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free hydroxyl group

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By Targets:	ADC Linker (2) Biochemical Assay Reagents (6) Drug Derivative (2) Drug Intermediate (2) Drug Metabolite (2) NO Synthase (1) Parasite (1) Phosphatase (1) Reactive Oxygen Species (ROS) (1) Reference Standards (1) TNF Receptor (1) Xanthine Oxidase (1)
By Research Areas:	Cardiovascular Disease (1) Infection (1) Inflammation/Immunology (4) Metabolic Disease (1)
Click Chemistry:	DBCO (1)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Click Chemistry

Targets Recommended: HMG Family

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P10069

Ac-pSar12-OH	Drug Intermediate ADC Linker	Others
Ac-pSar12-OH is a water-soluble polymer of the polysarcosine class and can be used as a linker. Ac-pSar12-OH is a linear polypeptide derivative composed of 12 arginine units. Ac-pSar12-OH N-terminus is modified with an acetyl group, while the C-terminus retains a free hydroxyl group, which can help enhance the stability of the polypeptide .

HY-W047187

Lavandoside	Xanthine Oxidase NO Synthase TNF Receptor	Others
Lavandoside is an ABTS ^?+ free radical scavenger and a moderate inhibitor of xanthine oxidase (XO), with an IC₅₀ of 71.6 μM for inhibiting NO production in LPS-induced macrophages. Lavandoside exerts its antioxidant and potential anti-inflammatory effects by directly scavenging free radicals and inhibiting XO activity, a mechanism related to the hydroxyl groups in its molecular structure. Lavandoside can be isolated from lavender and can be used in the development of natural antioxidants and in research on oxidative stress-related diseases and inflammation-related diseases .

HY-G0004

Acetaminophen metabolite 3-hydroxy-acetaminophen 3-Hydroxyacetaminophen	Drug Metabolite	Inflammation/Immunology
Acetaminophen metabolite 3-hydroxy-acetaminophen (3-Hydroxyacetaminophen) is a non-toxic metabolite and antioxidant of acetaminophen (HY-66005) with free radical scavenging activity. Acetaminophen metabolite 3-hydroxy-acetaminophen can reduce oxidative damage by exerting electron donation ability and antioxidant activity through phenolic hydroxyl groups. 3-hydroxy-acetaminophen can be used to study the toxicity mechanism and drug metabolism of acetaminophen .

HY-W021267

3-Demethylcolchicine	Reactive Oxygen Species (ROS)	Inflammation/Immunology
3-Demethylcolchicine, a colchicine metabolite and anti-inflammatory agent, exhibits potent tubulin-binding activity. 3-Demethylcolchicine inhibits carrageenan-induced rat paw edema. 3-Demethylcolchicine bears a hydroxyl group on its carbocyclic ring; this group participates in free radical scavenging processes, allowing it to act as a free radical scavenger. 3-Demethylcolchicine is applicable to studies related to carrageenan-induced paw edema .

HY-W039729

5-(Boc-amino)-1-pentanol	Biochemical Assay Reagents	Others
5-(Boc-amino)-1-pentanol is a linker containing a hydroxyl group and Boc-protected amino group. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The Boc group can be deprotected under mild acidic conditions to form the free amine.

HY-151822

Hydroxy-PEG3-DBCO	ADC Linker	Others
Hydroxy-PEG3-DBCO is a click chemistry reagent containing an azide group. Hydroxy-PEG3-DBCO is a PEG linker containing a DBCO moiety and a terminal primary hydroxyl group. The hydroxyl can react with a variety of functional groups and the hydrophilic PEG spacer arm can provide better solubility to labeled molecules. DBCO is commonly used for copper-free Click Chemistry reactions. Reagent grade, for research use only .

HY-116161

Bimatoprost isopropyl ester	Drug Intermediate	Cardiovascular Disease Others
15(R)-17-phenyl trinor Prostaglandin F2α isopropyl ester (15(R)-17-phenyl trinor PGF2α isopropyl ester) is the latanoprost-related isomer containing both a double bond at 13,14 and an inverted (β) hydroxyl group at C-15. Similar to 15(S)-latanoprost, 15(R)-17-phenyl trinor PGF2α isopropyl ester is a potential impurity in most commercial preparations of the latanoprost bulk drug product. The IC₅₀ values for the free acid forms of 15(S)-17-phenyl trinor PGF2α and 15(R)-17-phenyl trinor PGF2α were determined to be 0.71 nM and 30 nM, respectively, in a FP receptor binding assay using the cat iris sphincter muscle.1 A 3 μg dose of 15(R)-17-phenyl trinor PGF2α caused a 1.9 mmHg reduction of IOP in normotensive cynomolgus monkeys.

HY-G0004R

Acetaminophen metabolite 3-hydroxy-acetaminophen (Standard) 3-Hydroxyacetaminophen (Standard)	Reference Standards Drug Metabolite	Inflammation/Immunology
Acetaminophen metabolite 3-hydroxy-acetaminophen (3-Hydroxyacetaminophen) (Standard) is the analytical standard of Acetaminophen metabolite 3-hydroxy-acetaminophen (HY-G0004). This product is intended for research and analytical applications. Acetaminophen metabolite 3-hydroxy-acetaminophen is a non-toxic metabolite and antioxidant of acetaminophen (HY-66005) with free radical scavenging activity. Acetaminophen metabolite 3-hydroxy-acetaminophen can reduce oxidative damage by exerting electron donation ability and antioxidant activity through phenolic hydroxyl groups. 3-hydroxy-acetaminophen can be used to study the toxicity mechanism and drug metabolism of acetaminophen .

HY-N15727

2,5-Dimethylchromone-7-O-β-D-glucopyranoside	Others	Inflammation/Immunology
2,5-Dimethylchromone-7-O-β-D-glucopyranoside is an orally active chromone glycoside found in the underground parts of Rheum australe. 2,5-Dimethylchromone-7-O-β-D-glucopyranoside shows a DPPH radical scavenging activity with an IC₅₀ value of 66.9 μM. 2,5-Dimethylchromone-7-O-β-D-glucopyranoside scavenges free radicals by providing hydrogen atoms through phenolic hydroxyl groups, inhibiting lipid peroxidation. 2,5-Dimethylchromone-7-O-β-D-glucopyranoside is promising for research of oxidative stress-related diseases such as inflammation and skin diseases .

HY-E70914

Phosphatase, Escherichia coli	Phosphatase	Metabolic Disease
Phosphatase, Escherichia coli (EC 3.1.3.-) is an enzyme that removes a phosphate group from its substrate by hydrolysing phosphoric acid monoesters into a phosphate ion and a molecule with a free hydroxyl group.

HY-116655A

Hydroxy-PEG1-acid sodium salt	Biochemical Assay Reagents	Others
Hydroxy-PEG1-acid sodium is a PEG linker containing a hydroxyl group with a terminal carboxylic acid (as sodium salt form). The free acid form is not stable due to the reaction of OH with PEG-COOH group to form polymer. The sodium salt form is stable for storage and shipping. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups.

HY-W800656

Fmoc-PEG5-alcohol	Biochemical Assay Reagents	Others
Fmoc-PEG4-hydroxy is a PEG linker containing an Fmoc-protected amine and a hydroxyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The hydroxyl group enables further derivatization or replacement with other reactive functional groups.

HY-W800667

Hydroxy-PEG4-acid sodium	Biochemical Assay Reagents	Others
Hydroxy-PEG4-acid sodium is a PEG linker containing a hydroxyl group with a terminal carboxylic acid (as sodium salt form). The free acid form is not stable due to the reaction of OH with PEG-COOH group to form polymer. The sodium salt form is stable for storage and shipping. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups.

HY-W1048549H

HOOC-PEG1000-SH HOOC-PEG1000-Thiol	Biochemical Assay Reagents	Others
HOOC-PEG1000-SH (HOOC-PEG1000-Thiol) is a reactive thiol PEG derivative with a terminal carboxyl group. The carboxyl group can react with amine or hydroxyl groups to form a stable amide bond or an unstable ester bond. The reaction of the carboxyl group allows the amine or hydroxyl group to be converted into a free thiol with a linear PEG linkage. The generated thiol group can be used to modify the surface of gold nanoparticles or participate in other PEGylation reactions. The PEG linkage between the thiol and carboxyl groups has good water solubility, flexible linker distance and higher stability .

HY-W1048549J

HOOC-PEG40000-SH HOOC-PEG40000-Thiol	Biochemical Assay Reagents	Others
HOOC-PEG40000-SH (HOOC-PEG40000-Thiol) is a reactive thiol PEG derivative with a terminal carboxyl group. The carboxyl group can react with amine or hydroxyl groups to form a stable amide bond or an unstable ester bond. The reaction of the carboxyl group allows the amine or hydroxyl group to be converted into a free thiol with a linear PEG linkage. The generated thiol group can be used to modify the surface of gold nanoparticles or participate in other PEGylation reactions. The PEG linkage between the thiol and carboxyl groups has good water solubility, flexible linker distance and higher stability .

HY-N19879

Obliquetin	Drug Derivative	Others
Obliquetin is a coumarin derivative of aesculetin and 6-monomethyl ether of obliquetol, found in the heartwood of Ptaeroxylon obliquum .

HY-N19720

Bractein	Drug Derivative Parasite	Infection
Bractein is a natural aurone flavonoid with potential antioxidant activity. Bractein shows in vitro antileishmanial activity and inhibits promastigotes and intracellular amastigotes of Leishmania donovani. Bractein exhibits no obvious cytotoxicity against mammalian macrophages with an EC₅₀ value > 25.0 μg/mL. Bractein can be used for the research of Leishmania .

Cat. No.	Product Name	Type

HY-W1048549H

HOOC-PEG1000-SH HOOC-PEG1000-Thiol	Biochemical Assay Reagents
HOOC-PEG1000-SH (HOOC-PEG1000-Thiol) is a reactive thiol PEG derivative with a terminal carboxyl group. The carboxyl group can react with amine or hydroxyl groups to form a stable amide bond or an unstable ester bond. The reaction of the carboxyl group allows the amine or hydroxyl group to be converted into a free thiol with a linear PEG linkage. The generated thiol group can be used to modify the surface of gold nanoparticles or participate in other PEGylation reactions. The PEG linkage between the thiol and carboxyl groups has good water solubility, flexible linker distance and higher stability .

HOOC-PEG1000-SH

HOOC-PEG1000-Thiol

Biochemical Assay Reagents

HOOC-PEG1000-SH (HOOC-PEG1000-Thiol) is a reactive thiol PEG derivative with a terminal carboxyl group. The carboxyl group can react with amine or hydroxyl groups to form a stable amide bond or an unstable ester bond. The reaction of the carboxyl group allows the amine or hydroxyl group to be converted into a free thiol with a linear PEG linkage. The generated thiol group can be used to modify the surface of gold nanoparticles or participate in other PEGylation reactions. The PEG linkage between the thiol and carboxyl groups has good water solubility, flexible linker distance and higher stability .

HY-W1048549J

HOOC-PEG40000-SH HOOC-PEG40000-Thiol	Biochemical Assay Reagents
HOOC-PEG40000-SH (HOOC-PEG40000-Thiol) is a reactive thiol PEG derivative with a terminal carboxyl group. The carboxyl group can react with amine or hydroxyl groups to form a stable amide bond or an unstable ester bond. The reaction of the carboxyl group allows the amine or hydroxyl group to be converted into a free thiol with a linear PEG linkage. The generated thiol group can be used to modify the surface of gold nanoparticles or participate in other PEGylation reactions. The PEG linkage between the thiol and carboxyl groups has good water solubility, flexible linker distance and higher stability .

HOOC-PEG40000-SH

HOOC-PEG40000-Thiol

Biochemical Assay Reagents

HOOC-PEG40000-SH (HOOC-PEG40000-Thiol) is a reactive thiol PEG derivative with a terminal carboxyl group. The carboxyl group can react with amine or hydroxyl groups to form a stable amide bond or an unstable ester bond. The reaction of the carboxyl group allows the amine or hydroxyl group to be converted into a free thiol with a linear PEG linkage. The generated thiol group can be used to modify the surface of gold nanoparticles or participate in other PEGylation reactions. The PEG linkage between the thiol and carboxyl groups has good water solubility, flexible linker distance and higher stability .

Cat. No.	Product Name	Target	Research Area

HY-P10069

Ac-pSar12-OH	Drug Intermediate ADC Linker	Others
Ac-pSar12-OH is a water-soluble polymer of the polysarcosine class and can be used as a linker. Ac-pSar12-OH is a linear polypeptide derivative composed of 12 arginine units. Ac-pSar12-OH N-terminus is modified with an acetyl group, while the C-terminus retains a free hydroxyl group, which can help enhance the stability of the polypeptide .

Lavandoside	Structural Classification other families Onychium japonicum (Thunb.) Kunze Ketones, Aldehydes, Acids Plants	Xanthine Oxidase NO Synthase TNF Receptor
Lavandoside is an ABTS ^?+ free radical scavenger and a moderate inhibitor of xanthine oxidase (XO), with an IC₅₀ of 71.6 μM for inhibiting NO production in LPS-induced macrophages. Lavandoside exerts its antioxidant and potential anti-inflammatory effects by directly scavenging free radicals and inhibiting XO activity, a mechanism related to the hydroxyl groups in its molecular structure. Lavandoside can be isolated from lavender and can be used in the development of natural antioxidants and in research on oxidative stress-related diseases and inflammation-related diseases .

3-Demethylcolchicine	Alkaloids Structural Classification Monophenols other families Classification of Application Fields Other Alkaloids Phenols Plants Inflammation/Immunology Disease Research Fields Source Classification	Reactive Oxygen Species (ROS)
3-Demethylcolchicine, a colchicine metabolite and anti-inflammatory agent, exhibits potent tubulin-binding activity. 3-Demethylcolchicine inhibits carrageenan-induced rat paw edema. 3-Demethylcolchicine bears a hydroxyl group on its carbocyclic ring; this group participates in free radical scavenging processes, allowing it to act as a free radical scavenger. 3-Demethylcolchicine is applicable to studies related to carrageenan-induced paw edema .

2,5-Dimethylchromone-7-O-β-D-glucopyranoside	Rheum australe D. Don Polygonaceae Plants Saccharides Monosaccharides Source Classification	Others
2,5-Dimethylchromone-7-O-β-D-glucopyranoside is an orally active chromone glycoside found in the underground parts of Rheum australe. 2,5-Dimethylchromone-7-O-β-D-glucopyranoside shows a DPPH radical scavenging activity with an IC₅₀ value of 66.9 μM. 2,5-Dimethylchromone-7-O-β-D-glucopyranoside scavenges free radicals by providing hydrogen atoms through phenolic hydroxyl groups, inhibiting lipid peroxidation. 2,5-Dimethylchromone-7-O-β-D-glucopyranoside is promising for research of oxidative stress-related diseases such as inflammation and skin diseases .

Obliquetin	Structural Classification Rutaceae Coumarins Ptaeroxylon obliquum (Thunb.) Radlk. Phenylpropanoids Plants Source Classification	Drug Derivative
Obliquetin is a coumarin derivative of aesculetin and 6-monomethyl ether of obliquetol, found in the heartwood of Ptaeroxylon obliquum .

Bractein	Structural Classification Crotalaria albida Heyne ex Roth Phenols Polyphenols Plants Compositae Source Classification	Drug Derivative Parasite
Bractein is a natural aurone flavonoid with potential antioxidant activity. Bractein shows in vitro antileishmanial activity and inhibits promastigotes and intracellular amastigotes of Leishmania donovani. Bractein exhibits no obvious cytotoxicity against mammalian macrophages with an EC₅₀ value > 25.0 μg/mL. Bractein can be used for the research of Leishmania .

Cat. No.	Product Name		Classification

HY-151822

Hydroxy-PEG3-DBCO		DBCO
Hydroxy-PEG3-DBCO is a click chemistry reagent containing an azide group. Hydroxy-PEG3-DBCO is a PEG linker containing a DBCO moiety and a terminal primary hydroxyl group. The hydroxyl can react with a variety of functional groups and the hydrophilic PEG spacer arm can provide better solubility to labeled molecules. DBCO is commonly used for copper-free Click Chemistry reactions. Reagent grade, for research use only .

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free hydroxyl group

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

NaturalProducts

Click Chemistry

Natural
Products