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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
15 Results for "
mitochondrial respiratory complex I
" in MedChemExpress (MCE) Product Catalog:
Products (15)
15 Results for "mitochondrial respiratory complex I" in MCE Product Catalog:
11
11 Publications Verification
Synonyms: Phenethylbiguanide hydrochloride
Research Areas:
Phenformin (Phenethylbiguanide) hydrochloride is an orally active biguanide hypoglycemic agent. Phenformin hydrochloride inhibits mitochondrial respiratory chain complex I, leading to an increased AMP/ATP ratio, activation of AMPK, and subsequent inhibition of the mTOR pathway, thereby suppressing cell proliferation, inducing apoptosis and autophagy. Phenformin hydrochloride inhibits cancer stem cells (CSCs) and possesses potent antitumor potential .
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Research Areas:
Phenformin (Phenethylbiguanide) is an orally active biguanide hypoglycemic agent. Phenformin inhibits mitochondrial respiratory chain complex I, leading to an increased AMP/ATP ratio, activation of AMPK, and subsequent inhibition of the mTOR pathway, thereby suppressing cell proliferation, inducing apoptosis and autophagy. Phenformin inhibits cancer stem cells (CSCs) and possesses potent antitumor potential .
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1 Cited Publications
MS-L6 is a OXPHOS inhibitor and antimalarial agent. MS-L6 inhibits NADH oxidation and electron transport. MS-L6 induces OXPHOS uncoupling, dissipates mitochondrial membrane potential, increases non-ATP-coupled oxygen consumption, and reduces ATP synthesis. MS-L6 triggers the production of ROS. MS-L6 exhibits anti-amoebic activity. MS-L6 exerts antitumor activity in mouse lymphoma xenograft models. MS-L6 can be used in research related to B-cell lymphoma, T-cell lymphoma, and non-Hodgkin B-cell lymphoma .
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Cat. No.: HY-129115
CAS No.: 897613-29-5
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S1QEL1.1 is a small molecule inhibitor that specifically inhibits the generation of superoxide and hydrogen peroxide at the IQ site during reverse electron transfer in mitochondrial respiratory chain complex I (Complex I), with an IC50 of 0.07 μM. S1QEL1.1 can significantly reduce the activation of cysteine-aspartic protease (caspase) triggered by endoplasmic reticulum stress. S1QEL1.1 helps to decrease excessive proliferation of stem cells by inhibiting the Reactive Oxygen Species signaling pathway initiated by endoplasmic reticulum stress .
Cat. No.: HY-N9279
CAS No.: 23291-96-5
Synonyms: Monocrotaline pyrrole; MCTP; 3,8-Didehydromonocrotaline
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Cat. No.: HY-W049881
CAS No.: 2521-07-5
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9-Methyl-β-carboline is a monoamine oxidase inhibitor and dopaminergic modulator, with an IC50 of 1 μM against human MAO-A and an IC50 of 15.5 μM against human MAO-B. 9-Methyl-β-carboline possesses cognitive enhancement potential and can cross the blood-brain barrier. 9-Methyl-β-carboline increases dopamine levels by inhibiting monoamine oxidase activity and microglial proliferation. 9-Methyl-β-carboline activates PKA/PKC and mitochondrial respiratory chain complex I, promotes neurotrophic factor expression and reduces α-synuclein (α-synuclein) levels, thereby reversing neurotoxin-induced dopaminergic neuron damage. 9-Methyl-β-carboline also regulates the PI3K pathway and exerts an anti-proliferative effect on astrocytes. 9-Methyl-β-carboline is widely used in Parkinson's disease-related studies .
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BMT-297376 is an optimized derivative of Linrodostat (HY-101560). BMT-297376 inhibits IDO1 and the ubiquinone (Q) site of mitochondrial respiratory chain complex I. BMT-297376 is suitable for tumor immunology-related research .
Cat. No.: HY-158423
CAS No.: 615281-26-0
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NPD8790 is a species selective mitochondrial respiratory complex I inhibitor with an IC50 of 2.4 µM for C. elegans complex I. NPD8790 is more selective for nematode species mitochondria than human, bovine, and mouse mitochondria. NPD8790 is an anthelmintic that kills adult soil-transmitted helminths .
Cat. No.: HY-16397AS
Synonyms: Phenethylbiguanide-d5 hydrochloride
Cat. No.: HY-16397AR
CAS No.: 834-28-6
Synonyms: Phenethylbiguanide hydrochloride (Standard)
Research Areas:
Phenformin (Phenethylbiguanide) hydrochloride (Standard) is the analytical standard of Phenformin hydrochloride (HY-16397). This product is intended for research and analytical applications. Phenformin hydrochloride (Phenethylbiguanide) is an orally active biguanide hypoglycemic agent. Phenformin hydrochloride inhibits mitochondrial respiratory chain complex I, leading to an increased AMP/ATP ratio, activation of AMPK, and subsequent inhibition of the mTOR pathway, thereby suppressing cell proliferation, inducing apoptosis and autophagy. Phenformin hydrochloride inhibits cancer stem cells (CSCs) and possesses potent antitumor potential.
Research Areas:
Phenformin (Phenethylbiguanide) (Standard) is the analytical standard of Phenformin (HY-16397). This product is intended for research and analytical applications. Phenformin (Phenethylbiguanide) is an orally active biguanide hypoglycemic agent. Phenformin inhibits mitochondrial respiratory chain complex I, leading to an increased AMP/ATP ratio, activation of AMPK, and subsequent inhibition of the mTOR pathway, thereby suppressing cell proliferation, inducing apoptosis and autophagy. Phenformin inhibits cancer stem cells (CSCs) and possesses potent antitumor potential.
Cat. No.: HY-17516R
CAS No.: 129558-76-5
Research Areas:
Tolfenpyrad (Standard) is the analytical standard of Tolfenpyrad (HY-17516). This product is intended for research and analytical applications. Tolfenpyrad is an orally active insecticide, acaricide and antibacterial agent. Tolfenpyrad inhibits Complex I in the mitochondrial respiratory electron transport chain, interfering with the cell respiration process. Tolfenpyrad has significant insecticidal activity against a variety of insect pests such as H. contortus, Coccinella septempunctata. Tolfenpyrad has antibacterial activity against Francisella novicida, with an IC50 of 1.2 µM or 1.5 µM .
Cat. No.: HY-P86984
Synonyms: 24kDa subunit of complex I antibody; CI-24k antibody; complex I 24kDa subunit antibody; complex I, mitochondrial respiratory 2 antibody; mitochondrial antibody; NADH dehydrogenase (ubiquinone) flavoprotein 2 antibody; NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa antibody; NADH dehydrogenase [ubiquinone] flavoprotein 2 antibody; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial antibody; NADH ubiquinone oxidoreductase 24 kDa subunit antibody; 24kDa subunit of complex I antibody; CI-24k antibody; complex I 24kDa subunit antibody; complex I, mitochondrial respiratory 2 antibody; mitochondrial antibody; NADH dehydrogenase (ubiquinone) flavoprotein 2 antibody; NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa antibody; NADH dehydrogenase [ubiquinone] flavoprotein 2 antibody; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial antibody; NADH ubiquinone oxidoreductase 24 kDa subunit antibody; NADH-ubiquinone oxidoreductase 24 kDa subunit antibody; NADH-ubiquinone oxidoreductase flavoprotein 2 antibody; NDUFV2 antibody; NDUV2_HUMAN antibody; nuclear-encoded mitochondrial NADH-ubiquinone reductase 24Kd subunit antibody; Ubiquinoneflavoprotein 2 antibody; Ubiquinoneflavoprotein 2, mitochondrial precursor antibody;
Cat. No.: HY-138439
CAS No.: 173662-97-0
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Mandestrobin is a fungicide that exerts fungal killing activity by inhibiting mitochondrial respiratory chain complex III. Mandestrobin exhibits differential fungicidal activity between its enantiomers, and the R-enantiomer possesses stronger activity than the S-enantiomer. Mandestrobin is used in studies related to fungal infections and the agricultural field .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
