	Animals Ketones, Aldehydes, Acids Source Classification	Bacterial
SAAP Fraction 3 is an antimicrobial peptide. SAAP Fraction 3 is active against P. haemolytica in Zn-saline buffer .

HY-N3621

Corchoionol C	Periandra mediterranea (Vell.) Taub. Natural Products Plants Compositae Source Classification	Others
Corchoionol C is a n-butanol-soluble fraction of the whole plant extract of Pulicaria undulate .

HY-N4245

Siegesmethyletheric acid	Classification of Application Fields Ketones, Aldehydes, Acids Bituminaria morisiana (Pignatti & Metlesics) Greuter Other Diseases Plants Compositae Disease Research Fields Source Classification	Others
Siegesmethyletheric acid is isolated from the ethyl acetate fraction of Siegesbeckia orientalis L. (Asteraceae) .

HY-N9900

Demethyldaphnoretin-7-O-glucoside Demethyldaphnoretin-7-O-β-D-glucopyranoside	Daphne oleoides Schreb. Thymelaeaceae Coumarins Phenylpropanoids Plants Source Classification	Others
Demethyldaphnoretin-7-O-β-Dglucopyranoside (Demethyldaphnoretin-7-O-glucoside)(compound 1) is a natural product isolated from the ethyl acetate fraction of the roots of Daphne oleoides .

HY-N9379

Fissistigine A	Alkaloids Structural Classification Monophenols Classification of Application Fields Goniothalamus amuyon (Bl.) Merr. Other Diseases Phenols Plants Annonaceae Isoquinoline Alkaloids Disease Research Fields Source Classification	Others
Fissistigine A is an alkaloid separated of the basic fractions from Formosan Fissistigma glaucescens, F. oldhamii and Goniothalamus amuyon . Fissistigine A has a weak inhibitory effect on amyloid beta 42 aggregation (IC₅₀ 50 µM).

HY-N10791

Neobritannilactone B	Zingiber officinale Roscoe Terpenoids Sesquiterpenes Plants Source Classification Zingiberaceae	Others
Neobritannilactone B, a sesquiterpene, can be isolated from the chloroform fraction of the I. britannica. Neobritannilactone B is cytotoxic. Other extracts of I. britannica are also Dihydrofolate reductase (DHFR) inhibitors, which inhibit Shigella dysenteriae type 1 .

HY-N8254

Haginin A	Anthocyans Flavonoids Leguminosae Lespedeza cyrtobotrya Miq. Plants Source Classification	Others
Haginin A (compound 3）can be isolated from the EtOAc fraction of Lespedeza cyrtobotrya. Haginin A has radical scavenging activity with IC₅₀ values of 9.0 μM and 37.7 μM in the ABTS system and DPPH system, respectively .

HY-N0786R

Ginkgolide J (Standard)	Structural Classification Ginkgoaceae Terpenoids Diterpenoids Plants Ginkgo biloba Source Classification	Reference Standards Others
Ginkgolide J (Standard) is the analytical standard of Ginkgolide J. This product is intended for research and analytical applications. Ginkgolide J is a main constituent of the non-flavone fraction of Ginkgo biloba with an IC₅₀ range of 12-54 μM, has neuroprotective and anti neuronal apoptotic ability .

HY-W209558

Acoramone 2,4,5-Trimethoxyphenylacetone	Natural Products Araceae Acorus calamus L. Plants Source Classification	Endogenous Metabolite
Acoramone (2,4,5-Trimethoxyphenylacetone) is a natural product that can be isolated from phenylpropane. Acoramone is one of the main metabolites identified in the ¹H NMR spectrum of fraction b of the supernatant from the incubation of liver microsomes from Aroclor 1254-pretreated rats .

HY-N2852

α-Terthienylmethanol	Natural Products Alysicarpus ovalifolius (Schumacher) J. Leonard Plants Compositae Source Classification	Reactive Oxygen Species (ROS)
α-Terthienylmethanol is a terthiophene isolated from the n-hexane fraction of E. prostrata. α-Terthienylmethanol has potent cytotoxic activity against human endometrial cancer cells (Hec1A and Ishikawa) (IC₅₀ < 1 μM). α-Terthienylmethanol increases the intracellular level of ROS and decreases that of GSH .

HY-N2274

23-Hydroxylongispinogenin 12-Oleanene-3β,16β,23,28-tetrol; 3β,16β-12-Oleanene-3, 16,23,28-tetrol	Triterpenes Classification of Application Fields Terpenoids Asclepiadaceae Lysimachia heterogenea Klatt Plants Primulaceae Disease Research Fields Gymnema sylvestre (Retz.) Schult. Source Classification Cancer	Others
23-Hydroxylongispinogenin (12-Oleanene-3β,16β,23,28-tetrol) is extracted from Lysimachia heterogenea Klatt. Lysimachia heterogenea Klatt is a perennial herb, which is used as a folk medicine in subduing swelling and detoxicating in China. The effective fraction LH-1 of L. heterogene has antitumor activity .

HY-N9300

1,6-Dihydro-4,7-epoxy-1-methoxy-3,4-methylenedioxy-6-oxo-3,8-lignan	Philadelphus coronarius L. Magnoliaceae Lignans Plants Source Classification	Platelet-activating Factor Receptor (PAFR)
1,6-Dihydro-4,7-epoxy-1-methoxy-3,4-methylenedioxy-6-oxo-3,8-lignan, a lignan derivative from the ethyl acetate soluble fraction of twigs of Magnolia denudate (Magnoliaceae), exhibits anti-platelet-activating factor (PAF) activity. PAF is a potent lipid mediator in inflammation and asthma .

HY-N8977

4-O-Methylgrifolic acid	Monophenols Microorganisms Ketones, Aldehydes, Acids Phenols Source Classification	Others
4-O-Methylgrifolic acid is a farnesylphenols that can be isolated from the lipophilic fraction of Polyporus dispansus .

HY-N12551

2-O-β-D-Glucopyranosylcucurbitacin F 25-acetate	Triterpenes Structural Classification Tetracyclic Triterpenoids Terpenoids Rubiaceae Plants Exostema mexicanum Gray Source Classification	Others
2-O-β-D-Glucopyranosylcucurbitacin F 25-acetate is a cucurbitacin glucoside that can isolated from the more polar fractions of the MeOH extract of Cigarrilla mexicana .

HY-N6703A

(R)-ar-Turmerone (-)-ar-Turmerone	Structural Classification Natural Products Plants Curcuma longa Source Classification Zingiberaceae	Drug Derivative
(R)-ar-Turmerone is a sesquiterpene ketone that can be found in the sesquiterpene ketone fraction of Curcuma longa L. (R)-ar-Turmerone converts to ar-(+)-juvabione with juvenile hormone activity .

HY-N17537

Norwogonin-7-O-glucoside	Structural Classification Flavonoids Labiatae Centaurea aspera stenophylla Plants Other Flavonoids Source Classification	Drug Derivative
Norwogonin-7-O-glucoside is a flavonoid found in the root of Scutellaria discolor COLEBR .

HY-169872

17-Hydroxystearic acid	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source Classification	Endogenous Metabolite
17-Hydroxystearic acid isolable from Torulopsis magnoliae fermentation oil. 17-Hydroxystearic acid is a saturated C₁₈ ω2-hydroxy fatty acid existing in D- and L-enantiomeric forms .

HY-N18198

Notoginsenoside A	Structural Classification Tetracyclic Triterpenoids Panax quinquefolium Terpenoids Plants Araliaceae Source Classification	Others
Notoginsenoside A (Compound 6) is a dammarane-type triterpene oligoglycoside found in the roots of Panax quinquefolium L. .

HY-N17505

(1S,2R,4S)-Borneol β-D-glucopyranoside	Structural Classification Terpenoids Labiatae Sesquiterpenes Derris elliptica (Roxb.) Benth. Plants Source Classification	Others
(1S,2R,4S)-Borneol β-D-glucopyranoside (Compound 10) is a monoterpenoid glucoside.(1S,2R,4S)-Borneol β-D-glucopyranoside can be found in the leaf of Thymus vulgaris .

HY-N18038

Zoxamide metabolite 1	Structural Classification Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Drug Metabolite
Zoxamide metabolite 1 (Compound M1) is a monodechlorinated Zoxamide (HY-120921) metabolite. Zoxamide metabolite 1 undergoes dechlorination most plausibly at the reactive α-chloro ketone position .

HY-N17590

Dihydrogingerenone B	Structural Classification Phenols Plants Alpinia oxyphylla Miq. Source Classification Zingiberaceae	Others
Dihydrogingerenone B (Compound 78) is a diarylheptanoid that can be found in the dried mature fruit of Alpinia oxyphylla fructus .

HY-N9899

Giraldoid A	Structural Classification Thymelaeaceae Daphne giraldii Nitsche Coumarins Phenylpropanoids Plants Source Classification	Drug Derivative
Giraldoid A (compound 1) is a dicoumarinoid glycoside found in the bark and rhizome of Daphne giraldii Nitsche.Giraldoid A can be used for the research of rheumatoid arthritis .

HY-N17911

Plicatol D	Structural Classification Orchidaceae Phenols Polyphenols Plants Dendrobium fimbriatum Hook. Source Classification	Others
Plicatol D is a phenanthrene found in the whole plant of Dendrobium fimbriatum Hook .

HY-N17589

Purpurin-1-methylether	Quinones Structural Classification Galium aparine L. Anthraquinones Rubiaceae Plants Source Classification	Others
Purpurin-1-methylether (Compound 7) is an anthraquinone found in Galium spurium var. echinospermon Hayek .

HY-N11241

Cascaroside B	Quinones Structural Classification Liliaceae Anthraquinones Plants Lilium davidii Duchartre ex Elwes Source Classification	Fungal
Cascaroside B is a flavonoid and antifungal agent found in the Pseudomonas aeruginosa Ld-08 .

HY-W708825

Methyl 4-methylpentanoate Methyl isohexanoate	Structural Classification Natural Products Microorganisms Source Classification	Others
Methyl 4-methylpentanoate (Methyl isohexanoate) is a natural product. Methyl 4-methylpentanoate can be isolated from the essential oil of Bourbon geranium (Pelargonium sp.) from Reunion .

HY-N18016

4'-Hydroxy-5,7,3'-trimethoxyflavanone Hesperitin-5,7-dimethyl-ether	Structural Classification Flavonoids Animals Flavonones Source Classification	Drug Derivative
4'-Hydroxy-5,7,3'-trimethoxyflavanone (Hesperitin-5,7-dimethyl-ether) (Compound 13) is an O-methylated flavanone and a derivative of Hesperetin (HY-N0168) .

HY-N17374

Laevigatin A	Structural Classification Rosa laevigata Michx. Rosaceae Phenols Polyphenols Plants Source Classification	Others
Laevigatin A (Compound 8) is a hydrolyzable tannin found in Rosa laevigata .

HY-N18387

trans-Psoralenoside	Structural Classification Ketones, Aldehydes, Acids Ficus palmata Forssk. Plants Moraceae Source Classification	Drug Isomer
trans-Psoralenoside is the trans isomer of Psoralenoside (HY-N7503). trans-Psoralenoside is present in the aerial parts of Ficus palmata. trans-Psoralenoside can be used in studies of liver diseases, kidney diseases and peptic ulcers .

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P71677

	FAM20C Protein, Human (HEK293, Myc, His) C76981; Dentin matrix protein 4; Family with sequence similarity 20 member C; GEF CK; Golgi enriched fraction casein kinase; Protein FAM20C; RNS	Human	HEK293
	The FAM20C protein is a Golgi kinase that phosphorylates secretory pathway proteins and contributes to the biomineralization of bones and teeth. FAM20C phosphorylates caseins and proteins involved in biomineralization and also affects lipid homeostasis, wound healing, and cell migration and adhesion. FAM20C Protein, Human (HEK293, Myc, His) is the recombinant human-derived FAM20C protein, expressed by HEK293 , with N-His, C-Myc labeled tag.

Compare Products


Products	In-stock - + Add to Cart
Cat. No.
Species
Source
Tag
Accession
Gene ID
Molecular Weight
Purity
Endotoxin Level
Biological Activity
Appearance
Formulation
Storage & Stability
Shipping
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Product Name	Chemical Structure

HY-W742940

O-Arachidonoyl glycidol-d5

O-Arachidonoyl glycidol-d₅ is the deuterium labeled O-Arachidonoyl glycidol (HY-131995). O-Arachidonoyl glycidol (compound 1) is a 2-arachidonoylglycerol (2-AG) analog. O-Arachidonoyl glycidol inhibits cytosolic 2-oleoylglycerol (2-OG) hydrolysis with an IC₅₀ value of 4.5 μM. O-Arachidonoyl glycidol blocks 2-OG hydrolysis in membrane fractions and anandamide hydrolysis with IC₅₀s of 19, 12 μM, respectively .

Cat. No.	Product Name		Classification

HY-W782122

Photoclick cholesterol		Alkynes
Photoclick cholesterol is a photoreactive cholesterol analog capable of undergoing click reactions. Photoclick cholesterol enables specific, saturable photoaffinity labeling of the mitochondrial translocator protein TSPO .

HY-P11331

Az-NC-002		Azide
Az-NC-002 is a Proteasome trypsin-like site (β2) and immunoproteasome β2i-specific active probe. Az-NC-002 has weak off-target effects with no significant inhibition for Cathepsin D (HY-P2750), but this inhibition reacts outside of the active site or influence on a small fraction of the enzyme .

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

fraction

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

NaturalProducts

Recombinant Proteins

Isotope-Labeled Compounds

Click Chemistry

Natural
Products