897613-29-5
Chemical Structure
S1QEL1.1
- CAS No.: 897613-29-5
- Formula:C23H24N4O3S
- Molecular Weight:436.53
IUPAC Name: N1-(3-acetamidophenyl)-N2-(2-(4-methyl-2-(p-tolyl)thiazol-5-yl)ethyl)oxalamide
InChIKey: BFNBJUBXXJKBFN-UHFFFAOYSA-N
SMILES: O=C(NC1=CC=CC(NC(C)=O)=C1)C(NCCC2=C(C)N=C(C3=CC=C(C)C=C3)S2)=O
Biological Activity: S1QEL1.1 is a cell-permeable selective site IQ electron leak inhibitor and mitochondrial complex I site IQ superoxide/hydrogen peroxide production inhibitor (IC50 of 70.3 nM for IQr; IC50 of 64.0 nM for IQf), exerting cytoprotective effects by inhibiting site IQ-dependent ROS production during reverse and forward electron transport without affecting oxidative phosphorylation and normal electron transport. S1QEL1.1 can be used for research on ischemia-reperfusion injury[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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S1QEL1.1 | 99.9% | S1QEL1.1 is a cell-permeable selective site IQ electron leak inhibitor and mitochondrial complex I site IQ superoxide/hydrogen peroxide production inhibitor (IC50 of 70.3 nM for IQr; IC50 of 64.0 nM for IQf), exerting cytoprotective effects by inhibiting site IQ-dependent ROS production during reverse and forward electron transport without affecting oxidative phosphorylation and normal electron transport. S1QEL1.1 can be used for research on ischemia-reperfusion injury. | ||||||||||||||||||||
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References
- [1]. Gibbs ET, et al. Site IQ in mitochondrial complex I generates S1QEL-sensitive superoxide/hydrogen peroxide in both the reverse and forward reactions. The Biochemical journal. 2023 Mar 15;480(5):363-384.
- [2]. Brand MD, et al. Suppressors of Superoxide-HO Production at Site I of Mitochondrial Complex I Protect against Stem Cell Hyperplasia and Ischemia-Reperfusion Injury. Cell metabolism. 2016 Oct 11;24(4):582-592. [Content Brief]
