78934-83-5
Chemical Structure
Sandoz 58-035
- CAS No.: 78934-83-5
- Formula:C30H47NOSi
- Molecular Weight:465.79
IUPAC Name: 3-(decyldimethylsilyl)-N-(1-phenyl-2-(p-tolyl)ethyl)propanamide
InChIKey: NBYATBIMYLFITE-UHFFFAOYSA-N
SMILES: O=C(NC(C1=CC=CC=C1)CC2=CC=C(C)C=C2)CC[Si](C)(CCCCCCCCCC)C
Biological Activity: Sandoz 58-035 is a selective acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor. Sandoz 58-035 inhibits this enzyme in intact cells and isolated microsomal fractions. Sandoz 58-035 blocks the esterification of exogenous vesicle-derived cholesterol and the incorporation of oleic acid into cellular cholesterol esters, reducing the formation and accumulation of cholesterol esters. Sandoz 58-035 causes a slight increase in cellular free cholesterol, and at high concentrations, it also causes a slight reduction in overall cellular protein synthesis. Sandoz 58-035 can be used in studies related to cellular cholesterol regulation[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Sandoz 58-035 | 99.34% | Sandoz 58-035 is a selective acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor. Sandoz 58-035 inhibits this enzyme in intact cells and isolated microsomal fractions. Sandoz 58-035 blocks the esterification of exogenous vesicle-derived cholesterol and the incorporation of oleic acid into cellular cholesterol esters, reducing the formation and accumulation of cholesterol esters. Sandoz 58-035 causes a slight increase in cellular free cholesterol, and at high concentrations, it also causes a slight reduction in overall cellular protein synthesis. Sandoz 58-035 can be used in studies related to cellular cholesterol regulation. | ||||||||||||||||||||
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References
- [1]. Slotte JP. Intracellular processing of exogenously derived non-lipoprotein [3H]cholesterol in normal and mutant human skin fibroblasts deficient in acid sterol ester hydrolase. Biochim Biophys Acta. 1987 Feb 14;917(2):231-7.
- [2]. Ross AC, et al. Selective inhibition of acyl coenzyme A:cholesterol acyltransferase by compound 58-035. J Biol Chem. 1984;259(2):815-819. [Content Brief]
