NPD8790
NPD8790 is a species selective mitochondrial respiratory complex I inhibitor with an IC50 of 2.4 µM for C. elegans complex I. NPD8790 is more selective for nematode species mitochondria than human, bovine, and mouse mitochondria. NPD8790 is an anthelmintic that kills adult soil-transmitted helminths.
For research use only. We do not sell to patients.
- CAS No.: 615281-26-0
- Formula: C20H24N2
- Molecular Weight:292.42
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Biological Activity
NPD8790 shows marks species selectivity, inhibiting C. elegans complex I (IC50 = 2.4 µM) more potently than complex I from either bovine (IC50 = 27.2 µM), murine heart mitochondria (IC50 = 28.8 µM) or human mitochondria (IC50 > 75 μM)[1].
NPD8790 against complex I is similar for all nematode species (C. briggsae, IC50 = 1.6 μM; P. pacificus, IC50 = 2.1 μM; P. hermaphrodita, IC50 = 1.1 μM)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 615281-26-0
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Molecular Weight 292.42
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Formula C20H24N2
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SMILES
CC(CC1=CC=C(C=C1)C(C2=NC3=C(N2C)C=CC=C3)C)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
NPD8790 Related Classifications
HY-158423 Related Classifications
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