5 Results for "

human renin active site

" in MedChemExpress (MCE) Product Catalog:
Products (5)

5 Results for "human renin active site" in MCE Product Catalog:

2
2 Cited Publications
Cat. No.: HY-13240
CAS No.: 1262036-50-9
Purity:  99.72%
Target:  

Beta-secretase

Research Areas:  

Neurological Disease

LY2886721 is a potent, selective and orally active beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor with an IC50 of 20.3 nM for recombinant human BACE1. LY2886721 is selectivity against cathepsin D, pepsin, and renin, but lacking selectivity against BACE2 (IC50 of 10.2 nM). LY2886721 can across blood-brain barrier and has the potential for Alzheimer's disease treatment .
loading...
    loading...
Cat. No.: HY-13240A
CAS No.: 1262036-49-6
Target:  

Beta-secretase

Research Areas:  

Neurological Disease

LY2886721 hydrochloride is a potent, selective and orally active beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor with an IC50 of 20.3 nM for recombinant human BACE1. LY2886721 hydrochloride is selectivity against cathepsin D, pepsin, and renin, but lacking selectivity against BACE2 (IC50 of 10.2 nM). LY2886721 hydrochloride can across blood-brain barrier and has the potential for Alzheimer's disease treatment .
loading...
    loading...
Cat. No.: HY-P1609
CAS No.: 105116-61-8
Target:  

Renin Enteropeptidase

Research Areas:  

Cardiovascular Disease

CP-69799 is an azahomostatine-containing oligopeptide transition-state analogue inhibitor with a hog renin IC50 of 6e-9 M, human plasma renin IC50 of 3e-7 M and Ki of 0.310 μM, and endothiapepsin Ki of 0.27 μM. CP-69799 binds endothiapepsin’s active site cleft in extended conformation, fills S4 to S3' pockets, displaces native solvent molecules, induces domain rotation, and reduces thermal mobility of endothiapepsin’s flap and helix regions. CP-69799 acts as a transition-state analogue inhibitor of hog renin and human plasma renin. CP-69799 contains a polar lysine residue at the P2' position, with a nitrogen atom replacing the P1' Cα atom of the hydroxyethylene dipeptide isostere. CP-69799 can be used for the research of hypertension .
loading...
    loading...
Cat. No.: HY-P1696
CAS No.: 114376-16-8
Target:  

Renin

Research Areas:  

Cardiovascular Disease

U 70714E is a Renin inhibitor with an IC50 of 3.0 nM. U 70714E is used for the research of renin-related hypertension .
loading...
    loading...
Cat. No.: HY-117641
CAS No.: 121584-61-0
Target:  

Ser/Thr Protease

Research Areas:  

Cardiovascular Disease

CP 81282 is a tripeptide aspartic protease inhibitor, with an IC50 of 1 nM against human renin and an IC50 of 11 nM against endopeptidase. CP 81282 is applicable to the research of hypertension .
loading...
    loading...