249296-45-5
Chemical Structure
Zoniporide mesylate
Synonym(s): CP-597396 mesylate
- CAS No.: 249296-45-5
- Formula:C18H20N6O4S
- Molecular Weight:416.45
IUPAC Name: N-carbamimidoyl-5-cyclopropyl-1-(quinolin-5-yl)-1H-pyrazole-4-carboxamide methanesulfonate
InChIKey: LEHNUSLKIYRRQJ-UHFFFAOYSA-N
SMILES: N=C(N)NC(C1=C(C2CC2)N(C3=C4C(N=CC=C4)=CC=C3)N=C1)=O.CS(=O)(O)=O
Biological Activity: Zoniporide mesylate (CP-597396 mesylate) is a potent and selective NHE-1 inhibitor with cardioprotective activity. Zoniporide inhibits 22Na+ uptake by human NHE-1-expressing fibroblasts in a concentration-dependent manner (IC50=14 nM). Zoniporide inhibits platelet swelling in vitro with an IC50 of 0.059 μM. Zoniporide can be used in the study of cardiovascular disease[1].
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Zoniporide mesylate | Zoniporide mesylate (CP-597396 mesylate) is a potent and selective NHE-1 inhibitor with cardioprotective activity. Zoniporide inhibits 22Na+ uptake by human NHE-1-expressing fibroblasts in a concentration-dependent manner (IC50=14 nM). Zoniporide inhibits platelet swelling in vitro with an IC50 of 0.059 μM. Zoniporide can be used in the study of cardiovascular disease. | |||||||||||||||||||||
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Keywords
