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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
10 Results for "
myocardial necrosis
" in MedChemExpress (MCE) Product Catalog:
Products (10)
10 Results for "myocardial necrosis" in MCE Product Catalog:
2
2 Cited Publications
Synonyms: CP-597396 hydrochloride hydrate
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Zoniporide hydrochloride hydrate (CP-597396 hydrochloride hydrate) is a selective Na +/H + exchanger subtype 1 (NHE1) inhibitor with cardioprotective activity, with IC50 values of 67 nM and 73 nM against rat NHE1. Zoniporide hydrochloride hydrate reduces intracellular Na + and Ca 2+ overload, preserves mitochondrial integrity, activates pro-survival ERK1/2 and STAT3 signaling pathways, reduces necrosis and apoptosis, and decreases neutrophil aggregation. Zoniporide hydrochloride hydrate is applicable to research related to myocardial ischemia-reperfusion injury and heart graft ischemia-reperfusion injury .
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Zoniporide (CP-597396) is a selective Na +/H + exchanger subtype 1 (NHE1) inhibitor with cardioprotective activity, with IC50 values of 67 nM and 73 nM against rat NHE1. Zoniporide reduces intracellular Na + and Ca 2+ overload, preserves mitochondrial integrity, activates pro-survival ERK1/2 and STAT3 signaling pathways, reduces necrosis and apoptosis, and decreases neutrophil aggregation. Zoniporide is applicable to research related to myocardial ischemia-reperfusion injury and heart graft ischemia-reperfusion injury .
Cat. No.: HY-176716
CAS No.: 2988020-77-3
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ALDH2 activator 1 (Compound Z17) is an allosteric aldehyde dehydrogenase 2 (ALDH2) agonist. ALDH2 activator 1 enhances cardiac function and reduces myocardial necrosis in a mouse model of myocardial ischemia-reperfusion. ALDH2 activator 1 is promising for research of cardiovascular diseases such as myocardial infarction (MI) .
Cat. No.: HY-105064A
CAS No.: 249296-45-5
Synonyms: CP-597396 mesylate
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Zoniporide mesylate (CP-597396 mesylate) is a selective Na +/H + exchanger subtype 1 (NHE1) inhibitor with cardioprotective activity, with IC50 values of 67 nM and 73 nM against rat NHE1. Zoniporide mesylate reduces intracellular Na + and Ca 2+ overload, preserves mitochondrial integrity, activates pro-survival ERK1/2 and STAT3 signaling pathways, reduces necrosis and apoptosis, and decreases neutrophil aggregation. Zoniporide mesylate is applicable to research related to myocardial ischemia-reperfusion injury and heart graft ischemia-reperfusion injury .
Cat. No.: HY-170774
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Hypoxia inducer-1 (Compound N6) is an orally active hypoxia activated nitric oxide (NO) donor compound. Hypoxia inducer-1 exhibits highly selective NO release under hypoxic conditions and inhibits hypoxia-induced apoptosis, necrosis, and the increase in ROS levels. Hypoxia inducer-1 regulates vascular dilation and has a protective effect in a mouse model of myocardial hypoxia injury. Hypoxia inducer-1 can be used in the research of coronary heart disease .
Cat. No.: HY-105064B
CAS No.: 241800-97-5
Synonyms: CP-597396 hydrochloride
Target:
Zoniporide hydrochloride (CP-597396 hydrochloride) is a selective Na +/H + exchanger subtype 1 (NHE1) inhibitor with cardioprotective activity, with IC50 values of 67 nM and 73 nM against rat NHE1. Zoniporide hydrochloride reduces intracellular Na + and Ca 2+ overload, preserves mitochondrial integrity, activates pro-survival ERK1/2 and STAT3 signaling pathways, reduces necrosis and apoptosis, and decreases neutrophil aggregation. Zoniporide hydrochloride is applicable to research related to myocardial ischemia-reperfusion injury and heart graft ischemia-reperfusion injury .
Cat. No.: HY-105064C
CAS No.: 241799-10-0
Synonyms: CP-597396 dihydrochloride
Target:
Zoniporide dihydrochloride (CP-597396 dihydrochloride) is a selective Na +/H + exchanger subtype 1 (NHE1) inhibitor with cardioprotective activity, with IC50 values of 67 nM and 73 nM against rat NHE1. Zoniporide dihydrochloride reduces intracellular Na + and Ca 2+ overload, preserves mitochondrial integrity, activates pro-survival ERK1/2 and STAT3 signaling pathways, reduces necrosis and apoptosis, and decreases neutrophil aggregation. Zoniporide dihydrochloride is applicable to research related to myocardial ischemia-reperfusion injury and heart graft ischemia-reperfusion injury .
Cat. No.: HY-105064DR
CAS No.: 863406-85-3
Synonyms: CP-597396 hydrochloride hydrate (Standard)
Zoniporide hydrochloride hydrate (Standard) (CP-597396 hydrochloride hydrate (Standard)) is the analytical standard of Zoniporide hydrochloride hydrate (HY-105064D). This product is intended for research and analytical applications. Zoniporide hydrochloride hydrate (CP-597396 hydrochloride hydrate) is a selective Na +/H + exchanger subtype 1 (NHE1) inhibitor with cardioprotective activity, with IC50 values of 67 nM and 73 nM against rat NHE1. Zoniporide hydrochloride hydrate reduces intracellular Na + and Ca 2+ overload, preserves mitochondrial integrity, activates pro-survival ERK1/2 and STAT3 signaling pathways, reduces necrosis and apoptosis, and decreases neutrophil aggregation. Zoniporide hydrochloride hydrate is applicable to research related to myocardial ischemia-reperfusion injury and heart graft ischemia-reperfusion injury .
Cat. No.: HY-105064R
CAS No.: 241800-98-6
Synonyms: CP-597396 (Standard)
Zoniporide (Standard) (CP-597396 (Standard)) is the analytical standard of Zoniporide (HY-105064). This product is intended for research and analytical applications. Zoniporide (CP-597396) is a selective Na +/H + exchanger subtype 1 (NHE1) inhibitor with cardioprotective activity, with IC50 values of 67 nM and 73 nM against rat NHE1. Zoniporide reduces intracellular Na + and Ca 2+ overload, preserves mitochondrial integrity, activates pro-survival ERK1/2 and STAT3 signaling pathways, reduces necrosis and apoptosis, and decreases neutrophil aggregation. Zoniporide is applicable to research related to myocardial ischemia-reperfusion injury and heart graft ischemia-reperfusion injury .
Cat. No.: HY-P992212
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
