2251031-81-7
2251031-81-7
Chemical Structure
BMT-297376
- CAS No.: 2251031-81-7
- Formula:C23H29F2N3O3
- Molecular Weight:433.49
IUPAC Name: N-((R)-1-((1s,4S)-4-(3-(difluoromethyl)-2-methoxypyridin-4-yl)cyclohexyl)propyl)-6-methoxynicotinamide
InChIKey: VUXXMKIAYMJEHC-RVKKMQEKSA-N
SMILES: FC(C1=C(OC)N=CC=C1[C@H]2CC[C@@](CC2)([H])[C@@H](CC)NC(C3=CN=C(OC)C=C3)=O)F
Biological Activity: BMT-297376 is an optimized derivative of Linrodostat (HY-101560). BMT-297376 inhibits IDO1 and the ubiquinone (Q) site of mitochondrial respiratory chain complex I. BMT-297376 is suitable for tumor immunology-related research[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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BMT-297376 | 99.14% | BMT-297376 is an optimized derivative of Linrodostat (HY-101560). BMT-297376 inhibits IDO1 and the ubiquinone (Q) site of mitochondrial respiratory chain complex I. BMT-297376 is suitable for tumor immunology-related research. | ||||||||||||||||||||
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References
- [1]. Nimje RY, et al. Development of a stereoselective and scalable synthesis for the potent indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor, BMT-297376. Organic Process Research & Development, 2021, 25(7): 1680-1689.
- [2]. Dreute J, et al. Synergistic targeting of cancer cells through simultaneous inhibition of key metabolic enzymes. Cell Death Differ. 2025;32(12):2239-2256. [Content Brief]
